Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress

Archives of Biochemistry and Biophysics

Volumn 488, Issue 1, 2009, Pages 34-41

  Ohnuma, Tomokazu ^a   Komatsu, Takao ^b   Nakayama, Shinji ^c   Nishiyama, Takahito ^a   Ogura, Kenichiro ^a   Hiratsuka, Akira ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b Nippon Chemiphar Co Ltd   (Japan)

^c TOYAMA CHEMICAL CO LTD   (Japan)

Author keywords

ARE; Cytotoxicity; Drug metabolizing enzyme; Falcarindiol; Menadione; Nrf2

Indexed keywords

ANTIOXIDANT; CATALASE; DRUG METABOLIZING ENZYME; FALCARINDIOL; GLUTATHIONE TRANSFERASE; MENADIONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL STRESS; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DRUG MECHANISM; ELECTROPHILIC STRESS; MEDICINAL PLANT; NONHUMAN; NOTOPTERYGIUM INCISUM; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIOXIDANTS; APIACEAE; CELL DEATH; CLONE CELLS; CYTOPROTECTION; CYTOTOXINS; DIYNES; ELECTRONS; ENZYME INDUCTION; ENZYMES; FATTY ALCOHOLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HUMANS; METABOLIC DETOXICATION, PHASE II; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RESPONSE ELEMENTS; RNA, MESSENGER; SIGNAL TRANSDUCTION; VITAMIN K 3;

NOTOPTERYGIUM INCISUM; RATTUS;

EID: 67651108823     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.06.006     Document Type: Article

References (37)

1. Ching S. Dictionary of Chinese Crude Drugs (1977), New Medical College, Shanghai p. 1172
2. Kozawa M., Fukumoto M., Matsuyama Y., and Baba K. Chem. Pharm. Bull. 31 (1983) 2712-2717
3. Gu Z.M., Zhang D.X., Yang X.W., Hattori M., and Namba T. Chem. Pharm. Bull. 38 (1990) 2498-2502
4. Okuyama E., Nishimura S., Ohmori S., Ozaki Y., Satake M., and Yamazaki M. Chem. Pharm. Bull. 41 (1993) 926-929
5. Yang X.W., Gu Z.M., Wang B.X., Hattori M., and Namba T. Planta Med. 57 (1991) 399-402
6. Zidorn C., Jöhrer K., Ganzera M., Schubert B., Sigmund E.M., Mader J., Greil R., Ellmerer E.P., and Stuppner H. J. Agric. Food Chem. 53 (2005) 2518-2523
7. Bernart M.W., Cardellina J.H., Balaschak M.S., Alexander M.R., Shoemaker R.H., and Boyd M.R. J. Nat. Prod. 59 (1996) 748-753
8. Hayes J.D., Ellis E.M., Neal G.E., Harrison D.J., and Manson M.M. Biochem. Soc. Symp. 64 (1999) 141-168
9. Talalay P., Dinkova-Kostova A.T., and Holtzclaw W.D. Adv. Enzyme Regul. 43 (2003) 121-134
10. Hayes J.D., Flanagan J.U., and Jowsey I.R. Annu. Rev. Pharmacol. Toxicol. 45 (2005) 51-88
11. Lind C., Hochstein P., and Ernster L. Arch. Biochem. Biophys. 216 (1982) 178-185
12. Ryter S.W., Otterbein L.E., Morse D., and Choi A.M. Mol. Cell. Biochem. 234/235 (2002) 249-263
13. Friling R.S., Bensimon A., Tichauer Y., and Daniel V. Proc. Natl. Acad. Sci. USA 87 (1990) 6258-6262
14. Favreau L.V., and Pickett C.B. J. Biol. Chem. 266 (1991) 4556-4561
15. Alam J., Camhi S., and Choi A.M. J. Biol. Chem. 270 (1995) 11977-11984
16. Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., and Nabeshima Y. Biochem. Biophys. Res. Commun. 236 (1997) 313-322
17. Kensler T.W., Egner P.A., Dolan P.M., Groopman J.D., and Roebuck B.D. Cancer Res. 47 (1987) 4271-4277
18. De Long M.J., Prochaska H.J., and Talalay P. Cancer Res. 45 (1985) 546-551
19. Fahey J.W., Zhang Y., and Talalay P. Proc. Natl. Acad. Sci. USA 94 (1997) 10367-10372
20. Talalay P., Fahey J.W., Healy Z.R., Wehage S.L., Benedict A.L., Min C., and Dinkova-Kostova A.T. Proc. Natl. Acad. Sci. USA 104 (2007) 17500-17505
21. Habig W.H., Pabst M.J., and Jakoby W.B. J. Biol. Chem. 249 (1974) 7130-7139
22. Ernster L. Methods Enzymol. 10 (1967) 309-317
23. Aebi H. Methods Enzymol. 105 (1984) 121-126
24. Bansal S.K., and Gessner T. Anal. Biochem. 109 (1984) 321-329
25. Cohn V.H., and Lyle J. Anal. Biochem. 14 (1966) 434-440
26. Morimitsu Y., Nakagawa Y., Hayashi K., Fujii H., Kumagai T., Nakamura Y., Osawa T., Horio F., Itoh K., Iida K., Yamamoto M., and Uchida K. J. Biol. Chem. 277 (2002) 3456-3463
27. Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J.D., and Yamamoto M. Genes Dev. 13 (1999) 76-86
28. Morrison H., Jernström B., Nordenskjöld M., Thor H., and Orrenius S. Biochem. Pharmcol. 33 (1984) 1763-1769
29. Liu R.M., Nebert D.W., and Shertzer H.G. Toxicol. Appl. Pharmacol. 122 (1993) 101-107
30. Buffinton G.D., Öllinger K., Brunmark A., and Cadenas E. Biochem. J. 257 (1989) 561-571
31. Nishiyama T., Ohnuma T., Inoue Y., Kishi T., Ogura K., and Hiratsuka A. Biochem. Biophys. Res. Commun. 371 (2008) 247-250
32. Zschocke S., Lehner M., and Bauer R. Planta Med. 63 (1997) 203-206
33. Matsuda H., Sato N., Tokunaga M., Naruto S., and Kubo M. Nat. Med. 56 (2002) 113-116
34. Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., Yamamoto M., and Talalay P. Proc. Natl. Acad. Sci. USA 99 (2002) 11908-11913
35. Wakabayashi N., Dinkova-Kostova A.T., Holtzclaw W.D., Kang M.I., Kobayashi A., Yamamoto M., Kensler T., and Talalay P. Proc. Natl. Acad. Sci. USA 101 (2004) 2040-2045
36. Hong F., Freeman M.L., and Liebler D.C. Chem. Res. Toxicol. 18 (2005) 1917-1926
37. Chung J.H., Seo D.C., Chung S.H., Lee J.Y., and Seung S.A. Toxicol. Appl. Pharmacol. 142 (1997) 378-385