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Volumn 453, Issue 1, 2013, Pages 215-224

Lipid-based formulations for oral administration of poorly water-soluble drugs

Author keywords

In vitro lipolysis; Lipid digestion; Lipid based drug delivery systems; Lipids; Lymphatic transport; Poorly water soluble drug

Indexed keywords

DIGESTION; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG SOLUBILITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPID BASED FORMULATION; PRIORITY JOURNAL; REVIEW;

EID: 84884160665     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.03.054     Document Type: Review
Times cited : (290)

References (123)
  • 2
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification - The correlation of in-vitro drug product dissolution and in-vivo bioavailability
    • Amidon, G.L., Lennernas, H., Shah, V.P., Crison, J.R., 1995. A theoretical basis for a biopharmaceutic drug classification - the correlation of in-vitro drug product dissolution and in-vivo bioavailability. Pharm. Res. 12, 413-420.
    • (1995) Pharm. Res. , vol.12 , pp. 413-420
    • Amidon, G.L.1    Lennernas, H.2    Shah, V.P.3    Crison, J.R.4
  • 3
    • 33846871453 scopus 로고    scopus 로고
    • Lipases and lipolysis in the human digestive tract: Where do we stand?
    • DOI 10.1097/MCO.0b013e3280177687, PII 0007519720070300000007
    • Armand, M., 2007. Lipases and lipolysis in the human digestive tract: where do we stand? Curr. Opin. Clin. Nutr. Metab. Care 10, 156-164. (Pubitemid 46220307)
    • (2007) Current Opinion in Clinical Nutrition and Metabolic Care , vol.10 , Issue.2 , pp. 156-164
    • Armand, M.1
  • 4
    • 77952887062 scopus 로고    scopus 로고
    • SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I. Development and optimization
    • Basalious, E.B., Shawky, N., Badr-Eldin, S.M., 2010. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I. Development and optimization. Int. J. Pharm. 391, 203-211.
    • (2010) Int. J. Pharm. , vol.391 , pp. 203-211
    • Basalious, E.B.1    Shawky, N.2    Badr-Eldin, S.M.3
  • 5
    • 0033818432 scopus 로고    scopus 로고
    • Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats
    • Caliph, S.M., Charman, W.N., Porter, C.J., 2000. Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J. Pharm. Sci. 89, 1073-1084.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 1073-1084
    • Caliph, S.M.1    Charman, W.N.2    Porter, C.J.3
  • 6
    • 0015894416 scopus 로고
    • Biopharmaceutics of drugs administered in lipid-containing dosage forms. 1. Gi-absorption of griseofulvin from an oil-in-water emulsion in rat
    • Carrigan, P.J., Bates, T.R., 1973. Biopharmaceutics of drugs administered in lipid-containing dosage forms. 1. Gi-absorption of griseofulvin from an oil-in-water emulsion in rat. J. Pharm. Sci. 62, 1476-1479.
    • (1973) J. Pharm. Sci. , vol.62 , pp. 1476-1479
    • Carrigan, P.J.1    Bates, T.R.2
  • 7
    • 84884163544 scopus 로고    scopus 로고
    • Hamilton, R.J., Cast, J. (Eds.), CRC Press LLC, Boca Raton
    • Cast, J., Hamilton, R.J., 1999. In: Hamilton, R.J., Cast, J. (Eds.), Spectral Properties of Lipids. CRC Press LLC, Boca Raton, pp. 1-19.
    • (1999) Spectral Properties of Lipids , pp. 1-19
    • Cast, J.1    Hamilton, R.J.2
  • 8
    • 0039600169 scopus 로고
    • Sebedio, J.-L., Perkins, E.G. (Eds.), AOCS Press, Champaign
    • Castera, A., 1995. In: Sebedio, J.-L., Perkins, E.G. (Eds.), New Trends in Lipid and Lipoprotein Analyses. AOCS Press, Champaign, pp. 10-16.
    • (1995) New Trends in Lipid and Lipoprotein Analyses , pp. 10-16
    • Castera, A.1
  • 9
    • 0017902248 scopus 로고
    • Bioavailability of phenytoin in lipid containing dosage forms in rats
    • Chakrabarti, S., Belpaire, F.M., 1978. Bioavailability of phenytoin in lipid containing dosage forms in rats. J. Pharm. Pharmacol. 30, 330-331. (Pubitemid 8334369)
    • (1978) Journal of Pharmacy and Pharmacology , vol.30 , Issue.5 , pp. 330-331
    • Chakrabarti, S.1    Belpaire, F.M.2
  • 10
    • 68349160715 scopus 로고    scopus 로고
    • Lipid - An emerging platform for oral delivery of drugs with poor bioavailability
    • Chakraborty, S., Shukla, D., Mishra, B., Singh, S., 2009. Lipid - an emerging platform for oral delivery of drugs with poor bioavailability. Eur. J. Pharm. Biopharm. 73, 1-15.
    • (2009) Eur. J. Pharm. Biopharm. , vol.73 , pp. 1-15
    • Chakraborty, S.1    Shukla, D.2    Mishra, B.3    Singh, S.4
  • 11
    • 0017114559 scopus 로고
    • Mechanism of pancreatic lipase action. 1. Interfacial activation of pancreatic lipase
    • Chapus, C., Sémériva, M., Bovier-Lapierre, C., Desnuelle, P., 1976. Mechanism of pancreatic lipase action. 1. Interfacial activation of pancreatic lipase. Biochemistry 15, 4980-4987.
    • (1976) Biochemistry , vol.15 , pp. 4980-4987
    • Chapus, C.1    Sémériva, M.2    Bovier-Lapierre, C.3    Desnuelle, P.4
  • 12
    • 0022980134 scopus 로고
    • Effects of lipid class and lipid vehicle volume on the intestinal lymphatic transport of DDT
    • Charman, W.N.A., Stella, V.J., 1986a. Effects of lipid class and lipid vehicle volume on the intestinal lymphatic transport of DDT. Int. J. Pharm. 33, 165- 172.
    • (1986) Int. J. Pharm. , vol.33 , pp. 165-172
    • Charman, W.N.A.1    Stella, V.J.2
  • 13
    • 0023276505 scopus 로고
    • Estimating the maximal potential for intestinal lymphatic transport of lipophilic drug molecules
    • Charman, W.N.A., Stella, V.J., 1986b. Estimating the maximal potential for intestinal lymphatic transport of lipophilic drug molecules. Int. J. Pharm. 34, 175-178.
    • (1986) Int. J. Pharm. , vol.34 , pp. 175-178
    • Charman, W.N.A.1    Stella, V.J.2
  • 14
    • 5644294406 scopus 로고    scopus 로고
    • Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols
    • DOI 10.1016/j.ejps.2004.08.003, PII S0928098704002003
    • Christensen, J.O., Schultz, K., Mollgaard, B., Kristensen, H.G., Mullertz, A., 2004. Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols. Eur. J. Pharm. Sci. 23, 287-296. (Pubitemid 39369884)
    • (2004) European Journal of Pharmaceutical Sciences , vol.23 , Issue.3 , pp. 287-296
    • Christensen, J.O.1    Schultz, K.2    Mollgaard, B.3    Kristensen, H.G.4    Mullertz, A.5
  • 16
    • 0021951281 scopus 로고
    • Rapid separation and quantification of lipid classes by high performance liquid chromatography and mass (light-scattering) detection
    • Christie, W.W., 1985. Rapid separation and quantification of lipid classes by high performance liquid chromatography and mass (light-scattering) detection. J. Lipid Res. 26, 507-512. (Pubitemid 15099377)
    • (1985) Journal of Lipid Research , vol.26 , Issue.4 , pp. 507-512
    • Christie, W.W.1
  • 17
    • 33745664623 scopus 로고    scopus 로고
    • Digestion and absorption of glycerides
    • Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B.D., Tokimitsu, I., Matlock, M.G. (Eds.), AOCS Press, Champaign
    • Christophe, A.B., 2004. Digestion and absorption of glycerides. In: Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B.D., Tokimitsu, I., Matlock, M.G. (Eds.), Diacylglycerol Oil. AOCS Press, Champaign, pp. 16-29.
