Bioactive acetylenic metabolites

Phytomedicine

Volumn 20, Issue 13, 2013, Pages 1145-1159

  Kuklev, Dmitry V ^a   Domb, Abraham J ^b   Dembitsky, Valery M ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Acetylenic metabolits; Acids; Antibacterial Fatty alcohols; Antifungal; Antitumor; Carotenoids; Cyclohexanoids; Fungi; Plants; Polyacetylenes; Polyynes

Indexed keywords

10 HYDROXY 2,4,6,8 UNDECATETRAYNAMIDE; 18 BROMO 9 HYDROXY 12,13 TRANS EPOXY OCTADECA 10,15 DIENE 17 YNOIC ACID METHYL ESTER; 3,4,13 TRIHYDROXY TETRADECA 5,7,9,11TETRAYNOIC ACID GAMMA LACTONE; ACETYLENE DERIVATIVE; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; ASPERPENTYN; BIFORMIN; BIOFORMINIC ACID; CAROTENOID; DROSOPHILIN C; DROSOPHILIN D; DRUG METABOLITE; ETHER DERIVATIVE; FALCARINDIOL; FATTY ALCOHOL; GAMMA GLUTAMYL L 2 AMINOHEX 4 YNOIC ACID; GAMMA L GLUTAMYL L ERYTHRO 2 AMINO 3 HYDROXYHEX 4YNOIC ACID; HARVEYNONE; KETONE DERIVATIVE; MASUTAKIC ACID A; MYCENON; MYCOMYCIN; OXIRAPENTYN; OXIRAPENTYNS B; PANAXYNOL; REPANDIOL; TRICHOLOMENYNS A; TRICHOLOMENYNS B; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; ASPERGILLUS OCHRACEUS; BIOLOGICAL ACTIVITY; CANDIDA ALBICANS; CYTOTOXICITY; DROSOPHILA; EDIBLE MUSHROOM; FUNGUS CULTURE; IC 50; NONHUMAN; PRIORITY JOURNAL; TRICHOPHYTON MENTAGROPHYTES;

FUNGI;

ACETYLENIC METABOLITS; ACIDS; ANTIBACTERIAL; ANTIFUNGAL; ANTITUMOR; CAROTENOIDS; CYCLOHEXANOIDS; FATTY ALCOHOLS; FUNGI; PLANTS; POLYACETYLENES; POLYYNES;

ALKYNES; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; FUNGI; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MEDICINE, CHINESE TRADITIONAL; MOLECULAR STRUCTURE; PLANT ROOTS; PLANTS;

EID: 84884210912     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.06.009     Document Type: Article

References (213)

1. M. Ahmed, M.T.W. Hearn, E.R.H. Jones, and V. Thaller Natural acetylenes. Part LI. Biosynthetic studies with C18 acetylenic precursors in fungal cultures. Origin of the carbon skeletons of mycomycin and drosophilins C and D Journal of Chemical Research 5S 1977 125 131
2. B.Z. Ahn, and S.I. Kim Relation between structure and cytotoxic activity of panaxydol analogs against L1210 cells Archiv der Pharmazie (Weinheim) 321 1988 61 63
3. J. Alanko, Y. Kurahashi, T. Yoshimoto, S. Yamamoto, and K. Baba Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases Biochemical Pharmacology 48 1994 1979 1981
4. M. Anchel Acetylenic compounds from fungi Journal of the American Chemical Society 74 1952 1588 1590
5. M. Anchel Characterization of drosophilin C as a polyacetylene Archives of Biochemistry and Biophysics 43 1953 127 135
6. M. Anchel Some naturally occurring antibiotic polyacetylenes Transactions of the New York Academy of Sciences 16 1954 337 342
7. M. Anchel, and M.P. Cohen Biformin. I. Its characterization as a polyacetylenic 9-carbon glycol Journal of Biological Chemistry 208 1954 319 326
8. A.B. Andersen, J. Lam, and P. Wrang Polyunsaturated compounds of Centaurea scabiosa Phytochemistry 16 1977 1829 1831
9. A. Andolfi, L. Mugnai, J. Luque, G. Surico, A. Cimmino, and A. Evidente Phytotoxins produced by fungi associated with grapevine trunk diseases Toxins 3 2011 1569 1605
10. T. Anke, B.M. Giannetti, and W.Z. Steglich Antibiotics from basidiomycetes. XV. 1-Hydroxy-2-nonyn-4-one, an antifungal and cytotoxic metabolite from Ischnoderma benzoinum (Wahl.) Karst Zeitschrift fuer Naturforschung 37C 1982 1 4
11. I.N. Asheshov, F. Strelitz, E.A. Hall, and H. Flon A survey of actinomycetes for antiphage activity Antibiotics and Chemotherapy (Washington) 4 1954 380 394
12. P. Bador, and J. Paris Acetylenic enzymic inhibitors: chemotherapeutic interest Pharmaceutica Acta Helvetiae 65 1990 305 310
13. Bae, H.O., Chae, G.Y., Chung, H.T., Jang, S.I., Kwon, T.O., Lee, H.S., Oh, H.C., Yun, Y.G., 2003. Acetylene compounds separated from Acanthopanax senticosus and composition containing the same to induce apoptosis. Kongkae Taeho Kongbo. Korean Patent: KP 2003059643 A 20030710.
