메뉴 건너뛰기




Volumn 63, Issue 10-11, 2011, Pages 923-942

Intestinal lymphatic transport for drug delivery

Author keywords

Absorption; Chylomicron; Delivery; Drugs; Formulation; Intestine; Lipid; Lymph; Oral; Transport

Indexed keywords

CHYLOMICRON; DELIVERY; DRUGS; FORMULATION; INTESTINE; LYMPH; ORAL; TRANSPORT;

EID: 80052168589     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2011.05.019     Document Type: Review
Times cited : (208)

References (287)
  • 1
    • 0023276505 scopus 로고
    • Estimating the maximum potential for intestinal lymphatic transport of lipophillic drug molecules
    • Charman W.N., Stella V.J. Estimating the maximum potential for intestinal lymphatic transport of lipophillic drug molecules. Int. J. Pharm. 1986, 34:175-178.
    • (1986) Int. J. Pharm. , vol.34 , pp. 175-178
    • Charman, W.N.1    Stella, V.J.2
  • 2
    • 39149108776 scopus 로고    scopus 로고
    • Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update
    • Trevaskis N.L., Charman W.N., Porter C.J. Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update. Adv. Drug Deliv. Rev. 2008, 60:702-716.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 702-716
    • Trevaskis, N.L.1    Charman, W.N.2    Porter, C.J.3
  • 3
    • 0035940046 scopus 로고    scopus 로고
    • An examination of the factors affecting intestinal lymphatic transport of dietary lipids
    • Nordskog B.K., Phan C.T., Nutting D.F., Tso P. An examination of the factors affecting intestinal lymphatic transport of dietary lipids. Adv. Drug Deliv. Rev. 2001, 50:21-44.
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , pp. 21-44
    • Nordskog, B.K.1    Phan, C.T.2    Nutting, D.F.3    Tso, P.4
  • 4
    • 33748687177 scopus 로고    scopus 로고
    • New insights in the lymphatic spread of oesophageal cancer and its implications for the extent of surgical resection
    • Cense H.A., van Eijck C.H., Tilanus H.W. New insights in the lymphatic spread of oesophageal cancer and its implications for the extent of surgical resection. Best Pract. Res. Clin. Gastroenterol. 2006, 20:893-906.
    • (2006) Best Pract. Res. Clin. Gastroenterol. , vol.20 , pp. 893-906
    • Cense, H.A.1    van Eijck, C.H.2    Tilanus, H.W.3
  • 6
    • 0019171955 scopus 로고
    • Lymphatic delivery of drugs and its application to cancer chemotherapy (author's transl)
    • Muranishi S. Lymphatic delivery of drugs and its application to cancer chemotherapy (author's transl). Yakugaku Zasshi 1980, 100:687-698.
    • (1980) Yakugaku Zasshi , vol.100 , pp. 687-698
    • Muranishi, S.1
  • 7
    • 0020556575 scopus 로고
    • 1,3-dipalmitoylglycerol ester of chlorambucil as a lymphotropic, orally administrable antineoplastic agent
    • Garzon-Aburbeh A., Poupaert J.H., Claesen M., Dumont P., Atassi G. 1,3-dipalmitoylglycerol ester of chlorambucil as a lymphotropic, orally administrable antineoplastic agent. J. Med. Chem. 1983, 26:1200-1203.
    • (1983) J. Med. Chem. , vol.26 , pp. 1200-1203
    • Garzon-Aburbeh, A.1    Poupaert, J.H.2    Claesen, M.3    Dumont, P.4    Atassi, G.5
  • 9
    • 0027263920 scopus 로고
    • The role of lymphoid organs in the immunopathogenesis of HIV infection
    • Pantaleo G., Graziosi C., Fauci A.S. The role of lymphoid organs in the immunopathogenesis of HIV infection. AIDS 1993, 7(Suppl. 1):S19-S23.
    • (1993) AIDS , vol.7 , Issue.SUPPL. 1
    • Pantaleo, G.1    Graziosi, C.2    Fauci, A.S.3
  • 11
    • 33744899576 scopus 로고    scopus 로고
    • Receptor (SLAM [CD150]) recognition and the V protein sustain swift lymphocyte-based invasion of mucosal tissue and lymphatic organs by a morbillivirus
    • von Messling V., Svitek N., Cattaneo R. Receptor (SLAM [CD150]) recognition and the V protein sustain swift lymphocyte-based invasion of mucosal tissue and lymphatic organs by a morbillivirus. J. Virol. 2006, 80:6084-6092.
    • (2006) J. Virol. , vol.80 , pp. 6084-6092
    • von Messling, V.1    Svitek, N.2    Cattaneo, R.3
  • 12
    • 33646788730 scopus 로고    scopus 로고
    • Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs
    • Lan N.T., Yamaguchi R., Inomata A., Furuya Y., Uchida K., Sugano S., Tateyama S. Comparative analyses of canine distemper viral isolates from clinical cases of canine distemper in vaccinated dogs. Vet. Microbiol. 2006, 115:32-42.
    • (2006) Vet. Microbiol. , vol.115 , pp. 32-42
    • Lan, N.T.1    Yamaguchi, R.2    Inomata, A.3    Furuya, Y.4    Uchida, K.5    Sugano, S.6    Tateyama, S.7
  • 13
    • 33745586747 scopus 로고    scopus 로고
    • Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells
    • Spiegel M., Schneider K., Weber F., Weidmann M., Hufert F.T. Interaction of severe acute respiratory syndrome-associated coronavirus with dendritic cells. J. Gen. Virol. 2006, 87:1953-1960.
    • (2006) J. Gen. Virol. , vol.87 , pp. 1953-1960
    • Spiegel, M.1    Schneider, K.2    Weber, F.3    Weidmann, M.4    Hufert, F.T.5
  • 14
    • 33947575181 scopus 로고    scopus 로고
    • Chronic HCV-related autoimmunity: a consequence of viral persistence and lymphotropism
    • Kessel A., Toubi E. Chronic HCV-related autoimmunity: a consequence of viral persistence and lymphotropism. Curr. Med. Chem. 2007, 14:547-554.
    • (2007) Curr. Med. Chem. , vol.14 , pp. 547-554
    • Kessel, A.1    Toubi, E.2
  • 16
    • 0004442367 scopus 로고    scopus 로고
    • Intestinal lymphatic transport of lipids
    • Tso P. Intestinal lymphatic transport of lipids. Adv. Drug Deliv. Rev. 2001, 50:21-44.
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , pp. 21-44
    • Tso, P.1
  • 17
    • 0035289931 scopus 로고    scopus 로고
    • Intestinal lipid absorption and transport
    • Phan C.T., Tso P. Intestinal lipid absorption and transport. Front. Biosci. 2001, 6:D299-D319.
    • (2001) Front. Biosci. , vol.6
    • Phan, C.T.1    Tso, P.2
  • 18
    • 0001297576 scopus 로고
    • Intestinal lipid absorption
    • Raven Press, New York, L.R. Johnson (Ed.)
    • Tso P. Intestinal lipid absorption. Physiology of the Gastrointestinal Tract 1994, 1867-1907. Raven Press, New York. L.R. Johnson (Ed.).
    • (1994) Physiology of the Gastrointestinal Tract , pp. 1867-1907
    • Tso, P.1
  • 20
    • 0001991508 scopus 로고
    • Cellular and molecular mechanisms of small intestinal lipid transport
    • Raven Press, New York, L.R. Johnson (Ed.)
    • Davidson N.O. Cellular and molecular mechanisms of small intestinal lipid transport. Physiology of the Gastrointestinal Tract 1994, 1909-1934. Raven Press, New York. L.R. Johnson (Ed.).
    • (1994) Physiology of the Gastrointestinal Tract , pp. 1909-1934
    • Davidson, N.O.1
  • 24
    • 0019461547 scopus 로고
    • Fat digestion in the newborn. Characterization of lipase in gastric aspirates of premature and term infants
    • Hamosh M., Scanlon J.W., Ganot D., Likel M., Scanlon K.B., Hamosh P. Fat digestion in the newborn. Characterization of lipase in gastric aspirates of premature and term infants. J. Clin. Invest. 1981, 67:838-846.
    • (1981) J. Clin. Invest. , vol.67 , pp. 838-846
    • Hamosh, M.1    Scanlon, J.W.2    Ganot, D.3    Likel, M.4    Scanlon, K.B.5    Hamosh, P.6
  • 25
    • 0014982028 scopus 로고
    • Lipolytic activity of human gastric and duodenal juice against medium and long chain triglycerides
    • Cohen M., Morgan R.G., Hofmann A.F. Lipolytic activity of human gastric and duodenal juice against medium and long chain triglycerides. Gastroenterology 1971, 60:1-15.
    • (1971) Gastroenterology , vol.60 , pp. 1-15
    • Cohen, M.1    Morgan, R.G.2    Hofmann, A.F.3
  • 26
    • 0014231519 scopus 로고
    • Hydrolysis of primary and secondary esters of glycerol by pancreatic juice
    • Mattson F.H., Volpenhein R.A. Hydrolysis of primary and secondary esters of glycerol by pancreatic juice. J. Lipid Res. 1968, 9:79-84.
    • (1968) J. Lipid Res. , vol.9 , pp. 79-84
    • Mattson, F.H.1    Volpenhein, R.A.2
  • 27
    • 0019398065 scopus 로고
    • Mechanism of intestinal fat absorption
    • Shiau Y.F. Mechanism of intestinal fat absorption. Am. J. Physiol. 1981, 240:G1-G9.
    • (1981) Am. J. Physiol. , vol.240
    • Shiau, Y.F.1
  • 28
    • 0001455273 scopus 로고
    • The specificity of pancreatic lipase for the primary hydroxyl groups of glycerides
    • Mattson F.H., Beck L.W. The specificity of pancreatic lipase for the primary hydroxyl groups of glycerides. J. Biol. Chem. 1956, 219:735-740.
    • (1956) J. Biol. Chem. , vol.219 , pp. 735-740
    • Mattson, F.H.1    Beck, L.W.2
  • 29
    • 0000286663 scopus 로고
    • The digestion and absorption of triglycerides
    • Mattson F.H., Volpenhein R.A. The digestion and absorption of triglycerides. J. Biol. Chem. 1964, 239:2772-2777.
    • (1964) J. Biol. Chem. , vol.239 , pp. 2772-2777
    • Mattson, F.H.1    Volpenhein, R.A.2
  • 30
    • 50549218397 scopus 로고
    • Hydrolysis of long-chain monoglycerides in micellar solution by pancreatic lipase
    • Hofmann A.F., Borgstrom B. Hydrolysis of long-chain monoglycerides in micellar solution by pancreatic lipase. Biochim. Biophys. Acta 1963, 70:317-331.
    • (1963) Biochim. Biophys. Acta , vol.70 , pp. 317-331
    • Hofmann, A.F.1    Borgstrom, B.2
  • 31
    • 70449169903 scopus 로고
    • Studies of intestinal digestion and absorption in the human
    • Borgstrom B., Dahlqvist A., Lundh G., Sjovall J. Studies of intestinal digestion and absorption in the human. J. Clin. Invest. 1957, 36:1521-1536.
    • (1957) J. Clin. Invest. , vol.36 , pp. 1521-1536
    • Borgstrom, B.1    Dahlqvist, A.2    Lundh, G.3    Sjovall, J.4
  • 33
    • 0002014781 scopus 로고
    • Cholesterol absoprtion
    • MTP Press Ltd., London, K. Rommel, H. Goebell, R. Bhomer (Eds.)
    • McIntyre N. Cholesterol absoprtion. Lipid Absorption: Biochemical and Clinical Aspects 1976, 73-84. MTP Press Ltd., London. K. Rommel, H. Goebell, R. Bhomer (Eds.).
    • (1976) Lipid Absorption: Biochemical and Clinical Aspects , pp. 73-84
    • McIntyre, N.1
  • 34
    • 0016807765 scopus 로고
    • Purification, properties, and substrate specificity of a carboxylesterase in pancreatic juice
    • Erlanson C. Purification, properties, and substrate specificity of a carboxylesterase in pancreatic juice. Scand. J. Gastroenterol. 1975, 10:401-408.
    • (1975) Scand. J. Gastroenterol. , vol.10 , pp. 401-408
    • Erlanson, C.1
  • 35
    • 0025239461 scopus 로고
    • Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings
    • Staggers J.E., Hernell O., Stafford R.J., Carey M.C. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings. Biochemistry 1990, 29:2028-2040.
    • (1990) Biochemistry , vol.29 , pp. 2028-2040
    • Staggers, J.E.1    Hernell, O.2    Stafford, R.J.3    Carey, M.C.4
  • 36
    • 0025264030 scopus 로고
    • Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings
    • Hernell O., Staggers J.E., Carey M.C. Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings. Biochemistry 1990, 29:2041-2056.
    • (1990) Biochemistry , vol.29 , pp. 2041-2056
    • Hernell, O.1    Staggers, J.E.2    Carey, M.C.3
  • 37
    • 0025177088 scopus 로고
    • Mechanism of intestinal fatty acid uptake in the rat: the role of an acidic microclimate
    • Shiau Y.F. Mechanism of intestinal fatty acid uptake in the rat: the role of an acidic microclimate. J. Physiol. 1990, 421:463-474.
