The impact of vehicle on assessment of relative skin sensitization potency of 1,4-dihydroquinone in the local lymph node assay

American Journal of Contact Dermatitis

Volumn 10, Issue 4, 1999, Pages 213-218

  Lea, Linda J ^b   Warbrick, E Vicky ^b   Dearman, Rebecca J ^b   Kimber, Ian ^b   Basketter, David A ^a  

^a UNILEVER RESEARCH   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDROQUINONE; QUINONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CHEMOSENSITIVITY; CONTACT ALLERGY; CONTACT DERMATITIS; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SKIN SENSITIZATION;

EID: 0032735354     PISSN: 1046199X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01634989-199912000-00006     Document Type: Article

References (24)

1. Basketter DA, Gerberick GF, Kimber I, et al: The local lymph node assay: A viable alternative to currently accepted skin sensitization tests. Food Chem Toxicol 34:985-997, 1996
2. Chamberlain M, Basketter DA: The local lymph node assay: Status of validation. Food Chem Toxicol 34:999-1002, 1996
3. Gerberick GF, Ryan CA, Kimber I, et al: Local lymph node assay: Validation for regulatory purposes. Am J Contact Derm 11:2000 (in press)
4. Kimber I, Basketter DA: The murine local lymph node assay: A commentary on collaborative studies and new directions. Food Chem Toxicol 30:165-169, 1992
5. Basketter DA, Lea LJ, Cooper KJ, et al: Thresholds for classification as a skin sensitizer in the local lymph node assay: A statistical evaluation. Food Chem Toxicol (in press)
6. Kimber I, Basketter DA: Contact sensitization: A new approach to risk assessment. Human Ecol Risk Assess 3:385-395, 1997
7. Basketter DA, Lea LJ, Dickens A, et al: A comparison of statistical approaches to derivation of EC3 values from local lymph node assay dose responses. J Appl Toxicol 19:261-266, 1999
8. Dearman RJ, Hilton J, Evans P, et al: Temporal stability of local lymph nodes assay response to hexyl cinnamic aldehyde. J Appl Toxicol 18:281-284, 1998
9. Warbrick EV, Dearman RJ, Lea LJ, et al: Local lymph node assay responses to paraphenylenediamine: Intra- and interlaboratory evaluations. J Appl Toxicol 19:255-260, 1999
10. Hilton J, Dearman RJ, Harvey P, et al: Estimation of relative skin sensitizing potency using the local lymph node assay: A comparison of formaldehyde with glutaraldehyde. AmJ Contact Dermal 9:29-33, 1998
11. Basketter DA: The value of animal assays and the quenching phenomenon. in Frosch PJ, Johansen JD, White I (eds): Proceedings of the Fragrance Symposium. Springer-Verlag, Heidelberg, Germany, 1997, pp 166-174
12. Kligman AM: The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis. J Invest Dermatol 47:375-392, 1996
13. Marzulli FN, Maibach HI: Effects of vehicles and elicitation concentration in contact dermatitis testing. Contact Dermatitis 2:325-329, 1976
14. Van't Erve EHM, Wijand E, Bol M, et al: The vehicle modulates cellular and humoral responses in contact hypersensitivity to oxazolone. Toxicol Sci 44:39-45, 1998
15. Heylings JR, Clowes HM, Cumberbatch M, et al: Sensitization to 2,4-dinitrochlorobenzene: Influence of vehicle on absorption and lymph node activation. Toxicology 109:57-65, 1996
16. Basketter DA, Lidén C: Further investigation of the prohapten concept: Reactions to benzene derivatives in man. Contact Dermatitis 27:90-97, 1992
17. Warbrick EV, Dearman RJ, Basketter DA, et al: Influence of application vehicle on skin sensitization to the isothiazolinone CMLT: An analysis using the local lymph node assay. Comments Toxicol (in press)
18. Basketter DA, Gerberick GF, Robinson MK: Risk assessment, in Kimber I, Maurer TH (eds): Toxicology of Contact Hypersensitivity. Taylor and Francis, 1996, pp 152-164
19. Robinson MK, Parsell KW, Breneman DL, et al: Evaluation of the primary skin irritation and allergic contact sensitization potential of transdermal triprolidone. Fundam Appl Toxicol 17:103-119, 1991
20. Barratt MD, Basketter DA, Roberts DW: Skin sensitisation structure activity relationships for phenyl benzoates. Toxicol Vitro 8:823-826, 1994
21. Andersen KE, Volund A, Frankild S: The guinea pig maximization test with a multiple dose design. Acta Derm Venereol 75:463-469, 1995
22. Gerberick GF, House RE, Fletcher RE, et al: Examination of the local lymph node assay for use in contact sensitization risk assessment. Fundam Appl Toxicol 19:438-445, 1992
23. Kimber I, Dearman RJ: Investigation of lymph node cell proliferation as a possible immunological correlate of contact sensitizing potential. Food Chem Toxicol 29:125-129, 1991
24. Grabbe S, Steinert M, Mahnke K, et al: Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice. Evidence that not the antigenic component but nonspecific proinflammatory effects of haptens determine the concentration-dependent elicitation of allergic contact dermatitis. J Clin Invest 98:1158-1164, 1996