Gold derivatives for the treatment of cancer

Critical Reviews in Oncology/Hematology

Volumn 42, Issue 3, 2002, Pages 225-248

  Tiekink, Edward R T ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cancer; Gold(I); Gold(III); Phosphines; Rheumatoid arthritis; Thiolates

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIRHEUMATIC AGENT; ARSINE DERIVATIVE; AURANOFIN; CHEMICAL COMPOUND; CISPLATIN; CYCLOPHOSPHAMIDE; DNA; FERROCENE DERIVATIVE; GOLD DERIVATIVE; IMINE; MERCAPTOPURINE; ORGANOMETALLIC COMPOUND; PHOSPHINE DERIVATIVE; SULFUR; THIOL DERIVATIVE; THIOLATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER; CANCER CHEMOTHERAPY; CHEMICAL BINDING; CHIRALITY; CLINICAL TRIAL; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG TARGETING; GENE TARGETING; GOLD THERAPY; HUMAN; HYDROPHILICITY; MITOCHONDRION; NONHUMAN; REVIEW; RHEUMATOID ARTHRITIS; STRUCTURE ANALYSIS;

ANIMALS; DRUG EVALUATION, PRECLINICAL; GOLD COMPOUNDS; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036268977     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1040-8428(01)00216-5     Document Type: Review

References (109)