    • (2004) Diacylglycerol Oil , pp. 16-29
    • Christophe, A.B.1
  • 18
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    • DOI 10.1023/A:1016268311867
    • Constantinides, P.P., 1995. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm. Res. 12, 1561-1572. (Pubitemid 26005509)
    • (1995) Pharmaceutical Research , vol.12 , Issue.11 , pp. 1561-1572
    • Constantinides, P.P.1
  • 19
    • 0031692823 scopus 로고    scopus 로고
    • The hydrophobic surface of colipase influences lipase activity at an oil-water interface
    • Cordle, R.A., Lowe, M.E., 1998. The hydrophobic surface of colipase influences lipase activity at an oil-water interface. J. Lipid Res. 39, 1759-1767. (Pubitemid 28411163)
    • (1998) Journal of Lipid Research , vol.39 , Issue.9 , pp. 1759-1767
    • Cordle, R.A.1    Lowe, M.E.2
  • 20
    • 0032507707 scopus 로고    scopus 로고
    • Formulation of a lyophilized dry emulsion tablet for the delivery of poorly soluble drugs
    • DOI 10.1016/S0378-5173(98)00024-6, PII S0378517398000246
    • Corveleyn, S., Remon, J.P., 1998. Formulation of a lyophilized dry emulsion tablet for the delivery of poorly soluble drugs. Int. J. Pharm. 166, 65-74. (Pubitemid 28239740)
    • (1998) International Journal of Pharmaceutics , vol.166 , Issue.1 , pp. 65-74
    • Corveleyn, S.1    Remon, J.P.2
  • 21
    • 0027301116 scopus 로고
    • An investigation into the physico-chemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis
    • Craig, D.Q.M., Lievens, H.S.R., Pitt, K.G., Storey, D.E., 1993. An investigation into the physico-chemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis. Int. J. Pharm. 96, 147-155. (Pubitemid 23233280)
    • (1993) International Journal of Pharmaceutics , vol.96 , Issue.1-3 , pp. 147-155
    • Craig, D.Q.M.1    Lievens, H.S.R.2    Pitt, K.G.3    Storey, D.E.4
  • 22
    • 34250867442 scopus 로고    scopus 로고
    • The effect of different lipid based formulations on the oral absorption of lipophilic drugs: The ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats
    • DOI 10.1016/j.ejpb.2007.01.017, PII S0939641107000227
    • Dahan, A., Hoffman, A., 2007. The effect of different lipid based formulations on the oral absorption of lipophilic drugs: the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats. Eur. J. Pharm. Biopharm. 67, 96-105. (Pubitemid 46991342)
    • (2007) European Journal of Pharmaceutics and Biopharmaceutics , vol.67 , Issue.1 , pp. 96-105
    • Dahan, A.1    Hoffman, A.2
  • 23
    • 33845576641 scopus 로고    scopus 로고
    • Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil
    • DOI 10.1016/j.ijpharm.2006.08.038, PII S0378517306006958
    • Date, A.A., Nagarsenker, M.S., 2007. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int. J. Pharm. 329, 166-172. (Pubitemid 44937527)
    • (2007) International Journal of Pharmaceutics , vol.329 , Issue.1-2 , pp. 166-172
    • Date, A.A.1    Nagarsenker, M.S.2
  • 24
    • 57349119914 scopus 로고    scopus 로고
    • Formulation and in vivo evaluation of selfnanoemulsifying granules for oral delivery of a combination of ezetimibe and simvastatin
    • Dixit, R.P., Nagarsenker, M.S., 2008a. Formulation and in vivo evaluation of selfnanoemulsifying granules for oral delivery of a combination of ezetimibe and simvastatin. Drug Dev. Ind. Pharm. 34, 1285-1296.
    • (2008) Drug Dev. Ind. Pharm. , vol.34 , pp. 1285-1296
    • Dixit, R.P.1    Nagarsenker, M.S.2
  • 25
    • 50449091497 scopus 로고    scopus 로고
    • Self-nanoemulsifying granules of ezetimibe: Design, optimization and evaluation
    • Dixit, R.P., Nagarsenker, M.S., 2008b. Self-nanoemulsifying granules of ezetimibe: design, optimization and evaluation. Eur. J. Pharm. Sci. 35, 183-192.
    • (2008) Eur. J. Pharm. Sci. , vol.35 , pp. 183-192
    • Dixit, R.P.1    Nagarsenker, M.S.2
  • 26
    • 0041667788 scopus 로고    scopus 로고
    • Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs
    • DOI 10.1016/S0928-0987(03)00134-9
    • Dollo, G., Le Corre, P., Guerin, A., Chevanne, F., Burgot, J.L., Leverge, R., 2003. Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs. Eur. J. Pharm. Sci. 19, 273-280. (Pubitemid 36918420)
    • (2003) European Journal of Pharmaceutical Sciences , vol.19 , Issue.4 , pp. 273-280
    • Dollo, G.1    Le, C.P.2    Guerin, A.3    Chevanne, F.4    Burgot, J.L.5    Leverge, R.6
  • 28
    • 34548567075 scopus 로고    scopus 로고
    • Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by Small-angle X-ray scattering
    • DOI 10.1007/s11095-007-9304-6
    • Fatouros, D.G., Deen, G.R., Arleth, L., Bergenstahl, B., Nielsen, F.S., Pedersen, J.S., Mullertz, A., 2007. Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering. Pharm. Res. 24, 1844-1853. (Pubitemid 47389238)
    • (2007) Pharmaceutical Research , vol.24 , Issue.10 , pp. 1844-1853
    • Fatouros, D.G.1    Deen, G.R.2    Arleth, L.3    Bergenstahl, B.4    Nielsen, F.S.5    Pedersen, J.S.6    Mullertz, A.7
  • 29
    • 48149100781 scopus 로고    scopus 로고
    • In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks
    • Fatouros, D., Nielsen, F., Douroumis, D., Hadjileontiadis, L., Müllertz, A., 2008. In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks. Eur. J. Pharm. Biopharm. 69, 887-898.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 887-898
    • Fatouros, D.1    Nielsen, F.2    Douroumis, D.3    Hadjileontiadis, L.4    Müllertz, A.5
  • 30
    • 77955468413 scopus 로고    scopus 로고
    • Phospholipids and lipid-based formulations in oral drug delivery
    • Fricker, G., et al., 2010. Phospholipids and lipid-based formulations in oral drug delivery. Pharm. Res. 27, 1469-1486.
    • (2010) Pharm. Res. , vol.27 , pp. 1469-1486
    • Fricker, G.1
  • 31
    • 79955478925 scopus 로고    scopus 로고
    • Mixture experiment methods in the development and optimization of microemulsion formulations
    • Furlanetto, S., Cirri, M., Piepel, G., Mennini, N., Mura, P., 2011. Mixture experiment methods in the development and optimization of microemulsion formulations. J. Pharm. Biomed. Anal. 55, 610-617.
