Therapeutic potential of monoacylglycerol lipase inhibitors

Life Sciences

Volumn 92, Issue 8-9, 2013, Pages 492-497

  Mulvihill, Melinda M ^a   Nomura, Daniel K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cancer; Cannabinoid; Eicosanoid; Endocannabinoid; Inflammation; JZL184; MAGL; mgll; Monoacylglycerol lipase; Neurodegenerative disease; Prostaglandin

Indexed keywords

ACYLGLYCEROL LIPASE; DICLOFENAC; ENZYME INHIBITOR; ESTERASE INHIBITOR; JZL 184; MONOACYLGLYCEROL LIPASE INHIBITOR; NOCICEPTIN; RIMONABANT; UNCLASSIFIED DRUG;

ADDICTION; ANXIETY; BIOCHEMISTRY; CONFERENCE PAPER; DEGENERATIVE DISEASE; DEPRESSION; DRUG MECHANISM; GASTROINTESTINAL HEMORRHAGE; HUMAN; INFLAMMATION; LOW DRUG DOSE; NONHUMAN; OBESITY; PROTEIN FUNCTION; SIDE EFFECT; SUICIDAL BEHAVIOR;

ANIMALS; ANXIETY; ENZYME INHIBITORS; HUMANS; INFLAMMATION; MONOACYLGLYCEROL LIPASES; NEOPLASMS; PAIN; SUBSTANCE-RELATED DISORDERS;

CANNABIS SATIVA;

EID: 84874652001     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.10.025     Document Type: Conference Paper

References (84)