14. K.H. Bae, and H.J. Jung Biological polyacetylenes from Gymnaster koraiensis (Nakai) Kitamura. Recent Advances in Natural Products Research Proceedings of the International Symposium on Recent Advances in Natural Products Research 3rd, Seoul, Republic of Korea, Nov. 19 1999 37 41
15. J. Baeuerle, T. Anke, R. Jente, and F. Bosold Antibiotics from Basidiomycetes. XVI. Antimicrobial and cytotoxic polyines from Mycena viridimarginata Karst Archives of Microbiology 132 1982 194 196
16. M. Baranska, H. Schulz, R. Baranski, T. Nothnagel, and L.P. Christensen In situ simultaneous analysis of polyacetylenes, carotenoids and polysaccharides in carrot roots Journal of the Agriculture and Food Chemistry 53 2005 6565 6571
17. J. Beer Natural alkynes Wiadomosci Chemiczne (Polska) 9 1955 460 481
18. F. Bellina, A. Carpita, L. Mannocci, and R. Rossi First total synthesis of naturally occurring (-)-nitidon and its enantiomer European Journal of Organic Chemistry 12 2004 2610 2619
19. J. Bero, M. Frederich, and J. Quetin-Leclercq Antimalarial compounds isolated from plants used in traditional medicine Journal of Pharmacy and Pharmacology 61 2009 1401 1433
20. F. Bohlmann, C. Arndt, H. Bornowski, H. Jastrow, and K.M. Kleine Polyacetylenic compounds. XXXVIII. New polyynes from the tribe Anthemideae Berichte 95 1962 1320 1327
21. F. Bohlmann, and J. Ziesche Naturally occurring terpene derivatives. Part 253. New guaianolides and acetylenic compounds from Ptilostemon species Phytochemistry 19 1980 692 696
22. D.L. Campbell The Tea Book 1995 Pelican Publishing Gretna 223
23. N.M. Carballeira New advances in fatty acids as antimalarial, antimycobacterial and antifungal agents Progress in Lipid Research 47 2008 50 61
24. L. Casu, L. Bonsignore, M. Pinna, M. Casu, C. Floris, J. Gertsch, and F. Cottiglia Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus Journal of Natural Products 69 2006 295 298
25. E.B. Chain Chemistry and biochemistry of new antibiotics Giornae Italian Chemioterapea 4 1958 213 242
26. X.L. Chang, Y.B. Ma, X.M. Zhang, Z.Y. Jiang, and J.J. Chen Studies on chemical constituents of rhizomes of Ligusticum chuanxiong Zhongguo Zhong Yao Za Zhi 32 2007 1533 1536
27. J. Chen, W. Zhang, T. Lu, J. Li, Y. Zheng, and L. Kong Morphological and genetic characterization of a cultivated Cordyceps sinensis fungus and its polysaccharide component possessing antioxidant property in H-22 tumor bearing mice Life Sciences 78 2006 2742 2748
28. L.P. Christensen, and H.B. Jakobsen Polyacetylenes: distribution in higher plants, pharmacological effects and analysis Chromatographic Science Series 99 2008 757 816
29. L.P. Christensen, and S. Kreutzmann Determination of polyacetylenes in carrot roots (Daucus carota L.) by high-performance liquid chromatography coupled with diode array detection Journal of Separation Science 30 2007 483 490
30. S.Y. Choi, E.M. Ahn, M.C. Song, D.W. Kim, J.H. Kang, O.S. Kwon, T.C. Kang, and N.I. Baek In vitro GABA-transaminase inhibitory compounds from the root of Angelica dahurica Phytotherapy Research 19 2005 839 845
31. B. Czeczuga, A. Semeniuk, and E. Czeczuga-Semeniuk Phycobiliprotein in the cells of Nostoc sp. - a cyanobiont of various lichen species of the genus Peltigera Current Topics in Phytochemistry 10 2011 17 27
32. A. Czepa, and T. Hofmann Quantitative studies and sensory analyses on the influence of cultivar, spatial tissue distribution, and industrial processing on the bitter off-taste of carrots (Daucus carota L.) and carrot products Journal of the Agriculture and Food Chemistry 52 2004 4508 4514
33. A. Czepa, and T. Hofmann Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree Journal of the Agriculture and Food Chemistry 51 2003 3865 3873
34. E. Dagne, S. Asmellash, and D. Abate An antifungal polyacetylenic compound from the culture filtrate of the fungus Trametes pubescens Journal of Natural Products 57 1994 390 392
35. E. Defrancq, J. Gordon, A. Brodard, and R. Tabacchi The synthesis of a novel epoxycyclohexane from the fungus Eutypa lata (Pers:F) Tul Helveutica Chimica Acta 75 1992 276 281
36. V.M. Dembitsky Lipids of lichens Progress in Lipid Research 31 1992 373 397
37. V.M. Dembitsky Betaine ether-linked glycerolipids: chemistry and biology Progress in Lipid Research 35 1996 1 51
38. V.M. Dembitsky Anticancer activity of natural and synthetic acetylenic lipids Lipids 41 2006 883 924
39. V.M. Dembitsky Oxidation, epoxidation and sulfoxidation reactions catalysed by haloperoxidases Tetrahedron 59 2003 4701 4720
40. V.M. Dembitsky, I.A. Bychek, M.V. Shustov, and O.A. Rozentsvet Phospholipid and fatty acid composition of some lichen species Phytochemistry 30 1991 837 839
41. V.M. Dembitsky, I.A. Bychek, and O.A. Rozentsvet Diacylglyceryltrimethylhomoserines and phospholipids of some lichen species Phytochemistry 34 1993 1535 1536
42. V.M. Dembitsky, and D.O. Levitsky Acetylenic terrestrial anticancer agents Natural Product Communications 1 2006 405 429
43. V.M. Dembitsky, D.O. Levitsky, T.A. Gloriozova, and V.V. Poroikov Acetylenic aquatic anticancer agents and related compounds Natural Product Communications 1 2006 773 811
44. V.M. Dembitsky, and T. Maoka Allenic and cumulenic lipids Progress in Lipid Research 46 2007 328 375
45. V.M. Dembitsky, and T. Rezanka Metabolites produced by nitrogen-fixing Nostoc species Folia Microbiologica 50 2005 363 391
46. S. Deng, S.N. Chen, P. Yao, D. Nikolic, R.B. Van Breemen, J.L. Bolton, H.H. Fong, N.R. Farnsworth, and G.F. Pauli Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis Journal of Natural Products 69 2006 536 541
47. S. Deng, Y. Wang, T. Inui, S.N. Chen, N.R. Farnsworth, and S. Cho Anti-TB polyynes from the Stavri M. Gibbons S. The antimycobacterial constituents of dill (Anethum graveolens) Phytotherapy Research 19 2005 938 941
48. S. Deng, Y. Wang, T. Inui, S.N. Chen, N.R. Farnsworth, S. Cho, S.G. Franzblau, and G.F. Pauli Anti-TB polyynes from the roots of Angelica sinensis Phytotherapy Research 22 2008 878 882
49. R. Devaraju, and S. Satish Endophytic fungi: trapped or hidden store houses of bioactive compounds within plants: a review Journal of Pharmacy Research 3 2010 2986 2989
50. E.-M. Diaz, M. Sacristan, M.-E. Legaz, and C. Vicente Isolation and characterization of a cyanobacterium-binding protein and its cell wall receptor in the lichen Peltigera canina Plant Signaling and Behavior 4 2009 598 603
51. Dou, D., Liu, P., Kang, T., 2010. Method for preparing Oplopanax leaf total saponin extract with antitumor effect, 8 pp, Chinese Patent: Faming Zhuanli Shenqing CN 101732377 A.