    • (2011) J. Pharm. Biomed. Anal. , vol.55 , pp. 610-617
    • Furlanetto, S.1    Cirri, M.2    Piepel, G.3    Mennini, N.4    Mura, P.5
  • 32
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • DOI 10.1016/S0939-6411(00)00089-8, PII S0939641100000898
    • Gershanik, T., Benita, S., 2000. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur. J. Pharm. Biopharm. 50, 179-188. (Pubitemid 30326696)
    • (2000) European Journal of Pharmaceutics and Biopharmaceutics , vol.50 , Issue.1 , pp. 179-188
    • Gershanik, T.1    Benita, S.2
  • 33
    • 34447512868 scopus 로고    scopus 로고
    • Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: Dexanabinol and PRS-211,220
    • DOI 10.1016/j.ejps.2007.04.006, PII S0928098707001236
    • Gershkovich, P., Qadri, B., Yacovan, A., Amselem, S., Hoffman, A., 2007. Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220. Eur. J. Pharm. Sci. 31, 298-305. (Pubitemid 47079000)
    • (2007) European Journal of Pharmaceutical Sciences , vol.31 , Issue.5 , pp. 298-305
    • Gershkovich, P.1    Qadri, B.2    Yacovan, A.3    Amselem, S.4    Hoffman, A.5
  • 34
    • 34247137899 scopus 로고    scopus 로고
    • Bioavailability of seocalcitol. III. Administration of lipid-based formulations to minipigs in the fasted and fed state
    • DOI 10.1016/j.ejps.2007.01.007, PII S0928098707000279
    • Grove, M., Mullertz, A., Pedersen, G.P., Nielsen, J.L., 2007. Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state. Eur. J. Pharm. Sci. 31, 8-15. (Pubitemid 46601865)
    • (2007) European Journal of Pharmaceutical Sciences , vol.31 , Issue.1 , pp. 8-15
    • Grove, M.1    Mullertz, A.2    Pedersen, G.P.3    Nielsen, J.L.4
  • 35
    • 25444464372 scopus 로고    scopus 로고
    • Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats - Effect of medium and long chain triglycerides
    • DOI 10.1002/jps.20403
    • Grove, M., Pedersen, G.P., Nielsen, J.L., Mullertz, A., 2005. Bioavailability of seocalcitol I: relating solubility in biorelevant media with oral bioavailability in rats - effect of medium and long chain triglycerides. J. Pharm. Sci. 94, 1830-1838. (Pubitemid 41360876)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.8 , pp. 1830-1838
    • Grove, M.1    Pedersen, G.P.2    Nielsen, J.L.3    Mullertz, A.4
  • 36
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    • DOI 10.1016/j.biopha.2004.02.001, PII S0753332204000319
    • Gursoy, R.N., Benita, S., 2004. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed. Pharmacother. 58, 173-182. (Pubitemid 38479922)
    • (2004) Biomedicine and Pharmacotherapy , vol.58 , Issue.3 , pp. 173-182
    • Gursoy, R.N.1    Benita, S.2
  • 37
    • 0018341421 scopus 로고
    • A review. Fat digestion in the newborn: Role of lingual lipase and preduodenal digestion
    • Hamosh, M., 1979. Review - fat digestion in the newborn - role of lingual lipase and pre-duodenal digestion. Pediatr. Res. 13, 615-622. (Pubitemid 9150193)
    • (1979) Pediatric Research , vol.13 , Issue.5 I , pp. 615-622
    • Hamosh, M.1
  • 38
    • 0015547044 scopus 로고
    • Lingual lipase and its role in digestion of dietary lipid
    • Hamosh, M., Scow, R.O., 1973. Lingual lipase and its role in digestion of dietary lipid. J. Clin. Invest. 52, 88-95.
    • (1973) J. Clin. Invest. , vol.52 , pp. 88-95
    • Hamosh, M.1    Scow, R.O.2
  • 39
    • 68649090154 scopus 로고    scopus 로고
    • Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: Effects of lipid composition and formulation
    • Han, S.F., Yao, T.T., Zhang, X.X., Gan, L., Zhu, C.L., Yua, H.Z., Gan, Y., 2009. Lipid-based formulations to enhance oral bioavailability of the poorly water-soluble drug anethol trithione: effects of lipid composition and formulation. Int. J. Pharm. 379, 18-24.
    • (2009) Int. J. Pharm. , vol.379 , pp. 18-24
    • Han, S.F.1    Yao, T.T.2    Zhang, X.X.3    Gan, L.4    Zhu, C.L.5    Yua, H.Z.6    Gan, Y.7
  • 41
    • 34548049221 scopus 로고    scopus 로고
    • Oral lipid-based formulations
    • DOI 10.1016/j.addr.2007.05.006, PII S0169409X07000853
    • Hauss, D.J., 2007. Oral lipid-based formulations. Adv. Drug Deliv. Rev. 59, 667-676. (Pubitemid 47285409)
    • (2007) Advanced Drug Delivery Reviews , vol.59 , Issue.7 , pp. 667-676
    • Hauss, D.J.1
  • 42
    • 0002321010 scopus 로고    scopus 로고
    • Christie, W.W. (Ed.), The Oily Press, Dundee
    • Heinz, E., 1996. In: Christie, W.W. (Ed.), Advances in Lipid Methodology - Three. The Oily Press, Dundee, pp. 211-332.
