메뉴 건너뛰기




Volumn , Issue , 2013, Pages 647-664

Overview of the Nonclinical Development Strategies and Class-Effects of Oligonucleotide-Based Therapeutics

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84883997458     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-387815-1.00026-5     Document Type: Chapter
Times cited : (8)

References (79)
  • 2
    • 0032700656 scopus 로고    scopus 로고
    • Molecular mechanisms of action of antisense drugs
    • Crooke S.T. Molecular mechanisms of action of antisense drugs. Biochim Biophys Acta 1999, 1489(1):31-44.
    • (1999) Biochim Biophys Acta , vol.1489 , Issue.1 , pp. 31-44
    • Crooke, S.T.1
  • 3
    • 61349102407 scopus 로고    scopus 로고
    • Ribonuclease H: the enzymes in eukaryotes
    • Cerritelli S.M., Crouch R.J. Ribonuclease H: the enzymes in eukaryotes. FEBS J 2009, 276(6):1494-1505.
    • (2009) FEBS J , vol.276 , Issue.6 , pp. 1494-1505
    • Cerritelli, S.M.1    Crouch, R.J.2
  • 4
    • 0041582974 scopus 로고
    • Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
    • Zamecnik P.C., Stephenson M.L. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Natl Acad Sci 1978, 75(1):280-284.
    • (1978) Proc Natl Acad Sci , vol.75 , Issue.1 , pp. 280-284
    • Zamecnik, P.C.1    Stephenson, M.L.2
  • 5
    • 2342427578 scopus 로고    scopus 로고
    • Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs
    • Wu H., Lima W.F., Zhang H., Fan A., Sun H., Crooke S.T. Determination of the role of the human RNase H1 in the pharmacology of DNA-like antisense drugs. J Biol Chem 2004, 279(17):17181-17189.
    • (2004) J Biol Chem , vol.279 , Issue.17 , pp. 17181-17189
    • Wu, H.1    Lima, W.F.2    Zhang, H.3    Fan, A.4    Sun, H.5    Crooke, S.T.6
  • 6
    • 79951893904 scopus 로고    scopus 로고
    • Mipomersen, an antisense apolipoprotein B synthesis inhibitor
    • Bell D.A., Hooper A.J., Burnett J.R. Mipomersen, an antisense apolipoprotein B synthesis inhibitor. Expert Opin Investig Drugs 2011, 20(2):265-272.
    • (2011) Expert Opin Investig Drugs , vol.20 , Issue.2 , pp. 265-272
    • Bell, D.A.1    Hooper, A.J.2    Burnett, J.R.3
  • 7
    • 80052468423 scopus 로고    scopus 로고
    • Randomized phase II trial of Custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel
    • Saad F., Hotte S., North S., Eigl B., Chi K., Czaykowski P., et al. Randomized phase II trial of Custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel. Clin Cancer Res 2011, 17(17):5765-5773.
    • (2011) Clin Cancer Res , vol.17 , Issue.17 , pp. 5765-5773
    • Saad, F.1    Hotte, S.2    North, S.3    Eigl, B.4    Chi, K.5    Czaykowski, P.6
  • 8
    • 84884048650 scopus 로고    scopus 로고
    • ISIS 113715, A Novel PTP-1B Antisense Inhibitor, Improves Glycemic Control and Dyslipidemia and Increases Adiponectin Levels in T2DM Subjects Uncontrolled on Stable Sulfonylurea Therapy
    • Brandt T.A., Crooke S.T., Ackermann E.J., Xia S., Morgan E.S., Liu Q., et al. ISIS 113715, A Novel PTP-1B Antisense Inhibitor, Improves Glycemic Control and Dyslipidemia and Increases Adiponectin Levels in T2DM Subjects Uncontrolled on Stable Sulfonylurea Therapy. Diabetes 2010, 59(suppl1):A84.