    • (1990) J. Physiol. , vol.421 , pp. 463-474
    • Shiau, Y.F.1
  • 38
    • 0014708765 scopus 로고
    • The relationship between uptake in vitro of oleic acid and micellar solubilization
    • Hoffman N.E. The relationship between uptake in vitro of oleic acid and micellar solubilization. Biochim. Biophys. Acta 1970, 196:193-203.
    • (1970) Biochim. Biophys. Acta , vol.196 , pp. 193-203
    • Hoffman, N.E.1
  • 39
    • 0015377980 scopus 로고
    • The role of micellar solubilization in lipid absorption
    • Simmonds W.J. The role of micellar solubilization in lipid absorption. Aust. J. Exp. Biol. Med. Sci. 1972, 50:403-421.
    • (1972) Aust. J. Exp. Biol. Med. Sci. , vol.50 , pp. 403-421
    • Simmonds, W.J.1
  • 40
    • 0021436520 scopus 로고
    • Effect of intraluminal pH on cholesterol and oleic acid absorption from micellar solutions in the rat
    • Chijiiwa K., Linscheer W.G. Effect of intraluminal pH on cholesterol and oleic acid absorption from micellar solutions in the rat. Am. J. Physiol. 1984, 246:G492-G499.
    • (1984) Am. J. Physiol. , vol.246
    • Chijiiwa, K.1    Linscheer, W.G.2
  • 41
    • 0025089190 scopus 로고
    • Acidic mucin layer facilitates micelle dissociation and fatty acid diffusion
    • Shiau Y.F., Kelemen R.J., Reed M.A. Acidic mucin layer facilitates micelle dissociation and fatty acid diffusion. Am. J. Physiol. 1990, 259:G671-G675.
    • (1990) Am. J. Physiol. , vol.259
    • Shiau, Y.F.1    Kelemen, R.J.2    Reed, M.A.3
  • 42
    • 0023197804 scopus 로고
    • Mechanism of pH effect on oleic acid and cholesterol absorption in the rat
    • Chijiiwa K., Linscheer W.G. Mechanism of pH effect on oleic acid and cholesterol absorption in the rat. Am. J. Physiol. 1987, 252:G506-G510.
    • (1987) Am. J. Physiol. , vol.252
    • Chijiiwa, K.1    Linscheer, W.G.2
  • 44
    • 0028822059 scopus 로고
    • Role of a brush border membrane fatty acid binding protein in oleic acid uptake into rat and rabbit jejunal brush border membrane
    • Schoeller C., Keelan M., Mulvey G., Stremmel W., Thomson A.B. Role of a brush border membrane fatty acid binding protein in oleic acid uptake into rat and rabbit jejunal brush border membrane. Clin. Invest. Med. 1995, 18:380-388.
    • (1995) Clin. Invest. Med. , vol.18 , pp. 380-388
    • Schoeller, C.1    Keelan, M.2    Mulvey, G.3    Stremmel, W.4    Thomson, A.B.5
  • 46
    • 0021981778 scopus 로고
    • Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes
    • Stremmel W., Lotz G., Strohmeyer G., Berk P.D. Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes. J. Clin. Invest. 1985, 75:1068-1076.
    • (1985) J. Clin. Invest. , vol.75 , pp. 1068-1076
    • Stremmel, W.1    Lotz, G.2    Strohmeyer, G.3    Berk, P.D.4
  • 47
    • 0024244050 scopus 로고
    • Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein
    • Stremmel W. Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein. J. Clin. Invest. 1988, 82:2001-2010.
    • (1988) J. Clin. Invest. , vol.82 , pp. 2001-2010
    • Stremmel, W.1
  • 48
    • 0029948676 scopus 로고    scopus 로고
    • Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP)
    • Poirier H., Degrace P., Niot I., Bernard A., Besnard P. Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP). Eur. J. Biochem. 1996, 238:368-373.
    • (1996) Eur. J. Biochem. , vol.238 , pp. 368-373
    • Poirier, H.1    Degrace, P.2    Niot, I.3    Bernard, A.4    Besnard, P.5
  • 49
    • 0000832952 scopus 로고
    • Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths
    • Bloom B., Chaikoff I.L., Reinhardt Intestinal lymph as pathway for transport of absorbed fatty acids of different chain lengths. Am. J. Physiol. 1951, 166:451-455.
    • (1951) Am. J. Physiol. , vol.166 , pp. 451-455
    • Bloom, B.1    Chaikoff, I.L.2    Reinhardt3
  • 51
    • 0001021433 scopus 로고
    • Participation of phospholipides in lymphatic transport of absorbed fatty acids
    • Bloom B., Chaikoff I.L., Reinhardt W.O., Dauben W.G. Participation of phospholipides in lymphatic transport of absorbed fatty acids. J. Biol. Chem. 1951, 189:261-267.
    • (1951) J. Biol. Chem. , vol.189 , pp. 261-267
    • Bloom, B.1    Chaikoff, I.L.2    Reinhardt, W.O.3    Dauben, W.G.4
  • 52
    • 0000483832 scopus 로고
    • The portal transport of absorbed fatty acids
    • Kiyasu J.Y., Bloom B., Chaikoff I.L. The portal transport of absorbed fatty acids. J. Biol. Chem. 1952, 199:415-419.
    • (1952) J. Biol. Chem. , vol.199 , pp. 415-419
    • Kiyasu, J.Y.1    Bloom, B.2    Chaikoff, I.L.3
  • 53
    • 0034717896 scopus 로고    scopus 로고
    • The fatty acid transport function of fatty acid-binding proteins
    • Storch J., Thumser A.E. The fatty acid transport function of fatty acid-binding proteins. Biochim. Biophys. Acta 2000, 1486:28-44.
    • (2000) Biochim. Biophys. Acta , vol.1486 , pp. 28-44
    • Storch, J.1    Thumser, A.E.2
  • 54
    • 0032884918 scopus 로고    scopus 로고
    • Cytoplasmic transport of fatty acids in rat enterocytes: role of binding to fatty acid-binding protein
    • Luxon B.A., Milliano M.T. Cytoplasmic transport of fatty acids in rat enterocytes: role of binding to fatty acid-binding protein. Am. J. Physiol. 1999, 277:G361-G366.
    • (1999) Am. J. Physiol. , vol.277
    • Luxon, B.A.1    Milliano, M.T.2
  • 55
    • 0026677724 scopus 로고
    • Fatty acid binding proteins: recent concepts of regulation and function
    • Ockner R.K., Kaikaus R.M., Bass N.M. Fatty acid binding proteins: recent concepts of regulation and function. Prog. Clin. Biol. Res. 1992, 375:189-204.
    • (1992) Prog. Clin. Biol. Res. , vol.375 , pp. 189-204
    • Ockner, R.K.1    Kaikaus, R.M.2    Bass, N.M.3
  • 56
    • 0034004499 scopus 로고    scopus 로고
    • Liver and intestinal fatty acid-binding proteins obtain fatty acids from phospholipid membranes by different mechanisms
    • Thumser A.E., Storch J. Liver and intestinal fatty acid-binding proteins obtain fatty acids from phospholipid membranes by different mechanisms. J. Lipid Res. 2000, 41:647-656.
    • (2000) J. Lipid Res. , vol.41 , pp. 647-656
    • Thumser, A.E.1    Storch, J.2
  • 57
    • 0033959591 scopus 로고    scopus 로고
    • Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine
    • Alpers D.H., Bass N.M., Engle M.J., DeSchryver-Kecskemeti K. Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine. Biochim. Biophys. Acta 2000, 1483:352-362.
    • (2000) Biochim. Biophys. Acta , vol.1483 , pp. 352-362
    • Alpers, D.H.1    Bass, N.M.2    Engle, M.J.3    DeSchryver-Kecskemeti, K.4
  • 59
    • 0035940057 scopus 로고    scopus 로고
    • Intestinal lymphatic drug transport: an update
    • Porter C.J., Charman W.N. Intestinal lymphatic drug transport: an update. Adv. Drug Deliv. Rev. 2001, 50:61-80.
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , pp. 61-80
    • Porter, C.J.1    Charman, W.N.2
  • 60
    • 0000409247 scopus 로고
    • Direct esterification of monoglycerides with palmityl coenzyme A by intestinal epithelial subcellular fractions
    • Senior J.R., Isselbacher K.J. Direct esterification of monoglycerides with palmityl coenzyme A by intestinal epithelial subcellular fractions. J. Biol. Chem. 1962, 237:1454-1459.
    • (1962) J. Biol. Chem. , vol.237 , pp. 1454-1459
    • Senior, J.R.1    Isselbacher, K.J.2
  • 61
    • 0029037488 scopus 로고
    • Caco-2 cells as a model for intestinal lipoprotein synthesis and secretion
    • Levy E., Mehran M., Seidman E. Caco-2 cells as a model for intestinal lipoprotein synthesis and secretion. FASEB J. 1995, 9:626-635.
    • (1995) FASEB J. , vol.9 , pp. 626-635
    • Levy, E.1    Mehran, M.2    Seidman, E.3
  • 62
    • 0014606943 scopus 로고
    • Very low density lipoproteins in intestinal lymph: origin, composition, and role in lipid transport in the fasting state
    • Ockner R.K., Hughes F.B., Isselbacher K.J. Very low density lipoproteins in intestinal lymph: origin, composition, and role in lipid transport in the fasting state. J. Clin. Invest. 1969, 48:2079-2088.
    • (1969) J. Clin. Invest. , vol.48 , pp. 2079-2088
    • Ockner, R.K.1    Hughes, F.B.2    Isselbacher, K.J.3
  • 63
    • 0033991176 scopus 로고    scopus 로고
    • A proposed model for the assembly of chylomicrons
    • Hussain M.M. A proposed model for the assembly of chylomicrons. Atherosclerosis 2000, 148:1-15.
    • (2000) Atherosclerosis , vol.148 , pp. 1-15
    • Hussain, M.M.1
  • 64
    • 0023653657 scopus 로고
    • Factors regulating the formation of chylomicrons and very-low-density lipoproteins by the rat small intestine
    • Tso P., Lindstrom M.B., Borgstrom B. Factors regulating the formation of chylomicrons and very-low-density lipoproteins by the rat small intestine. Biochim. Biophys. Acta 1987, 922:304-313.
    • (1987) Biochim. Biophys. Acta , vol.922 , pp. 304-313
    • Tso, P.1    Lindstrom, M.B.2    Borgstrom, B.3
  • 65
    • 0014630115 scopus 로고
    • Very low density lipoproteins in intestinal lymph: role in triglyceride and cholesterol transport during fat absorption
    • Ockner R.K., Hughes F.B., Isselbacher K.J. Very low density lipoproteins in intestinal lymph: role in triglyceride and cholesterol transport during fat absorption. J. Clin. Invest. 1969, 48:2367-2373.
    • (1969) J. Clin. Invest. , vol.48 , pp. 2367-2373
    • Ockner, R.K.1    Hughes, F.B.2    Isselbacher, K.J.3
  • 66
    • 0031743510 scopus 로고    scopus 로고
    • Chylomicron synthesis by intestinal cells in vitro and in vivo
    • van Greevenbroek M.M., de Bruin T.W. Chylomicron synthesis by intestinal cells in vitro and in vivo. Atherosclerosis 1998, 141(Suppl. 1):S9-S16.
    • (1998) Atherosclerosis , vol.141 , Issue.SUPPL. 1
    • van Greevenbroek, M.M.1    de Bruin, T.W.2
  • 67
    • 0034717836 scopus 로고    scopus 로고
    • Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly
    • Gordon D.A., Jamil H. Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly. Biochim. Biophys. Acta 2000, 1486:72-83.
    • (2000) Biochim. Biophys. Acta , vol.1486 , pp. 72-83
    • Gordon, D.A.1    Jamil, H.2
  • 68
    • 0019082474 scopus 로고
    • Effect of hydrophobic surfactant (Pluronic L-81) on lymphatic lipid transport in the rat
    • Tso P., Balint J.A., Rodgers J.B. Effect of hydrophobic surfactant (Pluronic L-81) on lymphatic lipid transport in the rat. Am. J. Physiol. 1980, 239:G348-G353.
    • (1980) Am. J. Physiol. , vol.239
    • Tso, P.1    Balint, J.A.2    Rodgers, J.B.3
  • 69
    • 0021731040 scopus 로고
    • Evidence for separate pathways of chylomicron and very low-density lipoprotein assembly and transport by rat small intestine
    • Tso P., Drake D.S., Black D.D., Sabesin S.M. Evidence for separate pathways of chylomicron and very low-density lipoprotein assembly and transport by rat small intestine. Am. J. Physiol. 1984, 247:G599-G610.
    • (1984) Am. J. Physiol. , vol.247
    • Tso, P.1    Drake, D.S.2    Black, D.D.3    Sabesin, S.M.4
  • 70
    • 0041190517 scopus 로고
    • Acute inhibition of intestinal lipid transport by Pluronic L-81 in the rat
    • Tso P., Balint J.A., Bishop M.B., Rodgers J.B. Acute inhibition of intestinal lipid transport by Pluronic L-81 in the rat. Am. J. Physiol. 1981, 241:G487-G497.
    • (1981) Am. J. Physiol. , vol.241
    • Tso, P.1    Balint, J.A.2    Bishop, M.B.3    Rodgers, J.B.4
  • 71
    • 0022475420 scopus 로고
    • Formation and transport of chylomicrons by enterocytes to the lymphatics
    • Tso P., Balint J.A. Formation and transport of chylomicrons by enterocytes to the lymphatics. Am. J. Physiol. 1986, 250:G715-G726.