1. K. Ahn, M.K. McKinney, and B.F. Cravatt Enzymatic pathways that regulate endocannabinoid signaling in the nervous system Chem Rev 108 2008 1687 1707 (Pubitemid 351796405)
2. S. Aid, and F. Bosetti Targeting cyclooxygenases-1 and -2 in neuroinflammation: therapeutic implications Biochimie 93 2011 46 51
3. M. Alhouayek, D.M. Lambert, N.M. Delzenne, P.D. Cani, and G.G. Muccioli Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation FASEB J 25 2011 2711 2721
4. S. Batkai, D. Osei-Hyiaman, H. Pan, O. El-Assal, M. Rajesh, and P. Mukhopadhyay Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury FASEB J 21 2007 1788 1800 (Pubitemid 46855625)
5. J.L. Blankman, G.M. Simon, and B.F. Cravatt A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol Chem Biol 14 2007 1347 1356 (Pubitemid 350257008)
6. J.V. Bonventre, Z. Huang, M.R. Taheri, E. O'Leary, E. Li, and M.A. Moskowitz Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2 Nature 390 1997 622 625 (Pubitemid 28016198)
7. P.D. Bos, X.H.F. Zhang, C. Nadal, W.P. Shu, R.R. Gomis, and D.X. Nguyen Genes that mediate breast cancer metastasis to the brain Nature 459 2009 1005 U1137
8. D. Bridges, K. Ahmad, and A.S. Rice The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain Br J Pharmacol 133 2001 586 594 (Pubitemid 32591925)
9. M.W. Buczynski, D.S. Dumlao, and E.A. Dennis An integrated omics analysis of eicosanoid biology (vol 50, pg 1015, 2009) J Lipid Res 50 2009 1505-1505
10. A. Busquets-Garcia, E. Puighermanal, A. Pastor, R. de la Torre, R. Maldonado, and A. Ozaita Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses Biol Psychiatry 70 2011 479 486
11. M.C. Cathcart, J. Lysaght, and G.P. Pidgeon Eicosanoid signalling pathways in the development and progression of colorectal cancer: novel approaches for prevention/intervention Cancer Metastasis Rev 30 2011 363 385
12. P.K. Chanda, Y. Gao, L. Mark, J. Btesh, B.W. Strassle, and P.M. Lu Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system Mol Pharmacol 78 2010 996 1003
13. S.H. Choi, and F. Bosetti Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid Aging-Us 1 2009 234 244
14. Y.C. Chung, E. Bok, S.H. Huh, J.Y. Park, S.H. Yoon, and S.R. Kim Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation J Immunol 187 2011 6508 6517
15. B. Costa, M. Colleoni, S. Conti, A.E. Trovato, M. Bianchi, and M.L. Sotgiu Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain Br J Pharmacol 141 2004 4 8 (Pubitemid 38241157)
16. B.F. Cravatt, K. Demarest, M.P. Patricelli, M.H. Bracey, D.K. Giang, and B.R. Martin Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase Proc Natl Acad Sci U S A 98 2001 9371 9376 (Pubitemid 32743923)
17. V. Di Marzo A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists Trends Pharmacol Sci 27 2006 134 140
18. V. Di Marzo, M. Bifulco, and L. De Petrocellis The endocannabinoid system and its therapeutic exploitation Nat Rev Drug Discov 3 2004 771 784 (Pubitemid 39242829)
19. C.A. Dinarello Anti-inflammatory agents: present and future Cell 140 2010 935 950
20. T.P. Dinh, D. Carpenter, F.M. Leslie, T.F. Freund, I. Katona, and S.L. Sensi Brain monoglyceride lipase participating in endocannabinoid inactivation Proc Natl Acad Sci U S A 99 2002 10819 10824
21. T.P. Dinh, S. Kathuria, and D. Piomelli RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol Mol Pharmacol 66 2004 1260 1264 (Pubitemid 39411065)
22. A. Fox, A. Kesingland, C. Gentry, K. McNair, S. Patel, and L. Urban The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain Pain 92 2001 91 100 (Pubitemid 32367940)
23. S.H. Fox, B. Henry, M. Hill, A. Crossman, and J. Brotchie Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's disease Mov Disord 17 2002 1180 1187 (Pubitemid 36041331)
24. Y. Gao, D.V. Vasilyev, M.B. Goncalves, F.V. Howell, C. Hobbs, and M. Reisenberg Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice J Neurosci 30 2010 2017 2024
25. M. Garcia-Arencibia, S. Gonzalez, E. de Lago, J.A. Ramos, R. Mechoulam, and J. Fernandez-Ruiz Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties Brain Res 1134 2007 162 170 (Pubitemid 46135535)
26. C.K. Glass, K. Saijo, B. Winner, M.C. Marchetto, and F.H. Gage Mechanisms underlying inflammation in neurodegeneration Cell 140 2010 918 934
27. J. Guindon, A. Guijarro, D. Piomelli, and A.G. Hohmann Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain Br J Pharmacol 163 2011 1464 1478
28. M. Guzman Cannabinoids: potential anticancer agents Nat Rev Cancer 3 2003 745 755 (Pubitemid 37328813)
29. M.M. Ibrahim, H. Deng, A. Zvonok, D.A. Cockayne, J. Kwan, and H.P. Mata Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS Proc Natl Acad Sci U S A 100 2003 10529 10533 (Pubitemid 37071912)