    • (1996) Advances in Lipid Methodology - Three , pp. 211-332
    • Heinz, E.1
  • 43
    • 33749454734 scopus 로고    scopus 로고
    • Optimization of self-microemulsifying drug delivery systems (SMEDDS) using a D-optimal design and the desirability function
    • DOI 10.1080/03639040600559024, PII M276R23GW2KR3366
    • Holm, R., Jensen, I.H.M., Sonnergaard, J., 2006a. Optimization of self-microemulsifying drug delivery systems (SMEDDS) using a D-optimal design and the desirability function. Drug Dev. Ind. Pharm. 32, 1025-1032. (Pubitemid 44521820)
    • (2006) Drug Development and Industrial Pharmacy , vol.32 , Issue.9 , pp. 1025-1032
    • Holm, R.1    Jensen, I.H.M.2    Sonnergaard, J.3
  • 45
    • 0041331755 scopus 로고    scopus 로고
    • Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides
    • DOI 10.1016/S0928-0987(03)00174-X
    • Holm, R., Porter, C.J.H., Edwards, G.A., Mullertz, A., Kristensen, H.G., Charman, W.N., 2003. Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides. Eur. J. Pharm. Sci. 120, 91-97. (Pubitemid 37103236)
    • (2003) European Journal of Pharmaceutical Sciences , vol.20 , Issue.1 , pp. 91-97
    • Holm, R.1    Porter, C.J.H.2    Edwards, G.A.3    Mullertz, A.4    Kristensen, H.G.5    Charman, W.N.6
  • 46
    • 0343963156 scopus 로고    scopus 로고
    • Improved bioavailability of vitamin E with a self emulsifying formulation
    • DOI 10.1016/S0378-5173(00)00337-9, PII S0378517300003379
    • Julianto, T., Yuen, K.H., Noor, A.M., 2000. Improved bioavailability of vitamin E with a self emulsifying formulation. Int. J. Pharm. 200, 53-57. (Pubitemid 30177249)
    • (2000) International Journal of Pharmaceutics , vol.200 , Issue.1 , pp. 53-57
    • Julianto, T.1    Yuen, K.H.2    Noor, A.M.3
  • 47
    • 0029964775 scopus 로고    scopus 로고
    • Intestinal synthesis and lymphatic secretion of apolipoprotein A-IV vary with chain length of intestinally infused fatty acids in rats
    • Kalogeris, T.J., Monroe, F., DeMichele, S.J., Tso, P., 1996. Intestinal synthesis and lymphatic secretion of apolipoprotein A-IV vary with chain length of intestinally infused fatty acids in rats. J. Nutr. 126, 2720-2729. (Pubitemid 26376607)
    • (1996) Journal of Nutrition , vol.126 , Issue.11 , pp. 2720-2729
    • Kalogeris, T.J.1    Monroe, F.2    Demichele, S.J.3    Tso, P.4
  • 48
    • 1242291941 scopus 로고    scopus 로고
    • Drug Solubilization Behavior during in Vitro Digestion of Suspension Formulations of Poorly Water-Soluble Drugs in Triglyceride Lipids
    • DOI 10.1023/B:PHAM.0000016283.87709.a9
    • Kaukonen, A.M., Boyd, B.J., Charman, W.N., Porter, C.J.H., 2004a. Drug solubilization behavior during in vitro digestion of suspension formulations of poorly watersoluble drugs in triglyceride lipids. Pharm. Res. 21, 254-260. (Pubitemid 38221970)
    • (2004) Pharmaceutical Research , vol.21 , Issue.2 , pp. 254-260
    • Kaukonen, A.M.1    Boyd, B.J.2    Charman, W.N.3    Porter, C.J.H.4
  • 49
    • 1242292226 scopus 로고    scopus 로고
    • Drug Solubilization Behavior during in Vitro Digestion of Simple Triglyceride Lipid Solution Formulations
    • DOI 10.1023/B:PHAM.0000016282.77887.1f
    • Kaukonen, A.M., Boyd, B.J., Porter, C.J.H., Charman, W.N., 2004b. Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations. Pharm. Res. 21, 245-253. (Pubitemid 38221969)
    • (2004) Pharmaceutical Research , vol.21 , Issue.2 , pp. 245-253
    • Kaukonen, A.M.1    Boyd, B.J.2    Porter, C.J.H.3    Charman, W.N.4
  • 50
    • 77955097506 scopus 로고    scopus 로고
    • Biorelevant media simulating fed state intestinal fluids: Colloid phase characterization and impact on solubilization capacity
    • Kleberg, K., Jacobsen, F., Fatouros, D.G., Mullertz, A., 2010a. Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity. J. Pharm. Sci. 99, 3522-3532.
    • (2010) J. Pharm. Sci. , vol.99 , pp. 3522-3532
    • Kleberg, K.1    Jacobsen, F.2    Fatouros, D.G.3    Mullertz, A.4
  • 51
    • 78649653098 scopus 로고    scopus 로고
    • Characterising the behaviour of poorly water soluble drugs in the intestine: Application of biorelevant media for solubility, dissolution and transport studies
    • Kleberg, K., Jacobsen, J., Mullertz, A., 2010b. Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies. J. Pharm. Pharmacol. 62, 1656-1668.
    • (2010) J. Pharm. Pharmacol. , vol.62 , pp. 1656-1668
    • Kleberg, K.1    Jacobsen, J.2    Mullertz, A.3
  • 52
    • 78349310868 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems: An approach to enhance oral bioavailability
    • Kohli, K., Chopra, S., Dhar, D., Arora, S., Khar, R.K., 2010. Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability. Drug Discovery Today 15, 958-965.
    • (2010) Drug Discovery Today , vol.15 , pp. 958-965
    • Kohli, K.1    Chopra, S.2    Dhar, D.3    Arora, S.4    Khar, R.K.5
  • 53
    • 33745637470 scopus 로고    scopus 로고
    • Diacylglycerol oil does not affect portal vein transport of nonesterified fatty acids but decreases the postprandial plasma lipid response in catheterized pigs
    • Kristensen, J., Jorgensen, H., Mu, H., 2006. Diacylglycerol oil does not affect portal vein transport of nonesterified fatty acids but decreases the postprandial plasma lipid response in catheterized pigs. J. Nutr. 136, 1800-1805. (Pubitemid 43973579)
    • (2006) Journal of Nutrition , vol.136 , Issue.7 , pp. 1800-1805
    • Kristensen, J.B.1    Jorgensen, H.2    Mu, H.3
  • 54
    • 79952224749 scopus 로고    scopus 로고
    • Oral self-emulsifying drug delivery systems, from biopharmaceutical to technical formulation aspects
    • Kuentz, M., 2011. Oral self-emulsifying drug delivery systems, from biopharmaceutical to technical formulation aspects. J. Drug Deliv. Sci. Technol. 21, 17-26.
    • (2011) J. Drug Deliv. Sci. Technol. , vol.21 , pp. 17-26
    • Kuentz, M.1
  • 55
    • 34347376910 scopus 로고    scopus 로고
    • Application of a statistical method to the absorption of a new model drug from micellar and lipid formulations - Evaluation of qualitative excipient effects
    • DOI 10.1080/10837450701212651, PII 780134495
    • Kuentz, M., Wyttenbach, N., Kuhlmann, O., 2007. Application of a statistical method to the absorption of a new model drug from micellar and lipid formulations - evaluation of qualitative excipient effects. Pharm. Develop. Technol. 12, 275-283. (Pubitemid 47027069)
    • (2007) Pharmaceutical Development and Technology , vol.12 , Issue.3 , pp. 275-283
    • Kuentz, M.1    Wyttenbach, N.2    Kuhlmann, O.3
  • 56
    • 57149136074 scopus 로고    scopus 로고
    • Lipid-based formulations for danazol containing a digestible surfactant, labrafil m2125cs: In vivo bioavailability and dynamic in vitro lipolysis
    • Larsen, A., Holm, R., Pedersen, M.L., Mullertz, A., 2008. Lipid-based formulations for danazol containing a digestible surfactant, labrafil m2125cs: in vivo bioavailability and dynamic in vitro lipolysis. Pharm. Res. 25, 2769-2777.
    • (2008) Pharm. Res. , vol.25 , pp. 2769-2777
    • Larsen, A.1    Holm, R.2    Pedersen, M.L.3    Mullertz, A.4
  • 57
    • 80052265520 scopus 로고    scopus 로고
    • In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems
    • Larsen, A.T., Sassene, P., Mullertz, A., 2011. In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems. Int. J. Pharm. 417, 245-255.
    • (2011) Int. J. Pharm. , vol.417 , pp. 245-255
    • Larsen, A.T.1    Sassene, P.2    Mullertz, A.3
  • 58
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • DOI 10.1016/S1056-8719(00)00107-6, PII S1056871900001076
    • Lipinski, C.A., 2000. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 44, 235-249. (Pubitemid 32239479)
    • (2000) Journal of Pharmacological and Toxicological Methods , vol.44 , Issue.1 , pp. 235-249
    • Lipinski, C.A.1
  • 59
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • DOI 10.1016/S0169-409X(96)00423-1, PII S0169409X96004231
    • Lipinski, C.A., Lombardo, F., Dominy, B.W., Feeney, P.J., 1997. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23, 3-25. (Pubitemid 27046991)
    • (1997) Advanced Drug Delivery Reviews , vol.23 , Issue.1-3 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 60
    • 74749093382 scopus 로고    scopus 로고
    • An improved formulation screening and optimization method applied to the development of a self-microemulsifying drug delivery system
    • Liu, Y., Chen, Z.Q., Zhang, X., Feng, N.P., Zhao, J.H., Wu, S., Tan, R., 2010. An improved formulation screening and optimization method applied to the development of a self-microemulsifying drug delivery system. Chem. Pharm. Bull. 58, 16-22.
