Genotoxic pyrrolizidine alkaloids - Mechanisms leading to DNA adductformation and tumorigenicity

International Journal of Molecular Sciences

Volumn 3, Issue 9, 2002, Pages 948-964

  Fu, Peter P ^a   Xia, Qingsu ^a   Lin, Ge ^b   Chou, Ming W ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

DNA adducts; Genotoxic mechanism; Pyrrolizidine alkaloids; Riddelliine; Tumorigenicity

Indexed keywords

6,7 DIHYDRO 7 HYDROXY 1 HYDROXYMETHYL 5H PYRROLIZINE; BIOLOGICAL MARKER; CARCINOGEN; CLIVORINE; HELIOTRIDINE; HELIOTRINE; HYDROXYSENKIRKINE; INTERMEDINE; ISATIDINE; JACOBINE; LASIOCARPINE; LYCOPASAMINE; LYCOPSAMINE; MONOCROTALINE; OTONECINE; PATASITENINE; PLATYNECINE; PYRROLIZIDINE ALKALOID; PYRROLIZINE DERIVATIVE; RETRONECINE; RETRORSINE; RIDDELLINE; SENECIONINE; SENECIPHYLLINE; SENKIRKINE; SYMPHYTINE; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENICITY; DNA ADDUCT; DNA BINDING; DNA CROSS LINKING; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; HYDROXYLATION; LIVER TOXICITY; LIVER TUMOR; METABOLIC ACTIVATION; MUTAGENESIS; NONHUMAN; OXIDATION; PROTEIN CROSS LINKING; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 3242790981     PISSN: 14220067     EISSN: None     Source Type: Journal    
DOI: 10.3390/i3090948     Document Type: Article

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