Application of a statistical method to the absorption of a new model drug from micellar and lipid formulations - Evaluation of qualitative excipient effects

Pharmaceutical Development and Technology

Volumn 12, Issue 3, 2007, Pages 275-283

  Kuentz, Martin ^a,b   Wyttenbach, Nicole ^c   Kuhlmann, Olaf ^c  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^b Institute of Pharma Technology   (Switzerland)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Bioavailability; Excipient effects; Formulation parameters; Lipid drug delivery; Multivariate methods

Indexed keywords

COMPOUND A; COSURFACTANT; CREMOPHOR; DRUG ANALOG; EXCIPIENT; LONG CHAIN TRIACYLGLYCEROL; PHOSPHATIDYLCHOLINE; POLYSORBATE 80; SOLUTOL HS 15; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORRELATION COEFFICIENT; DATA ANALYSIS; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; EMULSION; INTESTINE FLUID; LIPID SOLUBILITY; MALE; MICELLE; MULTIVARIATE ANALYSIS; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; RAT; STATISTICAL ANALYSIS; WISTAR RAT;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; EMULSIONS; EXCIPIENTS; LIPIDS; MALE; MICELLES; MULTIVARIATE ANALYSIS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RATS; RATS, WISTAR;

EID: 34347376910     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450701212651     Document Type: Article

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