The murine local lymph node assay: Regulatory and potency considerations under REACH

Toxicology

Volumn 238, Issue 2-3, 2007, Pages 71-89

  McGarry, Helen F ^a  

^a Corporate Health Specialist Division 1 ^*  (United Kingdom)

Author keywords

Irritants; Local lymph node assay (LLNA); Potency; REACH; Skin sensitization; Vehicle effects

Indexed keywords

ACETONE; DODECYL SULFATE SODIUM; IRRITANT AGENT; OLIVE OIL; PROPYLENE GLYCOL;

ANIMAL WELFARE; DOSE RESPONSE; EVALUATION; GUINEA PIG; HUMAN; LABORATORY DIAGNOSIS; LAW; LOCAL LYMPH NODE ASSAY; NONHUMAN; PRIORITY JOURNAL; REGISTRATION; REVIEW; RISK ASSESSMENT; SKIN SENSITIZATION;

ANIMALS; DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; EUROPEAN UNION; GREAT BRITAIN; HAZARDOUS SUBSTANCES; LOCAL LYMPH NODE ASSAY; MICE; TOXICOLOGY;

ANIMALIA; CAVIA; MURINAE;

EID: 34547811350     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.06.002     Document Type: Review

References (125)

1. Aiba S., and Katz S.I. Phenotypic and functional characteristics of in vivo-activated Langerhans cells. J. Immunol. 145 (1990) 2791-2796
2. Andersen K.E., Carlsen L., Egsgaard H., and Larsen E. Contact sensitivity and bioavailability of chlorocresol. Cont. Derm. 13 (1985) 246-251
3. Andersen K.E., Volund A., and Frankild S. The guinea pig maximization test with a multiple dose design. Acta Dermatol. Venereol. 75 (1995) 463-469
4. Arfsten D.P., Azadi S., Butterworth L.F., and Meade B.J. Hydrocarbon-based weapons maintenance compounds produce evidence of contact hypersensitivity in BALB/c mice. Cutan. Ocul. Toxicol. 25 (2006) 185-194
5. Arts J.H.E., Mommers C., and de Heer C. Dose-response relationships and threshold levels in skin and respiratory allergy. Crit. Rev. Toxicol. 36 (2006) 219-251
6. Basketter D.A., Andersen K.E., Liden C., van Loveren H., Boman A., Kimber I., Alanko K., and Berggren E. Evaluation of the skin sensitizing potency of chemicals by using the existing methods and considerations of relevance for elicitation. Cont. Derm. 52 (2005) 39-43
7. Basketter D.A., Blaikie L., Dearman R.J., Kimber I., Ryan C.A., Gerberick G.F., Harvey P., Evans P., White I.R., and Rycroft R.J.G. Use of the local lymph node assay for the estimation of relative contact allergenic potency. Cont. Derm. 42 (2000) 344-348
8. Basketter D.A., and Cadby P. Reproducible prediction of contact allergenic potency using the local lymph node assay. Cont. Derm. 50 (2004) 15-17
9. Basketter D.A., and Chamberlain M. Validation of skin sensitization assays. Food Chem. Toxicol. 12 (1995) 1057-1059
10. Basketter D.A., Clapp C., Jefferies D., Safford B., Ryan C.A., Gerberick G.F., Dearman R.J., and Kimber I. Predictive identification of human skin sensitisation thresholds. Cont. Derm. 53 (2005) 260-267
11. Basketter D.A., Cookman G., Gerberick G.F., Hamaide N., and Potokar M. Skin sensitization thresholds: determination in predictive models. Food Chem. Toxicol. 35 (1997) 417-425
12. Basketter D.A., Gerberick G.F., and Kimber I. Skin sensitisation, vehicle effects and the local lymph node assay. Food Chem. Toxicol. 39 (2001) 621-627
13. Basketter D.A., Gerberick G.F., and Kimber I. Strategies for identifying false positive responses in predictive skin sensitization tests. Food Chem. Toxicol. 36 (1998) 327-333
14. Basketter D.A., Gerberick G.F., Kimber I., and Loveless S.E. The local lymph node assay: a viable alternative to currently accepted skin sensitization tests. Food Chem. Toxicol. 34 (1996) 985-997
15. Basketter D.A., and Kimber I. Olive oil: suitability for use as a vehicle in the local lymph node assay. Cont. Derm. 35 (1996) 190-191
16. Basketter D.A., Lea L.J., Cooper K., Stocks J., Dickens A., Pate I., Dearman R.J., and Kimber I. Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation. Food Chem. Toxicol. 37 (1999) 1167-1174
