A new solid self-microemulsifying formulation prepared by spray-drying to improve the oral bioavailability of poorly water soluble drugs

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 2, 2008, Pages 439-444

  Yi, Tao ^a   Wan, Jiangling ^a   Xu, Huibi ^a   Yang, Xiangliang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Bioavailability; Poorly soluble drugs; Self microemulsifying; Solid dosage form; Spray drying

Indexed keywords

CREMOPHOR; DEXTRAN; LABRASOL; NIMODIPINE; OLEIC ACID ETHYL ESTER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; IMAGE ANALYSIS; MAXIMUM PLASMA CONCENTRATION; MICROEMULSION; NONHUMAN; PHOTO CORRELATON SPECTROSCOPY; RABBIT; SCANNING ELECTRON MICROSCOPY; SOLID SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; SOLID STATE; SPECTROSCOPY; SPRAY DRYING; TRANSMISSION ELECTRON MICROSCOPY; X RAY POWDER DIFFRACTION;

ABSORPTION; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; EMULSIONS; MALE; NIMODIPINE; RABBITS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL;

EID: 52949125231     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.05.001     Document Type: Article

References (31)

1. Veiga F., Fernandes C., and Teixeira F. Oral bioavailability and hypoglycemic activity of tolbutamide/cyclodextrin inclusion complexes. Int. J. Pharm. 202 (2000) 165-171
2. Serajuddin T.M. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J. Pharm. Sci. 88 (1999) 1058-1066
3. Patravale V.B., Date A.A., and Kulkarni R.M. Nanosuspensions: a promising drug delivery strategy. J. Pharm. Pharmacol. 56 (2004) 827-840
4. Lawrence M.J., and Rees G.D. Microemulsion-based media as novel drug delivery system. Adv. Drug Deliv. Rev. 45 (2000) 89-121
5. Humberstone A.J., and Charman W.N. Lipid-based vehicles for the oral delivery of poorly water soluble drugs. Adv. Drug Deliv. Rev. 25 (1997) 103-128
6. Holm R., Porter C.J.H., Edwards G.A., Müllertz A., Kristensen H.G., and Charman W.N. Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides. Eur. J. Pharm. Sci. 20 (2003) 91-97
7. Kang B.K., Lee J.S., Chon S.K., Jeong S.Y., Yuk S.H., Khang G., Lee H.B., and Cho S.H. Development of self-microemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int. J. Pharm. 274 (2004) 65-73
8. Pouton C.W. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur. J. Pharm. Sci. 11 (2000) S93-S98
9. Pouton C.W. Formulation of self-emulsifying drug delivery systems. Adv. Drug Deliv. Rev. 25 (1997) 47-58
10. Charman W.N., Porter C.J.H., Mithani S., and Dressman J.B. Physicochemical and physiological mechanisms for the effects of food on drug absorption: the role of lipids and pH. J. Pharm. Sci. 86 (1997) 269-282
11. Franceschinis E., Voinovich D., Grassi M., Perissutti B., Filipovic-Grcic J., Martinac A., and Meriani-Merlo F. Self-emulsifying pellets prepared by wet granulation in high-shear mixer: influence of formulation variables and preliminary study on the in vitro absorption. Int. J. Pharm. 291 (2005) 87-97
12. Tuleu C., Newton J.M., Rose J., Euler D., Saklatvala R., Clarke A., and Booth S. Comparative bioavailability study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone. J. Pharm. Sci. 93 (2004) 1495-1502
13. Nazzal S., and Khan M.A. Controlled release of a self-emulsifying formulation from a tablet dosage form: Stability assessment and optimization of some processing parameters. Int. J. Pharm. 315 (2006) 110-121
14. Kim C.K., Shin H.J., Yang S.G., Kim J.H., and Oh Y.K. Once-a-day oral dosing regimen of cyclosporin A: combined therapy of cyclosporin A premicroemulsion concentrates and enteric coated solid-state premicroemulsion concentrates. Pharm. Res. 18 (2001) 454-459
15. Nazzal S., Nutan M., Palamakula A., Shah R., Zaghloul A.A., and Khan M.A. Optimization of a self-nanoemulsified tablet dosage form of Ubiquinone using response surface methodology: effect of formulation ingredients. Int. J. Pharm. 240 (2002) 103-114
16. Newton J.M., Petersson J., Podczeck F., Clarke A., and Booth S. The influence of formulation variables on the properties of pellets containing a self-emulsifying mixture. J. Pharm. Sci. 90 (2001) 987-995
17. Newton J.M., Pinto M.R., and Podczeck F. The preparation of pellets containing a surfactant or a mixture of mono- and di-gylcerides by extrusion/spheronization. Eur. J. Pharm. Sci. 30 (2007) 333-342
18. Abdalla A., and Mader K. Preparation and characterization of a self-emulsifying pellet formulation. Eur. J. Pharm. Biopharm. 66 (2007) 220-226
19. Serratoni M., Newton J.M., Booth S., and Clarke A. Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system. Eur. J. Pharm. Biopharm. 65 (2007) 94-98
20. Christensen K.L., Pedersen G.P., and Kristensen H.G. Physical stability of redispersible dry emulsions containing amorphous sucrose. Eur. J. Pharm. Biopharm. 53 (2002) 147-153
21. Dollo G., Corre P.L., Guérin A., Chevanne F., Burgot J.L., and Leverge R. Spray-dried redispersible oil-in-water emulsion to improve oral bioavailability of poorly soluble drugs. Eur. J. Pharm. Sci. 19 (2003) 273-280
22. Christensen K.L., Pedersen G.P., and Kristensen H.G. Preparation of redispersible dry emulsions by spray drying. Int. J. Pharm. 212 (2001) 187-194
23. Langley M.S., and Sorkin E.M. Nimodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic. Drugs 37 (1989) 669-699
24. Grunenberg A., Keil B., and Henck J.O. Polymorphism in binary mixture, as exemplified by nimodipine. Int. J. Pharm. 118 (1995) 11-21
25. Tu Q.R., Zhu Y., and Zhu J.B. Study on formulation of nimodipine self-microemulsifying drug delivery system. Chin. Pharm. J. 40 (2005) 43-46
26. He Z.G., Zhong D.F., Chen X.Y., Liu X.H., Tang X., and Zhao L.M. Development of a dissolution medium for nimodipine tablets based on bioavailability evaluation. Eur. J. Pharm. Sci. 21 (2004) 487-491
27. Swanepoel E., Liebenberg W., Devarakonda B., and Villiers M.M. Developing a discriminating dissolution test for three mebendazole poly-morphs based on solubility difference. Pharmazie 58 (2003) 117-121
28. Yu L.X., Amidon G.L., Polli J.E., Zhao H., Mehta M.U., Conner D.P., Shah V.P., Lesko L.J., Chen M.L., Lee V.H., and Hussain A.S. Biopharmaceutics classification system: the scientific basis for biowaiver extensions. Pharm. Res. 19 (2002) 921-925
29. Dressman J.B., and Reppas C. In vitro-in vivo correlations for lipophilic, poorly water-soluble drugs. Eur. J. Pharm. Sci. 11 (2000) s73-s80
30. Kommuru T.R., Gurley B., Khan M.A., and Reddy I.K. Self-emulsifying drug delivery systems (SEDDS) of coenzyme Q10: formulation development and bioavailability assessment. Int. J. Pharm. 212 (2001) 233-246
31. Pouton C.W. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. Eur. J. Pharm. Sci. 29 (2006) 278-287