52. L. Du, and W. Hu Hepatic artery target embolic chemotherapy in treatment of late-stage primary hepatocellular carcinoma Shaanxi Yixue Zazhi 26 1997 9 11
53. G.-M. Dubin, A. Fkyerat, and R. Tabacchi Acetylenic aromatic compounds from Stereum hirsutum Phytochemistry 53 2000 571 574
54. R.B. Duda, B. Taback, B. Kessel, D.D. Dooley, H. Yang, J. Marchiori, B.M. Slomovic, and J.G. Alvarez pS2 expression induced by American ginseng in MCF-7 breast cancer cells Annals of Surgical Oncology 3 1996 515 520
55. D.S. Fabricant, and N.R. Farnsworth The value of plants used in traditional medicine for drug discovery Environmental Health Perspectives Supplements 109 2001 69 75
56. H. Fang, Q. Hu, Y. Ma, S. Sun, C. Xu, X. Zeng, Q. Zhang, and Y. Zhou Constituents of volatile oils. IV. Chemical constituents of the volatile oil from Bai Hua Hao (Artemisia lactiflora Wall) Zhongc 15 1984 99 101
57. A. Fkyerat, G.-M. Dubin, and R. Tabacchi The synthesis of natural acetylenic compounds from Stereum hirsutum Helvetica Chimica Acta 82 1999 1418 1422
58. Fujihashi, T., Okuma, T., Hirakura, K., Mihashi, H., 1991. Anticancer agents containing polyacetylenes. Japan Kokai Tokkyo Koho, 14 pp, Japanese Patent: JP 03200736 A2 19910902 Heisei.
59. Fujiki, Y., Sato, Y., Ushiyama, K., 1987. Anticancer agents containing heptadeca-4,6-diynes and formulations thereof. Japan Kokai Tokkyo Koho, 6 pp, Japanese Patent: JP 62207234 A2 19870911 Showa.
60. Fujimoto, Y., 1994. Panaquinquecols of Panax quinquefolium and their use as anticancer agents. Japan Kokai Tokyo Koho, 9 pp, Japanese Patent: JP 06009418 A2 19940118 Heisei.
61. Fujimoto, Y., Honma, Y., Sato, Y., Ushiyama, K., 1989. Fungicides containing heptadecadiyne derivatives. Japan Kokai Tokkyo Koho, 5 pp, Japanese Patent: JP 01006201 A2 19890110 Heisei.
62. Y. Fujimoto, and M. Sato A new cytotoxic chlorine-containing polyacetylene from the callus of Panax ginseng Chemical and Pharmaceutical Bulletin 36 1988 4206 4208
63. Y. Fujimoto, M. Satoh, N. Takeuchi, and M. Kirisawa Cytotoxic acetylene from Panax quinquefolium Chemical & Pharmaceutical Bulletin 39 1991 521 523
64. Y. Fujimoto, H. Wang, M. Kirisawa, M. Satoh, and N. Takeuchi Acetylenes from Panax quinquefolium Phytochemistry 31 1992 3499 3501
65. Y. Fujimoto, H. Wang, M. Satoh, and N. Takeuchi Polyacetylenes from Panax quinquefolium Phytochemistry 35 1994 1255 1257
66. F. Fullas, D.M. Brown, M.C. Wani, M.E. Wall, T.E. Chagwedera, N.R. Farnesworth, J.M. Pezzuto, and A.D. Kinghorn Gummiferol, a cytotoxic polyacetylene from the leaves of Adenia gummifera Journal of Natural Products 58 1995 1625 1628
67. L. Garlaschelli, E. Magistrali, G. Vidari, and O. Zuffardi Fungal metabolites. 38. Tricholomenyns A and B, novel antimitotic acetylenic cyclohexenone derivatives from the fruiting bodies of Tricholoma acerbum Tetrahedron Letters 36 1995 5633 5636
68. L. Garlaschelli, G. Vidari, and P. Vita-Finzi Fungal metabolites. 41. Tricholomenyns C, D, and E, novel dimeric dienyne geranyl cyclohexenones from the fruiting bodies of Tricholoma acerbum Tetrahedron Letters 37 1996 6223 6226
69. A. Gehrt, G. Erkel, T. Anke, and O. Sterner Nitidon, a new bioactive metabolite from the basidiomycete Junghuhnia nitida Zeitschrift fuer Naturforschung 53C 1998 89 92
70. A.G. Gonzalez, J. Bermejo Barrera, J.G. Diaz, T. Zaragoza Garcia, and P.P. De Paz Distribution of acetylenes and sesquiterpene lactones in Argyranthemum from Tenerife Biochemical Systematics and Ecology 16 1987 17 21
71. A.G. Gonzalez, R. Estevez-Reyes, A. Estevez-Braun, A.G. Ravelo, I.A. Jimenez, I.L. Bazzocchi, M.A. Aguilar, and L. Moujir Biological activities of some Argyranthemum species Phytochemistry 45 1997 963 967
72. S.I. Hatanaka, Y. Niimura, and K. Taniguch Biochemical studies on nitrogen compounds of fungi. V. Another new amino acid of the acetylene type from Tricholomopsis rutilans Zeitschrift fuer Naturforschung 28C 1973 475 478
73. R. Hautzel, H. Anke, and W.S. Sheldrick Mycenon, a new metabolite from a Mycena species TA 87202 (Basidiomycetes) as an inhibitor of isocitrate lyase Journal of Antibiotics 43 1990 1240 1244
74. P. Herbst The alkyne acids from fungi Planta M 8 1960 394 402
75. S. Hertzberg, V. Partali, and S. Liaaen-Jensen Animal carotenoids. 32. Carotenoids of Mytilus edulis (edible mussel) Acta Chemica Scandinavica 42B 1988 495 503
76. K. Hirakura, H. Takagi, M. Morita, K. Nakajima, K. Niitsu, H. Sasaki, M. Maruno, and M. Okada Cytotoxic activity of acetylenic compounds from Panax ginseng Natural Medicines (Tokyo) 54 2000 342 345
77. S.S. Hong, J.H. Lee, W. Jeong, N. Kim, H.Z. Jin, B.Y. Hwang, H.-J. Lee, S.-J. Lee, D.S. Jang, and D. Lee Acetylenic acid analogues from the edible mushroom Chanterelle (Cantharellus cibarius) and their effects on the gene expression of peroxisome proliferator-activated receptor-gamma target genes Bioorganic and Medicinal Chemistry Letters 22 2012 2347 2349
78. D.E. Jenkins Mycomycin: a new antibiotic with tuberculostatic properties Journal of Laboratory and Clinical Medicine 36 1950 841 842
79. R. Jente, F. Bosold, J. Bauerle, and T. Anke Tetra-acetylenic metabolites from Mycena viridimarginata Phytochemistry 24 1985 553 559
