Novel bradykinin-1 antagonists containing a (1,2,3,4-tetrahydro-isoquinolin-1-yl)acetic acid scaffold

European Journal of Medicinal Chemistry

Volumn 43, Issue 7, 2008, Pages 1552-1558

  Huszár, József ^a   Timár, Zoltán ^a   Szalai, Krisztina Katalin ^b   Keseru, György ^b   Fülöp, Ferenc ^c   Penke, Botond ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Gedeon Richter Nyrt   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

B1 antagonist; Bradykinin; Bradykinin 1 receptor; Isoquinoline; Peptidomimetic

Indexed keywords

(1,2,3,4 TETRAHYDRO ISOQUINOLIN 1 YL)ACETIC ACID; 2 [6,7 DIMETHOXY 2 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 1 YL] N (4 GUANIDINOBUTYL)ACETAMIDE; [1 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL]ACETIC ACID; [6,7 DIMETHOXY 2 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 1 YL]ACETIC ACID; ACETIC ACID; BRADYKININ; BRADYKININ 1 ANTAGONIST; ISOQUINOLIN 1 YLACETIC ACID; N (4 AMINOBUTYL) 2 [1 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDRO ISOQUINOLIN 2 YL]ACETAMIDE; N (4 AMINOBUTYL) 2 [6,7 DIMETHOXY 2 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 1 YL]ACETAMIDE; N (4 GUANIDINOBUTYL) 2 [1 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL]ACETAMIDE; N (6 AMINOHEXYL) 2 [1 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL]ACETAMIDE; N (6 AMINOHEXYL) 2 [6,7 DIMETHOXY 2 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 1 YL] ACETAMIDE; N [2 [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ETHYL] 2 [1 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL]ACETAMIDE; N [2 [4 (4,5 DIHYDRO 1H PYRROL 2 YL)PHENYL]ETHYL] 2 [6,7 DIMETHOXY 2 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 1 YL] ACETAMIDE; N CYCLOHEPTYL 2 [1 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL]ACETAMIDE; N CYCLOHEPTYL 2 [6,7 DIMETHOXY 1 (TOLUENE 4 SULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL]ACETAMIDE;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLUOROMETRY; HUMAN;

CALCIUM; CYTOPLASM; FLUOROMETRY; MAGNETIC RESONANCE SPECTROSCOPY; RECEPTORS, BRADYKININ; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TETRAHYDROISOQUINOLINES;

EID: 45849118024     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2007.10.030     Document Type: Article

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