Development of a 32p-postlabeling/HPLC method for detection of dehydroretronecine-derived DNA adducts in vivo and in vitro

Chemical Research in Toxicology

Volumn 14, Issue 1, 2001, Pages 91-100

  Yang, Ya Chen ^a   Yan, Jian ^a   Churchwell, Mona ^a   Beger, Richard ^a   Chan, Po Cheun ^b   Doerge, Daniel R ^a   Fu, Peter P ^a   Chou, Ming W ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEHYDRORETRONECINE; DEOXYGUANOSINE PHOSPHATE; DNA; PHOSPHORUS 32; PYRROLIZIDINE ALKALOID; PYRROLIZIDINE DERIVATIVE; RETRONECINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; DNA ADDUCT; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SYNTHESIS;

ANIMALS; ASPERGILLUS NUCLEASE S1; CARCINOGENS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYADENINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DNA; DNA ADDUCTS; EXONUCLEASES; FEMALE; ISOTOPE LABELING; MICROCOCCAL NUCLEASE; MONOCROTALINE; PHOSPHORUS RADIOISOTOPES; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0035148628     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000149o     Document Type: Article

References (4)

1. Bull, L. B., Culvenor, C. C. J., and Dick, A. J. (1968) The Pyrrolizidine Alkaloids. Their Chemistry, Pathogenicity and other Biological Properties, North-Holland, Amsterdam.
2. International Agency for Research on Cancer (1976) Pyrrolizidine alkaloids. In IARC Monograph on the Evaluation of Carcinogenic Risk of Chemicals to Man: Some Naturally Occurring Substance, Vol. 10, pp 265-342, International Agency for Research on Cancer, Lyon, France.
3. Schoental, R. (1976) Carcinogens in plants and microorganisms. In Chemical Carcinogens (Searle, C. E., Ed.) ACS Monograph 173, American Chemical Society, Washington, DC.
4. World Health Organization (1988) Pyrrolizidine Alkaloids. In International Programme on Chemical Safety, Environmental Health Criteria, Vol. 80, p 337, World Health Organization, Geneva.