메뉴 건너뛰기




Volumn 62, Issue 11, 2010, Pages 1622-1636

New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

Author keywords

lipid and surfactant based drug delivery systems; lipolysis; poorly soluble drug

Indexed keywords

ALFACALCIDOL; ALPHA TOCOPHEROL; AMPRENAVIR; BEXAROTENE; CALCITRIOL; CIPROFLOXACIN; CLOFAZIMINE; CLOMETHIAZOLE; CYCLOSPORIN A; DETRO; DIACYLGLYCEROL; DOXERCALCIFEROL; DRONABINOL; DUTASTERIDE; EFAVIRENZ; EPADEL; EXCIPIENT; FENOFIBRATE; FENOGAL; IBUDILAST; INDOMETACIN FARNESIL; ISOTRETINOIN; LIPID; LOPINAVIR PLUS RITONAVIR; MENATETRENONE; MONOACYLGLYCEROL; MORPHINE SULFATE; OIL; PARICALCITOL; PROGESTERONE; RAPAMYCIN; RETINOIC ACID; RITONAVIR; SAQUINAVIR; SIDMARK; SOLVENT; SURFACTANT; TEPRENONE; TESTOSTERONE UNDECANOATE; TIPRANAVIR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID;

EID: 78049499869     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2010.01107.x     Document Type: Review
Times cited : (267)

References (76)
  • 1
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    • Gursoy RN, Benita S,. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004; 58: 173-182.
    • (2004) Biomed Pharmacother , vol.58 , pp. 173-182
    • Gursoy, R.N.1    Benita, S.2
  • 2
    • 0035895309 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: Formulation development and bioavailability assessment
    • Kommuru TR, et al. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int J Pharm 2001; 212: 233-246.
    • (2001) Int J Pharm , vol.212 , pp. 233-246
    • Kommuru, T.R.1
  • 3
    • 39149113817 scopus 로고    scopus 로고
    • Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies
    • Pouton CW, Porter CJ,. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv Drug Deliv Rev 2008; 60: 625-637.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 625-637
    • Pouton, C.W.1    Porter, C.J.2
  • 4
    • 39149126301 scopus 로고    scopus 로고
    • Biopharmaceutical challenges associated with drugs with low aqueous solubility: The potential impact of lipid-based formulations
    • O'Driscoll CM, Griffin BT,. Biopharmaceutical challenges associated with drugs with low aqueous solubility: the potential impact of lipid-based formulations. Adv Drug Deliv Rev 2008; 60: 617-624.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 617-624
    • O'Driscoll, C.M.1    Griffin, B.T.2
  • 5
    • 0035997323 scopus 로고    scopus 로고
    • Biopharmaceutics classification system: The scientific basis for biowaiver extensions
    • Yu LX, et al. Biopharmaceutics classification system: the scientific basis for biowaiver extensions. Pharm Res 2002; 19: 921-925.
    • (2002) Pharm Res , vol.19 , pp. 921-925
    • Yu, L.X.1
  • 6
    • 0028948839 scopus 로고
    • A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vitro bioavailability
    • Amidon GL, et al. A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vitro bioavailability. Pharm Res 1995; 12: 413-420.
    • (1995) Pharm Res , vol.12 , pp. 413-420
    • Amidon, G.L.1
  • 7
    • 0035095847 scopus 로고    scopus 로고
    • Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers
    • Forster A, et al. Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers. J Pharm Pharmacol 2001; 53: 303-315.
    • (2001) J Pharm Pharmacol , vol.53 , pp. 303-315
    • Forster, A.1
  • 8
    • 85047682766 scopus 로고    scopus 로고
    • Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy
    • Heinz A, et al. Analysis of solid-state transformations of pharmaceutical compounds using vibrational spectroscopy. J Pharm Pharmacol 2009; 61: 971-988.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 971-988
    • Heinz, A.1
  • 9
    • 68349160715 scopus 로고    scopus 로고
    • Lipid: An emerging platform for oral delivery of drugs with poor bioavailability
    • Chakraborty S, et al. Lipid: an emerging platform for oral delivery of drugs with poor bioavailability. Eur J Pharm Biopharm 2009; 73: 1-15.
    • (2009) Eur J Pharm Biopharm , vol.73 , pp. 1-15
    • Chakraborty, S.1
  • 10
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • Gershanik T, Benita S,. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 2000; 50: 179-188.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 179-188
    • Gershanik, T.1    Benita, S.2
  • 11
    • 34247536339 scopus 로고    scopus 로고
    • Morphological observations on a lipid-based drug delivery system during in vitro digestion
    • Fatouros DG, et al. Morphological observations on a lipid-based drug delivery system during in vitro digestion. Eur J Pharm Sci 2007; 31: 85-94.