    • (1986) Am. J. Physiol. , vol.250
    • Tso, P.1    Balint, J.A.2
  • 72
    • 0015153937 scopus 로고
    • Lipoproteins associated with the Golgi apparatus isolated from epithelial cells of rat small intestine
    • Mahley R.W., Bennett B.D., Morre D.J., Gray M.E., Thistlethwaite W., LeQuire V.S. Lipoproteins associated with the Golgi apparatus isolated from epithelial cells of rat small intestine. Lab. Investig. 1971, 25:435-444.
    • (1971) Lab. Investig. , vol.25 , pp. 435-444
    • Mahley, R.W.1    Bennett, B.D.2    Morre, D.J.3    Gray, M.E.4    Thistlethwaite, W.5    LeQuire, V.S.6
  • 73
    • 0019193079 scopus 로고
    • Differential transport of cholesterol and oleic acid in lymph lipoproteins: sex differences in puromycin sensitivity
    • Vahouny G.V., Blendermann E.M., Gallo L.L., Treadwell C.R. Differential transport of cholesterol and oleic acid in lymph lipoproteins: sex differences in puromycin sensitivity. J. Lipid Res. 1980, 21:415-424.
    • (1980) J. Lipid Res. , vol.21 , pp. 415-424
    • Vahouny, G.V.1    Blendermann, E.M.2    Gallo, L.L.3    Treadwell, C.R.4
  • 74
    • 0019352962 scopus 로고
    • Role of biliary phosphatidylcholine in the absorption and transport of dietary triolein in the rat
    • Tso P., Kendrick H., Balint J.A., Simmonds W.J. Role of biliary phosphatidylcholine in the absorption and transport of dietary triolein in the rat. Gastroenterology 1981, 80:60-65.
    • (1981) Gastroenterology , vol.80 , pp. 60-65
    • Tso, P.1    Kendrick, H.2    Balint, J.A.3    Simmonds, W.J.4
  • 75
    • 0024433995 scopus 로고
    • Further studies on the mechanism of inhibition of intestinal chylomicron transport by Pluronic L-81
    • Nutting D., Hall J., Barrowman J.A., Tso P. Further studies on the mechanism of inhibition of intestinal chylomicron transport by Pluronic L-81. Biochim. Biophys. Acta 1989, 1004:357-362.
    • (1989) Biochim. Biophys. Acta , vol.1004 , pp. 357-362
    • Nutting, D.1    Hall, J.2    Barrowman, J.A.3    Tso, P.4
  • 76
    • 0033538497 scopus 로고    scopus 로고
    • Assembly and secretion of chylomicrons by differentiated Caco-2 cells. Nascent triglycerides and preformed phospholipids are preferentially used for lipoprotein assembly
    • Luchoomun J., Hussain M.M. Assembly and secretion of chylomicrons by differentiated Caco-2 cells. Nascent triglycerides and preformed phospholipids are preferentially used for lipoprotein assembly. J. Biol. Chem. 1999, 274:19565-19572.
    • (1999) J. Biol. Chem. , vol.274 , pp. 19565-19572
    • Luchoomun, J.1    Hussain, M.M.2
  • 77
    • 0025742664 scopus 로고
    • Carboxyl-terminal truncation of apolipoprotein B results in gradual loss of the ability to form buoyant lipoproteins in cultured human and rat liver cell lines
    • Graham D.L., Knott T.J., Jones T.C., Pease R.J., Pullinger C.R., Scott J. Carboxyl-terminal truncation of apolipoprotein B results in gradual loss of the ability to form buoyant lipoproteins in cultured human and rat liver cell lines. Biochemistry 1991, 30:5616-5621.
    • (1991) Biochemistry , vol.30 , pp. 5616-5621
    • Graham, D.L.1    Knott, T.J.2    Jones, T.C.3    Pease, R.J.4    Pullinger, C.R.5    Scott, J.6
  • 78
    • 0027993932 scopus 로고
    • Carboxyl-terminal truncation impairs lipid recruitment by apolipoprotein B100 but does not affect secretion of the truncated apolipoprotein B-containing lipoproteins
    • McLeod R.S., Zhao Y., Selby S.L., Westerlund J., Yao Z. Carboxyl-terminal truncation impairs lipid recruitment by apolipoprotein B100 but does not affect secretion of the truncated apolipoprotein B-containing lipoproteins. J. Biol. Chem. 1994, 269:2852-2862.
    • (1994) J. Biol. Chem. , vol.269 , pp. 2852-2862
    • McLeod, R.S.1    Zhao, Y.2    Selby, S.L.3    Westerlund, J.4    Yao, Z.5
  • 80
    • 0031846319 scopus 로고    scopus 로고
    • Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency
    • Hamilton R.L., Wong J.S., Cham C.M., Nielsen L.B., Young S.G. Chylomicron-sized lipid particles are formed in the setting of apolipoprotein B deficiency. J. Lipid Res. 1998, 39:1543-1557.
    • (1998) J. Lipid Res. , vol.39 , pp. 1543-1557
    • Hamilton, R.L.1    Wong, J.S.2    Cham, C.M.3    Nielsen, L.B.4    Young, S.G.5
  • 81
    • 27144434353 scopus 로고    scopus 로고
    • Bile increases intestinal lymphatic drug transport in the fasted rat
    • Trevaskis N.L., Porter C.J., Charman W.N. Bile increases intestinal lymphatic drug transport in the fasted rat. Pharm. Res. 2005, 22:1863-1870.
    • (2005) Pharm. Res. , vol.22 , pp. 1863-1870
    • Trevaskis, N.L.1    Porter, C.J.2    Charman, W.N.3
  • 82
    • 0013869884 scopus 로고
    • Origin and characteristics of endogenous lipid in thoracic duct lymph in rat
    • Baxter J. Origin and characteristics of endogenous lipid in thoracic duct lymph in rat. J. Lipid Res. 1966, 7:158-166.
    • (1966) J. Lipid Res. , vol.7 , pp. 158-166
    • Baxter, J.1
  • 83
    • 27144455920 scopus 로고
    • Site of origin of plasma triglyceride
    • Byers S.O., Friedman M. Site of origin of plasma triglyceride. Am. J. Physiol. 1960, 198:629-631.
    • (1960) Am. J. Physiol. , vol.198 , pp. 629-631
    • Byers, S.O.1    Friedman, M.2
  • 84
    • 0018225457 scopus 로고
    • Intestinal contribution to secretion of very low density lipoproteins into plasma
    • Risser T.R., Reaven G.M., Reaven E.P. Intestinal contribution to secretion of very low density lipoproteins into plasma. Am. J. Physiol. 1978, 234:E277-E281.
    • (1978) Am. J. Physiol. , vol.234
    • Risser, T.R.1    Reaven, G.M.2    Reaven, E.P.3
  • 86
    • 0027068797 scopus 로고
    • Uptake and metabolism of circulating fatty acids by rat intestine
    • Mansbach C.M., Dowell R.F. Uptake and metabolism of circulating fatty acids by rat intestine. Am. J. Physiol. 1992, 263:G927-G933.
    • (1992) Am. J. Physiol. , vol.263
    • Mansbach, C.M.1    Dowell, R.F.2
  • 87
    • 0029090378 scopus 로고
    • Role of the intestine in chylomicron remnant clearance
    • Mansbach C.M., Dowell R.F. Role of the intestine in chylomicron remnant clearance. Am. J. Physiol. 1995, 269:G144-G152.
    • (1995) Am. J. Physiol. , vol.269
    • Mansbach, C.M.1    Dowell, R.F.2
  • 88
    • 0022358656 scopus 로고
    • Factors influencing triacylglycerol delivery into mesenteric lymph
    • Mansbach C.M., Arnold A., Cox M.A. Factors influencing triacylglycerol delivery into mesenteric lymph. Am. J. Physiol. 1985, 249:G642-G648.
    • (1985) Am. J. Physiol. , vol.249
    • Mansbach, C.M.1    Arnold, A.2    Cox, M.A.3
  • 89
    • 0017699602 scopus 로고
    • Role of biliary lecithin in lymphatic transport of fat
    • Tso P., Balint J.A., Simmonds W.J. Role of biliary lecithin in lymphatic transport of fat. Gastroenterology 1977, 73:1362-1367.
    • (1977) Gastroenterology , vol.73 , pp. 1362-1367
    • Tso, P.1    Balint, J.A.2    Simmonds, W.J.3
  • 90
    • 73049167589 scopus 로고
    • Physico-chemical state of lipids in intestinal content during their digestion and absorption
    • Hofmann A.F., Borgstrom B. Physico-chemical state of lipids in intestinal content during their digestion and absorption. Fed. Proc. 1962, 21:43-50.
    • (1962) Fed. Proc. , vol.21 , pp. 43-50
    • Hofmann, A.F.1    Borgstrom, B.2
  • 91
    • 0041430944 scopus 로고    scopus 로고
    • Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs
    • Shackleford D.M., Faassen W.A., Houwing N., Lass H., Edwards G.A., Porter C.J., Charman W.N. Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs. J. Pharmacol. Exp. Ther. 2003, 306:925-933.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 925-933
    • Shackleford, D.M.1    Faassen, W.A.2    Houwing, N.3    Lass, H.4    Edwards, G.A.5    Porter, C.J.6    Charman, W.N.7
  • 93
    • 0037370043 scopus 로고    scopus 로고
    • Important effect of food on the bioavailability of oral testosterone undecanoate
    • Bagchus W.M., Hust R., Maris F., Schnabel P.G., Houwing N.S. Important effect of food on the bioavailability of oral testosterone undecanoate. Pharmacotherapy 2003, 23:319-325.
    • (2003) Pharmacotherapy , vol.23 , pp. 319-325
    • Bagchus, W.M.1    Hust, R.2    Maris, F.3    Schnabel, P.G.4    Houwing, N.S.5
  • 94
    • 0034762181 scopus 로고    scopus 로고
    • A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine
    • Khoo S.M., Edwards G.A., Porter C.J., Charman W.N. A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine. J. Pharm. Sci. 2001, 90:1599-1607.
    • (2001) J. Pharm. Sci. , vol.90 , pp. 1599-1607
    • Khoo, S.M.1    Edwards, G.A.2    Porter, C.J.3    Charman, W.N.4
  • 95
    • 0036278429 scopus 로고    scopus 로고
    • A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs
    • Khoo S.M., Prankerd R.J., Edwards G.A., Porter C.J., Charman W.N. A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs. J. Pharm. Sci. 2002, 91:647-659.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 647-659
    • Khoo, S.M.1    Prankerd, R.J.2    Edwards, G.A.3    Porter, C.J.4    Charman, W.N.5
  • 96
    • 0016255066 scopus 로고
    • Fatty acid-binding protein in small intestine. Identification, isolation, and evidence for its role in cellular fatty acid transport
    • Ockner R.K., Manning J.A. Fatty acid-binding protein in small intestine. Identification, isolation, and evidence for its role in cellular fatty acid transport. J. Clin. Invest. 1974, 54:326-338.
    • (1974) J. Clin. Invest. , vol.54 , pp. 326-338
    • Ockner, R.K.1    Manning, J.A.2
  • 97
    • 0013809384 scopus 로고
    • The composition and structure of lymph chylomicrons in dog, rat, and man
    • Zilversmit D.B. The composition and structure of lymph chylomicrons in dog, rat, and man. J. Clin. Invest. 1965, 44:1610-1622.
    • (1965) J. Clin. Invest. , vol.44 , pp. 1610-1622
    • Zilversmit, D.B.1
  • 99
    • 0014875613 scopus 로고
    • The characteristics of mixed micellar solutions with particular reference to bile
    • Carey M.C., Small D.M. The characteristics of mixed micellar solutions with particular reference to bile. Am. J. Med. 1970, 49:590-608.
    • (1970) Am. J. Med. , vol.49 , pp. 590-608
    • Carey, M.C.1    Small, D.M.2
  • 100
    • 0021800756 scopus 로고
    • Apolipoprotein B synthesis in humans: liver synthesizes only apolipoprotein B-100
    • Edge S.B., Hoeg J.M., Schneider P.D., Brewer H.B. Apolipoprotein B synthesis in humans: liver synthesizes only apolipoprotein B-100. Metabolism 1985, 34:726-730.
    • (1985) Metabolism , vol.34 , pp. 726-730
    • Edge, S.B.1    Hoeg, J.M.2    Schneider, P.D.3    Brewer, H.B.4
  • 102
    • 0025743782 scopus 로고
    • Apolipoprotein synthesis in normal and abetalipoproteinemic intestinal mucosa
    • Glickman R.M., Glickman J.N., Magun A., Brin M. Apolipoprotein synthesis in normal and abetalipoproteinemic intestinal mucosa. Gastroenterology 1991, 101:749-755.
    • (1991) Gastroenterology , vol.101 , pp. 749-755
    • Glickman, R.M.1    Glickman, J.N.2    Magun, A.3    Brin, M.4
  • 104
    • 0013898628 scopus 로고
    • The lipoproteins and lipid transport in abetalipoproteinemia
    • Levy R.I., Fredrickson D.S., Laster L. The lipoproteins and lipid transport in abetalipoproteinemia. J. Clin. Invest. 1966, 45:531-541.