30. K. Jaworski, M. Ahmadian, R.E. Duncan, E. Sarkadi-Nagy, K.A. Varady, and M.K. Hellerstein AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency Nat Med 15 2009 159 168
31. I.A. Khasabova, A. Chandiramani, C. Harding-Rose, D.A. Simone, and V.S. Seybold Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain Pharmacol Res 64 2011 60 67
32. S.G. Kinsey, J.Z. Long, S.T. O'Neal, R.A. Abdullah, J.L. Poklis, and D.L. Boger Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain J Pharmacol Exp Ther 330 2009 902 910
33. S.G. Kinsey, A. Mahadevan, B.J. Zhao, H. Sun, P.S. Naidu, and R.K. Razdan The CB(2) cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects Neuropharmacology 60 2011 244 251
34. S.G. Kinsey, D.K. Nomura, S.T. O'Neal, J.Z. Long, A. Mahadevan, and B.F. Cravatt Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice J Pharmacol Exp Ther 338 2011 795 802
35. S.G. Kinsey, S.T. O'Neal, J.Z. Long, B.F. Cravatt, and A.H. Lichtman Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay Pharmacol Biochem Behav 98 2011 21 27
36. F. Kopp, T. Komatsu, D.K. Nomura, S.A. Trauger, J.R. Thomas, and G. Siuzdak The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice Chem Biol 17 2010 831 840
37. L.A. Kotilinek, M.A. Westerman, Q. Wang, K. Panizzon, G.P. Lim, and A. Simonyi Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity Brain 131 2008 651 664 (Pubitemid 351294724)
38. A. Ligresti, S. Petrosino, and V. Di Marzo From endocannabinoid profiling to 'endocannabinoid therapeutics' Curr Opin Chem Biol 13 2009 321 331
39. J.Z. Long, and B.F. Cravatt The metabolic serine hydrolases and their functions in mammalian physiology and disease Chem Rev 111 2011 6022 6063
40. J.Z. Long, W. Li, L. Booker, J.J. Burston, S.G. Kinsey, and J.E. Schlosburg Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects Nat Chem Biol 5 2009 37 44
41. J.Z. Long, D.K. Nomura, and B.F. Cravatt Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism Chem Biol 16 2009 744 753
42. J.Z. Long, D.K. Nomura, R.E. Vann, D.M. Walentiny, L. Booker, and X. Jin Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo Proc Natl Acad Sci U S A 106 2009 20270 20275
43. A.C. McKee, I. Carreras, L. Hossain, H. Ryu, W.L. Klein, and S. Oddo Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice Brain Res 1207 2008 225 236
44. R. Mechoulam, S. Benshabat, L. Hanus, M. Ligumsky, N.E. Kaminski, and A.R. Schatz Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors Biochem Pharmacol 50 1995 83 90
45. J. Miner, and A. Hoffhines The discovery of aspirin's antithrombotic effects Tex Heart Inst J 34 2007 179 186 (Pubitemid 47066594)
46. J.A. Mitchell, and T.D. Warner COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs Nat Rev Drug Discov 5 2006 75 86
47. F.A. Moreira, M. Grieb, and B. Lutz Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression Best Pract Res Clin Endocrinol Metab 23 2009 133 144
48. K. Nithipatikom, M.P. Endsley, M.A. Isbell, J.R. Falck, Y. Iwamoto, and C.J. Hillard 2-Arachidonoylglycerol: a novel inhibitor of androgen-independent prostate cancer cell invasion Cancer Res 64 2004 8826 8830 (Pubitemid 39665485)
49. K. Nithipatikom, M.P. Endsley, M.A. Isbell, C.E. Wheelock, B.D. Hammock, and W.B. Campbell A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells Biochem Biophys Res Commun 332 2005 1028 1033 (Pubitemid 40798189)
50. K. Nithipatikom, M.A. Isbell, M.P. Endsley, J.E. Woodliff, and W.B. Campbell Anti-proliferative effect of a putative endocannabinoid, 2-arachidonylglyceryl ether in prostate carcinoma cells Prostaglandins Other Lipid Mediat 94 2011 34 43
51. D.K. Nomura, D.P. Lombardi, J.W. Chang, S. Niessen, A.M. Ward, and J.Z. Long Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer Chem Biol 18 2011 846 856
52. D.K. Nomura, B.E. Morrison, J.L. Blankman, J.Z. Long, S.G. Kinsey, and M.C. Marcondes Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation Science 334 2011 809 813
53. B. Pan, W. Wang, J.Z. Long, D.L. Sun, C.J. Hillard, and B.F. Cravatt Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl) piperidine-1-carboxylate (JZL184) enhances retrograde endocannabinoid signaling J Pharmacol Exp Ther 331 2009 591 597
54. D. Parolaro, and T. Rubino The role of the endogenous cannabinoid system in drug addiction Drug News Perspect 21 2008 149 157 (Pubitemid 351809138)
55. C. Patrono, L.A. Garcia Rodriguez, R. Landolfi, and C. Baigent Low-dose aspirin for the prevention of atherothrombosis N Engl J Med 353 2005 2373 2383 (Pubitemid 41713749)
56. Piro JR, Benjamin DI, Duerr JM, Pi Y, Gonzales C, Wood KM, et al. A dysregulated endocannabinoid-eicosanoid network supports pathogenesis in a mouse model of Alzheimer's disease. Cell Rep in press.
57. D.A. Price, A.A. Martinez, A. Seillier, W. Koek, Y. Acosta, and E. Fernandez WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease Eur J Neurosci 29 2009 2177 2186
