Falcarindiol, a polyacetylenic compound isolated from Peucedanum japonicum, inhibits mammalian DNA topoisomerase I

Journal of Microbiology and Biotechnology

Volumn 10, Issue 3, 2000, Pages 394-398

  Lee, Gwang ^a   Park, Hyoung Gun ^a   Choi, Mi Lim ^a   Kim, Young Ho ^a   Park, Yong Bok ^a   Song, Kyung Sik ^a   Cheong, Chaejoon ^b   Bae, Young Seuk ^a  

^a Kyungpook National University   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

Antifungal activity; Cytotoxicity; DNA topoisomerase I inhibitor; Falcarindiol; Peucedanum japonicum

Indexed keywords

DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; FALCARINDIOL;

ANTIFUNGAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CHEMOTHERAPY; DRUG ISOLATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PLANT ROOT;

EID: 0033913679     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Bernart, M. W., J. H. Cardellina, M. S. Balaschak, M. R. Alexander, R. H. Shoemarker, and M. R. Boyd. 1996. Cytotoxic falcarinol oxylipins from Dendropanax arboreus. J. Nat. Prod. 59: 748-753.
2. Giovanella, B. C., J. S. Stehlin, M. E. Wall, M. C. Wani, A. W. Nicholas, L. F. Liu, and M. Potmesil. 1989. DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. Science 246: 1046-1048.
3. Fujii, N., Y. Yamashita, Y. Saitoh, and H. Nakano. 1993. Induction of mammalian DNA topoisomerase I-mediated DNA cleavage and DNA winding by bulgarein. J. Biol. Chem. 268: 13160-13165.
4. Gupta, M., A. Fujimori, and Y. Pommier. 1995. Eukaryotic DNA topoisomerase I. Biochim. Biophys. Acta 1262: 1-14.
5. Horwitz, S. B. 1975. Camptothecin, PP. 48-57. In J. W. Corcoran and F. E. Hahn (eds.), Antibiotics: Mechanism of Action of Antimicrobial and Antitumor Agents, vol. 3. Springer-Verlag, New York, U.S.A.
6. Hsiang, Y. H., R. Hertzberg, S. Hecht, and L. F. Liu. 1985. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260: 14873-14878.
7. Ikeda, R., T. Nagao, H. Okabe, Y. Nakano, H. Matsunaga, M. Katano, and M. Mori. 1998. Antiproliferative constituents in Umbelliferae plants. III. Constituents in the root and ground part of Anthriscus sylvestris Hoffm. Chem. Pharm. Bull. (Tokyo) 46: 871-814.
8. Kozawa, M., M. Fukumoto, Y. Matsuyama, and K. Baba. 1983. Chemical studies on the constituents of the Chinese crude drug Quiang Huo. Chem. Pharm. Bull. 31: 2712-2717.
9. Lee, D.-S. and S.-D. Hong, 1998. Inhibition of DNA topoisomerase I by cryptotanshinone from Salvia miltiorrhiza. J. Microbiol. Biotechnol. 8: 89-91.
10. Li, C. J., L. Averboukh, and A. Pardee. 1993. β-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from Camptothecin. J. Biol. Chem. 268: 22463-22468.
11. Liu, L. F. 1989. DNA topoisomerase poisons as antitumor drugs. Annu. Rev. Biochem. 58: 351-375.
12. Matsuda, H., T. Murakami, T. Kageura, K. Ninomiya, I. Toguchida, N. Nishida, and M. Yoshikawa. 1998. Hepatoprotective and nitric oxide production inhibitory activities of coumarin and polyacetylene constituents from the roots of Angelica furcijuga. Bioorg. Med. Chem. Lett. 8: 2191-2196.
13. Miyazawa, M., H. Shimamura, R. C. Bhuva, S. I. Nakamura, and H. Kameoka. 1996. Antimutagenic activity of falcarindiol from Pseucedanum praeruptorum. J. Agric. Food Chem. 44: 3444-3448.
14. Nakano, Y., H. Matsunaga, T. Saita, M. Mori, M. Katano, and H. Okabe. 1998. Antiproliferative constituents in Umbelliferae plants. II. Screening for polyacetylenes in some Umbelliferae plants, and isolation of panaxynol and falcarindiol from the root of Heracleum moellendorffii. Biol. Pharm. Bull. 21: 257-261.
15. Namba, T. 1993. The Encyclopedia of Wakan-Yaku with Color Pictures, vol. 1, pp. 107- 109. Hoikusha, Japan.
16. Pauweis, R., J. Balzarini, M. Baba, R. Snoeck, D. Schols, P. Herdewijin, J. Desmyster, and E. De. Clercq. 1988. Rapid and automated tetrazolium-based colorimetric assay for detection of anti-HIV compounds. J. Virol. Methods 20: 309-321.
17. Porter, S. and J. J. Champoux. 1989. The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I. Nucleic Acids Res. 17: 8521-8532.
18. Potmesil, M., Y. H. Hsiang, L. F. Liu, B. Bank, H. Grossberg, S. Kirschenbaum, T. J. Forlenza, A. Penziner, D. Kanganis, D. Knowles, F. Traganos, and R. Silber. 1988. Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II. Cancer Res. 48: 3537-3543.
19. Ray, S., B. Hazra, B. Mittra, A. Das, and H. K. Majumder. 1998. Diospyrin, a bisnaphthoquinone: A novel inhibitor of type I DNA topoisomerase of Leishmania donovani. Mol. Pharm. 54: 994-999.
20. Rothenberg, M. L. and C. D. Blanke. 1999. Topoisomerase I inhibitors in the treatment of colorectal cancer. Semin. Oncol. 26: 632-639.
21. Slichenmeyer, W. J., E. K. Rowinsky, R. C. Donehower, and S. H. Kaufnan. 1993. The current status of camptothecin analogues as antitumor agents. J. Natl. Cancer Inst. 85: 271-289.
22. Wang. J. C. 1987. Recent studies of DNA topoisomerases. Biochim. Biophys. Acta 909: 1-9.
23. Wang, J. C. 1996. DNA topoisomerases. Annu. Rev. Biochem. 65: 635-692.
24. Zhang, H., J. C. Wang, and L. F. Liu. 1988. Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc. Natl. Acad. Sci. USA 85: 1060-1064.