17. Basketter D.A., Lea L.J., Dickens A., Briggs D., Pate I., Dearman R.J., and Kimber I. A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses. J. Appl. Toxicol. 19 (1999) 261-266
18. Basketter D.A., Rodford R., Kimber I., Smith I., and Wahlberg J.E. Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides. Cont. Derm. 40 (1999) 150-154
19. Basketter D.A., and Scholes E.W. Comparison of the local lymph node assay with the guinea-pig maximization test for the detection of a range of contact allergens. Food Chem. Toxicol. 30 (1992) 65-69
20. Basketter D.A., Scholes E.W., and Kimber I. The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food Chem. Toxicol. 32 (1994) 543-547
21. Basketter D.A., Wright Z.M., Warbrick E.V., Dearman R.J., Kimber I., Ryan C.A., Gerberick G.F., and White I.R. Human potency predictions for aldehydes using the local lymph node assay. Cont. Derm. 45 (2001) 89-94
22. Betts C.J., Beresford L., Dearman R.J., Lalko J., Api A.P., and Kimber I. The use of ethanol:diethylphthalate as a vehicle for the local lymph node assay. Cont. Derm. 56 (2007) 70-75
23. Betts C.J., Dearman R.J., Heylings J.R., Kimber I., and Basketter D.A. Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experience. Cont. Derm. 55 (2006) 140-147
24. Betts C.J., Dearman R.J., Kimber I., Ryan C.A., Gerberick G.F., Lalko J., and Api A.M. B220 analysis with the local lymph node assay: proposal for a more flexible prediction model. J. Appl. Toxicol. (2007) (e-pub ahead of publication)
25. Botham P.A., Basketter D.A., Maurer T., Mueller D., Potokar M., and Bontinck W.J. Skin sensitisation-a critical review of predictive test methods in animals and man. Food Chem. Toxicol. 29 (1991) 275-286
26. Boukhman M.P., and Maibach H.I. Thresholds in contact sensitization: immunologic mechanisms and experimental evidence in humans-an overview. Food Chem. Toxicol. 39 (2001) 1125-1134
27. Boussiquet-Leroux C., Durand-Cavagna G., Herlin K., and Holder D. Evaluation of lymphocyte proliferation by immunohistochemistry in the local lymph node assay. J. Appl. Toxicol. 15 (1995) 465-475
28. Calvin G. Risk management case history-detergents. In: Richardson M.L. (Ed). Risk Management of Chemicals (1992), The Royal Society of Chemistry, Cambridge 120-136
29. Cockshott A., Evans P., Ryan C.A., Gerberick G.F., Betts C.J., Dearman R.J., Kimber I., and Basketter D.A. The local lymph node assay in practice: a current regulatory perspective. Hum. Exp. Toxicol. 25 (2006) 387-394
30. Cosmetic Ingredient Review Expert Panel, 2003. Safety assessment of salicylic acid, butyloctyl salicylate, calcium salicylate, C12-15 alkyl salicylate, capryloyl salicylic acid, hexyldodecyl salicylate, isocetyl salicylate, isodecyl salicylate, magnesium salicylate, MEA-salicylate, ethylhexyl salicylate, potassium salicylate, methyl salicylate, myristyl salicylate, sodium salicylate, TEA-salicylate, and tridecyl salicylate. Int. J. Toxicol. 22 (S3), 1-108.
31. Craig A.M., Karchesy J.J., Blythe L.L., del Pilar González-Hernández M., and Swan L.R. Toxicity studies on western juniper oil (Juniperus occidentalis) and Port-Orford-cedar oil (Chamaecyparis lawsoniana) extracts utilizing local lymph node and acute dermal irritation assays. Toxicol. Lett. 143 (2004) 217-224
32. Cumberbatch M., Gould S.J., Peters S.W., Basketter D.A., Dearman R.J., and Kimber I. Influence of topical exposure to chemical allergens on murine Langerhans cells. Comparison of 2,4-dinitrochlorobenzene with trimellitic anhydride. J. Clin. Lab. Immunol. 37 (1992) 65-81
33. Cumberbatch M., Scott R.C., Basketter D.A., Scholes E.W., Hilton J., Dearman R.J., and Kimber I. Influence of sodium lauryl sulphate on 2,4-dinitrochlorobenzene-induced lymph node activation. Toxicologist 77 (1993) 181-191