1. The history of gold therapy in rheumatoid disease
2. Gold in medicine
3. Immunopharmacology of gold
4. Gold compounds for rheumatoid arthritis
5. Gold(I) thiolates: Slow-acting anti-arthritic drugs
6. The biological chemistry of gold: A metallo-drug and heavy-atom label with variable valency
7. Medicinal gold compounds
8. The use of gold compounds in medicine
9. Gold complex research in medical science. Difficulties with experimental design
10. Gold in medicine - Chrysotherapy
11. Gold and silver in medicine
12. Gold complexes in cancer chemotherapy
13. The chemistry of gold drugs
14. Gold
15. Gold in medicine
16. Medical uses of gold compounds: Past, present and future
17. Medicinal chemistry and pharmacology of gold compounds
18. Metal complexes in medicine: Design and mechanism of action
19. Gold-based therapeutic agents
20. 2O
21. Crystal structure of the antiarthritic drug gold thiomalate (Myochrysine): A double-helical geometry in the solid state
22. An EXAFS study of gold coordination in the antiarthritic drugs myocrisin and solganol
23. EXAFS and WAXS structure determination for an antiarthritic drug, sodium gold(I) thiomalate
24. Structures of gold(I) and silver(I) thiolate complexes of medicinal interest: A review and recent results
25. 9PS
26. Complexes of metals other than platinum as antitumour agents
27. Medical applications of inorganic chemicals
28. Metal complexes in medicine: Design and mechanism of action
29. Metals in medicine
30. Treatment of rheumatoid arthritis with cytostatic drugs
31. Role of disease-modifying antirheumatic drugs versus cytotoxic agents in the therapy of rheumatoid arthritis
32. Cancer in rheumatoid arthritis: A prospective long-term study of mortality
33. Inhibitory effects of a new oral gold compound on HeLa cells
34. Effect of auranofin on DNA and protein synthesis in human lymphocytes
35. Cellular antiproliferative action exerted by auranofin
36. Screening trial with the coordinated gold compound auranofin using mouse lymphocytic leukemia P388
37. Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models
38. Primary tumor growth and formation of spontaneous lung metastases in mice bearing Lewis carcinoma treated with proteinase inhibitors
39. Antitumor effect of gold as revealed by growth suppression of cultured cancer cells
40. Effect of gold on survival of tumor-bearing mice
41. Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes
42. Cellular pharmacology of μ-[1,2-bis(diphenylphosphino)ethane]bis[(1-thio-β-D-glucopyranosato- S)gold(I)]: A novel antitumor agent
43. Antitumour activity of bis(diphenylphosphino)alkanes, their gold(I) coordination complexes, and related compounds
44. Copper(II) complexes with bidentate tertiary phosphine ligands: Solution chemistry and antitumor activity
45. Antimicrobial and anticancer activity of tetrahedral, chelated, diphosphine silver(I) complexes: Comparison with copper and gold
46. Modulation of the antitumor and biochemical properties of bis(diphenylphosphine)ethane with metals
47. + induced by thiols and blood plasma
48. 2O
49. Stable gold(I) complexes with chelate rings: Solution studies of bis(phosphino)ethane complexes and X-ray crystal structure of bis[1,2-bis(diphenylphosphino)ethane gold(I) hexafluoroantimonate-acetone (1/1)
50. Studies on the interaction of gold(I) phosphines with 2-thiouracil. Related studies with silver(I) phosphines
51. A novel anionic gold-indium cluster compound: Synthesis and molecular and electronic structure
52. In vivo antitumor activity and in vitro cytotoxic properties of bis[1,2-bis(diphenylphosphino)ethane]-gold(I) chloride
53. Cytotoxicity and antitumor activity of some tetrahedral bis(diphosphino)gold(I) chelates
54. Mechanism of alterations in isolated rat liver mitochondrial function induced by gold complexes of bidentate phosphines
55. Mechanism of toxicity of an experimental bidentate phosphine gold complexed antineoplastic agent in isolated rat hepatocytes
56. In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane
57. In vitro and in vivo hepatotoxicity of a novel antineoplastic agent SK and F 101772 in male beagle dogs
58. In vivo and in vitro cardiotoxicity of a gold-containing antineoplastic drug candidate in the rabbit
59. Structural and solution chemistry of gold(I) and silver(I) complexes of bidentate pyridyl phosphines: Selective antitumour agents
60. NMR and structural studies of gold(I) chloride adducts with bidentate 2-, 3- and 4-pyridyl phosphines
61. Antitumor phosphine complexes of gold(I) and silver(I): Relationship between lipophilicity, cellular uptake, and cytotoxicity
62. 2O
63. 6
64. Antitumor activity of gold(I), silver(I) and copper(I) complexes containing chiral tertiary phosphines
65. In vitro cytotoxic properties of gold(I) and platinum(II) compounds containing asymmetric [2-(methylsulfinyl)ethyl]diphenylarsine and its phosphorus analogue
66. Synthesis and anti-cancer activities of a pair of enantiomeric gold(I) complexes containing sulfanyl-substituted P-stereogenic phosphines
67. Chiral phosphine ligands derived from sugars 10. Syntheses, structure, characterization, and antitumor activity of the gold(I) complexes with sugar-substructure phosphine ligands
68. Anti-tumor activity of two binuclear gold(I) complexes with bridging dithiolate ligands
69. Synthesis and biological activity of gold and tin compounds in ovarian cancer cells
70. Nitrogen, sulfur and oxygen donor adducts with copper(II) complexes of antitumor 2-formylpyridinethiosemicarbazone analogs: Physiochemical and cytotoxic studies
71. 8-(Thiotheophyllinato)(triphenylphosphine)gold(I) (tTPau): A new complex of therapeutic gold ion
72. Intracellular accumulation and cytotoxic effect of (8-thiotheophyllinate)(triphenylphosphine)gold(I) in Friend leukemia cells
73. The 8-(thiotheophyllinato)(triphenylphosphine)gold(I) (tTPau): A new gold complex as an anticancer agent
74. Studies on the interaction of gold(I) phosphines with 2-thiouracil. Related studies with silver(I) phosphines
75. Phosphinegold(I) complexes containing the purine-6-thiolate anion, and their antiarthritic activity
76. Anti-arthritic activity in rats of some phosphinegold(I) thionucleobases and related thiolates
77. Triorganophosphinegold(I) thionucleobases
78. In vitro antitumour activity of some triorganophosphinegold(I) thionucleobases
79. Anti-tumor activity, in vitro and in vivo, of some triphenylphosphinegold(I) thionucleobases
80. 3PAu(SR′), R=Ph, Cy, Et; SR′H=6-mercaptopurine and R=Et; SR′H=6-thioguanine
81. Characterisation and in vitro cytotoxicity of triorganophosphinegold(I) 2-mercaptobenzoate complexes
82. Preparation and crystal structure of new gold(I) complexes linked to pyrimidines
83. Reaktionen von tetrachloroaurat mit verschiedenen aminen
84. Antitumour bis(cyclopentadienyl)metal complexes. Gold complexes in cancer chemotherapy
85. 1,1(-Bis(diphenylphosphino)ferrocene]bis(chlorogold): Synthesis, iron-57 and gold-197 Mossbauer spectroscopy, X-ray crystal structure, and antitumor activity
86. New potentially cytotoxic thiolatogold(I) comlpexes of 1,1(-bis(diphenylphosphino)ferrocene
87. New iron(II)- and gold(I)-containing metallocenes. X-ray structure of a three-coordinate gold(I) ferrocenophane-type representative
88. Synthesis, structure of nitrogen-containing phosphinegold(I) ferrocenes. In vitro activity against bladder and colon carcinoma cell lines
89. - anions
90. Interacciones moleculares entre los aniones complejos de los metales de transición y bases orgánicas nitrogenadas de importancia biológica
91. Bifunctional antitumor compounds: Synthesis and characterization of a Au(III)-streptonigrin complex with thiol-modulating properties
92. Chlorogold(I) and gold(III) complexes of 6-amino-1,3-dimethyl-5-arylazouracil derivatives: IR spectroscopy, growth inhibition of HeLa cells and X-ray crystal structure of 6-amino-1,3-dimethyl-5-phenylazoniumuracil dichloroaurate(I) sesquihydrate
93. Cytotoxicity and DNA binding properties of a chloro glycylhistidinate gold(III) complex (GHAu)
94. Cytotoxic activity of some gold(III) complexes
95. 2(pm)
96. Cytotoxic effects of gold(III) complexes on established human tumor cell lines sensitive and resistant to cisplatin
97. Gold(III) compounds as potential antitumor agents: Cytotoxicity and DNA binding properties of some selected polyamine-gold(III) complexes
98. 2(esal)]
99. Structure and cytotoxic properties of some selected gold(III) complexes
100. Gold(III) complexes as potential antitumour agents: Solution chemistry and cytotoxic properties of some selected gold(III) compounds
101. Chemical and biological studies of dichloro(2-((dimethylamino)methyl)phenyl)gold(III)
102. Antitumor properties of some 2-[(dimethylamino)methyl]phenylgold(III)
103. 2(dmamp)]
104. 2)-2-(OMe)-5}Au{RNC (O)NR}] (R=Ph and C(O)Me)
105. Organogold(III) metallacyclic chemistry. Part 4. Synthesis, characterisation, and biological activity of gold(III)-thiosalicylate and -salicylate complexes
106. Biologically active gold(III) complexes
107. A screening strategy for metal antitumor agents as exemplified by gold(III) complexes
108. 2]