    • (2010) Chem. Pharm. Bull. , vol.58 , pp. 16-22
    • Liu, Y.1    Chen, Z.Q.2    Zhang, X.3    Feng, N.P.4    Zhao, J.H.5    Wu, S.6    Tan, R.7
  • 62
    • 84862898541 scopus 로고    scopus 로고
    • Design of lipid-based formulations for oral administration of poorly water-soluble drug fenofibrate: Effects of digestion
    • Mohsin, K., 2012. Design of lipid-based formulations for oral administration of poorly water-soluble drug fenofibrate: effects of digestion. AAPS Pharm. Sci. Tech. 13, 637-646.
    • (2012) AAPS Pharm. Sci. Tech. , vol.13 , pp. 637-646
    • Mohsin, K.1
  • 63
    • 84884168340 scopus 로고    scopus 로고
    • Analysis of lipids by new hyphenated techniques
    • Akoh, C.C., Lai, O.M. (Eds.), AOCS Press, Champaign
    • Mu, H., 2005. Analysis of lipids by new hyphenated techniques. In: Akoh, C.C., Lai, O.M. (Eds.), Healthful Lipids. AOCS Press, Champaign, pp. 78-98.
    • (2005) Healthful Lipids , pp. 78-98
    • Mu, H.1
  • 64
    • 0345276011 scopus 로고    scopus 로고
    • The digestion of dietary triacylglycerols
    • DOI 10.1016/S0163-7827(03)00050-X
    • Mu, H., Høy, C.-E., 2004. The digestion of dietary triacylglycerols. Prog. Lipid Res. 43, 105-133. (Pubitemid 37487986)
    • (2004) Progress in Lipid Research , vol.43 , Issue.2 , pp. 105-133
    • Mu, H.1    Hoy, C.-E.2
  • 65
    • 0034363474 scopus 로고    scopus 로고
    • Chromatographic methods in the monitoring of lipase-catalyzed interesterification
    • Mu, H., Kalo, P., Xu, X., Høy, C.-E., 2000. Chromatographic methods in the monitoring of lipase-catalyzed interesterification. Eur. J. Lipid Sci. Technol. 102, 202-211.
    • (2000) Eur. J. Lipid Sci. Technol. , vol.102 , pp. 202-211
    • Mu, H.1    Kalo, P.2    Xu, X.3    Høy, C.-E.4
  • 66
    • 0033981094 scopus 로고    scopus 로고
    • Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols
    • Mu, H., Høy, C.-E., 2000. Effect of medium-chain fatty acids on lymphatic absorption of essential fatty acids in specific structured lipids. Lipids 35, 83-89. (Pubitemid 30084634)
    • (2000) Lipids , vol.35 , Issue.1 , pp. 83-89
    • Mu, H.1    Hoy, C.-E.2
  • 67
    • 27744587923 scopus 로고    scopus 로고
    • The metabolism of structured triacylglycerols
    • DOI 10.1016/j.plipres.2005.09.002, PII S0163782705000391
    • Mu, H., Porsgaard, T., 2005. The metabolism of structured triacylglycerols. Prog. Lipid Res. 44, 430-448. (Pubitemid 41613755)
    • (2005) Progress in Lipid Research , vol.44 , Issue.6 , pp. 430-448
    • Mu, H.1    Porsgaard, T.2
  • 68
    • 0034985837 scopus 로고    scopus 로고
    • Intestinal absorption of specific structured triacylglycerols
    • Mu, H., Hoy, C.E., 2001. Intestinal absorption of specific structured triacylglycerols. J. Lipid Res. 42, 792-798. (Pubitemid 32507179)
    • (2001) Journal of Lipid Research , vol.42 , Issue.5 , pp. 792-798
    • Mu, H.1    Hoy, C.-E.2
  • 69
    • 0028079609 scopus 로고
    • Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation
    • DOI 10.1023/A:1018922517162
    • Mueller, E.A., Kovarik, J.M., Vanbree, J.B., Grevel, J., Lucker, P.W., Kutz, K., 1994. Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulations. Pharm. Res. 11, 151-155. (Pubitemid 24040779)
    • (1994) Pharmaceutical Research , vol.11 , Issue.1 , pp. 151-155
    • Mueller, E.A.1    Kovarik, J.M.2    Van Bree, J.B.3    Grevel, J.4    Lucker, P.W.5    Kutz, K.6
  • 70
    • 84863115253 scopus 로고    scopus 로고
    • Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo
    • Müllertz, A., Fatouros, D.G., Smith, J.R., Vertzoni, M., Reppas, C., 2012. Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo. Mol. Pharmacol. 9, 237-247.
    • (2012) Mol. Pharmacol. , vol.9 , pp. 237-247
    • Müllertz, A.1    Fatouros, D.G.2    Smith, J.R.3    Vertzoni, M.4    Reppas, C.5
  • 71
    • 78049499869 scopus 로고    scopus 로고
    • New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs
    • Müllertz, A., Ogbonna, A., Ren, S., Rades, T., 2010. New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs. J. Pharm. Pharmacol. 62, 1622-1636.
    • (2010) J. Pharm. Pharmacol. , vol.62 , pp. 1622-1636
    • Müllertz, A.1    Ogbonna, A.2    Ren, S.3    Rades, T.4
  • 72
    • 43249122851 scopus 로고    scopus 로고
    • Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state
    • Nielsen, F.S., Petersen, K.B., Mullertz, A., 2008. Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state. Eur. J. Pharm. Biopharm. 69, 553-562.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , pp. 553-562
    • Nielsen, F.S.1    Petersen, K.B.2    Mullertz, A.3
  • 73
    • 0034229914 scopus 로고    scopus 로고
    • Characterization of the liquid-crystalline phases in the glycerol monooleate/diglycerol monooleate/water system
    • Pitzalis, P., Monduzzi, M., Krog, N., Larsson, H., Ljusberg-Wahren, H., Nylander, T., 2000. Characterization of the liquid-crystalline phases in the glycerol monooleate/diglycerol monooleate/water system. Langmuir 16, 6358-6365.