    • (1966) J. Clin. Invest. , vol.45 , pp. 531-541
    • Levy, R.I.1    Fredrickson, D.S.2    Laster, L.3
  • 107
    • 30344464375 scopus 로고    scopus 로고
    • Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism
    • Hooper A.J., van Bockxmeer F.M., Burnett J.R. Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism. Crit. Rev. Clin. Lab. Sci. 2005, 42:515-545.
    • (2005) Crit. Rev. Clin. Lab. Sci. , vol.42 , pp. 515-545
    • Hooper, A.J.1    van Bockxmeer, F.M.2    Burnett, J.R.3
  • 108
    • 0000519721 scopus 로고
    • Unusual causes of steatorrhoea in infancy and childhood
    • Anderson C.M., Townley R.R., Freemanm, Johansen P. Unusual causes of steatorrhoea in infancy and childhood. Med. J. Aust. 1961, 48(2):617-622.
    • (1961) Med. J. Aust. , vol.48 , Issue.2 , pp. 617-622
    • Anderson, C.M.1    Townley, R.R.2    Freemanm3    Johansen, P.4
  • 113
    • 0343895740 scopus 로고
    • The pathophysiology of metastasis within the lymphatic system
    • Hall, Boston, L. Weiss, H. Gilbert, S. Ballon (Eds.)
    • Weiss L. The pathophysiology of metastasis within the lymphatic system. Lymphatic System Metastases 1988, 2. Hall, Boston. L. Weiss, H. Gilbert, S. Ballon (Eds.).
    • (1988) Lymphatic System Metastases , pp. 2
    • Weiss, L.1
  • 114
    • 0022535594 scopus 로고
    • Lymphoscintigraphy in patients with lymphedema. A new approach using intradermal injections of technetium-99m human serum albumin
    • Ohtake E., Matsui K. Lymphoscintigraphy in patients with lymphedema. A new approach using intradermal injections of technetium-99m human serum albumin. Clin. Nucl. Med. 1986, 11:474-478.
    • (1986) Clin. Nucl. Med. , vol.11 , pp. 474-478
    • Ohtake, E.1    Matsui, K.2
  • 116
    • 0035940059 scopus 로고    scopus 로고
    • Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
    • Hussain N., Jaitley V., Florence A.T. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev. 2001, 50:107-142.
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , pp. 107-142
    • Hussain, N.1    Jaitley, V.2    Florence, A.T.3
  • 119
  • 122
    • 0043122366 scopus 로고    scopus 로고
    • Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs
    • Khoo S.M., Shackleford D.M., Porter C.J., Edwards G.A., Charman W.N. Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs. Pharm. Res. 2003, 20:1460-1465.
    • (2003) Pharm. Res. , vol.20 , pp. 1460-1465
    • Khoo, S.M.1    Shackleford, D.M.2    Porter, C.J.3    Edwards, G.A.4    Charman, W.N.5
  • 123
    • 28444470864 scopus 로고    scopus 로고
    • Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs
    • Lespine A., Chanoit G., Bousquet-Melou A., Lallemand E., Bassissi F.M., Alvinerie M., Toutain P.L. Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs. Eur. J. Pharm. Sci. 2006, 27:37-43.
    • (2006) Eur. J. Pharm. Sci. , vol.27 , pp. 37-43
    • Lespine, A.1    Chanoit, G.2    Bousquet-Melou, A.3    Lallemand, E.4    Bassissi, F.M.5    Alvinerie, M.6    Toutain, P.L.7
  • 124
    • 0026013402 scopus 로고
    • An experimental animal model for studying the effects of a novel lymphatic drug delivery system for propranolol
    • White D.G., Story M.J., Barnwell S.G. An experimental animal model for studying the effects of a novel lymphatic drug delivery system for propranolol. Int. J. Pharm. 1991, 69:169-174.
    • (1991) Int. J. Pharm. , vol.69 , pp. 169-174
    • White, D.G.1    Story, M.J.2    Barnwell, S.G.3
  • 125
    • 0030863437 scopus 로고    scopus 로고
    • Lymph flow pattern in the intact thoracic duct in sheep
    • Onizuka M., Flatebo T., Nicolaysen G. Lymph flow pattern in the intact thoracic duct in sheep. J. Physiol. 1997, 503(Pt 1):223-234.
    • (1997) J. Physiol. , vol.503 , Issue.PART 1 , pp. 223-234
    • Onizuka, M.1    Flatebo, T.2    Nicolaysen, G.3
  • 128
    • 14144249452 scopus 로고    scopus 로고
    • Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs
    • Dahan A., Hoffman A. Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs. Eur. J. Pharm. Sci. 2005, 24:381-388.
    • (2005) Eur. J. Pharm. Sci. , vol.24 , pp. 381-388
    • Dahan, A.1    Hoffman, A.2
  • 130
    • 0023276505 scopus 로고
    • Estimating the maximal potentital for intestinal lymphatic transport of lipophilic drug molecules
    • Charman W.N., Stella V.J. Estimating the maximal potentital for intestinal lymphatic transport of lipophilic drug molecules. Int. J. Pharm. 1986, 33:175-178.
    • (1986) Int. J. Pharm. , vol.33 , pp. 175-178
    • Charman, W.N.1    Stella, V.J.2
  • 131
    • 0029687274 scopus 로고    scopus 로고
    • Model systems for intestinal lymphatic transport studies
    • Plenum Press, New York, R.T. Borchardt, P.L. Smith, G. Wilson (Eds.)
    • Porter C.J.H., Charman W.N. Model systems for intestinal lymphatic transport studies. Models for Assessing Drug Absorption and Metabolism 1996, 85-102. Plenum Press, New York. R.T. Borchardt, P.L. Smith, G. Wilson (Eds.).
    • (1996) Models for Assessing Drug Absorption and Metabolism , pp. 85-102
    • Porter, C.J.H.1    Charman, W.N.2
  • 132
    • 0030003723 scopus 로고    scopus 로고
    • Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion
    • Porter C.J., Charman S.A., Humberstone A.J., Charman W.N. Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion. J. Pharm. Sci. 1996, 85:357-361.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 357-361
    • Porter, C.J.1    Charman, S.A.2    Humberstone, A.J.3    Charman, W.N.4
  • 133
    • 0029926358 scopus 로고    scopus 로고
    • Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion
    • Porter C.J., Charman S.A., Charman W.N. Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion. J. Pharm. Sci. 1996, 85:351-356.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 351-356
    • Porter, C.J.1    Charman, S.A.2    Charman, W.N.3
  • 135
    • 0021844307 scopus 로고
    • Lymphatic appearance of DDT in thoracic mesenteric lymph duct cannulated rats
    • Noguchi T., Charman W.N., Stella V.J. Lymphatic appearance of DDT in thoracic mesenteric lymph duct cannulated rats. Int. J. Pharm. 1985, 24:185-192.
    • (1985) Int. J. Pharm. , vol.24 , pp. 185-192
    • Noguchi, T.1    Charman, W.N.2    Stella, V.J.3
  • 136
    • 0017331682 scopus 로고
    • Intestinal lymph flow and lymphatic transport of protein during fat absorption
    • Turner S.G., Barrowman J.A. Intestinal lymph flow and lymphatic transport of protein during fat absorption. Q. J. Exp. Physiol. Cogn. Med. Sci. 1977, 62:175-180.
    • (1977) Q. J. Exp. Physiol. Cogn. Med. Sci. , vol.62 , pp. 175-180
    • Turner, S.G.1    Barrowman, J.A.2
  • 137
    • 0002239534 scopus 로고
    • Methodology for assessing intestinal lymphatic transport
    • CRC Press, Boca Raton, FL, W.N. Charman, V.J. Stella (Eds.)
    • Raub T.J., Douglas S.L., Melchior G.W., Charman W.N. Methodology for assessing intestinal lymphatic transport. Lymphatic Transport of Drugs 1992, 63-111. CRC Press, Boca Raton, FL. W.N. Charman, V.J. Stella (Eds.).
    • (1992) Lymphatic Transport of Drugs , pp. 63-111
    • Raub, T.J.1    Douglas, S.L.2    Melchior, G.W.3    Charman, W.N.4
  • 138
    • 0002721203 scopus 로고    scopus 로고
    • Chronic collection of mesenteric lymph from conscious, tethered rats
    • Hauss D., Fogal S., Ficorilli J. Chronic collection of mesenteric lymph from conscious, tethered rats. Contemp. Top. Lab. Anim. Sci. 1998, 37:56-58.
    • (1998) Contemp. Top. Lab. Anim. Sci. , vol.37 , pp. 56-58
    • Hauss, D.1    Fogal, S.2    Ficorilli, J.3
  • 139
    • 4244000929 scopus 로고    scopus 로고
    • A novel triple-canulaed conscious dog model for assessment of the absorption, enterocyte-based metablism and lymphocyte transport of candidate lipophilic drugs
    • Khoo S.M., Porter C.J.H., Edwards G.A., Charman W.N. A novel triple-canulaed conscious dog model for assessment of the absorption, enterocyte-based metablism and lymphocyte transport of candidate lipophilic drugs. Pharm. Sci. 1999, 1:S647.
    • (1999) Pharm. Sci. , vol.1
    • Khoo, S.M.1    Porter, C.J.H.2    Edwards, G.A.3    Charman, W.N.4
  • 140
    • 0015428427 scopus 로고
    • Creation of a thoracic duct fistula: an improved technique
    • Rajpal S.G., Kirkpatrick J.R. Creation of a thoracic duct fistula: an improved technique. J. Surg. Res. 1972, 13:260-261.
    • (1972) J. Surg. Res. , vol.13 , pp. 260-261
    • Rajpal, S.G.1    Kirkpatrick, J.R.2
  • 141
    • 0029055473 scopus 로고
    • Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
    • Kararli T.T. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm. Drug Dispos. 1995, 16:351-380.
    • (1995) Biopharm. Drug Dispos. , vol.16 , pp. 351-380
    • Kararli, T.T.1
  • 142
    • 0025008459 scopus 로고
    • External thoracic duct-venous shunt in conscious pigs for long term studies of connective tissue metabolites in lymph
    • Jensen L.T., Olesen H.P., Risteli J., Lorenzen I. External thoracic duct-venous shunt in conscious pigs for long term studies of connective tissue metabolites in lymph. Lab. Anim. Sci. 1990, 40:620-624.
    • (1990) Lab. Anim. Sci. , vol.40 , pp. 620-624
    • Jensen, L.T.1    Olesen, H.P.2    Risteli, J.3    Lorenzen, I.4
  • 144
    • 0034005256 scopus 로고    scopus 로고
    • Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection
    • Charman S.A., Segrave A.M., Edwards G.A., Porter C.J. Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection. J. Pharm. Sci. 2000, 89:168-177.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 168-177
    • Charman, S.A.1    Segrave, A.M.2    Edwards, G.A.3    Porter, C.J.4
  • 145
    • 0035940080 scopus 로고    scopus 로고
    • Lymphatic transport of proteins after s.c. injection: implications of animal model selection
    • Porter C.J., Edwards G.A., Charman S.A. Lymphatic transport of proteins after s.c. injection: implications of animal model selection. Adv. Drug Deliv. Rev. 2001, 50:157-171.
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , pp. 157-171
    • Porter, C.J.1    Edwards, G.A.2    Charman, S.A.3
  • 146
    • 0015905920 scopus 로고
    • Surgical techniques for long-term study of thoracic duct lymph circulation in dogs
    • Girardet R.E., Benninghoff D.L. Surgical techniques for long-term study of thoracic duct lymph circulation in dogs. J. Surg. Res. 1973, 15:168-175.
    • (1973) J. Surg. Res. , vol.15 , pp. 168-175
    • Girardet, R.E.1    Benninghoff, D.L.2
  • 147
    • 0014466871 scopus 로고
    • Preparation of chronic thoracic duct lymph fistulas in man and laboratory animals
    • Fish J.C., Sarles H.E., Mattingly A.T., Ross M.V., Remmers A.R. Preparation of chronic thoracic duct lymph fistulas in man and laboratory animals. J. Surg. Res. 1969, 9:101-106.
    • (1969) J. Surg. Res. , vol.9 , pp. 101-106
    • Fish, J.C.1    Sarles, H.E.2    Mattingly, A.T.3    Ross, M.V.4    Remmers, A.R.5
  • 148
    • 0016230197 scopus 로고
    • Technique for chronic cannulation of the canine thoracic duct
    • Gralla E.J., Cappiello F.M., Jonas A.M. Technique for chronic cannulation of the canine thoracic duct. Am. J. Vet. Res. 1973, 34:285-287.
    • (1973) Am. J. Vet. Res. , vol.34 , pp. 285-287
    • Gralla, E.J.1    Cappiello, F.M.2    Jonas, A.M.3
  • 149
    • 0016757670 scopus 로고
    • Exteriorization of thoracic duct lymph. Theoretical considerations and an experimental model
    • Dedo D.D., Ogura J.H. Exteriorization of thoracic duct lymph. Theoretical considerations and an experimental model. Arch. Otolaryngol. 1975, 101:671-674.
    • (1975) Arch. Otolaryngol. , vol.101 , pp. 671-674
    • Dedo, D.D.1    Ogura, J.H.2
  • 150
    • 0014909162 scopus 로고
    • A simplified method for cannulation of the normal canine cervical thoracic duct
    • Witte C.L., Witte M.H., Cole W.R. A simplified method for cannulation of the normal canine cervical thoracic duct. Lymphology 1970, 3:159-161.