    • (2010) Diabetes , vol.59 , Issue.SUPPL.1
    • Brandt, T.A.1    Crooke, S.T.2    Ackermann, E.J.3    Xia, S.4    Morgan, E.S.5    Liu, Q.6
  • 9
    • 84879117604 scopus 로고    scopus 로고
    • ISIS-FXIRx, A novel and specific antisense inhibitor of Factor XI, caused significant reduction in FXI antigen and activity and increased aPTT without causing bleeding in healthy volunteers
    • (ASH Annual Meeting Abstracts)
    • Liu Q., Bethune C., Dessouki E., Grundy J., Monia B.P., Bhanot S. ISIS-FXIRx, A novel and specific antisense inhibitor of Factor XI, caused significant reduction in FXI antigen and activity and increased aPTT without causing bleeding in healthy volunteers. Blood 2011, 118:209. (ASH Annual Meeting Abstracts).
    • (2011) Blood , vol.118 , pp. 209
    • Liu, Q.1    Bethune, C.2    Dessouki, E.3    Grundy, J.4    Monia, B.P.5    Bhanot, S.6
  • 10
    • 0022441296 scopus 로고
    • Inhibition of gene expression in plant cells by expression of antisense RNA
    • Ecker J.R., Davis R.W. Inhibition of gene expression in plant cells by expression of antisense RNA. Proc Natl Acad Sci 1986, 83(15):5372-5376.
    • (1986) Proc Natl Acad Sci , vol.83 , Issue.15 , pp. 5372-5376
    • Ecker, J.R.1    Davis, R.W.2
  • 11
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391(6669):806-811.
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 12
    • 65749110883 scopus 로고    scopus 로고
    • Small silencing RNAs: state-of-the-art
    • Grimm D. Small silencing RNAs: state-of-the-art. Adv Drug Deliv Rev 2009, 61(9):672-703.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.9 , pp. 672-703
    • Grimm, D.1
  • 13
    • 80052519945 scopus 로고    scopus 로고
    • The huge world of small RNAs: regulating networks of microRNAs
    • Rácz Z., Kaucsár T., Hamar P. The huge world of small RNAs: regulating networks of microRNAs. Acta Physiol Hung 2011, 98(3):243-251.
    • (2011) Acta Physiol Hung , vol.98 , Issue.3 , pp. 243-251
    • Rácz, Z.1    Kaucsár, T.2    Hamar, P.3
  • 14
    • 80052198750 scopus 로고    scopus 로고
    • Intercellular and systemic movement of RNA silencing signals
    • Melnyk C.W., Molnar A., Baulcombe D.C. Intercellular and systemic movement of RNA silencing signals. EMBO J 2011, 30(17):3553-3563.
    • (2011) EMBO J , vol.30 , Issue.17 , pp. 3553-3563
    • Melnyk, C.W.1    Molnar, A.2    Baulcombe, D.C.3
  • 15
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson B.L., McCray P.B. Current prospects for RNA interference-based therapies. Nat Rev Genet 2011, 12(5):329-340.
    • (2011) Nat Rev Genet , vol.12 , Issue.5 , pp. 329-340
    • Davidson, B.L.1    McCray, P.B.2
  • 16
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA 'off-target' transcript silencing mediated by seed.region sequence complementarity
    • Jackson A.L., Burchard J., Schelter J., Chau B.N., Cleary M., Lim L., et al. Widespread siRNA 'off-target' transcript silencing mediated by seed.region sequence complementarity. RNA 2006, 12:1179-1187.
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6
  • 17
    • 78449309070 scopus 로고    scopus 로고
    • Efficient and targeted delivery of siRNA in vivo
    • Shim M.S., Kwon Y.J. Efficient and targeted delivery of siRNA in vivo. FEBS J 2010, 277(23):4814-4827.
    • (2010) FEBS J , vol.277 , Issue.23 , pp. 4814-4827
    • Shim, M.S.1    Kwon, Y.J.2
  • 18
    • 80054825739 scopus 로고    scopus 로고
    • New insight into clinical development of nucleic acid aptamers
    • Esposito C.L., Catuogno S., de Franciscis V., Cerchia L. New insight into clinical development of nucleic acid aptamers. Discov Med 2011, 11(61):487-496.