34. Danneman P.J., Booman K.A., Dorsky J., Kohrman K.A., Rothenstein A.S., Sedlak R.I., Steltenkamp R.J., and Thompson G.R. Cinnamic aldehyde: a survey of consumer patch test sensitization. Food Chem. Toxicol. 21 (1983) 721-725
35. de Silva O., Perez M.J., Pineau N., Rougier A., and Dossou K.G. Local lymph node assay: study of the in vitro proliferation and control of the specificity of the response by FACScan analysis. Toxicol. in vitro 7 (1993) 299-303
36. Dearman R.J., Basketter D.A., and Kimber I. Local lymph node assay: use in hazard and risk assessment. J. Appl. Toxicol. 19 (1999) 299-306
37. Dearman R.J., Cumberbatch M., Hilton J., Clowes H.M., Fielding I., Heylings J.R., and Kimber I. Influence of dibutyl phthalate on dermal sensitization to fluorescein isothiocyanate. Fund. Appl. Toxicol. 33 (1996) 24-30
38. Dearman R.J., Hilton J., Evans P., Harvey P., Basketter D.A., and Kimber I. Temporal stability of local lymph node assay responses to hexyl cinnamic aldehyde. J. Appl. Toxicol. 18 (1998) 281-284
39. Dearman R.J., Wright Z.M., Basketter D.A., Ryan C.A., Gerberick G.F., and Kimber I. The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay. Cont. Derm. 44 (2001) 357-361
40. DeGroot A.C., Conemans J., and Liem D.H. Contact allergy to benzoxonium chloride (bradophen). Cont. Derm. 11 (1984) 324-325
41. Draeger H., Wu X., Roelofs-Haarhuis K., and Gleichmann E. Nickel allergy versus nickel tolerance: can oral uptake of nickel protect from sensitization?. J. Environ. Monit. 6 (2004) 146N-150N
42. EC, 2006. Regulation (EC) No. 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC. O. J. Eur. Comm. L396, 1-849.
43. ECETOC, 2000. Skin sensitisation testing for the purpose of hazard identification and risk assessment. Monograph No. 29, Brussels.
44. ECETOC, 2003. Contact sensitisation: classification according to potency. Technical Report No. 87, Brussels.
45. Edwards D.A., Soranno T.M., Amoruso M.A., House R.V., Tummey A.C., Trimmer G.W., Thomas P.T., and Ribeiro P.L. Screening petrochemicals for contact hypersensitivity potential: a comparison of the murine local lymph node assay with guinea pig and human test data. Fund. Appl. Toxicol. 23 (1994) 179-187
46. Ehling, G., Hecht, M., Heusener, A., Huesler, J., Gamer, A.O., van Loveren, H., Maurer, T., Riecke, K., Ullmann, L., Ulrich, P., Vandebriel, R.J., Vohr, H.-W., 2005a. An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: 2nd round. Toxicology 212, 69-79.
47. Ehling G., Hecht M., Heusener A., Huesler J., Gamer A.O., van Loveren H., Maurer T., Riecke K., Ullmann L., Ulrich P., Vandebriel R.J., and Vohr H.-W. An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: first round. Toxicologist 212 (2005) 60-68
48. Felter S.P., Sailstad D.M., Basketter D.A., Gilmour N.J., and Gerberick G.F. Application of the risk assessment paradigm to the induction of allergic contact dermatitis. Reg. Toxicol. Pharmacol. 37 (2003) 1-10
49. Foussereau J.M., Petitjean J., and Lants J.P. Sodium lauryl sulfate. Cont. Derm. Newslett. 15 (1974) 460
50. Gad S.C., Dunn B.J., Dobbs D.W., Reilly C., and Walsh R.D. Development and validation of an alternative dermal sensitization test: the mouse ear swelling test (MEST). Toxicol. Appl. Pharmacol. 84 (1986) 93-114
51. Gerberick G.F., Cruse L.W., Miller C.M., Sikorski E.E., and Ridder G.M. Selective modulation of T cell memory markers CD62L and CD44 on murine draining lymph node cells following allergen and irritant treatment. Toxicol. Appl. Pharmacol. 146 (1997) 1-10
52. Gerberick G.F., Cruse L.W., Ryan C.A., Hulette B.C., Chaney J.G., Skinner R.A., Dearman R.J., and Kimber I. Use of a B cell marker (B220) to discriminate between allergens and irritants in the local lymph node assay. Toxicol. Sci. 68 (2002) 420-428