    • (1970) Lymphology , vol.3 , pp. 159-161
    • Witte, C.L.1    Witte, M.H.2    Cole, W.R.3
  • 151
    • 0019498917 scopus 로고
    • Canine thoracic duct cannulation revisited
    • Briscoe D.E. Canine thoracic duct cannulation revisited. Lymphology 1981, 14:32-34.
    • (1981) Lymphology , vol.14 , pp. 32-34
    • Briscoe, D.E.1
  • 152
    • 0033818432 scopus 로고    scopus 로고
    • Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats
    • Caliph S.M., Charman W.N., Porter C.J. Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J. Pharm. Sci. 2000, 89:1073-1084.
    • (2000) J. Pharm. Sci. , vol.89 , pp. 1073-1084
    • Caliph, S.M.1    Charman, W.N.2    Porter, C.J.3
  • 153
    • 0025352716 scopus 로고
    • Effect of eicosapentaenoic acid on triacylglycerol transport in CaCo-2 cells
    • Murthy S., Albright E., Mathur S.N., Field F.J. Effect of eicosapentaenoic acid on triacylglycerol transport in CaCo-2 cells. Biochim. Biophys. Acta 1990, 1045:147-155.
    • (1990) Biochim. Biophys. Acta , vol.1045 , pp. 147-155
    • Murthy, S.1    Albright, E.2    Mathur, S.N.3    Field, F.J.4
  • 154
    • 0024514551 scopus 로고
    • Inhibition of acylcoenzyme A: cholesterol acyltransferase activity in CaCo-2 cells results in intracellular triglyceride accumulation
    • Kam N.T., Albright E., Mathur S.N., Field F.J. Inhibition of acylcoenzyme A: cholesterol acyltransferase activity in CaCo-2 cells results in intracellular triglyceride accumulation. J. Lipid Res. 1989, 30:371-377.
    • (1989) J. Lipid Res. , vol.30 , pp. 371-377
    • Kam, N.T.1    Albright, E.2    Mathur, S.N.3    Field, F.J.4
  • 155
    • 0025633321 scopus 로고
    • Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells
    • Kam N.T., Albright E., Mathur S., Field F.J. Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells. Biochem. J. 1990, 272:427-433.
    • (1990) Biochem. J. , vol.272 , pp. 427-433
    • Kam, N.T.1    Albright, E.2    Mathur, S.3    Field, F.J.4
  • 156
    • 0023490564 scopus 로고
    • Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell line
    • Traber M.G., Kayden H.J., Rindler M.J. Polarized secretion of newly synthesized lipoproteins by the Caco-2 human intestinal cell line. J. Lipid Res. 1987, 28:1350-1363.
    • (1987) J. Lipid Res. , vol.28 , pp. 1350-1363
    • Traber, M.G.1    Kayden, H.J.2    Rindler, M.J.3
  • 157
    • 0038537242 scopus 로고    scopus 로고
    • The effects of pluronics block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells
    • Seeballuck F., Ashford M.B., O'Driscoll C.M. The effects of pluronics block copolymers and Cremophor EL on intestinal lipoprotein processing and the potential link with P-glycoprotein in Caco-2 cells. Pharm. Res. 2003, 20:1085-1092.
    • (2003) Pharm. Res. , vol.20 , pp. 1085-1092
    • Seeballuck, F.1    Ashford, M.B.2    O'Driscoll, C.M.3
  • 158
    • 17644402482 scopus 로고    scopus 로고
    • Stimulation of triglyceride-rich lipoprotein secretion by polysorbate 80: in vitro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model
    • Seeballuck F., Lawless E., Ashford M.B., O'Driscoll C.M. Stimulation of triglyceride-rich lipoprotein secretion by polysorbate 80: in vitro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model. Pharm. Res. 2004, 21:2320-2326.
    • (2004) Pharm. Res. , vol.21 , pp. 2320-2326
    • Seeballuck, F.1    Lawless, E.2    Ashford, M.B.3    O'Driscoll, C.M.4
  • 159
    • 33645234931 scopus 로고    scopus 로고
    • Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture
    • Karpf D.M., Holm R., Garafalo C., Levy E., Jacobsen J., Mullertz A. Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture. J. Pharm. Sci. 2006, 95:45-55.
    • (2006) J. Pharm. Sci. , vol.95 , pp. 45-55
    • Karpf, D.M.1    Holm, R.2    Garafalo, C.3    Levy, E.4    Jacobsen, J.5    Mullertz, A.6
  • 160
    • 39149126301 scopus 로고    scopus 로고
    • Biopharmaceutical challenges associated with drugs with low aqueous solubility - the potential impact of lipid-based formulations
    • O'Driscoll C.M., Griffin B.T. Biopharmaceutical challenges associated with drugs with low aqueous solubility - the potential impact of lipid-based formulations. Adv. Drug Deliv. Rev. 2008, 60:617-624.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 617-624
    • O'Driscoll, C.M.1    Griffin, B.T.2
  • 161
    • 0026655389 scopus 로고
    • Apolipoprotein B mRNA abundance is decreased by eicosapentaenoic acid in CaCo-2 cells. Effect on the synthesis and secretion of apolipoprotein B
    • Murthy S., Albright E., Mathur S.N., Davidson N.O., Field F.J. Apolipoprotein B mRNA abundance is decreased by eicosapentaenoic acid in CaCo-2 cells. Effect on the synthesis and secretion of apolipoprotein B. Arterioscler. Thromb. 1992, 12:691-700.
    • (1992) Arterioscler. Thromb. , vol.12 , pp. 691-700
    • Murthy, S.1    Albright, E.2    Mathur, S.N.3    Davidson, N.O.4    Field, F.J.5
  • 163
    • 0027191375 scopus 로고
    • Fatty acid esterification during differentiation of the human intestinal cell line Caco-2
    • Trotter P.J., Storch J. Fatty acid esterification during differentiation of the human intestinal cell line Caco-2. J. Biol. Chem. 1993, 268:10017-10023.
    • (1993) J. Biol. Chem. , vol.268 , pp. 10017-10023
    • Trotter, P.J.1    Storch, J.2
  • 164
    • 27644453872 scopus 로고    scopus 로고
    • Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability
    • Gershkovich P., Hoffman A. Uptake of lipophilic drugs by plasma derived isolated chylomicrons: linear correlation with intestinal lymphatic bioavailability. Eur. J. Pharm. Sci. 2005, 26:394-404.
    • (2005) Eur. J. Pharm. Sci. , vol.26 , pp. 394-404
    • Gershkovich, P.1    Hoffman, A.2
  • 165
    • 0029782643 scopus 로고    scopus 로고
    • Drug dissolution into micellar solutions: development of a convective diffusion model and comparison to the film equilibrium model with application to surfactant-facilitated dissolution of carbamazepine
    • Crison J.R., Shah V.P., Skelly J.P., Amidon G.L. Drug dissolution into micellar solutions: development of a convective diffusion model and comparison to the film equilibrium model with application to surfactant-facilitated dissolution of carbamazepine. J. Pharm. Sci. 1996, 85:1005-1011.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1005-1011
    • Crison, J.R.1    Shah, V.P.2    Skelly, J.P.3    Amidon, G.L.4
  • 166
    • 0031041732 scopus 로고    scopus 로고
    • Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate
    • Crison J.R., Weiner N.D., Amidon G.L. Dissolution media for in vitro testing of water-insoluble drugs: effect of surfactant purity and electrolyte on in vitro dissolution of carbamazepine in aqueous solutions of sodium lauryl sulfate. J. Pharm. Sci. 1997, 86:384-388.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 384-388
    • Crison, J.R.1    Weiner, N.D.2    Amidon, G.L.3
  • 168
    • 37849045222 scopus 로고    scopus 로고
    • Dissolution improvement of four poorly water soluble drugs by cogrinding with commonly used excipients
    • Vogt M., Kunath K., Dressman J.B. Dissolution improvement of four poorly water soluble drugs by cogrinding with commonly used excipients. Eur. J. Pharm. Biopharm. 2008, 68:330-337.
    • (2008) Eur. J. Pharm. Biopharm. , vol.68 , pp. 330-337
    • Vogt, M.1    Kunath, K.2    Dressman, J.B.3
  • 169
    • 44649133855 scopus 로고    scopus 로고
    • Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs
    • Dahan A., Hoffman A. Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs. J. Control Release 2008, 129:1-10.
    • (2008) J. Control Release , vol.129 , pp. 1-10
    • Dahan, A.1    Hoffman, A.2
  • 170
    • 0024674201 scopus 로고
    • The role of calcium ions and bile salts on the pancreatic lipase-catalyzed hydrolysis of triglyceride emulsions stabilized with lecithin
    • Alvarez F.J., Stella V.J. The role of calcium ions and bile salts on the pancreatic lipase-catalyzed hydrolysis of triglyceride emulsions stabilized with lecithin. Pharm. Res. 1989, 6:449-457.
    • (1989) Pharm. Res. , vol.6 , pp. 449-457
    • Alvarez, F.J.1    Stella, V.J.2
  • 171
    • 0035478436 scopus 로고    scopus 로고
    • In vitro assessment of oral lipid based formulations
    • Porter C.J., Charman W.N. In vitro assessment of oral lipid based formulations. Adv. Drug Deliv. Rev. 2001, 50(Suppl. 1):S127-S147.
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , Issue.SUPPL. 1
    • Porter, C.J.1    Charman, W.N.2
  • 173
    • 0031750861 scopus 로고    scopus 로고
    • Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs
    • Galia E., Nicolaides E., Horter D., Lobenberg R., Reppas C., Dressman J.B. Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs. Pharm. Res. 1998, 15:698-705.
    • (1998) Pharm. Res. , vol.15 , pp. 698-705
    • Galia, E.1    Nicolaides, E.2    Horter, D.3    Lobenberg, R.4    Reppas, C.5    Dressman, J.B.6
  • 175
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
    • Porter C.J., Trevaskis N.L., Charman W.N. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat. Rev. Drug Discov. 2007, 6:231-248.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 231-248
    • Porter, C.J.1    Trevaskis, N.L.2    Charman, W.N.3
  • 176
    • 1442324408 scopus 로고    scopus 로고
    • Successful in silico predicting of intestinal lymphatic transfer
    • Holm R., Hoest J. Successful in silico predicting of intestinal lymphatic transfer. Int. J. Pharm. 2004, 272:189-193.
    • (2004) Int. J. Pharm. , vol.272 , pp. 189-193
    • Holm, R.1    Hoest, J.2
  • 177
    • 0028268211 scopus 로고
    • A quantitative concept of the mechanism of intestinal lymphatic transfer of lipophilic molecules
    • Ichihashi T., Nagasaki T., Takagishi Y., Yamada H. A quantitative concept of the mechanism of intestinal lymphatic transfer of lipophilic molecules. Pharm. Res. 1994, 11:508-512.
    • (1994) Pharm. Res. , vol.11 , pp. 508-512
    • Ichihashi, T.1    Nagasaki, T.2    Takagishi, Y.3    Yamada, H.4
  • 178
    • 0026593458 scopus 로고
    • Factors affecting the lymphaic transport of penclomedine (NSC-338720), a lipophilic cytotoxic drug: comparison to DDT and hexachlorobenzene
    • Myers R.A., Stella V.J. Factors affecting the lymphaic transport of penclomedine (NSC-338720), a lipophilic cytotoxic drug: comparison to DDT and hexachlorobenzene. Int. J. Pharm. 1992, 80:511-562.
    • (1992) Int. J. Pharm. , vol.80 , pp. 511-562
    • Myers, R.A.1    Stella, V.J.2
  • 179
    • 0028234686 scopus 로고
    • Targeted lymphatic transport and modified systemic distribution of CI-976, a lipophilic lipid-regulator drug, via a formulation approach
    • Hauss D.J., Mehta S.C., Radebaugh G.W. Targeted lymphatic transport and modified systemic distribution of CI-976, a lipophilic lipid-regulator drug, via a formulation approach. Int. J. Pharm. 1994, 108:85-93.
    • (1994) Int. J. Pharm. , vol.108 , pp. 85-93
    • Hauss, D.J.1    Mehta, S.C.2    Radebaugh, G.W.3
  • 181
    • 0031872134 scopus 로고    scopus 로고
    • Predicting drug absorption from molecular surface properties based on molecular dynamics simulations
    • Krarup L.H., Christensen I.T., Hovgaard L., Frokjaer S. Predicting drug absorption from molecular surface properties based on molecular dynamics simulations. Pharm. Res. 1998, 15:972-978.
    • (1998) Pharm. Res. , vol.15 , pp. 972-978
    • Krarup, L.H.1    Christensen, I.T.2    Hovgaard, L.3    Frokjaer, S.4
  • 182
    • 0032979004 scopus 로고    scopus 로고
    • Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics
    • Norinder U., Osterberg T., Artursson P. Theoretical calculation and prediction of intestinal absorption of drugs in humans using MolSurf parametrization and PLS statistics. Eur. J. Pharm. Sci. 1999, 8:49-56.
    • (1999) Eur. J. Pharm. Sci. , vol.8 , pp. 49-56
    • Norinder, U.1    Osterberg, T.2    Artursson, P.3
  • 183
    • 0034625096 scopus 로고    scopus 로고
    • Molecular fields in quantitative structure-permeation relationships: the VolSurf approach
    • Cruciani G., Crivori P., Carrupt P.A., Testa B. Molecular fields in quantitative structure-permeation relationships: the VolSurf approach. J. Mol. Struct. Thoechem 2000, 503:17-30.
