Immunotoxicant Screening and Prioritization in the Twenty-first Century

Toxicologic Pathology

Volumn 40, Issue 2, 2012, Pages 294-299

  Luebke, Robert ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

allergic hypersensitivity; alternative methods; immunosuppression; immunotoxicity testing

Indexed keywords

CYCLIC AMP; CYCLOPHOSPHAMIDE; FOOD ADDITIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUSTRIAL CHEMICAL; INTERLEUKIN 1ALPHA; INTERLEUKIN 8; IONOMYCIN; METAL; PHORBOL;

ADAPTIVE IMMUNITY; ALLERGIC REACTION; ANAPHYLAXIS; ANTIBODY RESPONSE; AUTOIMMUNITY; B LYMPHOCYTE; CARCINOGENESIS; CELL CULTURE; CELL FUNCTION; CELL PROLIFERATION; CYTOKINE PRODUCTION; DATA ANALYSIS; DENDRITIC CELL; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HIGH THROUGHPUT SCREENING; HISTOPATHOLOGY; HUMAN; HYPERSENSITIVITY; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTOXICITY; IN VITRO STUDY; INNATE IMMUNITY; KERATINOCYTE; LAW; LUNG DISEASE; LYMPHOID ORGAN; METABOLIC ACTIVATION; MITOCHONDRION; NONHUMAN; NUTRITIONAL INTOLERANCE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REPRODUCTIVE TOXICITY; REVIEW; SKIN ALLERGY; T LYMPHOCYTE; TOXICITY TESTING;

ANIMALS; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNE SYSTEM; IMMUNOLOGIC FACTORS; TOXICOLOGY;

ANIMALIA;

EID: 84858789018     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623311427572     Document Type: Article

References (19)