58. A. Quartilho, H.P. Mata, M.M. Ibrahim, T.W. Vanderah, F. Porreca, and A. Makriyannis Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors Anesthesiology 99 2003 955 960 (Pubitemid 37186088)
59. D. Ramesh, G.R. Ross, J.E. Schlosburg, R.A. Owens, R.A. Abdullah, and S.G. Kinsey Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice J Pharmacol Exp Ther 339 2011 173 185
60. B.G. Ramirez, C. Blazquez, T. Gomez del Pulgar, M. Guzman, and M.L. de Ceballos Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation J Neurosci 25 2005 1904 1913 (Pubitemid 40289395)
61. A.B. Reksidler, M.M. Lima, S.M. Zanata, H.B. Machado, C. da Cunha, and R. Andreatini The COX-2 inhibitor parecoxib produces neuroprotective effects in MPTP-lesioned rats Eur J Pharmacol 560 2007 163 175 (Pubitemid 46341312)
62. J. Rogers, L.C. Kirby, S.R. Hempelman, D.L. Berry, P.L. McGeer, and A.W. Kaszniak Clinical trial of indomethacin in Alzheimer's disease Neurology 43 1993 1609 1611 (Pubitemid 23230557)
63. J. Romero, and J.M. Orgado Cannabinoids and neurodegenerative diseases CNS Neurol Disord Drug Targets 8 2009 440 450
64. C.A. Rouzer, and L.J. Marnett Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways Chem Rev 111 2011 5899 5921
65. R. Sanchez-Pernaute, A. Ferree, O. Cooper, M. Yu, A.L. Brownell, and O. Isacson Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease J Neuroinflammation 1 2004 6
66. J.E. Schlosburg, B.L. Carlson, D. Ramesh, R.A. Abdullah, J.Z. Long, and B.F. Cravatt Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice AAPS J 11 2009 342 352
67. J.E. Schlosburg, J.L. Blankman, J.Z. Long, D.K. Nomura, B. Pan, and S.G. Kinsey Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system Nat Neurosci 13 2010 1113 1119
68. C. Schneider, and A. Pozzi Cyclooxygenases and lipoxygenases in cancer Cancer Metastasis Rev 30 2011 277 294
69. N.R. Sciolino, W. Zhou, and A.G. Hohmann Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats Pharmacol Res 64 2011 226 234
70. E.L. Scotter, M.E. Abood, and M. Glass The endocannabinoid system as a target for the treatment of neurodegenerative disease Br J Pharmacol 160 2010 480 498
71. T. Seif, A. Makriyannis, G. Kunos, A. Bonci, and F.W. Hopf The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing Neuroscience 193 2011 21 33
72. M.A. Sticht, J.Z. Long, E.M. Rock, C.L. Limebeer, R. Mechoulam, and B.F. Cravatt Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats Br J Pharmacol 165 2012 2425 2435
73. A. Straiker, and K. Mackie Cannabinoid signaling in inhibitory autaptic hippocampal neurons Neuroscience 163 2009 190 201
74. A. Straiker, S.S.J. Hu, J.Z. Long, A. Arnold, J. Wager-Miller, and B.F. Cravatt Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons Mol Pharmacol 76 2009 1220 1227
75. T. Sugiura, S. Kondo, A. Sukagawa, S. Nakane, A. Shinoda, and K. Itoh 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain Biochem Biophys Res Commun 215 1995 89 97
76. J.J. Sumislawski, T.S. Ramikie, and S. Patel Reversible gating of endocannabinoid plasticity in the amygdala by chronic stress: a potential role for monoacylglycerol lipase inhibition in the prevention of stress-induced behavioral adaptation Neuropsychopharmacology 36 2011 2750 2761
77. B. Szabo, M.J. Urbanski, T. Bisogno, V. Di Marzo, A. Mendiguren, and W.U. Baer Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol J Physiol (Lond) 577 2006 263 280 (Pubitemid 44698254)
78. C.A. Szekely, J.C.S. Breitner, A.L. Fitzpatrick, T.D. Rea, B.M. Psaty, and L.H. Kuller NSAID use and dementia risk in the cardiovascular health study - role of APOE and NSAID type Neurology 70 2008 17 24
79. A. Tanimura, M. Yamazaki, Y. Hashimotodani, M. Uchigashima, S. Kawata, and M. Abe The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission Neuron 65 2010 320 327
80. P. Teismann, K. Tieu, D.K. Choi, D.C. Wu, A. Naini, and S. Hunot Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration Proc Natl Acad Sci U S A 100 2003 5473 5478 (Pubitemid 36542729)
81. R.F. Tuma, and S. Steffens Targeting the endocannabinoid system to limit myocardial and cerebral ischemic and reperfusion injury Curr Pharm Biotechnol 13 2012 46 58
82. K.J. Valenzano, L. Tafesse, G. Lee, J.E. Harrison, J.M. Boulet, and S.L. Gottshall Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy Neuropharmacology 48 2005 658 672 (Pubitemid 40462406)
83. L. Ye, B. Zhang, E.G. Seviour, K.X. Tao, X.H. Liu, and Y. Ling Monoacylglycerol lipase (MAGL) knockdown inhibits tumor cells growth in colorectal cancer Cancer Lett 307 2011 6 17
84. C. Zanettini, L.V. Panlilio, M. Alicki, S.R. Goldberg, J. Haller, and S. Yasar Effects of endocannabinoid system modulation on cognitive and emotional behavior Front Behav Neurosci 5 2011 57