Inhibition of tumor cell proliferation and induction of apoptosis in human lung carcinoma 95-D cells by a new sesquiterpene from hairy root cultures of Artemisia annua

Phytomedicine

Volumn 17, Issue 11, 2010, Pages 856-861

  Zhai, D D ^a   Supaibulwatana, K ^b   Zhong, J J ^a,c  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Mahidol University ^*  (Thailand)

^c Shanghai Jiao Tong University   (China)

Author keywords

Apoptosis; Artemisia annua; Cytotoxicity; Plant hairy root culture; Sesquiterpenoid

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 7 ACETOXY METHYL 11 METHYL 3 METHYLENE DODECA 1,6,10 TRIENE; CASPASE 3; CASPASE 9; SESQUITERPENE; UNCLASSIFIED DRUG;

95 D TUMOR CELL; APOPTOSIS; ARTEMISIA ANNUA; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG ISOLATION; FLOW CYTOMETRY; GROWTH INHIBITION; HAIRY ROOT CULTURE; HELA CELL; HUMAN; HUMAN CELL; IC 50; LIVER TUMOR; LUNG CARCINOMA; LUNG TUMOR; MITOCHONDRIAL MEMBRANE POTENTIAL; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL LINE; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ARTEMISIA ANNUA; CASPASE 3; CASPASE 9; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; SESQUITERPENES;

ARTEMISIA ANNUA;

EID: 77955944435     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.02.008     Document Type: Article

References (23)

1. Bhakuni R.S., Jain D.C., Sharma R.P., Kuma S. Secondary metabolites of Artemisia annua and their biological activity. Curr. Sci. 2001, 80:35-48.
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 1976, 72:248-254.
3. Chen M., Wang J. Initiator caspases in apoptosis signaling pathways. Apoptosis 2003, 7:313-319.
4. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281:1308-1312.
5. Hansen M.B., Nielsen S.E., Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell killing. J. Immunol. Methods 1989, 119:203-211.
6. Hengartner M.O. The biochemistry of apoptosis. Nature 2000, 407:770-776.
7. Hickman J.A. Apoptosis induced by anticancer drugs. Cancer Metast. Rev. 1992, 11:121-139.
8. Hu Y.W., Liu C.Y., Du C.M., Zhang J., Wu W.Q., Gu Z.L. Induction of apoptosis in human hepatocarcinoma SMMC-7721 cells in vitro by flavonoids from Astragalus complanatus. J. Ethnopharmacol. 2009, 123:293-301.
9. Kerr J.F.R., Winterford C.M., Harmon B.V. Apoptosis: its significance in cancer and cancer therapy. Cancer 1994, 73:2013-2016.
10. Kessel D., Luo Y. Cells in cryptophycin-induced cell-cycle arrest are susceptible to apoptosis. Cancer Lett. 2000, 151:25-29.
11. Lavrik I.N., Golks A., Krammer P.H. Caspases: pharmacological manipulation of cell death. J. Clin. Invest. 2005, 115:2665-2672.
12. Li Z.B., Wang J.Y., Jiang B., Zhang X.L., An L.J., Bao Y.M. Benzobijuglone, a novel cytotoxic compound from Juglans mandshurica, induced apoptosis in HeLa cervical cancer cells. Phytomedicine 2007, 14:846-852.
13. Liu C.Z., Zhao Y., Wang Y.C. Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug. Appl. Microbiol. Biotechnol. 2006, 72:11-20.
14. Murashige T., Skoog F. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol. Plant. 1962, 15:473-497.
15. Rueda A., Zubía E., Ortega M.J., Salvá J. New acyclic sesquiterpenes and norsesquiterpenes from the Caribbean gorgonian Plexaurella grisea. J. Nat. Prod. 2001, 64:401-405.
16. Tan R.X., Zheng W.F., Tang H.Q. Biologically active substances from the genus Artemisia. Planta Med. 1998, 64:295-302.
17. Tang W., Liu J.W., Zhao W.M., Wei D.Z., Zhong J.J. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci. 2006, 80:205-211.
18. Tsujimoto Y., Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis 2007, 12:835-840.
19. Wagner H., Ulrich-Merzenich G. Synergy research: approaching a new generation of phytopharmaceuticals. Phytomedicine 2009, 16:97-110.
20. Waldman T., Zhang Y.G., Dillehay L., Yu J., Kinzler K., Vogelstein B., Williams J. Cell-cycle arrest versus cell death in cancer therapy. Nat. Med. 1997, 3:1034-1036.
21. Zamzami N., Maisse C., Metivier D., Kroemer G. Measurement of membrane permeability and permeability transition of mitochondria. Method Cell. Biol. 2001, 65:147-158.
22. Zhai, D.D., Jin, H.Z., Zhong J.J., 2010. A new sesquiterpene from hairy root culture of Artemisia annua. Chin. Chem. Lett., doi:10.1016/j.cclet.2010.01.034.
23. Zheng G.Q. Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med. 1994, 60:54-57.