53. Gerberick G.F., House R.V., Fletcher E.R., and Ryan C.A. Examination of the local lymph node assay for use in contact sensitization risk assessment. Fund. Appl. Toxicol. 19 (1992) 438-445
54. Gerberick G.F., Robinson M.K., Felter S.P., White I.R., and Basketter D.A. Understanding fragrance allergy using an exposure-based risk assessment approach. Cont. Derm. 45 (2001) 333-340
55. Gerberick G.F., Robinson M.K., Ryan C.A., Dearman R.J., Kimber I., Basketter D.A., Wright Z.M., and Marks J.G. Contact allergenic potency: correlation of human and local lymph node assay data. Am. J. Cont. Derm. 12 (2001) 156-161
56. Gerberick G.F., Ryan C.A., Kern P.S., Schlatter H., Dearman R.J., Kimber I., Patlewicz G.Y., and Basketter D.A. Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis 16 (2005) 157-202
57. Gerberick G.F., Ryan C.A., Kimber I., Dearman R.J., Lea L.J., and Basketter D.A. Local lymph node assay: validation assessment for regulatory purposes. Am. J. Cont. Derm. 11 (2000) 3-18
58. Griem P., Goebel C., and Scheffler H. Proposal for a risk assessment methodology for skin sensitization based on sensitization potency data. Reg. Toxicol. Pharmacol. 38 (2003) 269-290
59. Heylings J.R., Clowes H.M., Cumberbatch M., Dearman R.J., Fielding I., Hilton J., and Kimber I. Sensitization to 2, 4-dinitrochlorobenzene: influence of vehicle on absorption and lymph node activation. Toxicologist 109 (1996) 57-65
60. Hilton J., Dearman R.J., Harvey P., Evans P., Basketter D.A., and Kimber I. Estimation of relative skin sensitizing potency using the local lymph node assay: a comparison of formaldehyde with glutaraldehyde. Am. J. Cont. Derm. 9 (1998) 29-33
61. Homey B., von Schilling C., Blümel J., Schuppe H.C., Ruzicka T., Ahr H.J., Lehmann P., and Vohr H.-W. An integrated model for the differentiation of chemical-induced allergic and irritant skin reactions. Toxicol. Appl. Pharmacol. 153 (1998) 83-94
62. Ikarashi Y., Tsuchiya T., and Nakamura A. Evaluation of contact sensitivity of rubber chemicals using the murine local lymph node assay. Cont. Derm. 28 (1993) 77-80
63. Ikarashi Y., Tsuchiya T., and Nakamura A. Detection of contact sensitivity of metal salts using the murine local lymph node assay. Toxicol. Lett. 62 (1992) 53-61
64. Ikarashi Y., Tsuchiya T., and Nakamura A. A sensitive mouse lymph node assay with two application phases for detection of contact allergens. Arch. Toxicol. 67 (1993) 629-636
65. Ikarashi Y., Tsukamoto Y., Tsuchiya T., and Nakamura A. Influence of irritants on lymph node cell proliferation and the detection of contact sensitivity to metal salts in the murine local lymph node assay. Cont. Derm. 29 (1993) 128-132
66. Kimber I. Alternative methods for contact sensitization testing. In: Kimber I., and Maurer T. (Eds). Toxicology of Contact Hypersensitivity (1996), Taylor & Francis, London 140-151
67. Kimber I., and Basketter D.A. Contact sensitization: a new approach to risk assessment. Hum. Ecol. Risk Assess. 3 (1997) 385-395
68. Kimber I., and Basketter D.A. The murine local lymph node assay: a commentary on collaborative studies and new directions. Food Chem. Toxicol. 30 (1992) 165-169
69. Kimber I., Basketter D.A., Berthold K., Butler M., Garrigue J.-L., Lea L., Newsome C., Roggeband R., Steiling W., Stropp G., Waterman S., and Wiemann C. Skin sensitization testing in potency and risk assessment. Toxicol. Sci. 59 (2001) 198-208
70. Kimber I., Basketter D.A., Butler M., Gamer A., Garrigue J.-L., Gerberick G.F., Newsome C., Steiling W., and Vohr H.-W. Classification of contact allergens according to potency: proposals. Food Chem. Toxicol. 41 (2003) 1799-1809
71. Kimber I., Bentley A.N., and Hilton J. Contact sensitization of mice to nickel sulphate and potassium dichromate. Cont. Derm. 23 (1990) 325-330
