The effect of different lipid based formulations on the oral absorption of lipophilic drugs: The ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 67, Issue 1, 2007, Pages 96-105

  Dahan, Arik ^a   Hoffman, Amnon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Bioavailability; Ex vivo Ussing chamber; In vitro lipolysis; Intestinal absorption; Intestinal permeability; Lipid based formulations; Lipophilic drugs

Indexed keywords

ARACHIS OIL; DEXAMETHASONE; GRISEOFULVIN; TRIACETIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIFFUSION CHAMBER; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG PENETRATION; EX VIVO STUDY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA PERMEABILITY; INTESTINE WALL; LIPOLYSIS; LIPOPHILICITY; MALE; NONHUMAN; RAT;

ALGORITHMS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBIOTICS, ANTIFUNGAL; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DEXAMETHASONE; FORECASTING; GRISEOFULVIN; INTESTINAL ABSORPTION; LIPIDS; LIPOLYSIS; MALE; PERMEABILITY; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 34250867442     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2007.01.017     Document Type: Article

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