3-Hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4- tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity

Journal of Medicinal Chemistry

Volumn 48, Issue 1, 2005, Pages 134-140

  Grunewald, Gary L ^a   Romero, F Anthony ^a   Criscione, Kevin R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYMETHYL 7 (N 2,2,2 TRIFLUOROETHYLAMINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 HYDROXYMETHYL 7 (N 3,3,3 TRIFLUOROPROPYLAMINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 HYDROXYMETHYL 7 (N 4 CHLOROPHENYLAMINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 HYDROXYMETHYL 7 (N ETHYLAMINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 HYDROXYMETHYL 7 (N PROPYLAMINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 HYDROXYMETHYL 7 (N THIOMORPHOLINOSULFONYL) 1,2,3,4 TETRAHYDROISOQUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; PHENYLETHANOLAMINE N METHYLTRANSFERASE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; DRUG BINDING; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY;

ANIMALS; BINDING SITES; BIOCHEMISTRY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; HYDROPHOBICITY; MALE; MODELS, MOLECULAR; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-2; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TETRAHYDROISOQUINOLINES;

EID: 12144276705     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049368n     Document Type: Article

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