80. M.-Y. Jiang, Y. Li, F. Wang, and J.-K. Liu Isoprenylated cyclohexanoids from the basidiomycete Hexagonia speciosa Phytochemistry 72 2011 923 928
81. M.-Y. Jiang, L. Zhang, R. Liu, Z.-J. Dong, J.-K. Liu, and A.-K. Speciosins Oxygenated cyclohexanoids from the basidiomycete Hexagonia speciosa Journal of Natural Products 72 2009 1405 1409
82. J.E. Johansen, W.A. Svec, S. Liaaen-Jensen, and F.T. Haxo Algal carotenoids. 10. carotenoids of dinophyceae Phytochemistry 13 1974 2261 2271
83. H.R. Jin, J. Zhao, Z. Zhang, Y. Liao, C.Z. Wang, W.H. Huang, S.P. Li, T.C. He, C.S. Yuan, and W. Du The antitumor natural compound falcarindiol promotes cancer cell death by inducing endoplasmic reticulum stress Cell Death and Disease 3 2012 122 127
84. E.R.H. Jones Natural polyacetylenes and their precursors Chemistry in Britannia 2 1966 6 13
85. E.R.H. Jones, P.R. Leeming, and W.A. Remers Chemistry of the higher fungi. XI. Polyacetylenic metabolites of Drosophila subatrata Journal of the Chemical Society 1960 2257 2263
86. H.J. Jung, B.S. Min, J.Y. Park, Y.H. Kim, H.K. Lee, and K.H. Bae Gymnasterkoreaynes A-F, cytotoxic polyacetylenes from Gymnaster koraiensis Journal of Natural Products 65 2002 897 901
87. T. Kamikubo, and K. Ogasawara Absolute configuration of (+)-PT-toxin: enantiodivergent synthesis of (+)- and (-)-PT-toxins Heterocycles 47 1998 69 72
88. F. Kavanagh Activities of twenty two antibacterial substances against nine species of bacteria Journal of Bacteriology 54 1947 761 766
89. F. Kavanagh, A. Hervey, and W.J. Robbins Antibiotic substances from basidiomycetes. IX. Drosophila subatrata Proceedings of the National Academy of Sciences of the United States of America 38 1952 555 560
90. Kawazu, K., Kobayashi, A., Oe, K., 1991. Cell division-inhibiting harveynones from Curvularia harveyi, 3 pp, Japanese Patent: Jpn. Kokai Tokkyo Koho.
91. A. Kobayashi, K. Ooe, and Y.S.K. Kawazu Chemical studies of microtubule assembly regulators of microbial origin Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 31 1989 388 395
92. C. Kim, M.-C. Kim, S.-M. Kim, D. Nam, S.-H. Choi, S.-H. Kim, K.S. Ahn, E.H. Lee, S.H. Jung, and K.S. Ahn Chrysanthemum indicum L. extract induces apoptosis through suppression of constitutive STAT3 activation in human prostate cancer DU145 Cells Phytotherapy Research 27 2013 30 38
93. H.-J. Kim, F. Vinale, E.L. Ghisalberti, C.M. Worth, K. Sivasithamparam, B.W. Skelton, and A.H. White An antifungal and plant growth promoting metabolite from a sterile dark ectotrophic fungus Phytochemistry 67 2006 2277 2280
94. S.I. Kim, K.S. Kang, and Y.H. Lee Panaxyne epoxide, a new cytotoxic polyyne from Panax ginseng root against L1210 cells Archives of Pharmacal Research 12 1989 48 51
95. S.I. Kim, Y.H. Lee, and K.S. Kang 10-Acetyl panaxytriol, a new cytotoxic polyacetylene from Panax ginseng Yakhak Hoechi 33 1989 118 123
96. Y.S. Kim, S.I. Kim, and D.R. Hahn Effect of polyacetylene compounds from Panax ginseng on macromolecular synthesis by lymphoid leukemia L1210 Yakhak Hoechi 32 1988 137 140
97. J.H. Kim, N. Mahoney, K.L. Chan, R.J. Molyneux, and B.C. Campbell Secondary metabolites of the grapevine pathogen Eutypa lata inhibit mitochondrial respiration, based on a model bioassay using the yeast Saccharomyces cerevisiae Current Microbiology 49 2004 282 287
98. D.S. King Tuberculosis New England Journal of Medicine 243 1950 530 536
99. P.M. Kirk, P.F. Cannon, D.W. Minter, and J.A. Stalpers Dictionary of the Fungi. 2008 CAB International Wallingford 784
100. I. Kitagawa, T. Taniyama, H. Shibuya, T. Noda, and M. Yoshikawa Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root Yakugaku Zasshi. Journal of the Pharmaceutical Society of Japan 107 1987 495 505
101. L. Kjellenberg, E. Johansson, K.E. Gustavsson, and M.E. Olsson Effects of harvesting date and storage on the amounts of polyacetylenes in carrots, Daucus carota Journal of the Agriculture and Food Chemistry 58 2010 11703 11708
102. S. Klaiklay, V. Rukachaisirikul, K. Tadpetch, Y. Sukpondma, S. Phongpaichit, J. Buatong, and J. Sakayaroj Chlorinated chromone and diphenyl ether derivatives from the mangrove-derived fungus Pestalotiopsis sp. PSU-MA69 Tetrahedron 68 2012 2299 2305
103. I. Konishi, M. Hosokawa, T. Sashima, H. Kobayashi, and K. Miyashita Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells Comparative Biochemistry and Physiology, Toxicology and Pharmacology 142C 2006 53 59
104. G. Kou, Y. Zhang, X. Yang, and R. Rong O-methylnotopterol, a new natural product from the roots and rhizomes of Notopterygium incisum Zhongguo Zhong Yao Za Zhi 35 2010 1134 1136
105. G. Kuropka, M. Neugebauer, and K.W. Glombitza Essential oils of Achillea ptarmica Planta Medica 57 1991 492 494
106. D. Kustrak Siberian ginseng or the root from taiga - Eleutherococcus senticosus Farmaceutski Glasnik 49 1993 1 7
107. T.H. Kwak, M.S. Shin, J.Y. Kim, and J.-K. Park Active fraction having anticancer and anti-metastasis isolated from Acanthopanax species and fruits PCT International 2003 43 WO 2003099309 A1 Application: WO 2003-KR1043 20030528
108. Z. Laufer, R.P. Beckett, F.V. Minibayeva, S. Luthje, and M. Bottger Occurrence of laccases in lichenized ascomycetes of the Peltigerineae Mycological Research 110 2006 846 853