    • (2000) J. Mol. Struct. Thoechem , vol.503 , pp. 17-30
    • Cruciani, G.1    Crivori, P.2    Carrupt, P.A.3    Testa, B.4
  • 184
    • 0033800498 scopus 로고    scopus 로고
    • VolSurf: a new tool for the pharmacokinetics optimization of lead compounds
    • Cruciani G., Pastor M., Guba W. VolSurf: a new tool for the pharmacokinetics optimization of lead compounds. Eur. J. Pharm. Sci. 2000, 11:S29-S39.
    • (2000) Eur. J. Pharm. Sci. , vol.11
    • Cruciani, G.1    Pastor, M.2    Guba, W.3
  • 185
    • 0029585123 scopus 로고
    • Atom/fragment contribution method for estimating octanol-water partition coefficients
    • Meylan W.M., Howard P.H. Atom/fragment contribution method for estimating octanol-water partition coefficients. J. Pharm. Sci. 1995, 84:83-92.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 83-92
    • Meylan, W.M.1    Howard, P.H.2
  • 186
    • 0002309097 scopus 로고
    • PLS-partial least-squares projections to latent structures
    • Escom, Leiden, H. Kubinyi (Ed.)
    • Wold S., Johansson E., Cocchi M. PLS-partial least-squares projections to latent structures. 3D QSAR in Drug Design 1993, 523-550. Escom, Leiden. H. Kubinyi (Ed.).
    • (1993) 3D QSAR in Drug Design , pp. 523-550
    • Wold, S.1    Johansson, E.2    Cocchi, M.3
  • 187
    • 43249121029 scopus 로고    scopus 로고
    • Gut instincts: explorations in intestinal physiology and drug delivery
    • McConnell E.L., Fadda H.M., Basit A.W. Gut instincts: explorations in intestinal physiology and drug delivery. Int. J. Pharm. 2008, 364:213-226.
    • (2008) Int. J. Pharm. , vol.364 , pp. 213-226
    • McConnell, E.L.1    Fadda, H.M.2    Basit, A.W.3
  • 188
    • 0030580951 scopus 로고    scopus 로고
    • Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption
    • Yu L.X., Lipka E., Crison J.R., Amidon G.L. Transport approaches to the biopharmaceutical design of oral drug delivery systems: prediction of intestinal absorption. Adv. Drug Deliv. Rev. 1996, 19:359-376.
    • (1996) Adv. Drug Deliv. Rev. , vol.19 , pp. 359-376
    • Yu, L.X.1    Lipka, E.2    Crison, J.R.3    Amidon, G.L.4
  • 189
    • 33646681244 scopus 로고    scopus 로고
    • Cytochromes P450 - a family of proteins and scientists-understanding their relationships
    • Sue Masters B., Marohnic C.C. Cytochromes P450 - a family of proteins and scientists-understanding their relationships. Drug Metab. Rev. 2006, 38:209-225.
    • (2006) Drug Metab. Rev. , vol.38 , pp. 209-225
    • Sue Masters, B.1    Marohnic, C.C.2
  • 190
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: translating functional genomics into rational therapeutics
    • Evans W.E., Relling M.V. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999, 286:487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 191
    • 0034534895 scopus 로고    scopus 로고
    • Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions
    • Ritter J.K. Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions. Chem. Biol. Interact. 2000, 129:171-193.
    • (2000) Chem. Biol. Interact. , vol.129 , pp. 171-193
    • Ritter, J.K.1
  • 192
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases: metabolism, expression, and disease
    • Tukey R.H., Strassburg C.P. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu. Rev. Pharmacol. Toxicol. 2000, 40:581-616.
    • (2000) Annu. Rev. Pharmacol. Toxicol. , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 193
    • 0344346398 scopus 로고
    • Androgens and anabolic steroids
    • MacMillan, New York, A.G. Gilman, L.S. Goodman, A. Gilman (Eds.)
    • Murad F., Haynes R.C. Androgens and anabolic steroids. The Pharmacological Basis of Therapeutics 1980, 1448. MacMillan, New York. A.G. Gilman, L.S. Goodman, A. Gilman (Eds.).
    • (1980) The Pharmacological Basis of Therapeutics , pp. 1448
    • Murad, F.1    Haynes, R.C.2
  • 195
    • 0016749625 scopus 로고
    • The pharmacology and metabolism of testosterone undecanoate (TU), a new orally active androgen
    • Coert A., Geelen J., de Visser J., van der Vies J. The pharmacology and metabolism of testosterone undecanoate (TU), a new orally active androgen. Acta Endocrinol. (Copenh) 1975, 79:789-800.
    • (1975) Acta Endocrinol. (Copenh) , vol.79 , pp. 789-800
    • Coert, A.1    Geelen, J.2    de Visser, J.3    van der Vies, J.4
  • 196
    • 0023376389 scopus 로고
    • Dietary fat inhibits the intestinal metabolism of the carcinogen benzo[a]pyrene in fish
    • Van Veld P.A., Vetter R.D., Lee R.F., Patton J.S. Dietary fat inhibits the intestinal metabolism of the carcinogen benzo[a]pyrene in fish. J. Lipid Res. 1987, 28:810-817.
    • (1987) J. Lipid Res. , vol.28 , pp. 810-817
    • Van Veld, P.A.1    Vetter, R.D.2    Lee, R.F.3    Patton, J.S.4
  • 197
    • 0021905619 scopus 로고
    • Coassimilation of dietary fat and benzo(a)pyrene in the small intestine: an absorption model using the killifish
    • Vetter R.D., Carey M.C., Patton J.S. Coassimilation of dietary fat and benzo(a)pyrene in the small intestine: an absorption model using the killifish. J. Lipid Res. 1985, 26:428-434.
    • (1985) J. Lipid Res. , vol.26 , pp. 428-434
    • Vetter, R.D.1    Carey, M.C.2    Patton, J.S.3
  • 199
    • 0028063517 scopus 로고
    • Fatty acid binding protein in locust and mammalian muscle. Comparison of structure, function and regulation
    • Haunerland N.H. Fatty acid binding protein in locust and mammalian muscle. Comparison of structure, function and regulation. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 1994, 109:199-208.
    • (1994) Comp. Biochem. Physiol. B Biochem. Mol. Biol. , vol.109 , pp. 199-208
    • Haunerland, N.H.1
  • 200
    • 0027214021 scopus 로고
    • Fatty acid-binding protein and its relation to fatty acid oxidation
    • Veerkamp J.H., van Moerkerk H.T. Fatty acid-binding protein and its relation to fatty acid oxidation. Mol. Cell. Biochem. 1993, 123:101-106.
    • (1993) Mol. Cell. Biochem. , vol.123 , pp. 101-106
    • Veerkamp, J.H.1    van Moerkerk, H.T.2
  • 201
    • 0035168901 scopus 로고    scopus 로고
    • A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids
    • Stremmel W., Pohl L., Ring A., Herrmann T. A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids. Lipids 2001, 36:981-989.
    • (2001) Lipids , vol.36 , pp. 981-989
    • Stremmel, W.1    Pohl, L.2    Ring, A.3    Herrmann, T.4
  • 202
    • 0036812324 scopus 로고    scopus 로고
    • Intracellular lipid binding proteins of the small intestine
    • Agellon L.B., Toth M.J., Thomson A.B. Intracellular lipid binding proteins of the small intestine. Mol. Cell. Biochem. 2002, 239:79-82.
    • (2002) Mol. Cell. Biochem. , vol.239 , pp. 79-82
    • Agellon, L.B.1    Toth, M.J.2    Thomson, A.B.3
  • 203
    • 0018387863 scopus 로고
    • A dual, concentration-dependent absorption mechanism of linoleic acid by rat jejunum in vitro
    • Chow S.L., Hollander D. A dual, concentration-dependent absorption mechanism of linoleic acid by rat jejunum in vitro. J. Lipid Res. 1979, 20:349-356.
    • (1979) J. Lipid Res. , vol.20 , pp. 349-356
    • Chow, S.L.1    Hollander, D.2
  • 206
    • 33749488939 scopus 로고    scopus 로고
    • Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system
    • Sarkadi B., Homolya L., Szakacs G., Varadi A. Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. Physiol. Rev. 2006, 86:1179-1236.
    • (2006) Physiol. Rev. , vol.86 , pp. 1179-1236
    • Sarkadi, B.1    Homolya, L.2    Szakacs, G.3    Varadi, A.4
  • 209
    • 0034753508 scopus 로고    scopus 로고
    • Role of ABCG1 and other ABCG famly members in lipid metabolism
    • Schmitz G., Langmann T., Heimerl S. Role of ABCG1 and other ABCG famly members in lipid metabolism. J. Lipid Res. 2001, 42:1513-1520.
    • (2001) J. Lipid Res. , vol.42 , pp. 1513-1520
    • Schmitz, G.1    Langmann, T.2    Heimerl, S.3
  • 213
    • 0033973926 scopus 로고    scopus 로고
    • Influence of dietary components on the gastrointestinal metabolism and transport of drugs
    • Evans A.M. Influence of dietary components on the gastrointestinal metabolism and transport of drugs. Ther. Drug Monit. 2000, 22:131-136.
    • (2000) Ther. Drug Monit. , vol.22 , pp. 131-136
    • Evans, A.M.1
  • 214
    • 0025912228 scopus 로고
    • Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein
    • Hunter J., Hirst B.H., Simmons N.L. Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein. Br. J. Cancer 1991, 64:437-444.
    • (1991) Br. J. Cancer , vol.64 , pp. 437-444
    • Hunter, J.1    Hirst, B.H.2    Simmons, N.L.3
  • 216
    • 0030775395 scopus 로고    scopus 로고
    • Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells
    • Stride B.D., Grant C.E., Loe D.W., Hipfner D.R., Cole S.P., Deeley R.G. Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol. Pharmacol. 1997, 52:344-353.
    • (1997) Mol. Pharmacol. , vol.52 , pp. 344-353
    • Stride, B.D.1    Grant, C.E.2    Loe, D.W.3    Hipfner, D.R.4    Cole, S.P.5    Deeley, R.G.6
  • 218
  • 219
    • 0032781499 scopus 로고    scopus 로고
    • Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)
    • Kawabe T., Chen Z.S., Wada M., Uchiumi T., Ono M., Akiyama S., Kuwano M. Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). FEBS Lett. 1999, 456:327-331.
    • (1999) FEBS Lett. , vol.456 , pp. 327-331
    • Kawabe, T.1    Chen, Z.S.2    Wada, M.3    Uchiumi, T.4    Ono, M.5    Akiyama, S.6    Kuwano, M.7
  • 220
    • 0347362498 scopus 로고    scopus 로고
    • Characterization of uremic toxin transport by organic anion transporters in the kidney
    • Deguchi T., Kusuhara H., Takadate A., Endou H., Otagiri M., Sugiyama Y. Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int. 2004, 65:162-174.
    • (2004) Kidney Int. , vol.65 , pp. 162-174
    • Deguchi, T.1    Kusuhara, H.2    Takadate, A.3    Endou, H.4    Otagiri, M.5    Sugiyama, Y.6
  • 221
    • 68149170038 scopus 로고    scopus 로고
    • The role of transporters in the pharmacokinetics of orally administered drugs
    • Shugarts S., Benet L.Z. The role of transporters in the pharmacokinetics of orally administered drugs. Pharm. Res. 2009, 26:2039-2054.
    • (2009) Pharm. Res. , vol.26 , pp. 2039-2054
    • Shugarts, S.1    Benet, L.Z.2
  • 222
    • 2442719906 scopus 로고    scopus 로고
    • Unmasking the dynamic interplay between efflux transporters and metabolic enzymes
    • Benet L.Z., Cummins C.L., Wu C.Y. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. Int. J. Pharm. 2004, 277:3-9.
    • (2004) Int. J. Pharm. , vol.277 , pp. 3-9
    • Benet, L.Z.1    Cummins, C.L.2    Wu, C.Y.3
  • 223
    • 0036175307 scopus 로고    scopus 로고
    • Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4
    • Cummins C.L., Jacobsen W., Benet L.Z. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. J. Pharmacol. Exp. Ther. 2002, 300:1036-1045.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 1036-1045
    • Cummins, C.L.1    Jacobsen, W.2    Benet, L.Z.3
  • 224
    • 0030614844 scopus 로고    scopus 로고
    • Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH
    • Charman W.N., Porter C.J., Mithani S., Dressman J.B. Physiochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J. Pharm. Sci. 1997, 86:269-282.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 269-282
    • Charman, W.N.1    Porter, C.J.2    Mithani, S.3    Dressman, J.B.4
  • 225
    • 85047692219 scopus 로고
    • Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism
    • Aungst B.J. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J. Pharm. Sci. 1993, 82:979-987.
    • (1993) J. Pharm. Sci. , vol.82 , pp. 979-987
    • Aungst, B.J.1
  • 226
    • 4344578729 scopus 로고    scopus 로고
    • Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation
    • Porter C.J., Kaukonen A.M., Boyd B.J., Edwards G.A., Charman W.N. Susceptibility to lipase-mediated digestion reduces the oral bioavailability of danazol after administration as a medium-chain lipid-based microemulsion formulation. Pharm. Res. 2004, 21:1405-1412.