    • (2011) Discov Med , vol.11 , Issue.61 , pp. 487-496
    • Esposito, C.L.1    Catuogno, S.2    de Franciscis, V.3    Cerchia, L.4
  • 19
    • 39049142223 scopus 로고    scopus 로고
    • Pegaptanib sodium for the treatment of age-related macular degeneration
    • Apte R.S. Pegaptanib sodium for the treatment of age-related macular degeneration. Expert Opin Pharmacother 2008, 9(3):499-508.
    • (2008) Expert Opin Pharmacother , vol.9 , Issue.3 , pp. 499-508
    • Apte, R.S.1
  • 20
    • 61749098024 scopus 로고    scopus 로고
    • Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists
    • Vollmer J., Krieg A.M. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv Drug Deliv Rev 2009, 61(3):195-204.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.3 , pp. 195-204
    • Vollmer, J.1    Krieg, A.M.2
  • 21
    • 84885566527 scopus 로고    scopus 로고
    • Basic Principles of the Pharmacokinetics of Antisense Oligonucleotide Drugs
    • Taylor and Francis, Boca Raton, S.T. Crooke (Ed.)
    • Levin A.A., Yu R.Y., Geary R.S. Basic Principles of the Pharmacokinetics of Antisense Oligonucleotide Drugs. Antisense Drug Technology: Principles, Strategies and Applications 2008, 183-216. Taylor and Francis, Boca Raton. S.T. Crooke (Ed.).
    • (2008) Antisense Drug Technology: Principles, Strategies and Applications , pp. 183-216
    • Levin, A.A.1    Yu, R.Y.2    Geary, R.S.3
  • 22
    • 0034015113 scopus 로고    scopus 로고
    • Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?
    • Eckstein F. Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?. Antisense Nucleic Acid Drug Dev 2000, 10:117-121.
    • (2000) Antisense Nucleic Acid Drug Dev , vol.10 , pp. 117-121
    • Eckstein, F.1
  • 23
    • 0029099305 scopus 로고
    • New access to 2′-O-alkylated ribonucleosides and properties of 2′-O-alkylated oligoribonucleotides
    • Martin P. New access to 2′-O-alkylated ribonucleosides and properties of 2′-O-alkylated oligoribonucleotides. Helv Chim Acta 1995, 78:486-504.
    • (1995) Helv Chim Acta , vol.78 , pp. 486-504
    • Martin, P.1
  • 25
    • 0027168725 scopus 로고
    • Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression
    • Monia B.P., Lesnik E.A., Gonzalez C., Lima W.F., McGee D., Guinosso C.J., et al. Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression. J Biol Chem 1993, 268:14514-14522.
    • (1993) J Biol Chem , vol.268 , pp. 14514-14522
    • Monia, B.P.1    Lesnik, E.A.2    Gonzalez, C.3    Lima, W.F.4    McGee, D.5    Guinosso, C.J.6
  • 26
    • 0030777046 scopus 로고    scopus 로고
    • Second generation antisense oligonucleotides - inhibition of pkc-alpha and c-raf kinase expression by chimeric oligonucleotides incorporating 6′-substituted carbocyclic nucleosides and 2′-O-ethylene glycol substituted ribonucleosides
    • Altmann K.H., Martin P., Dean N.M., Monia B.P. Second generation antisense oligonucleotides - inhibition of pkc-alpha and c-raf kinase expression by chimeric oligonucleotides incorporating 6′-substituted carbocyclic nucleosides and 2′-O-ethylene glycol substituted ribonucleosides. Nucleosides Nucleotides 1997, 16:917-926.
    • (1997) Nucleosides Nucleotides , vol.16 , pp. 917-926
    • Altmann, K.H.1    Martin, P.2    Dean, N.M.3    Monia, B.P.4
  • 27
    • 59449093219 scopus 로고    scopus 로고
    • Short antisense oligonucleotides with novel 2′-4′ conformationally restricted nucleoside analogues show improved potency without increased toxicity in animals
    • Seth P.P., Siwkowski A., Allerson C.R., Vasquez G., Lee S., Prakash T.P., et al. Short antisense oligonucleotides with novel 2′-4′ conformationally restricted nucleoside analogues show improved potency without increased toxicity in animals. J Med Chem 2009, 52:10-13.
