The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph3PAu[SC(OR) = NPh] (R = Me, et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways

Journal of Inorganic Biochemistry

Volumn 127, Issue , 2013, Pages 24-38

  Yeo, Chien Ing ^a   Ooi, Kah Kooi ^b   Akim, Abdah Md ^b   Ang, Kok Pian ^b   Fairuz, Zainal Abidin ^a   Halim, Siti Nadiah Binti Abdul ^a   Ng, Seik Weng ^a,c   Seng, Hoi Ling ^a   Tiekink, Edward R T ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Apoptosis; Cancer; Carbonimidothioate; Cell cycle; Phosphinegold(I) compounds; Thiolate

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 2; CASPASE 3; CASPASE 4; CASPASE 5; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CD27 ANTIGEN; CD70 ANTIGEN; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BID; PROTEIN MCL 1; PROTEIN P53; PROTEIN P73; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN C RECEPTOR; TRIPHENYLPHOSPHINE GOLD CARBONIMIDOTHIOATE DERIVATIVE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 4; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; COLON CANCER; CYTOTOXICITY; DNA FRAGMENTATION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE PERMEABILITY; POLYMERASE CHAIN REACTION;

APOPTOSIS; CANCER; CARBONIMIDOTHIOATE; CELL CYCLE; PHOSPHINEGOLD(I) COMPOUNDS; THIOLATE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; HT29 CELLS; HUMANS; MODELS, MOLECULAR; ORGANOGOLD COMPOUNDS; REFERENCE STANDARDS;

EID: 84884405478     PISSN: 01620134     EISSN: 18733344     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2013.05.011     Document Type: Article

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