72. Kimber I., Dearman R.J., Basketter D.A., Ryan C.A., and Gerberick G.F. The local lymph node assay: past, present and future. Cont. Derm. 47 (2002) 315-328
73. Kimber I., Dearman R.J., Scholes E.W., and Basketter D.A. The local lymph node assay: developments and applications. Toxicologist 93 (1994) 13-31
74. Kimber I., Hilton J., Botham P.A., Basketter D.A., Scholes E.W., Miller K., Robbins M.C., Harrison P.T., Gray T.J., and Waite S.J. The murine local lymph node assay: results of an inter-laboratory trial. Toxicol. Lett. 55 (1991) 203-213
75. Kimber I., Hilton J., Dearman R.J., Gerberick G.F., Ryan C.A., Basketter D.A., Lea L., House R.V., Ladics G.S., Loveless S.E., and Hastings K.L. Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation. J. Toxicol. Environ. Health A 53 (1998) 563-579
76. Kimber I., Hilton J., Dearman R.J., Gerberick G.F., Ryan C.A., Basketter D.A., Scholes E.W., Ladics G.S., Loveless S.E., House R.V., and Guy A. An international evaluation of the murine local lymph node assay and comparison of modified procedures. Toxicologist 103 (1995) 63-73
77. Kimber I., Hilton J., and Botham P.A. Identification of contact allergens using the murine local lymph node assay: comparisons with the Buehler occluded patch test in guinea pigs. J. Appl. Toxicol. 10 (1990) 173-180
78. Kimber I., and Weisenberger C. A murine local lymph node assay for the identification of contact allergens. Assay developments and results of an initial validation study. Arch. Toxicol. 63 (1989) 274-282
79. Kligman A.M. The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis. J. Invest. Dermatol. 47 (1966) 375-392
80. Kligman A.M., and Basketter D.A. A critical commentary and updating of the guinea pig maximization test. Cont. Derm. 32 (1995) 129-134
81. Kligman A.M., and Epstein W. Updating the maximization test for identifying contact allergens. Cont. Derm. 1 (1975) 231-239
82. Lalko J., and Api A. Use of a B cell marker to discriminate between the irritant and allergenic potential of D-limonene, Abstract ID 1145. Toxicologist 96 S-1 (2007)
83. Lalko J., Isola D., and Api A.M. Ethanol and diethyl phthalate: vehicle effects in the local lymph node assay. Int. J. Toxicol. 23 (2004) 171-177
84. Lea L.J., Warbrick E.V., Dearman R.J., Kimber I., and Basketter D.A. The impact of vehicle on assessment of relative skin sensitisation potency of 1,4-dihydroquinone in the local lymph node assay. Am. J. Cont. Derm. 10 (1999) 213-218
85. Liden C., and Boman A. Contact allergy to colour developing agents in the guinea pig. Cont. Derm. 19 (1988) 290-295
86. Loveless S.E., Ladics G.S., Gerberick G.F., Ryan C.A., Basketter D.A., Scholes E.W., House R.V., Dearman R.J., and Kimber I. Further evaluation of the local lymph node assay in the final phase of an international collaborative trial. Toxicol. 108 (1996) 141-152
87. Magnusson B., and Kligman A.M. Allergic Contact Dermatitis in the Guinea Pig (1970), Charles C. Thomas, Springfield, IL
88. Malmkvist Padoan S., Pettersson A., and Svensson A. Olive oil as a cause of contact allergy in patients with venous eczema, and occupationally. Cont. Derm. 23 (1990) 73-76
89. Marzulli F.N., and Maibach H.I. Effects of vehicles and elicitation concentration in contact dermatitis testing. I. Experimental contact sensitization in humans. Cont. Derm. 2 (1975) 325-329
90. Maurer T., Germer M., and Krinke A. Does the immunohistochemical detection of Langerhans cell help in the differential diagnosis of irritative and allergic skin reactions? Prog. Histochem. Cytochem. 23 (1991) 256-262
91. Montelius J., Boman A., Wahlkvist H., and Wahlberg J.E. The murine local lymph node assay: search for an alternative, more adequate, vehicle than acetone/olive oil (4:1). Cont. Derm. 34 (1996) 428-430