    • (2007) Eur J Pharm Sci , vol.31 , pp. 85-94
    • Fatouros, D.G.1
  • 12
    • 16444375502 scopus 로고    scopus 로고
    • Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drug
    • Kossena GA, et al. Influence of the intermediate digestion phases of common formulation lipids on the absorption of a poorly water-soluble drug. J Pharm Sci 2005; 94: 481-492.
    • (2005) J Pharm Sci , vol.94 , pp. 481-492
    • Kossena, G.A.1
  • 13
    • 0347022226 scopus 로고    scopus 로고
    • Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: Contribution of emulsification versus digestibility
    • De Smidt PC, et al. Intestinal absorption of penclomedine from lipid vehicles in the conscious rat: contribution of emulsification versus digestibility. Int J Pharm 2004; 270: 109-118.
    • (2004) Int J Pharm , vol.270 , pp. 109-118
    • De Smidt, P.C.1
  • 14
    • 27744515754 scopus 로고    scopus 로고
    • Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging
    • Schiller C, et al. Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging. Aliment Pharmacol Ther 2005; 22: 971-979.
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 971-979
    • Schiller, C.1
  • 15
    • 78649653098 scopus 로고    scopus 로고
    • Characterising the behaviour of poorly water soluble drugs in the intestine: Application of biorelevant media for solubility, dissolution and transport studies
    • Kleberg K, et al. Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies. J Pharm Pharmacol 2010; 62: 1656-1668.
    • (2010) J Pharm Pharmacol , vol.62 , pp. 1656-1668
    • Kleberg, K.1
  • 16
    • 34848853277 scopus 로고    scopus 로고
    • Low dose lipid formulations: Effects on gastric emptying and biliary secretion
    • Kossena GA, et al. Low dose lipid formulations: effects on gastric emptying and biliary secretion. Pharm Res 2007; 24: 2084-2096.
    • (2007) Pharm Res , vol.24 , pp. 2084-2096
    • Kossena, G.A.1
  • 17
    • 0027250231 scopus 로고
    • Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans
    • Carriere F, et al. Secretion and contribution to lipolysis of gastric and pancreatic lipases during a test meal in humans. Gastroenterology 1993; 105: 876-888.
    • (1993) Gastroenterology , vol.105 , pp. 876-888
    • Carriere, F.1
  • 18
    • 34247638077 scopus 로고    scopus 로고
    • Comparative study on digestive lipase activities on the self emulsifying excipient Labrasol, medium chain glycerides and PEG esters
    • Fernandez S, et al. Comparative study on digestive lipase activities on the self emulsifying excipient Labrasol, medium chain glycerides and PEG esters. Biochim Biophys Acta 2007; 1771: 633-640.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 633-640
    • Fernandez, S.1
  • 19
    • 48649092538 scopus 로고    scopus 로고
    • Lipolysis of the semi-solid self-emulsifying excipient Gelucire 44/14 by digestive lipases
    • Fernandez S, et al. Lipolysis of the semi-solid self-emulsifying excipient Gelucire 44/14 by digestive lipases. Biochim Biophys Acta 2008; 1781: 367-375.
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 367-375
    • Fernandez, S.1
  • 20
    • 0025239461 scopus 로고
    • Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption 1. phasebehavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human-beings
    • Staggers JE, et al. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption 1. phasebehavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human-beings. Biochemistry 1990; 29: 2028-2040.
    • (1990) Biochemistry , vol.29 , pp. 2028-2040
    • Staggers, J.E.1
  • 21
    • 70349578959 scopus 로고    scopus 로고
    • Nonlamellar liquid crystalline nanostructured particles: Advances in materials and structure determination
    • Boyd BJ, et al. Nonlamellar liquid crystalline nanostructured particles: advances in materials and structure determination. J Liposome Res 2009; 19: 12-28.
    • (2009) J Liposome Res , vol.19 , pp. 12-28
    • Boyd, B.J.1
  • 22
    • 44649133855 scopus 로고    scopus 로고
    • Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs
    • Dahan A, Hoffman A,. Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs. J Control Release 2008; 129: 1-10.