1. Adler S. Basketter D. Creton S. Olavi Pelkonen O. van Benthem J. Zuang V. Andersen K.E. Angers-Loustau A. Aptula A. Bal-Price A. Benfenati E. Bernauer U. Bessems J. Bois F.Y. Boobis A. Brandon E. Bremer S. Broschard T. Casati S. Coecke S. Corvi F. Cronin M. Daston G. Dekant W. Felter S. Grignard E. Gundert-Remy U. Heinonen T. Kimber I. Kleinjans J. Komulainen H. Kreiling R. Kreysa J. Leite S. B. Loizou G. Maxwell G. Mazzatorta P. Munn S. Pfuhler S. Phrakonkham P. Piersma A. Poth A. Prieto P. Repetto G. Rogiers V. Schoeters G. Schwarz M. Serafimova R. Tähti H. Testai E. van Delft J. van Loveren H. Vinken M. Worth A. Zaldivar J. M. (2011). Alternative (non-animal) methods for cosmetics testing: Current status and future prospects—2010. Arch Toxicol 85, 367–485.
2. Aeby P. Ashikaga T. Bessou-Touya S. Schepky A. Gerberick F. Kern P. Marrec-Fairley M. Maxwell G. Ovigne J. M. Sakaguchi H. Reisinger K. Tailhardat M. Martinozzi-Teissier S. Winkler P. (2010). Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program. Toxicol In Vitro 24, 1465–73.
3. Collinge M. Cole S. H. Schneider P. A. Donovan C. B. Kamperschroer C. Kawabata T. T. (2010). Human lymphocyte activation assay: An in vitro method for predictive immunotoxicity testing. J Immunotoxicol 7, 357–66.
4. Corsini E. Mitjans M. Galbiati V. Lucchi L. Galli C. L. Marinovich M. (2009). Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens. Toxicol In Vitro 23, 789–96.
5. Galvão dos Santos G. Reinders J. Ouwehand K. Rustemeyer T. Scheper R. J. Gibbs S. (2009). Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol Appl Pharmacol 236, 372–82.
6. Gennari A. Ban M. Braun A. Casati S. Corsini E. Dastych J. Descotes J. Hartung T. Hooghe-Peters R. House R. Pallardy M Peters R. Reid L. Tryphonas H. Tschirhart E. Tuschl H. Vandebriel R. Gribaldo L. (2005). The use of in vitro systems for evaluating immunotoxicity: The report and recommendations of an ECVAM workshop. J Immunotoxicol 2, 61–83.
7. Gerberick G. F. Aleksic M. Basketter D. A. Casati S. Karlberg A. T. Kern P. Kimber I. Lepoittevin J. P. Natsch A. Ovigne J. M. Rovida C. Sakaguchi H. Schultz T. W. (2008). Chemical reactivity measurement and the predictive identification of skin sensitisers. The report and recommendations of ECVAM Workshop 64. Alt Lab Anim 36, 215–42.
8. Haglund C. Aleskog A. Håkansson L. D. Höglund M. Jacobsson S. Larsson R. Lindhagen E. (2010). The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing. Toxicol Lett 194, 102–7.
9. Houck K. A. Dix D. J. Judson R. Kavlock R. J. Yang J. Berg E. L. (2009). Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems. J Biomol Screen 14, 1054–66.
10. Koeper L. M. Vohr H. W. (2009) Functional assays are mandatory for a correct prediction of immunotoxic properties of compounds in vitro. Food Chem Toxicol 47, 110–18.
11. Martin S. F. Esser P. R. Schmucker S. Dietz L. Naisbitt D. J. Park B. K. Vocanson M. Nicolas J. F. Keller M. Pichler W. J. Peiser M. Luch A. Wanner R. Maggi E. Cavani A. Rustemeyer T. Richter A. Thierse H. J. Sallusto F. (2010). T-cell recognition of chemicals, protein allergens and drugs: Towards the development of in vitro assays. Cell Mol Life Sci 67, 4171–84.
12. Mitjans M. Galbiati V. Lucchi L. Viviani B. Marinovich M. Galli C. L. Corsini E. (2010). Use of IL-8 release and p38 MAPK activation in THP-1 cells to identify allergens and to assess their potency in vitro. Toxicol In Vitro 24, 1803–9.
13. Ringerike T. Ullerås E. Völker R. Verlaan B. Eikeset A. Trzaska D. Adamczewska V. Olszewski M. Walczak-Drzewiecka A. Arkusz J. van Loveren H. Nilsson G. Lovik M. Dastych J. Vandebriel R. J. (2005). Detection of immunotoxicity using T-cell based cytokine reporter cell lines (“Cell Chip”). Toxicology 206, 257–72.
14. Sakaguchi H. Ryan C. Ovigne J. M. Schroeder K. R. Ashikaga T. (2010). Predicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials. Toxicol In Vitro 24, 1810–20.
15. Ullerås E. Trzaska D. Arkusz J. Ringerike T. Adamczewska V. Olszewski M. Wyczółkowska J. Walczak-Drzewiecka A. Al-Nedawi K. Nilsson G. Białek-Wyrzykowska U. Stepnik M. van Loveren H. Vandebriel R. J. Løvik M. Rydzyński K. Dastych J. (2005). Development of the “Cell Chip”: A new in vitro alternative technique for immunotoxicity testing. Toxicology 206, 245–56.
16. US EPA (2003). Health effects test guidelines. OPPTS 870.2600: Skin Sensitization. United States Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances, Washington, DC (EPA 12-C-03-197).
17. US EPA (2007). Health effects test guidelines. OPPTS 870.7800: Immunotoxicity. United States Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances, Washington, DC (EPA 712–C–98–351).
18. Van Och F. M. van Loveren H. Van Wolfswinkel J. C. Machielsen A. J. Vandebriel R. J. (2005). Assessment of potency of allergenic activity of low molecular weight compounds based on IL-1alpha and IL-18 production by a murine and human keratinocyte cell line. Toxicology 210, 95–109.
19. Zurlo J. Rudacille D. Golderg A. M. 1996. The three Rs: The way forward. Environ Health Perspect 104, 878–80.