    • (2000) Langmuir , vol.16 , pp. 6358-6365
    • Pitzalis, P.1    Monduzzi, M.2    Krog, N.3    Larsson, H.4    Ljusberg-Wahren, H.5    Nylander, T.6
  • 74
    • 18244379602 scopus 로고    scopus 로고
    • Size and number of lymph particles measured by a particle sizer during absorption of structured oils in rats
    • DOI 10.1007/s11745-005-1382-4, L9665
    • Porsgaard, T., Kansky, J., Mason, S., Mu, H., 2005. Size and number of lymph particles measured by particle sizer during absorption of structured oils in rats. Lipids 40, 273-279. (Pubitemid 40628265)
    • (2005) Lipids , vol.40 , Issue.3 , pp. 273-279
    • Porsgaard, T.1    Kansky, J.2    Mason, S.3    Mu, H.4
  • 75
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • DOI 10.1038/nrd2197, PII NRD2197
    • Porter, C.J., Trevaskis, N.L., Charman, W.N., 2007. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat. Rev. Drug Discov. 6, 231-248. (Pubitemid 46344627)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.3 , pp. 231-248
    • Porter, C.J.H.1    Trevaskis, N.L.2    Charman, W.N.3
  • 77
    • 1942498896 scopus 로고    scopus 로고
    • Use of in Vitro Lipid Digestion Data to Explain the in Vivo Performance of Triglyceride-Based Oral Lipid Formulations of Poorly Water-Soluble Drugs: Studies with Halofantrine
    • DOI 10.1002/jps.20039
    • Porter, C.J.H., Kaukonen, A.M., Taillardat-Bertschinger, A., Boyd, B.J., O'Connor, J.M., Edwards, G.A., Charman, W.N., 2004. Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine. J. Pharm. Sci. 93, 1110-1121. (Pubitemid 38529685)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.5 , pp. 1110-1121
    • Porter, C.J.H.1    Kaukonen, A.M.2    Taillardat-Bertschinger, A.3    Boyd, B.J.4    O'Connor, J.M.5    Edwards, G.A.6    Charman, W.N.7
  • 78
    • 39149092022 scopus 로고    scopus 로고
    • Enhancing intestinal drug solubilisation using lipid-based delivery systems
    • Porter, C., Pouton, C.W., Cuine, J.F., Charman, W.N., 2008. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv. Drug Deliv. Rev 60, 673-691.
    • (2008) Adv. Drug Deliv. Rev , vol.60 , pp. 673-691
    • Porter, C.1    Pouton, C.W.2    Cuine, J.F.3    Charman, W.N.4
  • 79
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    • Pouton, C.W., 2000. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur. J. Pharm. Sci. 11, S93-S98.
    • (2000) Eur. J. Pharm. Sci. , vol.11
    • Pouton, C.W.1
  • 80
    • 33751014029 scopus 로고    scopus 로고
    • Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system
    • DOI 10.1016/j.ejps.2006.04.016, PII S0928098706001151
    • Pouton, C.W., 2006. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur. J. Pharm. Sci. 29, 278-287. (Pubitemid 44740131)
    • (2006) European Journal of Pharmaceutical Sciences , vol.29 , Issue.3-4 SPEC. ISS. , pp. 278-287
    • Pouton, C.W.1
  • 81
    • 39149113817 scopus 로고    scopus 로고
    • Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies
    • Pouton, C., Porter, C.J., 2008. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv. Drug Deliv. Rev. 60, 625-637.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 625-637
    • Pouton, C.1    Porter, C.J.2
  • 83
    • 79959350104 scopus 로고    scopus 로고
    • Oral lipid based drug delivery system (LBDDS): Formulation, characterization and application: A review
    • Rahman, M.A., Harwansh, R., Mirza, M.A., Hussain, S., Hussain, A., 2011. Oral lipid based drug delivery system (LBDDS): formulation, characterization and application: a review. Curr. Drug Deliv. 8, 330-345.
    • (2011) Curr. Drug Deliv. , vol.8 , pp. 330-345
    • Rahman, M.A.1    Harwansh, R.2    Mirza, M.A.3    Hussain, S.4    Hussain, A.5
  • 84
    • 39149097505 scopus 로고    scopus 로고
    • What determines drug solubility in lipid vehicles: Is it predictable?
    • Rane, S.S., Anderson, B.D., 2008. What determines drug solubility in lipid vehicles: is it predictable? Adv. Drug Deliv. Rev 60, 638-656.
    • (2008) Adv. Drug Deliv. Rev , vol.60 , pp. 638-656
    • Rane, S.S.1    Anderson, B.D.2
  • 85
    • 84875878549 scopus 로고    scopus 로고
    • Optimization of self-nanoemulsifying drug delivery system for poorly water soluble drug using response surface methodology
    • Ren, S., Mu, H.L., Alchaer, F., Chtatou, A., Müllertz, A., 2013. Optimization of self-nanoemulsifying drug delivery system for poorly water soluble drug using response surface methodology. Drug Develop. Ind. Pharm. 39, 799-806.
    • (2013) Drug Develop. Ind. Pharm. , vol.39 , pp. 799-806
    • Ren, S.1    Mu, H.L.2    Alchaer, F.3    Chtatou, A.4    Müllertz, A.5
  • 86
    • 84871660981 scopus 로고    scopus 로고
    • Prediction of drug solubility in lipid mixtures from the individual ingredients
    • Sacchetti, M., Nejati, E., 2012. Prediction of drug solubility in lipid mixtures from the individual ingredients. AAPS Pharm. Sci. Tech. 13, 1103-1109.
    • (2012) AAPS Pharm. Sci. Tech. , vol.13 , pp. 1103-1109
    • Sacchetti, M.1    Nejati, E.2
  • 87
    • 38949176370 scopus 로고    scopus 로고
    • Fabrication and chemical surface modification of mesoporous silicon for biomedical applications
    • DOI 10.1016/j.cej.2007.09.001, PII S1385894707006031
    • Salonen, J., Lehto, V.P., 2008. Fabrication and chemical surface modification of mesoporous silicon for biomedical applications. Chem. Eng. J. 137, 162-172. (Pubitemid 351226634)
    • (2008) Chemical Engineering Journal , vol.137 , Issue.1 , pp. 162-172
    • Salonen, J.1    Lehto, V.-P.2
  • 88
    • 75549090471 scopus 로고    scopus 로고
    • Porous magnesium aluminometasilicate tablets as carrier of a cyclosporine self-emulsifying formulation
    • Sander, C., Holm, P., 2009. Porous magnesium aluminometasilicate tablets as carrier of a cyclosporine self-emulsifying formulation. AAPS Pharm. Sci. Tech. 10, 1388-1395.
    • (2009) AAPS Pharm. Sci. Tech. , vol.10 , pp. 1388-1395
    • Sander, C.1    Holm, P.2
  • 89
    • 78049518013 scopus 로고    scopus 로고
    • Precipitation of a poorly soluble model drug during in vitro lipolysis: Characterization and dissolution of the precipitate
    • Sassene, P.J., Knopp, M.M., Hesselkilde, J.Z., Koradia, V., Larsen, A., Rades, T., Mullertz, A., 2010. Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitate. J. Pharm. Sci. 99, 4982-4991.
    • (2010) J. Pharm. Sci. , vol.99 , pp. 4982-4991
    • Sassene, P.J.1    Knopp, M.M.2    Hesselkilde, J.Z.3    Koradia, V.4    Larsen, A.5    Rades, T.6    Mullertz, A.7
  • 90
    • 0018324166 scopus 로고
    • Pancreatic lipase and colipase. An example of heterogeneous biocatalysis
    • Sémériva, M., Desnuelle, P., 1979. Pancreatic lipase and colipase. An example of heterogeneous biocatalysis. Adv. Enzymol. 48, 319-370.
    • (1979) Adv. Enzymol. , vol.48 , pp. 319-370
    • Sémériva, M.1    Desnuelle, P.2
  • 91
    • 0042378902 scopus 로고    scopus 로고
    • Interfacial and emulsifying properties of diacylglycerol
    • Shimada, A., Ohashi, K., 2003. Interfacial and emulsifying properties of diacylglycerol. Food Sci. Tech. Res. 9, 142-147. (Pubitemid 37044195)
    • (2003) Food Science and Technology Research , vol.9 , Issue.2 , pp. 142-147
    • Shimada, A.1    Ohashi, K.2
  • 92
    • 79251476579 scopus 로고    scopus 로고
    • Lipid-based oral multiparticulate formulations - advantages, technological advances and industrial applications
    • Shukla, D., Chakraborty, S., Singh, S., Mishra, B., 2011. Lipid-based oral multiparticulate formulations - advantages, technological advances and industrial applications. Expert Opin. Drug Deliv. 8, 207-224.
