Synthesis, cytotoxicity and QSAR study of N-tosyl-1,2,3,4- tetrahydroisoquinoline derivatives

Archives of Pharmacal Research

Volumn 36, Issue 9, 2013, Pages 1066-1077

  Pingaew, Ratchanok ^a   Worachartcheewan, Apilak ^b   Nantasenamat, Chanin ^b   Prachayasittikul, Supaluk ^b   Ruchirawat, Somsak ^c   Prachayasittikul, Virapong ^b  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c Toxicology and Management of Chemicals   (Thailand)

Author keywords

Cytotoxicity; Isoquinoline; Multiple linear regression; Pictet Spengler reaction; QSAR; Sulfonamide

Indexed keywords

1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 (2 HYDROXYPHENYL)ISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 (3 HYDROXY 4 METHOXYPHENYL)ISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 (3,4,5 TRIMETHOXYPHENYL)ISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 (4 BROMOPHENYL)ISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 (4 HYDROXY 3 METHOXYPHENYL)ISOQUINOLONE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 (4 HYDROXY 3,5 DIMETHOXYPHENYL)ISOQUINOLONE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 (4 HYDROXYPHENYL)ISOQUINOLONE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 (4 METHOXYPHENYL)ISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 METHYLISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL] 1 OHENYLISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4 METHYLPHENYL)SULFONYL]ISOQUINOLINE; 1,2,3,4 TETRAHYDRO 6,7 DIMETHOXY 2 [(4METHYLPHENYL)SULFONYL] 1 (3 PYRIDYL)ISOQUINOLINE; DOXORUBICIN; ETOPOSIDE; N TOSYL 1,2,3,4 TETRAHYDROISOQUINOLINE DERIVATIVE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; LIVER CELL CARCINOMA; LUNG CARCINOMA; LYMPHATIC LEUKEMIA; MOLECULAR WEIGHT; PHARMACOPHORE; PHYSICAL CHEMISTRY; PICTET SPENGLER REACTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG DESIGN; DRUGS, INVESTIGATIONAL; HUMANS; HYDROXYLATION; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; NEOPLASMS; PHYSICOCHEMICAL PHENOMENA; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TETRAHYDROISOQUINOLINES; TOSYL COMPOUNDS;

EID: 84884209513     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-013-0111-9     Document Type: Article

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