Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 4, 2012, Pages 1293-1298

  Morikawa, Takayuki ^a   Kajimura, Mayumi ^a,b   Nakamura, Tomomi ^a,c   Hishiki, Takako ^a   Nakanishi, Tsuyoshi ^a,d   Yukutake, Yoshinori ^a,b   Nagahata, Yoshiko ^b   Ishikawa, Mami ^a   Hattori, Katsuji ^a   Takenouchi, Toshiki ^a   Takahashi, Takao ^a   Ishii, Isao ^a   Matsubara, Kazuko ^a   Kabe, Yasuaki ^a,b   Uchiyama, Shinichiro ^c   Nagata, Eiichiro ^e   Gadalla, Moataz M ^f   Snyder, Solomon H ^f   Suematsu, Makoto ^a,b  

^a KEIO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d SHIMADZU CORPORATION   (Japan)

^e TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Energy metabolism; Gas biology; Gasotransmitter; Neurovascular unit

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBON MONOXIDE; CYSTATHIONINE BETA SYNTHASE; HEME OXYGENASE 2; HYDROGEN SULFIDE;

ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; BLOOD VESSEL REACTIVITY; BRAIN CORTEX; BRAIN FUNCTION; BRAIN MICROCIRCULATION; BRAIN SLICE; HYPOXIA; LASER MICROSCOPY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMALS; ANOXIA; BLOTTING, WESTERN; CARBON MONOXIDE; CEREBRUM; CYSTATHIONINE BETA-SYNTHASE; DNA PRIMERS; HEME OXYGENASE (DECYCLIZING); HYDROGEN SULFIDE; IMMUNOHISTOCHEMISTRY; MASS SPECTROMETRY; MICE; MICROCIRCULATION; MICROSCOPY, CONFOCAL; REGIONAL BLOOD FLOW; VASODILATION;

MUS;

EID: 84863012580     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119658109     Document Type: Article

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