    • (2011) Expert Opin. Drug Deliv. , vol.8 , pp. 207-224
    • Shukla, D.1    Chakraborty, S.2    Singh, S.3    Mishra, B.4
  • 93
    • 84857214169 scopus 로고    scopus 로고
    • Assembling nanoparticle coatings to improve the drug delivery performance of lipid based colloids
    • Simovic, S., Barnes, T.J., Tan, A., Prestidge, C.A., 2012. Assembling nanoparticle coatings to improve the drug delivery performance of lipid based colloids. Nanoscale 4, 1220-1230.
    • (2012) Nanoscale , vol.4 , pp. 1220-1230
    • Simovic, S.1    Barnes, T.J.2    Tan, A.3    Prestidge, C.A.4
  • 94
    • 77952237639 scopus 로고    scopus 로고
    • An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles
    • Simovic, S., Hui, H., Song, Y.M., Davey, A.K., Rades, T., Prestidge, C.A., 2010. An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles. J. Control. Release 143, 367-373.
    • (2010) J. Control. Release , vol.143 , pp. 367-373
    • Simovic, S.1    Hui, H.2    Song, Y.M.3    Davey, A.K.4    Rades, T.5    Prestidge, C.A.6
  • 95
    • 80053087179 scopus 로고    scopus 로고
    • Oral formulation strategies to improve solubility of poorly water-soluble drugs
    • Singh, A., Worku, Z.A., Van den Mooter, G., 2011. Oral formulation strategies to improve solubility of poorly water-soluble drugs. Expert Opin. Drug Deliv. 8, 1361-1378.
    • (2011) Expert Opin. Drug Deliv. , vol.8 , pp. 1361-1378
    • Singh, A.1    Worku, Z.A.2    Van Den Mooter, G.3
  • 96
    • 76849109564 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS): Formulation development, characterization, and applications
    • Singh, B., Bandopadhyay, S., Kapil, R., Singh, R., Katare, O.P., 2009a. Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications. Crit. Rev. Ther. Drug Carrier Syst. 26, 427-521.
    • (2009) Crit. Rev. Ther. Drug Carrier Syst. , vol.26 , pp. 427-521
    • Singh, B.1    Bandopadhyay, S.2    Kapil, R.3    Singh, R.4    Katare, O.P.5
  • 97
    • 61449093624 scopus 로고    scopus 로고
    • Structuring food emulsions in the gastrointestinal tract to modify lipid digestion
    • Singh, H., Ye, A.Q., Horne, D., 2009b. Structuring food emulsions in the gastrointestinal tract to modify lipid digestion. Prog. Lipid Res. 48, 92-100.
    • (2009) Prog. Lipid Res. , vol.48 , pp. 92-100
    • Singh, H.1    Ye, A.Q.2    Horne, D.3
  • 98
    • 0014266665 scopus 로고
    • A classification of biologic lipids based upon their interaction in aqueous systems
    • Small, D.M., 1968. A classification of biologic lipids based upon their interaction in aqueous systems. J. Am. Oil Chem. Soc. 45, 108-119.
    • (1968) J. Am. Oil Chem. Soc. , vol.45 , pp. 108-119
    • Small, D.M.1
  • 100
    • 1242337285 scopus 로고    scopus 로고
    • Solubilizing Excipients in Oral and Injectable Formulations
    • DOI 10.1023/B:PHAM.0000016235.32639.23
    • Strickley, R.G., 2004. Solubilizing excipients in oral and injectable formulations. Pharm. Res. 21, 201-230. (Pubitemid 38221966)
    • (2004) Pharmaceutical Research , vol.21 , Issue.2 , pp. 201-230
    • Strickley, R.G.1
  • 101
    • 24744444477 scopus 로고    scopus 로고
    • Response surface methodology for the development of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate
    • DOI 10.1081/PDT-65675
    • Taha, E.I., Samy, A.M., Kassem, A.A., Khan, M.A., 2005. Response surface methodology for the development of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate. Pharm. Dev. Tech. 10, 363-370. (Pubitemid 41291473)
    • (2005) Pharmaceutical Development and Technology , vol.10 , Issue.3 , pp. 363-370
    • Taha, E.I.1    Samy, A.M.2    Kassem, A.A.3    Khan, M.A.4
  • 102
    • 0026327649 scopus 로고
    • Redispersible dry emulsion system as novel oral dosage form of oily drugs - In vivo studies in beagle dogs
    • Takeuchi, H., Sasaki, H., Niwa, T., Hino, T., Kawashima, Y., Uesugi, K., Ozawa, H., 1991. Redispersible dry emulsion system as novel oral dosage form of oily drugs - in vivo studies in beagle dogs. Chem. Pharm. Bull. 39, 3362-3364.
    • (1991) Chem. Pharm. Bull. , vol.39 , pp. 3362-3364
    • Takeuchi, H.1    Sasaki, H.2    Niwa, T.3    Hino, T.4    Kawashima, Y.5    Uesugi, K.6    Ozawa, H.7
  • 103
    • 80054768284 scopus 로고    scopus 로고
    • Silica-lipid hybrid (SLH) versus non-lipid formulations for optimising the dose-dependent oral absorption of celecoxib
    • Tan, A., Davey, A.K., Prestidge, C.A., 2011. Silica-lipid hybrid (SLH) versus non-lipid formulations for optimising the dose-dependent oral absorption of celecoxib. Pharm. Res. 28, 2273-2287.
    • (2011) Pharm. Res. , vol.28 , pp. 2273-2287
    • Tan, A.1    Davey, A.K.2    Prestidge, C.A.3
  • 104
    • 77950591046 scopus 로고    scopus 로고
    • Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems
    • Tan, A., Simovic, S., Davey, A.K., Rades, T., Boyd, B.J., Prestidge, C.A., 2010. Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems. Mol. Pharmacol. 7, 522-532.
    • (2010) Mol. Pharmacol. , vol.7 , pp. 522-532
    • Tan, A.1    Simovic, S.2    Davey, A.K.3    Rades, T.4    Boyd, B.J.5    Prestidge, C.A.6
  • 105
    • 59049088106 scopus 로고    scopus 로고
    • Silica-lipid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs
    • Tan, A., Simovic, S., Davey, A.K., Rades, T., Prestidge, C.A., 2009. Silica-lipid hybrid (SLH) microcapsules: a novel oral delivery system for poorly soluble drugs. J. Control. Release 134, 62-70.
    • (2009) J. Control. Release , vol.134 , pp. 62-70
    • Tan, A.1    Simovic, S.2    Davey, A.K.3    Rades, T.4    Prestidge, C.A.5
  • 106
    • 78349311319 scopus 로고    scopus 로고
    • In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice
    • Tanaka, T., et al., 2010. In vivo evaluation of safety of nanoporous silicon carriers following single and multiple dose intravenous administrations in mice. Int. J. Pharm. 402, 190-197.
    • (2010) Int. J. Pharm. , vol.402 , pp. 190-197
    • Tanaka, T.1
  • 107
    • 45849115831 scopus 로고    scopus 로고
    • Development of solid self-emulsifying drug delivery systems: Preparation techniques and dosage forms
    • Tang, B., Cheng, G., Gu, J.C., Xu, C.H., 2008. Development of solid self-emulsifying drug delivery systems: preparation techniques and dosage forms. Drug Discovery Today 13, 606-612.