    • (2009) J Med Chem , vol.52 , pp. 10-13
    • Seth, P.P.1    Siwkowski, A.2    Allerson, C.R.3    Vasquez, G.4    Lee, S.5    Prakash, T.P.6
  • 28
    • 78649877710 scopus 로고    scopus 로고
    • Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
    • Straarup E.M., Fisker N., Hedtjarn M., Lindholm M.W., Rosenbohm C., Aarup V., et al. Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates. Nucleic Acids Res 2010, 38(20):7100-7111.
    • (2010) Nucleic Acids Res , vol.38 , Issue.20 , pp. 7100-7111
    • Straarup, E.M.1    Fisker, N.2    Hedtjarn, M.3    Lindholm, M.W.4    Rosenbohm, C.5    Aarup, V.6
  • 29
    • 24344485512 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers
    • Amantana A., Iversen P.L. Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers. Curr Opin Pharmacol 2005, 5:550-555.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 550-555
    • Amantana, A.1    Iversen, P.L.2
  • 30
    • 0030747101 scopus 로고    scopus 로고
    • Specificity comparison of four antisense types: Morpholino, 2′-O-Methyl RNA, DNA, and Phosphorothioate DNA
    • Stein D., Foster E., Huang S.B., Weller D., Summerton J.A. Specificity comparison of four antisense types: Morpholino, 2′-O-Methyl RNA, DNA, and Phosphorothioate DNA. Antisense Nucleic Acid Drug Dev 1997, 7:151-157.
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 151-157
    • Stein, D.1    Foster, E.2    Huang, S.B.3    Weller, D.4    Summerton, J.A.5
  • 31
    • 4844225667 scopus 로고    scopus 로고
    • Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics
    • Arora V., Devi G.R., Iversen P.L. Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. Curr Pharm Biotechnol 2004, 5:431-439.
    • (2004) Curr Pharm Biotechnol , vol.5 , pp. 431-439
    • Arora, V.1    Devi, G.R.2    Iversen, P.L.3
  • 32
    • 84894521728 scopus 로고    scopus 로고
    • The Medicinal Chemistry of Oligonucleotides
    • Taylor and Francis, Boca Raton, S. Principles, S.T. Applications Crooke (Eds.)
    • Swayze E.E., Bhat B. The Medicinal Chemistry of Oligonucleotides. Antisense Drug Technology 2008, 143-182. Taylor and Francis, Boca Raton. S. Principles, S.T. Applications Crooke (Eds.).
    • (2008) Antisense Drug Technology , pp. 143-182
    • Swayze, E.E.1    Bhat, B.2
  • 33
    • 67649259757 scopus 로고    scopus 로고
    • Pharmacokinetic/Pharmacodynamic Properties of Phosphorothioate 2′-O-(2-Methoxyethyl)-Modified Antisense Oligonucleotides in Animals and Man
    • Taylor and Francis, Boca Raton, S.T. Crooke (Ed.)
    • Geary R.S., Yu R.Z., Siwkowski A., Levin A.A. Pharmacokinetic/Pharmacodynamic Properties of Phosphorothioate 2′-O-(2-Methoxyethyl)-Modified Antisense Oligonucleotides in Animals and Man. Antisense Drug Technology: Principles, Strategies and Applications 2008, 305-326. Taylor and Francis, Boca Raton. S.T. Crooke (Ed.).
    • (2008) Antisense Drug Technology: Principles, Strategies and Applications , pp. 305-326
    • Geary, R.S.1    Yu, R.Z.2    Siwkowski, A.3    Levin, A.A.4
  • 35
    • 0030778162 scopus 로고    scopus 로고
    • Effects of Intravenous Infusion of Phosphorothioate Oligonucleotides on Coagulation, Complement Activation and Hemodynamics
    • Henry S.P., Monteith D., Kombrust D.J., Levin A.A. Effects of Intravenous Infusion of Phosphorothioate Oligonucleotides on Coagulation, Complement Activation and Hemodynamics. Nucleosides & Nucleotides 1997, 16(7-9):1673-1676.