    • (2008) J Control Release , vol.129 , pp. 1-10
    • Dahan, A.1    Hoffman, A.2
  • 23
    • 39149092022 scopus 로고    scopus 로고
    • Enhancing intestinal drug solubilisation using lipid-based delivery systems
    • Porter CJ, et al. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev 2008; 60: 673-691.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 673-691
    • Porter, C.J.1
  • 25
    • 0014266665 scopus 로고
    • A classification of biologic lipids based upon their interaction in aqeous systems
    • Small DM,. A classification of biologic lipids based upon their interaction in aqeous systems. J Am Oil Chem Soc 1968; 45: 108-119.
    • (1968) J Am Oil Chem Soc , vol.45 , pp. 108-119
    • Small, D.M.1
  • 26
    • 16544380014 scopus 로고    scopus 로고
    • Studies on the intestinal absorption of low molecular weight heparin using saturated fatty acids and their derivatives as an absorption enhancer in rats
    • DOI 10.1248/bpb.27.418
    • Mori S, et al. Studies on the intestinal absorption of low molecular weight heparin using saturated fatty acids and their derivatives as an absorption enhancer in rats. Bio Pharm Bull 2004; 27: 418-421. (Pubitemid 41685491)
    • (2004) Biological and Pharmaceutical Bulletin , vol.27 , Issue.3 , pp. 418-421
    • Mori, S.1    Matsuura, A.2    Rama Prasad, Y.V.3    Takada, K.4
  • 27
    • 1242337285 scopus 로고    scopus 로고
    • Solubilizing excipients in oral and injectable formulations
    • Strickley RG,. Solubilizing excipients in oral and injectable formulations. Pharm Res 2004; 21: 201-230.
    • (2004) Pharm Res , vol.21 , pp. 201-230
    • Strickley, R.G.1
  • 28
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    • (Suppl.)
    • Pouton CW,. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur J Pharm Sci 2000; 11 (Suppl. 2): S93-S98.
    • (2000) Eur J Pharm Sci , vol.11 , Issue.2
    • Pouton, C.W.1
  • 29
    • 33751014029 scopus 로고    scopus 로고
    • Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system
    • Pouton CW,. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur J Pharm Sci 2006; 29: 278-287.
    • (2006) Eur J Pharm Sci , vol.29 , pp. 278-287
    • Pouton, C.W.1
  • 31
    • 56349143266 scopus 로고    scopus 로고
    • 62nd edn. Montvale: Thomson Healthcare
    • Physicians' Desk Reference, 62nd edn. Montvale: Thomson Healthcare, 2008.
    • (2008) Physicians' Desk Reference
  • 32
    • 0026586447 scopus 로고
    • Self-emulsifying drug delivery systems: Formulation and biopharmaceutic evaluation of an investigational lipophilic compound
    • Charman SA, et al. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharm Res 1992; 9: 87-93.
    • (1992) Pharm Res , vol.9 , pp. 87-93
    • Charman, S.A.1
  • 33
    • 0007793946 scopus 로고
    • The effect of surfactant HLB on the self-emulsifying efficiency of nonionic surfactant-vegetable oil mixtures
    • Wakerley MG, et al. The effect of surfactant HLB on the self-emulsifying efficiency of nonionic surfactant-vegetable oil mixtures. J Pharm Pharmacol 1986; 38: 2P.
    • (1986) J Pharm Pharmacol , vol.38
    • Wakerley, M.G.1
  • 34
    • 39149091886 scopus 로고    scopus 로고
    • Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs
    • Cuine JF, et al. Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. J Pharm Sci 2008; 97: 995-1012.
    • (2008) J Pharm Sci , vol.97 , pp. 995-1012
    • Cuine, J.F.1
  • 35
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • Gershanik T, Benita S,. Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur J Pharm Biopharm 2000; 50: 179-188.
    • (2000) Eur J Pharm Biopharm , vol.50 , pp. 179-188
    • Gershanik, T.1    Benita, S.2
  • 36
    • 33646813333 scopus 로고    scopus 로고
    • Bioavailability of seocalcitol II. Development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides
    • Grove M, et al. Bioavailability of seocalcitol II. Development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides. Eur J Pharm Sci 2006; 28: 233-242.
    • (2006) Eur J Pharm Sci , vol.28 , pp. 233-242
    • Grove, M.1
  • 37
    • 1842609789 scopus 로고    scopus 로고
    • Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs
    • Kang BK, et al. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm 2004; 274: 65-73.