109. D. Lechner, M. Stavri, M. Oluwatuyi, R. Pereda-Miranda, and S. Gibbons The anti-staphylococcal activity of Angelica dahurica (Bai Zhi) Phytochemistry 65 2004 331 335
110. G. Lee, H.-G. Park, M.-L. Choi, Y.H. Kim, Y.B. Park, K.-S. Song, C. Cheong, and Y.-S. Bae Falcarindiol, a polyacetylenic compound isolated from Peucedanum japonicum, inhibits mammalian DNA topoisomerase I Journal of Microbiology and Biotechnology 10 2000 394 398
111. L.M. Levy, G.M. Cabrera, J.E. Wright, and A.M. Seldes 5H-Furan-2-ones from fungal cultures of Aporpium caryae Phytochemistry 62 2003 239 243
112. C. Liers, R. Ullrich, M. Hofrichter, F.V. Minibayeva, and R.P. Beckett A heme peroxidase of the ascomyceteous lichen Leptogium saturminum oxidizes high-redox potential substrates Fungal Genetics and Biology 48 2011 1139 1145
113. J.H. Liu, C.-S. Lee, K.-M. Leung, Z.-K. Yan, B.-H. Shen, Z.-Z. Zhao, and Z.-H. Jiang Quantification of two polyacetylenes in radix ginseng and roots of Related Panax Species using a gas chromatography-mass spectrometric method Journal of the Agriculture and Food Chemistry 55 2007 8830 8835
114. J.H. Liu, S. Zschocke, E. Reininger, and R. Bauer Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase Planta Medica 64 1998 525 529
115. A.R. Loeblich III, and V.E. Smith Chloroplast pigments of marine dinoflagellate gyrodinium resplendens Lipids 3 1968 5 13
116. J.-M. Lu, Q. Yao, and C. Chen Ginseng compounds: an update on their molecular mechanisms and medical applications Current Vascular Pharmacology 7 2009 293 302
117. Z. Ma, W. Xu, L.Y. Liu-Chen, and D.Y. Lee Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors Bioorganic and Medicinal Chemistry 16 2008 3218 3223
118. D. Manns, and R. Hartmann Annuadiepoxide, a new polyacetylene from the aerial parts of Artemisia annua Journal of Natural Products 55 1992 29 32
119. T. Maoka, N. Akimoto, M. Murakoshi, K. Sugiyama, and H. Nishino Carotenoids in clams, Ruditapes philippinarum and Meretrix petechialis Journal of Agricultural and Food Chemistry 58 2010 5784 5788
120. T. Maoka, N. Akimoto, M. Tsushima, S. Komemushi, T. Mezaki, F. Iwase, Y. Takahashi, N. Sameshima, M. Mori, and Y. Sakagami Carotenoids in marine invertebrates living along the Kuroshio current coast Marine Drugs 9 2011 1419 1427
121. T. Maoka, Y. Fujiwara, K. Hashimoto, and N. Akimoto Carotenoids in three species of corbicula clams, Corbicula japonica, Corbicula sandai, and Corbicula sp. (Chinese freshwater corbicula clam) Journal of Agricultural and Food Chemistry 53 2005 8357 8364
122. T. Maoka, J. Ochi, M. Mori, and Y. Sakagami Identification of carotenoids in the freshwater shellfish unio douglasiae nipponensis, Anodonta lauta, Cipangopaludina chinensis laeta, and Semisulcospira libertine Journal of Oleo Science 61 2012 69 74
123. H. Matsunaga, M. Katano, H. Yamamoto, H. Fujito, M. Mori, and K. Takata Cytotoxic activity of polyacetylene compounds in Panax ginseng C A. Meyer. Chemical and Pharmaceutical Bulletin 38 1990 3480 3484
124. T. Matsuno, and M. Ookubo A new carotenoid, halocynthiaxanthin from the sea squirt, Halocynthia roretzi Tetrahedron Letters 22 1981 4659 4660
125. T. Matsuno, M. Ookubo, T. Nishizawa, and I. Shimizu Carotenoids of sea squirts. 1. New marine carotenoids, halocynthiaxanthin and mytiloxanthinone from Halocynthia roretzi Chemical and Pharmaceutical Bulletin 32 1984 4309 4315
126. P. Matsuzaki, G. Akisue, O.S.C. Salgado, S.L. Gorniak, and D.M.L. Zaidan Effect of Pfaffia paniculata (Brazilian ginseng) on the Ehrlich tumor in its ascitic form Life Sciences 74 2003 573 579
127. B.J. McAfee, and A. Taylor A review of the volatile metabolites of fungi found on wood substrates Natural Toxins 7 1999 283 303
128. B.T. Metzger, D.M. Barnes, and J.D. Reed Purple carrot (Daucus carota L.) polyacetylenes decrease lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells Journal of the Agriculture and Food Chemistry 56 2008 3554 3560
129. J.T. Millard, J.L. Katz, J. Goda, E.D. Frederick, S.E. Pierce, T.J. Speed, and D.M. Thamattoor DNA interstrand cross-linking by a mycotoxic diepoxide Biochimie 86 2004 419 423
130. R.E. Minto, and B.J. Blacklock Biosynthesis and function of polyacetylenes and allied natural products Progress in Lipid Research 47 2008 233 306
131. R.J. Molyneux, N. Mahoney, P. Bayman, R.Y. Wong, K. Meyer, and N. Irelan Eutypa dieback in grapevines: differential production of acetylenic phenol metabolites by strains of Eutypa lata Journal of the Agriculture and Food Chemistry 50 2002 1393 1399
132. A. Muehlenfeld, and H. Achenbach Metabolites of microorganisms. Part 36. Asperpentyn, a novel acetylenic cyclohexene epoxide from Aspergillus duricaulis Phytochemistry 27 1988 3853 3855
133. A. Murakami, and H. Ohigashi Cancer preventive potentials of edible plants from subtropical countries Food Style 3 1999 35 39
134. T. Nagata Tea quality components Chagyo Kenkyu Hokoku 72 1990 53 58
135. Y. Nakamura, Y. Ohto, A. Murakami, S. Jiwajinda, and H. Ohigashi Isolation and identification of acetylenic spiroketal enol ethers from Artemisia lactiflora as inhibitors of superoxide generation induced by a tumor promoter in differentiated HL-60 cells Journal of Agricultural and Food Chemistry 46 1998 5031 5036
