Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations

Biochemical and Biophysical Research Communications

Volumn 399, Issue 4, 2010, Pages 555-559

  Singla, Nikhil ^a,b   Goldgur, Yehuda ^a   Xu, Kai ^a   Paavilainen, Sari ^c   Nikolov, Dimitar B ^a,b   Himanen, Juha P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Eph; Ephrin; Loop flexibility; Receptor tyrosine kinase; X ray crystallography

Indexed keywords

EPHRIN; EPHRIN B2; EPHRIN RECEPTOR A1; EPHRIN RECEPTOR A2; EPHRIN RECEPTOR A4; LIGAND;

ARTICLE; CONFORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; HUMANS; LIGANDS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPHA4;

EID: 77956262547     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.07.109     Document Type: Article

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