92. Montelius J., Wahlkvist H., Boman A., Fernstrom P., Grabergs L., and Wahlberg J.E. Experience with the murine local lymph node assay: inability to discriminate between allergens and irritants. Acta Dermatol. Venereol. 74 (1994) 22-27
93. Montelius J., Wahlkvist H., Boman A., and Wahlberg J.E. Murine local lymph node assay for predictive testing of allergenicity: two irritants caused significant proliferation. Acta Dermatol. Venereol. 78 (1998) 433-437
94. National Institutes of Health, 1999. The murine local lymph node assay: a test method for assessing the allergic contact dermatitis potential of chemicals/compounds. Results of an independent peer review evaluation coordinated by the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) and the National Toxicology Program Centre for the Evaluation of Alternative Toxicological Methods (NICETAM), Research Triangle Park, N.C. (http://www.iccvam.niehs.nih.gov), NIH publication O 99-4494.
95. OECD, 1992. Guideline 406. Skin Sensitisation Paris: Organisation for Economic Cooperation and Development.
96. OECD, 2002. Guideline 429. Skin Sensitisation: Local Lymph Node Assay Paris: Organisation for Economic Cooperation and Development.
97. Prater E., Goring H.D., and Schubert H. Sodium lauryl sulfate-a contact allergen. Cont. Derm. 4 (1978) 242-243
98. Reeder M.K., Broomhead Y.M., DiDonato L., and DeGeorge G.L. Use of an enhanced local lymph node assay to correctly classify irritants and false positive substances, Abstract ID 1136. Toxicologist 96 S-1 (2007)
99. Robinson M.K., and Cruze C.A. Preclinical skin sensitization testing of antihistamines: guinea pig and local lymph node assay responses. Food Chem. Toxicol. 34 (1996) 495-506
100. Robinson M.K., Gerberick G.F., Ryan C.A., McNamee P., White I.R., and Basketter D.A. The importance of exposure estimation in the assessment of skin sensitization risk. Cont. Derm. 42 (2000) 251-259
101. Robinson M.K., Parsell K.W., Breneman D.L., and Cruze C.A. Evaluation of the primary skin irritation and allergic contact sensitization potential of transdermal triprolidine. Fund. Appl. Toxicol. 17 (1991) 103-119
102. Rudzki E., and Kloslowska A. Sensitivity to salicylic acid. Cont. Derm. 2 (1976) 178
103. Ryan C.A., Cruse L.W., Skinner R.A., Dearman R.J., Kimber I., and Gerberick G.F. Examination of a vehicle for use with water soluble material in the murine local lymph node assay. Food Chem. Toxicol. 40 (2002) 1719-1725
104. Ryan C.A., Gerberick G.F., Cruse L.W., Basketter D.A., Lea L., Blaikie L., Dearman R.J., Warbrick E.V., and Kimber I. Activity of human contact allergens in the murine local lymph node assay. Cont. Derm. 43 (2000) 95-102
105. Sailstad D.M. Murine local lymph node assay: an alternative test method for skin hypersensitivity testing. Lab. Anim. Eur. 2 (2002) 20-27
106. Schallreuter K.U., Schultz K.H., and Wood J.M. Induction of contact dermatitis in guinea pigs by quaternary ammonium compounds: the mechanism of antigen formation. Environ. Health Perspect. 70 (1986) 229-237
107. Schlede E., Aberer W., Fuchs T., Gerner I., Lessman H., Maurer T., Rossbacher R., Stropp G., Wagner E., and Kayser D. Chemical substances and contact allergy-244 substances ranked according to allergenic potency. Toxicologist 193 (2003) 219-259
108. Schneider K., and Akkan Z. Quantitative relationship between the local lymph node assay and human skin sensitization assays. Reg. Toxicol. Pharmacol. 39 (2004) 245-255
109. Scott A.E., Kashon M.L., Yucesoy B., Luster M.I., and Tinkle S.S. Insights into the quantitative relationship between sensitization and challenge for allergic contact dermatitis reactions. Toxicol. Appl. Pharmacol. 183 (2002) 66-70