    • (1997) Nucleosides & Nucleotides , vol.16 , Issue.7-9 , pp. 1673-1676
    • Henry, S.P.1    Monteith, D.2    Kombrust, D.J.3    Levin, A.A.4
  • 36
    • 0027730199 scopus 로고
    • Regulatory considerations for evaluating the pharmacology and toxicology of antisense drugs
    • Black L.E., Degeorge J.J., Cavagnaro J.A., Jordan A., Ahn C.H. Regulatory considerations for evaluating the pharmacology and toxicology of antisense drugs. Antisense Res Dev 1993, 3(4):399-404.
    • (1993) Antisense Res Dev , vol.3 , Issue.4 , pp. 399-404
    • Black, L.E.1    Degeorge, J.J.2    Cavagnaro, J.A.3    Jordan, A.4    Ahn, C.H.5
  • 37
    • 0028567504 scopus 로고
    • Regulatory considerations for oligonucleotide drugs: updated recommendations for pharmacology and toxicology studies
    • Black L.E., Farrelly J.G., Cavagnaro J.A., Ahn C.H., DeGeorge J.J., Taylor A.S., et al. Regulatory considerations for oligonucleotide drugs: updated recommendations for pharmacology and toxicology studies. Antisense Res Dev 1994, 4(4):299-301.
    • (1994) Antisense Res Dev , vol.4 , Issue.4 , pp. 299-301
    • Black, L.E.1    Farrelly, J.G.2    Cavagnaro, J.A.3    Ahn, C.H.4    DeGeorge, J.J.5    Taylor, A.S.6
  • 38
    • 0030797704 scopus 로고    scopus 로고
    • Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides
    • Geary R.S., Leeds J.M., Henry S.P., Monteith D.K., Levin A.A. Antisense oligonucleotide inhibitors for the treatment of cancer: 1. Pharmacokinetic properties of phosphorothioate oligodeoxynucleotides. Anticancer Drug Des 1997, 12(5):383-393.
    • (1997) Anticancer Drug Des , vol.12 , Issue.5 , pp. 383-393
    • Geary, R.S.1    Leeds, J.M.2    Henry, S.P.3    Monteith, D.K.4    Levin, A.A.5
  • 39
    • 0035138215 scopus 로고    scopus 로고
    • Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey
    • Yu R.Z., Geary R.S., Leeds J.M., Watanabe T., Moore M., Fitchett J., et al. Comparison of pharmacokinetics and tissue disposition of an antisense phosphorothioate oligonucleotide targeting human Ha-ras mRNA in mouse and monkey. J Pharm Sci 2001, 90(2):182-193.
    • (2001) J Pharm Sci , vol.90 , Issue.2 , pp. 182-193
    • Yu, R.Z.1    Geary, R.S.2    Leeds, J.M.3    Watanabe, T.4    Moore, M.5    Fitchett, J.6
  • 40
    • 0035043324 scopus 로고    scopus 로고
    • Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides
    • Geary R.S., Yu R.Z., Levin A.A. Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides. Curr Opin Investig Drugs 2001, 2(4):562-573.
    • (2001) Curr Opin Investig Drugs , vol.2 , Issue.4 , pp. 562-573
    • Geary, R.S.1    Yu, R.Z.2    Levin, A.A.3
  • 41
    • 0031081755 scopus 로고    scopus 로고
    • On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites
    • Gaus H.J., Owens S.R., Winniman M., Cooper S., Cummins L.L. On-line HPLC electrospray mass spectrometry of phosphorothioate oligonucleotide metabolites. Anal Chem 1997, 69(3):313-319.
    • (1997) Anal Chem , vol.69 , Issue.3 , pp. 313-319
    • Gaus, H.J.1    Owens, S.R.2    Winniman, M.3    Cooper, S.4    Cummins, L.L.5
  • 42
    • 0030937876 scopus 로고    scopus 로고
    • Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer
    • Griffey R.H., Greig M.J., Gaus H.J., Liu K., Monteith D., Winniman M., et al. Characterization of oligonucleotide metabolism in vivo via liquid chromatography/electrospray tandem mass spectrometry with a quadrupole ion trap mass spectrometer. J Mass Spectrom 1997, 32(3):305-313.
