Elucidating the Structure-Activity relationships of the vasorelaxation and antioxidation properties of thionicotinic acid derivatives

Molecules

Volumn 15, Issue 1, 2010, Pages 198-214

  Prachayasittikul, Supaluk ^a   Wongsawatkul, Orapin ^a   Worachartcheewan, Apilak ^b   Nantasenamat, Chanin ^b   Ruchirawat, Somsak ^c   Prachayasittikul, Virapong ^a,b  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c CHULABHORN RESEARCH INSTITUTE   (Thailand)

Author keywords

1 adamantylthionicotinic acid and derivatives; Antioxidants; Molecular modeling; Nitric oxide; Prostacyclin; Vasorelaxants

Indexed keywords

ACETYLCHOLINE; ANTIOXIDANT; DRUG DERIVATIVE; N(G) NITROARGININE METHYL ESTER; NICOTINAMIDE; NICOTINIC ACID; PROSTAGLANDIN SYNTHASE INHIBITOR; THIOL DERIVATIVE; THIONICOTINAMIDE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; IN VITRO STUDY; MALE; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; THORACIC AORTA; VASODILATATION;

ACETYLCHOLINE; ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; CYCLOOXYGENASE INHIBITORS; ENDOTHELIAL CELLS; MALE; MODELS, MOLECULAR; NG-NITROARGININE METHYL ESTER; NIACIN; NIACINAMIDE; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; VASODILATION;

EID: 75749143457     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15010198     Document Type: Article

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