136. Y. Nakamura, N. Kawamoto, Y. Ohto, K. Torikai, A. Murakami, and H. Ohigashi A diacetylenic spiroketal enol ether epoxide, AL-1, from Artemisia lactiflora inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion possibly by suppression of oxidative stress Cancer Letters 140 1999 37 45
137. M.S.R. Nair, and M. Anchel Frustulosinol, an antibiotic metabolite of Stereum fructulosum - revised structure of frustulosin Tetrahedron Letters 16 1975 2641 2642
138. M.S.R. Nair, and M. Anchel Frustulosinol, an antibiotic metabolite of Stereum frustulosum: revised structure of frustulosin Phytochemistry 16 1977 390 392
139. Y. Niimura, and S. Hatanaka Biochemical studies on nitrogen compounds of fungi. Part 15. Two gamma-glutamyl-peptides of acetylenic amino acids in Tricholomopsis rutilans Phytochemistry 16 1977 1435 1436
140. S.A. Nirmal, S.C. Pal, G. Velmani, and S.C. Mandal Scope of drug discovery from Indian traditional medicine Pharma Review 10 2012 122 128
141. S. Nishibe Bioactive lignans and flavonoids from traditional medicines Colloques: Institut National de la Recherche Agronomique 69 1995 113 122
142. H. Nishino, M. Tsushima, T. Matsuno, Y. Tanaka, J. Okuzumi, M. Murakoshi, Y. Satomi, J. Takayasu, H. Tokuda, and A. Nishino Antineoplastic effect of halocynthiaxanthin, a metabolite of fucoxanthin Anti-Cancer Drugs 3 1992 493 497
143. T.B. Ng Pharmacological activity of sanchi ginseng (Panax notoginseng) Journal of Pharmacy and Pharmacology 58 2006 1007 1019
144. Nozoe, S., Takahashi, A., Endo, T., 1993. Preparation of repandiol derivatives as antitumor agents. Jpn. Kokai Tokkyo Koho, JP 05247017 A 19930924.
145. M. Oh, Y.H. Choi, S. Choi, H. Chung, K. Kim, S.I. Kim, D.K. Kim, and N.D. Kim Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells International Journal of Oncology 14 1999 869 875
146. H. Ohigashi, Y. Nakamura, and A. Murakami Active components and antitumor effects of tropical Asian foods Food Style 2 1998 31 35
147. T. Ohnuma, T. Komatsu, S. Nakayama, T. Nishiyama, K. Ogura, and A. Hiratsuka Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress Archives of Biochemistry and Biophysics 488 2009 34 41
148. Okishi, H., 1977. 2-γ-Glutamylamino-4-hexynic acid and 2-γ-glutamylamino-3-hydroxy-4-hexynic acid. Japan Kokai Tokkyo Koho, 4 pp, Japanese Patent: JP 52054084 19770502 Showa.
149. H. Otsuka, T. Komiya, S. Fujioka, M. Goto, Y. Hiramatsu, and H. Fujimura Studies on anti-inflammatory agents. IV. Anti-inflammatory constituents from roots of Panax ginseng C.A. Meyer Yakugaku Zasshi 101 1981 1113 1117
150. J.S. Park, T.W. Lee, and K. Han Cell growth inhibitory effect of tissue cultured root of wild Panax ginseng C.A. Mayer extract on various cancer cell lines Natural Product Sciences 15 2009 1 7
151. V. Partali, K. Tangen, and S. Liaaen-Jensen Carotenoids in food chain studies. III. Resorption and metabolic transformation of carotenoids in Mytilus edulis (edible mussel) Comparative Biochemistry and Physiology, Part B: Biochemistry and Molecular Biology 92B 1989 239 246
152. R.N. Patel Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances Current Opinion in Biotechn 12 2001 587 604
153. J. Poplawski, J.T. Wrobel, and T. Glinka Panaxydol, a new polyacetylenic epoxide from Panax ginseng roots Phytochemistry 19 1980 1539 1541
154. S. Purup, E. Larsen, and L.P. Christensen Differential effects of falcarinol and related aliphatic C(17)-polyacetylenes on intestinal cell proliferation Journal of the Agriculture and Food Chemistry 57 2009 8290 8296
155. N. Quintana, T.L. Weir, J. Du, C.D. Broeckling, J.P. Rieder, F.R. Stermitz, M.W. Paschke, and J.M. Vivanco Phytotoxic polyacetylenes from roots of Russian knapweed (Acroptilon repens (L.) DC.) Phytochemistry 69 2008 2572 2578
156. S.Z.T. Rabe, M. Mahmoudi, A. Ahi, and S.A. Emami Antiproliferative effects of extracts from Iranian Artemisia species on cancer cell lines Pharmaceutical Biology (U.K.) 49 2011 962 969
157. D.K. Rai, N.P. Brunton, A. Koidis, A. Rawson, P. McLoughlin, and W.J. Griffiths Characterisation of polyacetylenes isolated from carrot (Daucus carota) extracts by negative ion tandem mass spectrometry Rapid Communications and Mass Spectrometry 25 2011 2231 2239
158. G. Rao, X. Wang, and W. Jin Polyacetylene compounds from Panax notoginseng Zhong Yao Cai 20 1997 298 299
159. A. Rawson, B.K. Tiwari, M.G. Tuohy, C.P. O'Donnell, and N. Brunton Effect of ultrasound and blanching pretreatments on polyacetylene and carotenoid content of hot air and freeze dried carrot discs Ultrason Sonochemistry 18 2011 1172 1179
160. J. Reisch, W. Spitzner, and K.E. Schulte On the problem of the microbiological activity of simple acetylene compounds Arzneimittel-Fors 17 1967 816 819
161. J.M. Renoud, G. Tsoupras, and R. Tabacchi Biologically active natural acetylenic compounds from Eutypa lata (Pers:F.) Tul Helveutica Chimica Acta 72 1989 929 932
162. T. Rezanka, and V.M. Dembitsky Novel brominated lipidic compounds from lichens of Central Asia Phytochemistry 51 1999 963 968
163. W.J. Robbins, F. Kavanagh, and A. Hervey Antibiotic substances from Basidiomycetes. II. Polyporus biformis Proceedings of the National Academy of Sciences of the United States of America 33 1947 176 182