    • (1997) J Mass Spectrom , vol.32 , Issue.3 , pp. 305-313
    • Griffey, R.H.1    Greig, M.J.2    Gaus, H.J.3    Liu, K.4    Monteith, D.5    Winniman, M.6
  • 44
    • 11344286752 scopus 로고    scopus 로고
    • Effects of an antisense oligonucleotide inhibitor of human ICAM-1 on fetal development in rabbits
    • Henry S.P., Denny K.H., Templin M.V., Yu R.Z., Levin A.A. Effects of an antisense oligonucleotide inhibitor of human ICAM-1 on fetal development in rabbits. Birth Defects Res B Dev Reprod Toxicol 2004, 71(6):368-373.
    • (2004) Birth Defects Res B Dev Reprod Toxicol , vol.71 , Issue.6 , pp. 368-373
    • Henry, S.P.1    Denny, K.H.2    Templin, M.V.3    Yu, R.Z.4    Levin, A.A.5
  • 45
    • 11344265415 scopus 로고    scopus 로고
    • Effects of human and murine antisense oligonucleotide inhibitors of ICAM-1 on reproductive performance, fetal development, and post-natal development in mice
    • Henry S.P., Denny K.H., Templin M.V., Yu R.Z., Levin A.A. Effects of human and murine antisense oligonucleotide inhibitors of ICAM-1 on reproductive performance, fetal development, and post-natal development in mice. Birth Defects Res B Dev Reprod Toxicol 2004, 71(6):359-367.
    • (2004) Birth Defects Res B Dev Reprod Toxicol , vol.71 , Issue.6 , pp. 359-367
    • Henry, S.P.1    Denny, K.H.2    Templin, M.V.3    Yu, R.Z.4    Levin, A.A.5
  • 48
    • 17244377075 scopus 로고    scopus 로고
    • Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi
    • Bilanges B., Stokoe D. Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi. Biochem J 2005, 388(Pt 2):573-583.
    • (2005) Biochem J , vol.388 , Issue.PT 2 , pp. 573-583
    • Bilanges, B.1    Stokoe, D.2
  • 49
    • 67149115119 scopus 로고    scopus 로고
    • Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    • Khan A.A., Betel D., Miller M.L., Sander C., Leslie C.S., Marks D.S. Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat Biotechnol 2009, 27:549-555.
    • (2009) Nat Biotechnol , vol.27 , pp. 549-555
    • Khan, A.A.1    Betel, D.2    Miller, M.L.3    Sander, C.4    Leslie, C.S.5    Marks, D.S.6
  • 51
    • 0037151062 scopus 로고    scopus 로고
    • Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis
    • Fisher A.A., Ye D., Sergueev D.S., Fisher M.H., Shaw B.R., Juliano R.L. Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis. J Biol Chem 2002, 277:22980-22984.
    • (2002) J Biol Chem , vol.277 , pp. 22980-22984
    • Fisher, A.A.1    Ye, D.2    Sergueev, D.S.3    Fisher, M.H.4    Shaw, B.R.5    Juliano, R.L.6
  • 53
    • 16244362066 scopus 로고    scopus 로고
    • Cationic lipids enhance siRNA-mediated interferon response in mice
    • Ma Z., Li J., He F., Wilson A., Pitt B., Li S. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Commun 2005, 330(3):755-759.
    • (2005) Biochem Biophys Res Commun , vol.330 , Issue.3 , pp. 755-759
    • Ma, Z.1    Li, J.2    He, F.3    Wilson, A.4    Pitt, B.5    Li, S.6
  • 54
    • 34548818764 scopus 로고    scopus 로고
    • Cationic lipids and polymers mediated vectors for delivery of siRNA
    • Zhang S., Zhao B., Jiang H., Wang B., Ma B. Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release 2007, 123(1):1-10.
    • (2007) J Control Release , vol.123 , Issue.1 , pp. 1-10
    • Zhang, S.1    Zhao, B.2    Jiang, H.3    Wang, B.4    Ma, B.5
  • 56
    • 0034780950 scopus 로고    scopus 로고
    • Drug properties of second-generation antisense oligonucleotides: how do they measure up to their predecessors?