    • (2008) Drug Discovery Today , vol.13 , pp. 606-612
    • Tang, B.1    Cheng, G.2    Gu, J.C.3    Xu, C.H.4
  • 108
    • 84861529172 scopus 로고    scopus 로고
    • In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS)
    • Thomas, N., Holm, R., Müllertz, A., Rades, T., 2012a. In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS). J. Control. Release 160, 25-32.
    • (2012) J. Control. Release , vol.160 , pp. 25-32
    • Thomas, N.1    Holm, R.2    Müllertz, A.3    Rades, T.4
  • 109
    • 84869114981 scopus 로고    scopus 로고
    • Characterising lipid lipolysis and its implication in lipid-based formulation development
    • Thomas, N., Holm, R., Rades, T., Mullertz, A., 2012b. Characterising lipid lipolysis and its implication in lipid-based formulation development. AAPS J. 14, 860-871.
    • (2012) AAPS J. , vol.14 , pp. 860-871
    • Thomas, N.1    Holm, R.2    Rades, T.3    Mullertz, A.4
  • 110
    • 84864323714 scopus 로고    scopus 로고
    • Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems
    • Thomas, N., Mullertz, A., Graf, A., Rades, T., 2012c. Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems. J. Pharm. Sci. 101, 1721-1731.
    • (2012) J. Pharm. Sci. , vol.101 , pp. 1721-1731
    • Thomas, N.1    Mullertz, A.2    Graf, A.3    Rades, T.4
  • 111
    • 0028033105 scopus 로고
    • Enhanced absorption of new oral cyclosporin microemulsion formulation, neoral, in liver transplant recipients with external biliary diversion
    • Trull, A.K., Tan, K.K.C., Tan, L., Alexander, G.J.M., Jamieson, N.V., 1994. Enhanced absorption of new oral cyclosporine microemulsion formulation, neoral, in liver-transplant recipients with external biliary diversion. Transplant. Proc. 26, 2977-2978. (Pubitemid 24329385)
    • (1994) Transplantation Proceedings , vol.26 , Issue.5 , pp. 2977-2978
    • Trull, A.K.1    Tan, K.K.C.2    Tan, L.3    Alexander, G.J.M.4    Jamieson, N.V.5
  • 112
    • 0021776079 scopus 로고
    • Gastrointestinal digestion and absorption of lipid
    • Tso, P., 1985. Gastrointestinal digestion and absorption of lipid. Adv. Lipid Res. 21, 143-186.
    • (1985) Adv. Lipid Res. , vol.21 , pp. 143-186
    • Tso, P.1
  • 113
    • 0001297576 scopus 로고
    • Intestinal lipid absorption
    • Johnson, L.R. (Ed.), Raven Press, New York
    • Tso, P., 1994. Intestinal lipid absorption. In: Johnson, L.R. (Ed.), Physiology of the Gastrointestinal Tract. Raven Press, New York, pp. 1867-1907.
    • (1994) Physiology of the Gastrointestinal Tract , pp. 1867-1907
    • Tso, P.1
  • 114
    • 2642540226 scopus 로고    scopus 로고
    • Comparative bioavailability study in dogs of self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone
    • DOI 10.1002/jps.20068
    • Tuleu, C., Newton, M., Rose, J., Euler, D., Saklatvala, R., Clarke, A., Booth, S., 2004. Comparative bioavailability study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone. J. Pharm. Sci. 93, 1495-1502. (Pubitemid 38725021)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.6 , pp. 1495-1502
    • Tuleu, C.1    Newton, M.2    Rose, J.3    Euler, D.4    Saklatvala, R.5    Clarke, A.6    Booth, S.7
  • 115
    • 84865963565 scopus 로고    scopus 로고
    • Incomplete desorption of liquid excipients reduces the in vitro and in vivo performance of self-emulsifying drug delivery systems solidified by adsorption onto an inorganic mesoporous carrier
    • Van Speybroeck, M., Williams, H.D., Nguyen, T.H., Anby, M.U., Porter, C.J.H., Augustijns, P., 2012. Incomplete desorption of liquid excipients reduces the in vitro and in vivo performance of self-emulsifying drug delivery systems solidified by adsorption onto an inorganic mesoporous carrier. Mol. Pharmacol. 9, 2750-2760.
    • (2012) Mol. Pharmacol. , vol.9 , pp. 2750-2760
    • Van Speybroeck, M.1    Williams, H.D.2    Nguyen, T.H.3    Anby, M.U.4    Porter, C.J.H.5    Augustijns, P.6
  • 116
    • 0002656064 scopus 로고
    • Self-emulsification of vegetable oil-nonionic surfactant mixtures
    • American Chemical Society, London
    • Wakerly, M.G., Pouton, C.W., Meakin, B.J., Morton, F.S., 1986. Self-emulsification of vegetable oil-nonionic surfactant mixtures. In: Phenomena in Mixed Surfactant Systems. American Chemical Society, London242-255.
    • (1986) Phenomena in Mixed Surfactant Systems , pp. 242-255
    • Wakerly, M.G.1    Pouton, C.W.2    Meakin, B.J.3    Morton, F.S.4
  • 117
    • 57449109685 scopus 로고    scopus 로고
    • Design and optimization of a new self-nanoemulsifying drug delivery system
    • Wang, L.J., Dong, J.F., Chen, J., Eastoe, J.L., Li, X.F., 2009. Design and optimization of a new self-nanoemulsifying drug delivery system. J. Colloid Interface Sci. 330, 443-448.
    • (2009) J. Colloid Interface Sci. , vol.330 , pp. 443-448
    • Wang, L.J.1    Dong, J.F.2    Chen, J.3    Eastoe, J.L.4    Li, X.F.5
  • 118
    • 33745665882 scopus 로고    scopus 로고
    • Digestion and absorption of diacylglycerol
    • Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B.D., Tokimitsu, I., Matlock, M.G. (Eds.), AOCS Press, Champaign
    • Watanabe, H., Tokimitsu, I., 2004. Digestion and absorption of diacylglycerol. In: Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B.D., Tokimitsu, I., Matlock, M.G. (Eds.), Diacylglycerol Oil. AOCS Press, Champaign, pp. 30-45.
    • (2004) Diacylglycerol Oil , pp. 30-45
    • Watanabe, H.1    Tokimitsu, I.2
  • 120
    • 52949125231 scopus 로고    scopus 로고
    • A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs
    • Yi, T., Wan, J.L., Xu, H.B., Yang, X.L., 2008. A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs. Eur. J. Pharm. Biopharm. 70, 439-444.
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , pp. 439-444
    • Yi, T.1    Wan, J.L.2    Xu, H.B.3    Yang, X.L.4
  • 122
    • 0034898463 scopus 로고    scopus 로고
    • A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium
    • DOI 10.1016/S0928-0987(01)00169-5, PII S0928098701001695
    • Zangenberg, N.H., Mullertz, A., Kristensen, H.G., Hovgaard, L., 2001a. A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium. Eur. J. Pharm. Sci. 14, 115-122. (Pubitemid 32737533)
    • (2001) European Journal of Pharmaceutical Sciences , vol.14 , Issue.2 , pp. 115-122
    • Zangenberg, N.H.1    Mullertz, A.2    Kristensen, H.G.3    Hovgaard, L.4


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