    • (2004) Int J Pharm , vol.274 , pp. 65-73
    • Kang, B.K.1
  • 38
    • 50549097100 scopus 로고    scopus 로고
    • Development of SMEDDS using natural lipophile: Application to beta-artemether delivery
    • Mandawgade SD, et al. Development of SMEDDS using natural lipophile: application to beta-artemether delivery. Int J Pharm 2008; 362: 179-183.
    • (2008) Int J Pharm , vol.362 , pp. 179-183
    • Mandawgade, S.D.1
  • 39
    • 51449124269 scopus 로고    scopus 로고
    • Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): Development and optimization
    • Singh AK, et al. Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): development and optimization. AAPS PharmSciTech 2008; 9: 628-634.
    • (2008) AAPS PharmSciTech , vol.9 , pp. 628-634
    • Singh, A.K.1
  • 40
    • 1842684453 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs
    • Gursoy RN, Benita S,. Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs. Biomed Pharmacother 2004; 58: 173-182.
    • (2004) Biomed Pharmacother , vol.58 , pp. 173-182
    • Gursoy, R.N.1    Benita, S.2
  • 41
    • 0028000096 scopus 로고
    • Rationale for the development of Sandimmune-Neoral
    • Vonderscher J, Meinzer A,. Rationale for the development of Sandimmune-Neoral. Transplant Proc 1994; 26: 2925-2927.
    • (1994) Transplant Proc , vol.26 , pp. 2925-2927
    • Vonderscher, J.1    Meinzer, A.2
  • 42
    • 0024565173 scopus 로고
    • Enhanced intestinal-absorption of cyclosporine in rats through the reduction of emulsion droplet size
    • Tarr BD, Yalkowsky SH,. Enhanced intestinal-absorption of cyclosporine in rats through the reduction of emulsion droplet size. Pharm Res 1989; 6: 40-43.
    • (1989) Pharm Res , vol.6 , pp. 40-43
    • Tarr, B.D.1    Yalkowsky, S.H.2
  • 43
    • 0032498581 scopus 로고    scopus 로고
    • Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A
    • Gao ZG, et al. Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A. Int J Pharm 1998; 161: 75-86.
    • (1998) Int J Pharm , vol.161 , pp. 75-86
    • Gao, Z.G.1
  • 44
    • 70349238697 scopus 로고    scopus 로고
    • Design of lipid-based formulations for oral administration of poorly water-soluble drugs: Precipitation of drug after dispersion of formulations in aqueous solution
    • Mohsin K, et al. Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution. J Pharm Sci 2009; 98: 3582-3595.
    • (2009) J Pharm Sci , vol.98 , pp. 3582-3595
    • Mohsin, K.1
  • 45
    • 77949523821 scopus 로고    scopus 로고
    • Effects of polysorbate 80 on the in vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats
    • Tonsberg H, et al. Effects of polysorbate 80 on the in vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats. J Pharm Pharmacol 2009; 62: 63-70.
    • (2009) J Pharm Pharmacol , vol.62 , pp. 63-70
    • Tonsberg, H.1
  • 46
    • 32644434556 scopus 로고    scopus 로고
    • Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: A case study with amprenavir
    • Brouwers J, et al. Intraluminal drug and formulation behavior and integration in in vitro permeability estimation: a case study with amprenavir. J Pharm Sci 2006; 95: 372-383.
    • (2006) J Pharm Sci , vol.95 , pp. 372-383
    • Brouwers, J.1
  • 47
    • 9144240623 scopus 로고    scopus 로고
    • Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients
    • Wood R, et al. Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients. Antimicrob Agents Chemother 2004; 48: 116-123.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 116-123
    • Wood, R.1
  • 48
    • 0014266665 scopus 로고
    • A classification of biologic lipids based upon their interaction in aqueous systems
    • Small DM,. A classification of biologic lipids based upon their interaction in aqueous systems. J Am Oil Chem Soc 1968; 45: 108-119.
    • (1968) J Am Oil Chem Soc , vol.45 , pp. 108-119
    • Small, D.M.1
  • 49
    • 0001896482 scopus 로고    scopus 로고
    • Rheological properties of microemulsion
    • In: Kumar P., Mittal K.L. eds. New York: Marcel Dekker
    • Gradzielski M, Hoffman H,. Rheological properties of microemulsion. In:, Kumar P, Mittal KL, eds. Handbook of Micro-emulsion Science and Technology. New York: Marcel Dekker, 1999: 357-386.
    • (1999) Handbook of Micro-emulsion Science and Technology , pp. 357-386
    • Gradzielski, M.1    Hoffman, H.2
  • 50
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: Physical and biopharmaceutical aspects
    • Constantinides PP,. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res 1995; 12: 1561-1572.