    • (2004) Pharm. Res. , vol.21 , pp. 1405-1412
    • Porter, C.J.1    Kaukonen, A.M.2    Boyd, B.J.3    Edwards, G.A.4    Charman, W.N.5
  • 227
    • 34147136099 scopus 로고    scopus 로고
    • A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: in-vivo and in-vitro evaluation of an indomethacin-lecithin conjugate
    • Dahan A., Duvdevani R., Dvir E., Elmann A., Hoffman A. A novel mechanism for oral controlled release of drugs by continuous degradation of a phospholipid prodrug along the intestine: in-vivo and in-vitro evaluation of an indomethacin-lecithin conjugate. J. Control Release 2007, 119:86-93.
    • (2007) J. Control Release , vol.119 , pp. 86-93
    • Dahan, A.1    Duvdevani, R.2    Dvir, E.3    Elmann, A.4    Hoffman, A.5
  • 228
    • 38549101558 scopus 로고    scopus 로고
    • The oral absorption of phospholipid prodrugs: in vivo and in vitro mechanistic investigation of trafficking of a lecithin-valproic acid conjugate following oral administration
    • Dahan A., Duvdevani R., Shapiro I., Elmann A., Finkelstein E., Hoffman A. The oral absorption of phospholipid prodrugs: in vivo and in vitro mechanistic investigation of trafficking of a lecithin-valproic acid conjugate following oral administration. J. Control Release 2008, 126:1-9.
    • (2008) J. Control Release , vol.126 , pp. 1-9
    • Dahan, A.1    Duvdevani, R.2    Shapiro, I.3    Elmann, A.4    Finkelstein, E.5    Hoffman, A.6
  • 230
    • 68949125157 scopus 로고    scopus 로고
    • Oral bioavailability assessment and intestinal lymphatic transport of Org 45697 and Org 46035, two highly lipophilic novel immunomodulator analogues
    • Caliph S.M., Faassen W.A., Vogel G.M., Porter C.J. Oral bioavailability assessment and intestinal lymphatic transport of Org 45697 and Org 46035, two highly lipophilic novel immunomodulator analogues. Curr. Drug Deliv. 2009, 6:359-366.
    • (2009) Curr. Drug Deliv. , vol.6 , pp. 359-366
    • Caliph, S.M.1    Faassen, W.A.2    Vogel, G.M.3    Porter, C.J.4
  • 231
    • 0342617694 scopus 로고    scopus 로고
    • Lipid-based vehicles for the oral delivery of poorly water soluble drugs
    • Humberstone A.J., Charman W.N. Lipid-based vehicles for the oral delivery of poorly water soluble drugs. Adv. Drug Deliv. Rev. 1997, 25:103-128.
    • (1997) Adv. Drug Deliv. Rev. , vol.25 , pp. 103-128
    • Humberstone, A.J.1    Charman, W.N.2
  • 232
    • 0343408485 scopus 로고    scopus 로고
    • Lipophilic prodrugs designed for intestinal lymphatic transport
    • Charman W.N., Porter C.J.H. Lipophilic prodrugs designed for intestinal lymphatic transport. Adv. Drug Deliv. Rev. 1996, 19:149-169.
    • (1996) Adv. Drug Deliv. Rev. , vol.19 , pp. 149-169
    • Charman, W.N.1    Porter, C.J.H.2
  • 233
    • 0035984949 scopus 로고    scopus 로고
    • Lipid-based formulations for intestinal lymphatic delivery
    • O'Driscoll C.M. Lipid-based formulations for intestinal lymphatic delivery. Eur. J. Pharm. Sci. 2002, 15:405-415.
    • (2002) Eur. J. Pharm. Sci. , vol.15 , pp. 405-415
    • O'Driscoll, C.M.1
  • 234
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    • Pouton C.W. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur. J. Pharm. Sci. 2000, 11(Suppl. 2):S93-S98.
    • (2000) Eur. J. Pharm. Sci. , vol.11 , Issue.SUPPL. 2
    • Pouton, C.W.1
  • 235
    • 33751014029 scopus 로고    scopus 로고
    • Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system
    • Pouton C.W. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur. J. Pharm. Sci. 2006, 29:278-287.
    • (2006) Eur. J. Pharm. Sci. , vol.29 , pp. 278-287
    • Pouton, C.W.1
  • 236
    • 39149113817 scopus 로고    scopus 로고
    • Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies
    • Pouton C.W., Porter C.J. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv. Drug Deliv. Rev. 2008, 60:625-637.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 625-637
    • Pouton, C.W.1    Porter, C.J.2
  • 237
    • 39149092022 scopus 로고    scopus 로고
    • Enhancing intestinal drug solubilisation using lipid-based delivery systems
    • Porter C.J., Pouton C.W., Cuine J.F., Charman W.N. Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv. Drug Deliv. Rev. 2008, 60:673-691.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 673-691
    • Porter, C.J.1    Pouton, C.W.2    Cuine, J.F.3    Charman, W.N.4
  • 238
    • 0041331755 scopus 로고    scopus 로고
    • Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides
    • Holm R., Porter C.J., Edwards G.A., Mullertz A., Kristensen H.G., Charman W.N. Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides. Eur. J. Pharm. Sci. 2003, 20:91-97.
    • (2003) Eur. J. Pharm. Sci. , vol.20 , pp. 91-97
    • Holm, R.1    Porter, C.J.2    Edwards, G.A.3    Mullertz, A.4    Kristensen, H.G.5    Charman, W.N.6
  • 239
    • 0029562489 scopus 로고
    • Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects
    • Constantinides P.P. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm. Res. 1995, 12:1561-1572.
    • (1995) Pharm. Res. , vol.12 , pp. 1561-1572
    • Constantinides, P.P.1
  • 240
    • 0035189031 scopus 로고    scopus 로고
    • Lipid-based formulations for oral administration: opportunities for bioavailability enhancement and lipoprotein targeting of lipophilic drugs
    • Porter C.J., Charman W.N. Lipid-based formulations for oral administration: opportunities for bioavailability enhancement and lipoprotein targeting of lipophilic drugs. J. Recept. Signal Transduct. Res. 2001, 21:215-257.
    • (2001) J. Recept. Signal Transduct. Res. , vol.21 , pp. 215-257
    • Porter, C.J.1    Charman, W.N.2
  • 241
    • 0343051915 scopus 로고    scopus 로고
    • Uptake of drugs into the intestinal lymphatics after oral administration
    • Porter C.J.H., Charman W.N. Uptake of drugs into the intestinal lymphatics after oral administration. Adv. Drug Deliv. Rev. 1997, 71-89.
    • (1997) Adv. Drug Deliv. Rev. , pp. 71-89
    • Porter, C.J.H.1    Charman, W.N.2
  • 242
    • 0021860852 scopus 로고
    • The effect of drug lipophilicity and lipid vehicles on the lymphatic absorption of various testosterone esters
    • Noguchi T., Charman W.N., Stella V.J. The effect of drug lipophilicity and lipid vehicles on the lymphatic absorption of various testosterone esters. Int. J. Pharm. 1985, 24:173-184.
    • (1985) Int. J. Pharm. , vol.24 , pp. 173-184
    • Noguchi, T.1    Charman, W.N.2    Stella, V.J.3
  • 243
    • 0026769371 scopus 로고
    • Effect of oily vehicles on absorption of mepitiostane by the lymphatic system in rats
    • Ichihashi T., Kinoshita H., Takagishi Y., Yamada H. Effect of oily vehicles on absorption of mepitiostane by the lymphatic system in rats. J. Pharm. Pharmacol. 1992, 44:560-564.
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 560-564
    • Ichihashi, T.1    Kinoshita, H.2    Takagishi, Y.3    Yamada, H.4
  • 244
    • 0023126917 scopus 로고
    • Lipid vehicles for intestinal lymphatic drug absorption
    • Cheema M., Palin K.J., Davis S.S. Lipid vehicles for intestinal lymphatic drug absorption. J. Pharm. Pharmacol. 1987, 39:55-56.
    • (1987) J. Pharm. Pharmacol. , vol.39 , pp. 55-56
    • Cheema, M.1    Palin, K.J.2    Davis, S.S.3
  • 246
    • 39149091886 scopus 로고    scopus 로고
    • Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs
    • Cuine J.F., McEvoy C.L., Charman W.N., Pouton C.W., Edwards G.A., Benameur H., Porter C.J. Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. J. Pharm. Sci. 2008, 97:995-1012.
    • (2008) J. Pharm. Sci. , vol.97 , pp. 995-1012
    • Cuine, J.F.1    McEvoy, C.L.2    Charman, W.N.3    Pouton, C.W.4    Edwards, G.A.5    Benameur, H.6    Porter, C.J.7
  • 247
    • 0022980134 scopus 로고
    • Effects of lipid class and lipid vehicle volume on the intestinal lymphatic transport of DDT
    • Charman W.N., Stella V.J. Effects of lipid class and lipid vehicle volume on the intestinal lymphatic transport of DDT. Int. J. Pharm. 1986, 33:165-172.
    • (1986) Int. J. Pharm. , vol.33 , pp. 165-172
    • Charman, W.N.1    Stella, V.J.2
  • 248
    • 0003041822 scopus 로고
    • Lipophilic prodrugs and the promotion of the intestinal lymphatic drug transport
    • CRC Press, Boca Raton, FL, W.N. Charman, V.J. Stella (Eds.)
    • Stella V.J., Pochopin N.L. Lipophilic prodrugs and the promotion of the intestinal lymphatic drug transport. Lymphatic Transport of Drugs 1992, 181-210. CRC Press, Boca Raton, FL. W.N. Charman, V.J. Stella (Eds.).
    • (1992) Lymphatic Transport of Drugs , pp. 181-210
    • Stella, V.J.1    Pochopin, N.L.2
  • 249
    • 0033796167 scopus 로고    scopus 로고
    • Rationale and applications of lipids as prodrug carriers
    • Lambert D.M. Rationale and applications of lipids as prodrug carriers. Eur. J. Pharm. Sci. 2000, 11(Suppl. 2):S15-S27.
    • (2000) Eur. J. Pharm. Sci. , vol.11 , Issue.SUPPL. 2
    • Lambert, D.M.1
  • 250
    • 16244403643 scopus 로고    scopus 로고
    • Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen
    • Khan M.S., Akhter M. Synthesis, pharmacological activity and hydrolytic behavior of glyceride prodrugs of ibuprofen. Eur. J. Med. Chem. 2005, 40:371-376.
    • (2005) Eur. J. Med. Chem. , vol.40 , pp. 371-376
    • Khan, M.S.1    Akhter, M.2
  • 251
    • 14244255978 scopus 로고    scopus 로고
    • Glyceride derivatives as potential prodrugs: synthesis, biological activity and kinetic studies of glyceride derivatives of mefenamic acid
    • Khan M.S., Akhter M. Glyceride derivatives as potential prodrugs: synthesis, biological activity and kinetic studies of glyceride derivatives of mefenamic acid. Pharmazie 2005, 60:110-114.
    • (2005) Pharmazie , vol.60 , pp. 110-114
    • Khan, M.S.1    Akhter, M.2
  • 252
    • 8144225516 scopus 로고    scopus 로고
    • Synthesis, biological evaluation and kinetic studies of glyceride prodrugs of diclofenac
    • Khan M.S., Akhter M. Synthesis, biological evaluation and kinetic studies of glyceride prodrugs of diclofenac. Indian J. Exp. Biol. 2004, 42:1066-1072.
    • (2004) Indian J. Exp. Biol. , vol.42 , pp. 1066-1072
    • Khan, M.S.1    Akhter, M.2
  • 254
    • 0027293527 scopus 로고
    • Deacylation-reacylation cycle: a possible absorption mechanism for the novel lymphotropic antitumor agent dipalmitoylphosphatidylfluorouridine in rats
    • Sakai A., Mori N., Shuto S., Suzuki T. Deacylation-reacylation cycle: a possible absorption mechanism for the novel lymphotropic antitumor agent dipalmitoylphosphatidylfluorouridine in rats. J. Pharm. Sci. 1993, 82:575-578.
    • (1993) J. Pharm. Sci. , vol.82 , pp. 575-578
    • Sakai, A.1    Mori, N.2    Shuto, S.3    Suzuki, T.4
  • 255
    • 0023952457 scopus 로고
    • Studies on intestinal lymphatic absorption of drugs. I. Lymphatic absorption of alkyl ester derivatives and alpha-monoglyceride derivatives of drugs
    • Sugihara J., Furuuchi S., Nakano K., Harigaya S. Studies on intestinal lymphatic absorption of drugs. I. Lymphatic absorption of alkyl ester derivatives and alpha-monoglyceride derivatives of drugs. J. Pharmacobiodyn. 1988, 11:369-376.
    • (1988) J. Pharmacobiodyn. , vol.11 , pp. 369-376
    • Sugihara, J.1    Furuuchi, S.2    Nakano, K.3    Harigaya, S.4
  • 256
    • 0023753959 scopus 로고
    • Studies on intestinal lymphatic absorption of drugs. II. Glyceride prodrugs for improving lymphatic absorption of naproxen and nicotinic acid
    • Sugihara J., Furuuchi S., Ando H., Takashima K., Harigaya S. Studies on intestinal lymphatic absorption of drugs. II. Glyceride prodrugs for improving lymphatic absorption of naproxen and nicotinic acid. J. Pharmacobiodyn. 1988, 11:555-562.