164. R.J. Rodriguez, J.F. White Jr., A.E. Arnold, and R.S. Redman Fungal endophytes: diversity and functional roles New Phytologist 182 2009 314 330
165. M. Roman, J.C. Dobrowolski, M. Baranska, and R. Baranski Spectroscopic studies on bioactive polyacetylenes and other plant components in wild carrot root Journal of Natural Products 74 2011 1757 1763
166. T. Saita, M. Katano, H. Matsunaga, H. Yamamoto, H. Fujito, and M. Mori The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol Chemical and Pharmaceutical Bulletin 41 1993 549 552
167. T. Saita, M. Katano, H. Matsunaga, I. Kouno, H. Fujito, and M. Mori Screening of polyacetylenic alcohols in crude drugs using the ELISA for panaxytriol Biological and Pharmaceutical Bulletin (Tokyo) 18 1995 933 937
168. A. Satoh, Y. Narita, N. Endo, and H. Nishimura Potent allelochemical falcalindiol from Glehnia littoralis F. Schm Bioscience, Biotechnology, and Biochemistry 60 1996 152 153
169. L. Schmiech, C. Alayrac, B. Witulski, and T. Hofmann Structure determination of bisacetylenic oxylipins in carrots (Daucus carota L.) and enantioselective synthesis of falcarindiol Journal of Agricultural and Food Chemistry 57 2009 11030 11040
170. L. Schmiech, D. Uemura, and T. Hofmann Reinvestigation of the bitter compounds in carrots (Daucus carota L.) by using a molecular sensory science approach Journal of Agricultural and Food Chemistry 56 2008 10252 10260
171. W.N. Setzer, X. Gu, E.B. Wells, M.C. Setzer, and D.M. Moriarity Synthesis and cytotoxic activity of a series of diacetylenic compounds related to falcarindiol Chemical and Pharmaceutical Bulletin 48 2000 1776 1777
172. A. Siddiq, and V. Dembitsky Acetylenic anticancer agents Anti-Cancer Agents in Medicinal Chemistry 8 2008 132 170
173. T. Skjenstad, F.T. Haxo, and S. Liaaen-Jensen Algal carotenoids. 27. Carotenoids of clam, coral and nudibranch zooxanthellae in aposymbiotic culture Biochemical Systematics and Ecology 12 1984 149 153
174. G. Schlingmann, L. Milne, C.J. Pearce, D.B. Borders, M. Greenstein, W.M. Maiese, and G.T. Carter Isolation, characterization and structure of a new allenic polyene antibiotic produced by fungus LL-07F275 Journal of Antibiotics 48 1995 375 379
175. O.F. Smetanina, A.N. Yurchenko, S.Sh. Afiyatullov, A.I. Kalinovsky, M.A. Pushilin, Y.V. Khudyakova, N.N. Slinkina, S.P. Ermakova, and E.A. Yurchenko Oxirapentyns B-D produced by a marine sediment-derived fungus Isaria felina (DC.) Fr Phytochemistry Letters 5 2012 165 169
176. M. Smith, and H.S. Boon Counseling cancer patients about herbal medicine Patient Education and Counseling 38 1999 109 120
177. J. Sohn, C.H. Lee, D.J. Chung, S.H. Park, I. Kim, and W.I. Hwang Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells Experimental and Molecular Medicine 30 1998 47 51
178. M. Søltoft, M.R. Eriksen, A.W. Trager, J. Nielsen, K.H. Laursen, S. Husted, U. Halekoh, and P. Knuthsen Comparison of polyacetylene content in organically and conventionally grown carrots using a fast ultrasonic liquid extraction method Journal of Agricultural and Food Chemistry 58 2010 7673 7679
179. M. Stavri, and S. Gibbons The antimycobacterial constituents of dill (Anethum graveolens) Phytotherapy Research 19 2005 938 941
180. C.E. Stickings, and H. Raistrick Chemistry of the fungi Annual Review of Biochemistry 25 1956 225 256
181. S. Sun, G.J. Du, L.W. Qi, S. Williams, C.Z. Wang, and C.S. Yuan Hydrophobic constituents and their potential anticancer activities from Devil's Club (Oplopanax horridus Miq.) Journal of Ethnopharmacology 132 2010 280 285
182. M.-L. Sung, L. Fowden, D.S. Millington, and R.C. Sheppard Acetylenic amino acids from Euphoria longan Phytochemistry 8 1969 1227 1233
183. R. Tabacchi, A. Fkyerat, C. Poliart, and G.-M. Dubin Phytotoxins from fungi of esca of grapevine Phytopathologia Mediterranea 39 2000 156 161
184. Y. Takada, N.H. Greig, D.T. Vistica, S.I. Rapoport, and Q.R. Smith Affinity of antineoplastic amino acid drugs for the large neutral amino acid transporter of the blood-brain barrier Cancer Chemotherapy and Pharmacology 29 1991 89 94
185. A. Takahashi, T. Endo, and S. Nozoe Repandiol, a new cytotoxic diepoxide from the mushrooms Hydnum repandum and H. repandum var. album Chemical and Pharmaceutical Bulletin 40 1992 3181 3184
186. S. Takahashi, Y. Itoh, M. Takeuchi, K. Furuya, K. Kodama, A. Naito, T. Haneishi, S. Sato, and C. Tamura Isolation and structure of oxirapentyn Journal of Antibiotics 36 1983 418 420
187. M. Takasugi, S. Kawashima, N. Katsui, and A. Shirata Two polyacetylenic phytoalexins from Arctium lappa Phytochemistry 26 1987 2957 2958
188. K. Tursun, R. Zhan, H. Zhang, and S. Ababakri Study on antioxidant activity of Acroptilon repens Shengwu Jishu Tongxun 21 2010 406 412
189. V. Veljkovic, and D.I. Lalovic Correlation between the carcinogenicity of organic substances and their spectral characteristics Experientia 34 1978 1342 1343
190. C.N. Wang, Y.J. Shiao, Y.H. Kuo, C.C. Chen, and Y.L. Lin Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium Planta Medica 66 2000 644 647