    • (1995) Pharm Res , vol.12 , pp. 1561-1572
    • Constantinides, P.P.1
  • 51
    • 0025565050 scopus 로고
    • Spontaneous formation of a water-continuous emulsion from water-in-oil microemulsion
    • Greiner RW, Evans DF,. Spontaneous formation of a water-continuous emulsion from water-in-oil microemulsion. Langmuir 1990; 6: 1793-1796.
    • (1990) Langmuir , vol.6 , pp. 1793-1796
    • Greiner, R.W.1    Evans, D.F.2
  • 52
    • 70449524336 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies
    • Zhao Y, et al. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: formulation and bioavailability studies. Int J Pharm 2010; 383: 170-177.
    • (2010) Int J Pharm , vol.383 , pp. 170-177
    • Zhao, Y.1
  • 53
    • 1242292226 scopus 로고    scopus 로고
    • Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations
    • Kaukonen AM, et al. Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations. Pharm Res 2004; 21: 245-253.
    • (2004) Pharm Res , vol.21 , pp. 245-253
    • Kaukonen, A.M.1
  • 54
    • 0034898463 scopus 로고    scopus 로고
    • A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium
    • Zangenberg NH, et al. A dynamic in vitro lipolysis model. I. Controlling the rate of lipolysis by continuous addition of calcium. Eur J Pharm Sci 2001; 14: 115-122.
    • (2001) Eur J Pharm Sci , vol.14 , pp. 115-122
    • Zangenberg, N.H.1
  • 55
    • 0034836387 scopus 로고    scopus 로고
    • A dynamic in vitro lipolysis model. II: Evaluation of the model
    • Zangenberg NH, et al. A dynamic in vitro lipolysis model. II: Evaluation of the model. Eur J Pharm Sci 2001; 14: 237-244.
    • (2001) Eur J Pharm Sci , vol.14 , pp. 237-244
    • Zangenberg, N.H.1
  • 56
    • 34548567075 scopus 로고    scopus 로고
    • Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering
    • Fatouros DG, et al. Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering. Pharm Res 2007; 24: 1844-1853.
    • (2007) Pharm Res , vol.24 , pp. 1844-1853
    • Fatouros, D.G.1
  • 57
    • 48149100781 scopus 로고    scopus 로고
    • In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks
    • Fatouros DG, et al. In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks. Eur J Pharm Biopharm 2008; 69: 887-898.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 887-898
    • Fatouros, D.G.1
  • 58
    • 57149136074 scopus 로고    scopus 로고
    • Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: In vitro bioavailability and dynamic in vitro lipolysis
    • Larsen A, et al. Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vitro bioavailability and dynamic in vitro lipolysis. Pharm Res 2008; 25: 2769-2777.
    • (2008) Pharm Res , vol.25 , pp. 2769-2777
    • Larsen, A.1
  • 59
    • 70349238697 scopus 로고    scopus 로고
    • Design of lipid-based formulations for oral administration of poorly water-soluble drugs: Precipitation of drug after dispersion of formulations in aqueous solution
    • Mohsin K, et al. Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution. J Pharm Sci 2009; 98: 3582-3595.
    • (2009) J Pharm Sci , vol.98 , pp. 3582-3595
    • Mohsin, K.1
  • 60
    • 33744787859 scopus 로고    scopus 로고
    • Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone
    • Sek L, et al. Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone. J Pharm Pharmacol 2006; 58: 809-820.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 809-820
    • Sek, L.1
  • 61
    • 57149136074 scopus 로고    scopus 로고
    • Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: In vitro bioavailability and dynamic in vitro lipolysis
    • Larsen A, et al. Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vitro bioavailability and dynamic in vitro lipolysis. Pharm Res 2008; 25: 2769-2777.
    • (2008) Pharm Res , vol.25 , pp. 2769-2777
    • Larsen, A.1
  • 62
    • 43249122851 scopus 로고    scopus 로고
    • Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state
    • Nielsen FS, et al. Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state. Eur J Pharm Biopharm 2008; 69: 553-562.
    • (2008) Eur J Pharm Biopharm , vol.69 , pp. 553-562
    • Nielsen, F.S.1
  • 63
    • 0024745128 scopus 로고
    • Vesicle-micelle transition of phosphatidylcholine and octyl glucoside elucidated by cryo-transmission electron microscopy
    • Vinson PK, et al. Vesicle-micelle transition of phosphatidylcholine and octyl glucoside elucidated by cryo-transmission electron microscopy. Biophys J 1989; 56: 669-681.