    • (1988) J. Pharmacobiodyn. , vol.11 , pp. 555-562
    • Sugihara, J.1    Furuuchi, S.2    Ando, H.3    Takashima, K.4    Harigaya, S.5
  • 258
    • 38549118295 scopus 로고    scopus 로고
    • Lymphatic absorption of orally administered drugs
    • AAPS Press, New York, V.J. Stella, R.T. Borchardt, M.J. Hageman, R. Oliyai, H. Maag, J. Tilley (Eds.)
    • Shackleford D.M., Porter C.J.H., Charman W.N. Lymphatic absorption of orally administered drugs. Prodrugs: Challenges and Rewards 2007, 653-682. AAPS Press, New York. V.J. Stella, R.T. Borchardt, M.J. Hageman, R. Oliyai, H. Maag, J. Tilley (Eds.).
    • (2007) Prodrugs: Challenges and Rewards , pp. 653-682
    • Shackleford, D.M.1    Porter, C.J.H.2    Charman, W.N.3
  • 260
    • 0742324810 scopus 로고    scopus 로고
    • In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam
    • Bravo Gonzalez R.C., Huwyler J., Boess F., Walter I., Bittner B. In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam. Biopharm. Drug Dispos. 2004, 25:37-49.
    • (2004) Biopharm. Drug Dispos. , vol.25 , pp. 37-49
    • Bravo Gonzalez, R.C.1    Huwyler, J.2    Boess, F.3    Walter, I.4    Bittner, B.5
  • 261
    • 0036741452 scopus 로고    scopus 로고
    • Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers
    • Rege B.D., Kao J.P., Polli J.E. Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayers. Eur. J. Pharm. Sci. 2002, 16:237-246.
    • (2002) Eur. J. Pharm. Sci. , vol.16 , pp. 237-246
    • Rege, B.D.1    Kao, J.P.2    Polli, J.E.3
  • 262
    • 0034671884 scopus 로고    scopus 로고
    • Potential inhibitory effects of formulation ingredients on intestinal cytochrome P450
    • Mountfield R.J., Senepin S., Schleimer M., Walter I., Bittner B. Potential inhibitory effects of formulation ingredients on intestinal cytochrome P450. Int. J. Pharm. 2000, 211:89-92.
    • (2000) Int. J. Pharm. , vol.211 , pp. 89-92
    • Mountfield, R.J.1    Senepin, S.2    Schleimer, M.3    Walter, I.4    Bittner, B.5
  • 263
    • 0036453655 scopus 로고    scopus 로고
    • An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine
    • Johnson B.M., Charman W.N., Porter C.J. An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine. AAPS PharmSci 2002, 4:E40.
    • (2002) AAPS PharmSci , vol.4
    • Johnson, B.M.1    Charman, W.N.2    Porter, C.J.3
  • 264
    • 34848879536 scopus 로고    scopus 로고
    • Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells
    • Sachs-Barrable K., Thamboo A., Lee S.D., Wasan K.M. Lipid excipients Peceol and Gelucire 44/14 decrease P-glycoprotein mediated efflux of rhodamine 123 partially due to modifying P-glycoprotein protein expression within Caco-2 cells. J. Pharm. Pharm. Sci. 2007, 10:319-331.
    • (2007) J. Pharm. Pharm. Sci. , vol.10 , pp. 319-331
    • Sachs-Barrable, K.1    Thamboo, A.2    Lee, S.D.3    Wasan, K.M.4
  • 265
    • 0027136158 scopus 로고
    • Effects of nonionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance
    • Zordan-Nudo T., Ling V., Liu Z., Georges E. Effects of nonionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance. Cancer Res. 1993, 53:5994-6000.
    • (1993) Cancer Res. , vol.53 , pp. 5994-6000
    • Zordan-Nudo, T.1    Ling, V.2    Liu, Z.3    Georges, E.4
  • 266
    • 0032862767 scopus 로고    scopus 로고
    • Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells
    • Batrakova E., Lee S., Li S., Venne A., Alakhov V., Kabanov A. Fundamental relationships between the composition of pluronic block copolymers and their hypersensitization effect in MDR cancer cells. Pharm. Res. 1999, 16:1373-1379.
    • (1999) Pharm. Res. , vol.16 , pp. 1373-1379
    • Batrakova, E.1    Lee, S.2    Li, S.3    Venne, A.4    Alakhov, V.5    Kabanov, A.6
  • 267
    • 0034953105 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • Dean M., Hamon Y., Chimini G. The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 2001, 42:1007-1017.
    • (2001) J. Lipid Res. , vol.42 , pp. 1007-1017
    • Dean, M.1    Hamon, Y.2    Chimini, G.3
  • 268
    • 58149133945 scopus 로고    scopus 로고
    • Effects of monoglycerides on rhodamine 123 accumulation, estradiol 17 beta-d-glucuronide bidirectional transport and MRP2 protein expression within Caco-2 cells
    • Jia J.X., Wasan K.M. Effects of monoglycerides on rhodamine 123 accumulation, estradiol 17 beta-d-glucuronide bidirectional transport and MRP2 protein expression within Caco-2 cells. J. Pharm. Pharm. Sci. 2008, 11:45-62.
    • (2008) J. Pharm. Pharm. Sci. , vol.11 , pp. 45-62
    • Jia, J.X.1    Wasan, K.M.2
  • 269
    • 0032714228 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein by d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS)
    • Dintaman J.M., Silverman J.A. Inhibition of P-glycoprotein by d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS). Pharm. Res. 1999, 16:1550-1556.
    • (1999) Pharm. Res. , vol.16 , pp. 1550-1556
    • Dintaman, J.M.1    Silverman, J.A.2
  • 270
    • 0027417891 scopus 로고
    • Cremophor-EL enhances taxol efficacy in a multi-drug resistant C1300 neuroblastoma cell line
    • Chervinsky D.S., Brecher M.L., Hoelcle M.J. Cremophor-EL enhances taxol efficacy in a multi-drug resistant C1300 neuroblastoma cell line. Anticancer. Res. 1993, 13:93-96.
    • (1993) Anticancer. Res. , vol.13 , pp. 93-96
    • Chervinsky, D.S.1    Brecher, M.L.2    Hoelcle, M.J.3
  • 271
    • 67349238737 scopus 로고    scopus 로고
    • Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism
    • Trevaskis N.L., Shackleford D.M., Charman W.N., Edwards G.A., Gardin A., Appel-Dingemanse S., Kretz O., Galli B., Porter C.J. Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism. Pharm. Res. 2009, 26:1486-1495.
    • (2009) Pharm. Res. , vol.26 , pp. 1486-1495
    • Trevaskis, N.L.1    Shackleford, D.M.2    Charman, W.N.3    Edwards, G.A.4    Gardin, A.5    Appel-Dingemanse, S.6    Kretz, O.7    Galli, B.8    Porter, C.J.9
  • 272
    • 34447512868 scopus 로고    scopus 로고
    • Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220
    • Gershkovich P., Qadri B., Yacovan A., Amselem S., Hoffman A. Different impacts of intestinal lymphatic transport on the oral bioavailability of structurally similar synthetic lipophilic cannabinoids: dexanabinol and PRS-211,220. Eur. J. Pharm. Sci. 2007, 31:298-305.
    • (2007) Eur. J. Pharm. Sci. , vol.31 , pp. 298-305
    • Gershkovich, P.1    Qadri, B.2    Yacovan, A.3    Amselem, S.4    Hoffman, A.5
  • 273
    • 0026684608 scopus 로고
    • Effect of bile on absorption of mepitiostane by the lymphatic system in rats
    • Ichihashi T., Kinoshita H., Takagishi Y., Yamada H. Effect of bile on absorption of mepitiostane by the lymphatic system in rats. J. Pharm. Pharmacol. 1992, 44:565-569.
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 565-569
    • Ichihashi, T.1    Kinoshita, H.2    Takagishi, Y.3    Yamada, H.4
  • 275
    • 0021140493 scopus 로고
    • The effect of different oils on the absorption of probucol in the rat
    • Palin K.J., Wilson C.G. The effect of different oils on the absorption of probucol in the rat. J. Pharm. Pharmacol. 1984, 36:641-643.
    • (1984) J. Pharm. Pharmacol. , vol.36 , pp. 641-643
    • Palin, K.J.1    Wilson, C.G.2
  • 276
    • 0020526205 scopus 로고
    • Intestinal lymphatic absorption of cyclosporin A following oral administration in an olive oil solution in rats
    • Ueda C.T., Lemaire M., Gsell G., Nussbaumer K. Intestinal lymphatic absorption of cyclosporin A following oral administration in an olive oil solution in rats. Biopharm. Drug Dispos. 1983, 4:113-124.
    • (1983) Biopharm. Drug Dispos. , vol.4 , pp. 113-124
    • Ueda, C.T.1    Lemaire, M.2    Gsell, G.3    Nussbaumer, K.4
  • 277
    • 0031914282 scopus 로고    scopus 로고
    • Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor
    • Hauss D.J., Fogal S.E., Ficorilli J.V., Price C.A., Roy T., Jayaraj A.A., Keirns J.J. Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor. J. Pharm. Sci. 1998, 87:164-169.
    • (1998) J. Pharm. Sci. , vol.87 , pp. 164-169
    • Hauss, D.J.1    Fogal, S.E.2    Ficorilli, J.V.3    Price, C.A.4    Roy, T.5    Jayaraj, A.A.6    Keirns, J.J.7
  • 278
    • 0029877036 scopus 로고    scopus 로고
    • Intestinal lymphatic transport of three retinoids in the rat after oral administration: effect of lipophilicity and lipid vehicle
    • Nankervis R., Davis S.S., Day N.H., Shaw P.N. Intestinal lymphatic transport of three retinoids in the rat after oral administration: effect of lipophilicity and lipid vehicle. Int. J. Pharm. 1996, 130:57-64.
    • (1996) Int. J. Pharm. , vol.130 , pp. 57-64
    • Nankervis, R.1    Davis, S.S.2    Day, N.H.3    Shaw, P.N.4
  • 280
    • 0021729905 scopus 로고
    • Similar bioavailability and lymphatic transport of benzo(a)pyrene when administered to rats in different amounts of dietary fat
    • Laher J.M., Rigler M.W., Vetter R.D., Barrowman J.A., Patton J.S. Similar bioavailability and lymphatic transport of benzo(a)pyrene when administered to rats in different amounts of dietary fat. J. Lipid Res. 1984, 25:1337-1342.
    • (1984) J. Lipid Res. , vol.25 , pp. 1337-1342
    • Laher, J.M.1    Rigler, M.W.2    Vetter, R.D.3    Barrowman, J.A.4    Patton, J.S.5
  • 281
    • 0025899151 scopus 로고
    • Blood and lymph transport of DDT after oral and parenteral administration to anaesthetised rats
    • O'Driscoll C.M., Myers R.A., Stella V.J. Blood and lymph transport of DDT after oral and parenteral administration to anaesthetised rats. Int. J. Pharm. 1991, 73:177-183.
    • (1991) Int. J. Pharm. , vol.73 , pp. 177-183
    • O'Driscoll, C.M.1    Myers, R.A.2    Stella, V.J.3
  • 282
    • 25744472387 scopus 로고    scopus 로고
    • Intestinal lymphatic transport is the primary route for halofantrine after oral postprandial administration
    • Khoo S.M., Porter C.J.H., Edwards G.A., Charman W.N. Intestinal lymphatic transport is the primary route for halofantrine after oral postprandial administration. Pharm. Sci. 1999, 1:S-624.
    • (1999) Pharm. Sci. , vol.1
    • Khoo, S.M.1    Porter, C.J.H.2    Edwards, G.A.3    Charman, W.N.4
  • 284
    • 0025743455 scopus 로고
    • Intrinsic lymphatic partition rate of mepitiostane, epitiostanol, and oleic acid absorbed from rat intestine
    • Ichihashi T., Kinoshita H., Takagishi Y., Yamada H. Intrinsic lymphatic partition rate of mepitiostane, epitiostanol, and oleic acid absorbed from rat intestine. Pharm. Res. 1991, 8:1302-1306.
    • (1991) Pharm. Res. , vol.8 , pp. 1302-1306
    • Ichihashi, T.1    Kinoshita, H.2    Takagishi, Y.3    Yamada, H.4
  • 285
    • 0035172817 scopus 로고    scopus 로고
    • Comparison of the lymphatic transport of a lipophilic drug from vehicles containing a-tocopherol and/or triglycerides in rats
    • Neilson P.B., Mullertz A., Norling T., Kristensen H.G. Comparison of the lymphatic transport of a lipophilic drug from vehicles containing a-tocopherol and/or triglycerides in rats. J. Pharm. Pharmacol. 2001, 53:1439-1445.
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 1439-1445
    • Neilson, P.B.1    Mullertz, A.2    Norling, T.3    Kristensen, H.G.4
  • 287
    • 0028937137 scopus 로고
    • Mechanism of promotion of lymphatic drug absorption by milk fat globule membrane
    • Liu H.X., Adachi I., Horikoshi I., Ueno M. Mechanism of promotion of lymphatic drug absorption by milk fat globule membrane. Int. J. Pharm. 1995, 118:55-64.
    • (1995) Int. J. Pharm. , vol.118 , pp. 55-64
    • Liu, H.X.1    Adachi, I.2    Horikoshi, I.3    Ueno, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.