191. J. Wang, Z. Chen, Y. Wu, and G. Fan Fast determination of active components in Angelica dahurica extract using capillary electrochromatography with methacrylate ester-based monolithic columns Se Pu 28 2010 240 246
192. Y.L. Wang, Y.Z. Liang, B.M. Chen, Y.K. He, B.Y. Li, and Q.N. Hu LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui Analytical and Bioanalytical Chemistry 383 2005 247 254
193. D. Washida, and S. Kitanaka Determination of polyacetylenes and ginsenosides in Panax species using high performance liquid chromatography Chemical and Pharmaceutical Bulletin 51 2003 1314 1317
194. P.J. Weathers, P.R. Arsenault, P.S. Covello, A. McMickle, K.H. Teoh, and D.W. Reed Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases Phytochemical Reviews 10 2011 173 183
195. R. Whitehead Natural product chemistry. Annual Reports on the Progress of Chemistry Section B: Organic Chemistry 95 1999 183 205
196. V.K.W. Wong, S.S.F. Cheung, T. Li, Z.-H. Jiang, J.-R. Wang, H. Dong, X.Q. Yi, H. Zhou, and L. Liu Asian ginseng extract inhibits in vitro and in vivo growth of mouse lewis lung carcinoma via modulation of ERK-p53 and NF-κB signaling Journal of Cellular Biochemistry 111 2010 899 910
197. P.A. Wrang, and J. Lam Polyacetylenes from Chrysanthemum leucanthemum Phytochemistry 14 1975 1027 1035
198. L.L. Xu, T. Han, J.Z. Wu, Q.Y. Zhang, H. Zhang, B.K. Huang, K. Rahman, and L.P. Qin Comparative research of chemical constituents, antifungal and antitumor properties of ether extracts of Panax ginseng and its endophytic fungus Phytomedicine 16 2010 609 616
199. C. Xu, X. Sun, J. Yang, D. Yu, Q. Li, Y. Zhang, and S. Dou The structure of lactiflorasyne isolated from Artemisia lactiflora wall Yao Xue Xue Bao 21 1986 772 775
200. T. Xu, S.K. Tripathi, Q. Feng, M.C. Lorenz, M.A. Wright, M.R. Jacob, M.M. Mask, S.R. Baerson, X.-C. Li, A.M. Clark, and A.K. Agarwal A potent plant-derived antifungal acetylenic acid mediates its activity by interfering with fatty acid homeostasis Antimicrobial Agents and Chemotherapy 56 2012 2894 2907
201. J.S. Yadav, K. Boyapelly, S.R. Alugubelli, S. Pabbaraja, J.R. Vangala, and S.V. Kalivendi Stereoselective total synthesis of (+)-oploxyne A, (-)-oploxyne B, and their C-10 epimers and structure revision of natural oploxyne B Journal of Organic Chemistry 76 2011 2568 2576
202. M.C. Yang, H.C. Kwon, Y.-J. Kim, K.R. Lee, and H.O. Yang Oploxynes A and B, polyacetylenes from the stems of Oplopanax elatus Journal of Natural Products 73 2010 801 805
203. T. Yoshida, T. Maoka, S.K. Das, K. Kanazawa, M. Horinaka, M. Wakada, Y. Satomi, H. Nishino, and T. Sakai Halocynthiaxanthin and peridinin sensitize colon cancer cell lines to tumor necrosis factor-related apoptosis-inducing ligand Molecular Cancer Research 5 2007 615 625
204. K. Yoshikawa, S. Bando, S. Arihara, E. Matsumura, and S. Katayama A benzofuran glycoside and an acetylenic acid from the fungus Laetiporus sulphureus var. miniatus Chemical and Pharmaceutical Bulletin 49 2001 327 329
205. Y.S. Yun, S.Y. Lee, B.S. Kim, and T.K. Yun Studies on the mechanism of action of the cytotoxic fractions from Korean ginseng roots. II. Effects of ethyl acetate fraction from Korean ginseng roots on the biosynthesis of macromolecules in mammalian neoplastic cells Han'guk Saenghwa Hakhoechi 13 1980 219 234
206. Y.S. Yun, S.Y. Lee, B.S. Kim, and T.K. Yun Studies on the mechanism of action of the cytotoxic fraction from Korean ginseng roots. I. Effects of petroleum ether fraction from Korean ginseng roots on the biosynthesis of macromolecules in mammalian neoplastic cells Han'guk Saenghwa Hakhoechi 13 1980 203 217
207. D.-D. Zhai, K. Supaibulwatana, and J.-J. Zhong Inhibition of tumor cell proliferation and induction of apoptosis in human lung carcinoma 95-D cells by a new sesquiterpene from hairy root cultures of Artemisia annua Phytomedicine 17 2010 856 861
208. B. Zhang, Y. Wang, S.-P. Yang, Y. Zhou, W.-B. Wu, W. Tang, J.-P. Zuo, Y. Li, and J.-M. Yue Ivorenolide A, an unprecedented immunosuppressive macrolide from Khaya ivorensis: structural elucidation and bioinspired total synthesis Journal of the American Chemical Society 134 2012 20605 20608
209. Y. Zhang, B. Liu, and Y. Pei Pharmacological action of Acanthopanax senticosus (Rupr. et Maxim.) Harms Shenyang Yaoke Daxue Xuebao 19 2002 143 146
210. Zhang, Z., 2005. Manufacture of traditional Chinese medicine freeze dried powder injection for treating tumors. Faming Zhuanli Shenqing Gongkai Shuomingshu, 15 pp. Chinese Patent: CN 1559454 A 20050105.
211. Zhu, Y., Yang, S., Zhang, W., Xu, Q., 2012. Method for synthesis of 6-acetylenic acid-like compound and its application in preparing the medical formulations as antifungal agent. Chinese Patent: CN 2011-10084779, 5 pp., Faming Zhuanli Shenqing.
212. C. Zidorn, K. Johrer, M. Ganzera, B. Schubert, E.M. Sigmund, J. Mader, R. Greil, E.P. Ellmerer, and H. Stuppner Polyacetylenes from the Apiaceae vegetables carrot, celery, fennel, parsley, and parsnip and their cytotoxic activities Journal of Agricultural and Food Chemistry 53 2005 2518 2523
213. S. Zschocke, M. Lehner, and R. Bauer 5-Lipoxygenase and cyclooxygenase inhibitory active constituents from Qianghuo (Notopterygium incisum) Planta Medica 63 1997 203 206