Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases

Journal of Medicinal Chemistry

Volumn 53, Issue 4, 2010, Pages 1830-1842

  Long, Jonathan Z ^a   Jin, Xin ^a   Adibekian, Alexander ^a   Li, Weiwei ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 4 (HYDROXYBIS(4 METHOXYPHENYL)METHYL)PYRROLIDIN 2 ONE; 4 (DIPHENYLMETHYLENE)PIPERADINE; 4 NITROPHENYL 2,2 DIPHENYL 1 OXA 6 AZASPIROL[2.5]OCTANE 6 CARBOXYLATE; 4 NITROPHENYL 3 (HYDROXYBIS(4 METHOXYPHENYL)METHYL)PYRROLIDINE 1 CARBOXYLATE; 4 NITROPHENYL 3,3 DIPHENYLPROPYL(ETHYL)CARBAMATE; 4 NITROPHENYL 4 (4 BENZYLOXY) 2 METHOXYBENZYL)PIPERAZINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (4 METHOXYBENZYL)PIPERAZINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (BIPHENYL 2 YLMETHYL)PIPERAZINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (BIS(3,4 DIMETHOXYPHENYL)(HYDROXY)METHYL)PIPERIDINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (BIS(4 CHLOROPHENYL)(HYDROXY)METHYL)PIPERIDINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (BIS(4 DIMETHYLAMINO)PHENYL)HYDROXY)METHYL)PIPERIDINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (DIPHENYLMETHYLENE)PIPERADINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (HYDROXYBIS(2 METHOXYPHENYL)METHYL)PIPERIDINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (HYDROXYBIS(3 METHOXYPHENYL)METHYL)PIPERIDINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (HYDROXYDINAPHTHALEN 2 YLMETHYL)PIPERIDINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (HYDROXYDIPHENYLMETHYL)PIPERADINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (NAPHTHALEN 2 YLMETHYL)PIPERAZINE 1 CARBOXYLATE; 4 NITROPHENYL 4 (QUINOLIN 2 YLMETHYL)PIPERAZINE 1 CARBOXYLATE; 4 NITROPHENYL 4 BENZYLPIPERAZINE 1 CARBOXYLATE; 4 NITROPHENYL 4 BIPHENYL 4 YLMETHYL)PIPERZINE 1 CARBOXYLATE; CARBAMIC ACID DERIVATIVE; ENDOCANNABINOID; HYDROLASE INHIBITOR; PIPERAZINE; PIPERIDINE; SERINE; TERT BUTYL 4 (4 METHOXYBENZYL)PIPERAZINE 1 CARBOXYLATE; TERT BUTYL 4 HYDROXYBIS(4 METHOXYPHENYL)METHYL)PIPERADINE 1 CARBOXYLATE; TERT BUTYL 4 NAPHTHALEN 2 YLMETHYL)PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG SYNTHESIS; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANIMALS; BRAIN; CARBAMATES; MICE; MONOACYLGLYCEROL LIPASES; PIPERAZINES; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77649198453     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9016976     Document Type: Article

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