110. Seidenari S., Motolese A., and Belletti B. Pre-treatment of nickel test areas with sodium lauryl sulfate detects nickel sensitivity in subjects reacting negatively to routinely performed patch tests. Cont. Derm. 34 (1996) 88-92
111. Sikorski E.E., Gerberick G.F., Ryan C.A., Miller C.M., and Ridder G.M. Phenotypic analysis of lymphocyte subpopulations in lymph nodes draining the ear following exposure to contact allergens and irritants. Fund. Appl. Toxicol. 34 (1996) 25-35
112. Takeyoshi M., Iida K., Shiraishi K., and Hoshuyama S. Novel approach for classifying chemicals according to skin sensitizing potency by non-radioisotopic modification of the local lymph node assay. J. Appl. Toxicol. 25 (2005) 129-134
113. Ulrich P., Streich J., and Suter W. Intralaboratory validation of alternative endpoints in the murine local lymph node assay for the identification of contact allergic potential: primary ear skin irritation and ear-draining lymph node hyperplasia induced by topical chemicals. Arch. Toxicol. 74 (2001) 733-744
114. van Och F.M.M., Slob W., de Jong W.H., Vandebriel R.J., and van Loveren H. A quantitative method for assessing the sensitizing potency of low molecular weight chemicals using a local lymph node assay: employment of a regression method that includes determination of the uncertainty margins. Toxicologist 146 (2000) 49-59
115. van Och F.M.M., Vandebriel R.J., de Jong W.H., and van Loveren H. Effect of prolonged exposure to low antigen concentration for sensitization. Toxicologist 184 (2003) 23-30
116. van't Erve E.H.M., Wijand E., Bol M., Seinen W., and Pieters R.H.H. The vehicle modulates cellular and humoral responses in contact hypersensitivity to oxazolone. Toxicol. Sci. 44 (1998) 39-45
117. Vohr H.-W., and Ahr H.J. The local lymph node assay being too sensitive?. Arch. Toxicol. 79 (2005) 721-728
118. Vohr H.-W., Blümel J., Blotz B., Homey B., and Ahr H.J. An intra-laboratory validation of the Integrated Model for the Differentiation of Skin Reactions (IMDS): discrimination between (photo)allergic and (photo)irritant skin reactions in mice. Arch. Toxicol. 73 (2000) 501-509
119. Wahlberg J.E. Occupational allergic contact dermatitis. In: Kimber I., and Maurer T. (Eds). Toxicology of Contact Hypersensitivity (1996), Taylor & Francis Ltd, London 57-74
120. Warbrick E.V., Dearman R.J., Basketter D.A., and Kimber I. Influence of application vehicle on skin sensitization to methylchloroisothiazolinone/methylisothiazolinone: an analysis using the local lymph node assay. Cont. Derm. 41 (1999) 325-329
121. Warbrick E.V., Dearman R.J., Basketter D.A., and Kimber I. Failure of vehicle to influence local lymph node assay response to benzocaine. Cont. Derm. 42 (2000) 164-165
122. Warbrick E.V., Dearman R.J., Lea L.J., Basketter D.A., and Kimber I. Local lymph node assay responses to paraphenylenediamine: intra- and inter-laboratory evaluations. J. Appl. Toxicol. 19 (1999) 255-260
123. Woolhiser M.R., Wiescinski C., Botham P., Lees D., Debruyne E., Repetto-Larsay M., Ladics G.S., Hoban D., Gamer A., Remmele M., Wang-Fan W., Ullmann L., Billington R., and Mehta J. ECPA interlaboratory study investigating the suitability of an aqueous vehicle in the mouse local lymph node assay, Abstract ID 1142. Toxicologist 96 S-1 (2007)
124. Wright Z.M., Basketter D.A., Blaikie L., Cooper K.J., Warbrick E.V., Dearman R.J., and Kimber I. Vehicle effects on skin sensitizing potency of four chemicals: assessment using the local lymph node assay. Int. J. Cosmet. Sci. 23 (2001) 75-83
125. Yamano T., Shimizu M., and Noda T. Quantitative comparison of the results obtained by the multiple-dose guinea pig maximization test and the non-radioactive murine local lymph-node assay for various biocides. Toxicologist 211 (2005) 165-175