    • (1989) Biophys J , vol.56 , pp. 669-681
    • Vinson, P.K.1
  • 64
    • 0026348561 scopus 로고
    • Intermediate structures in the cholatephosphatidylcholine vesicle-micelle transition
    • Walter A, et al. Intermediate structures in the cholatephosphatidylcholine vesicle-micelle transition. Biophys J 1991; 60: 1315-1325.
    • (1991) Biophys J , vol.60 , pp. 1315-1325
    • Walter, A.1
  • 65
    • 21644461482 scopus 로고    scopus 로고
    • Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib
    • Subramanian N, et al. Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib. Biol Pharm Bull 2004; 27: 1993-1999.
    • (2004) Biol Pharm Bull , vol.27 , pp. 1993-1999
    • Subramanian, N.1
  • 66
    • 0036159683 scopus 로고    scopus 로고
    • Microemulsion formulation of clonixic acid: Solubility enhancement and pain reduction
    • Lee JM, et al. Microemulsion formulation of clonixic acid: solubility enhancement and pain reduction. J Pharm Pharmacol 2002; 54: 43-49.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 43-49
    • Lee, J.M.1
  • 67
    • 62749095208 scopus 로고    scopus 로고
    • Enhancement of oral absorption of curcumin by selfmicroemulsifying drug delivery systems
    • Cui J, et al. Enhancement of oral absorption of curcumin by selfmicroemulsifying drug delivery systems. Int J Pharm 2009; 371: 148-155.
    • (2009) Int J Pharm , vol.371 , pp. 148-155
    • Cui, J.1
  • 68
    • 34247472175 scopus 로고    scopus 로고
    • Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds
    • Nielsen FS, et al. Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds. J Pharm Sci 2007; 96: 876-892.
    • (2007) J Pharm Sci , vol.96 , pp. 876-892
    • Nielsen, F.S.1
  • 69
    • 4344578729 scopus 로고    scopus 로고
    • Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation
    • Porter CJH, et al. Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation. Pharm Res 2004; 21: 1405-1412.
    • (2004) Pharm Res , vol.21 , pp. 1405-1412
    • Porter, C.J.H.1
  • 70
    • 38849151208 scopus 로고    scopus 로고
    • Preparation and in vitro evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate
    • Patel AR, Vavia PR,. Preparation and in vitro evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. AAPS J 2007; 9: E344-E352.
    • (2007) AAPS J , vol.9
    • Patel, A.R.1    Vavia, P.R.2
  • 71
    • 36849061528 scopus 로고    scopus 로고
    • Improving the high variable bioavailability of griseofulvin by SEDDS
    • Arida AI, et al. Improving the high variable bioavailability of griseofulvin by SEDDS. Chem Pharm Bull 2007; 55: 1713-1719.
    • (2007) Chem Pharm Bull , vol.55 , pp. 1713-1719
    • Arida, A.I.1
  • 72
    • 0032103706 scopus 로고    scopus 로고
    • Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine
    • Khoo SM, et al. Formulation design and bioavailability assessment of lipidic self-emulsifying formulations of halofantrine. Int J Pharm 1998; 167: 155-164.
    • (1998) Int J Pharm , vol.167 , pp. 155-164
    • Khoo, S.M.1
  • 73
    • 57049152323 scopus 로고    scopus 로고
    • Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin
    • Liu Y, et al. Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin. Int J Pharm 2009; 365: 136-142.
    • (2009) Int J Pharm , vol.365 , pp. 136-142
    • Liu, Y.1
  • 74
    • 34248169123 scopus 로고    scopus 로고
    • Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin
    • Quan DQ, et al. Studies on preparation and absolute bioavailability of a self-emulsifying system containing puerarin. Chem Pharm Bull 2007; 55: 800-803.
    • (2007) Chem Pharm Bull , vol.55 , pp. 800-803
    • Quan, D.Q.1
  • 75
    • 34247137899 scopus 로고    scopus 로고
    • Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state
    • Grove M, et al. Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state. Eur J Pharm Sci 2007; 31: 8-15.
    • (2007) Eur J Pharm Sci , vol.31 , pp. 8-15
    • Grove, M.1
  • 76
    • 69749105594 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization
    • Elnaggar YS, et al. Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization. Int J Pharm 2009; 380: 133-141.
    • (2009) Int J Pharm , vol.380 , pp. 133-141
    • Elnaggar, Y.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.