    • Henry S.P., Geary R.S., Yu R., Levin A.A. Drug properties of second-generation antisense oligonucleotides: how do they measure up to their predecessors?. Curr Opin Investig Drugs 2001, 2(10):1444-1449.
    • (2001) Curr Opin Investig Drugs , vol.2 , Issue.10 , pp. 1444-1449
    • Henry, S.P.1    Geary, R.S.2    Yu, R.3    Levin, A.A.4
  • 58
    • 0032170976 scopus 로고    scopus 로고
    • Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex
    • Sheehan J.P., Lan H.C. Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex. Blood 1998, 92(5):1617-1625.
    • (1998) Blood , vol.92 , Issue.5 , pp. 1617-1625
    • Sheehan, J.P.1    Lan, H.C.2
  • 59
    • 0035942332 scopus 로고    scopus 로고
    • Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex by an allosteric mechanism
    • Sheehan J.P., Thao P.M. Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex by an allosteric mechanism. Biochemistry 2001, 40(16):4980-4989.
    • (2001) Biochemistry , vol.40 , Issue.16 , pp. 4980-4989
    • Sheehan, J.P.1    Thao, P.M.2
  • 60
    • 2942555464 scopus 로고    scopus 로고
    • RNA aptamer to thrombin binds anion- underbinding exosite-2 and alters protease inhibition by heparin-binding serpins
    • Jeter M.L., Ly L.V., Fortenberry Y.M., Whinna H.C., White R.R., Rusconi C.P., et al. RNA aptamer to thrombin binds anion- underbinding exosite-2 and alters protease inhibition by heparin-binding serpins. FEBS Lett 2004, 568(1-3):10-14.
    • (2004) FEBS Lett , vol.568 , Issue.1-3 , pp. 10-14
    • Jeter, M.L.1    Ly, L.V.2    Fortenberry, Y.M.3    Whinna, H.C.4    White, R.R.5    Rusconi, C.P.6
  • 62
    • 0036844423 scopus 로고    scopus 로고
    • Complement Activation is Responsible for Acute Toxicities in Rhesus Monkeys Treated with a Phosphorothioate Oligodeoxynucleotide
    • Henry S.P., Beattie G., Yeh G., Chappel A., Giclas P., Mortari A., et al. Complement Activation is Responsible for Acute Toxicities in Rhesus Monkeys Treated with a Phosphorothioate Oligodeoxynucleotide. Int Immunopharmacol 2002, 2(12):1657-1666.
    • (2002) Int Immunopharmacol , vol.2 , Issue.12 , pp. 1657-1666
    • Henry, S.P.1    Beattie, G.2    Yeh, G.3    Chappel, A.4    Giclas, P.5    Mortari, A.6
  • 64
    • 33745213356 scopus 로고    scopus 로고
    • Plasma Protein Binding of an Antisense Oligonucleotide Targeting Human ICAM-1 (ISIS 2302)
    • Watanabe T.A., Geary R.S., Levin A.A. Plasma Protein Binding of an Antisense Oligonucleotide Targeting Human ICAM-1 (ISIS 2302). Oligonucleotides 2006, 16(2):169-180.
    • (2006) Oligonucleotides , vol.16 , Issue.2 , pp. 169-180
    • Watanabe, T.A.1    Geary, R.S.2    Levin, A.A.3
  • 66
    • 0028326452 scopus 로고
    • Liposome-complement interactions in rat serum: implications for liposome survival studies
    • Devine D.V., Wong K., Serrano K., Chonn A., Cullis P.R. Liposome-complement interactions in rat serum: implications for liposome survival studies. Biochim Biophys Acta 1994, 1191(1):43-51.
    • (1994) Biochim Biophys Acta , vol.1191 , Issue.1 , pp. 43-51
    • Devine, D.V.1    Wong, K.2    Serrano, K.3    Chonn, A.4    Cullis, P.R.5
  • 67
    • 51149102888 scopus 로고    scopus 로고
    • Liposome-mediated triggering of complement cascade
    • Moghimi S.M., Hamad I. Liposome-mediated triggering of complement cascade. J Liposome Res 2008, 18(3):195-209.
    • (2008) J Liposome Res , vol.18 , Issue.3 , pp. 195-209
    • Moghimi, S.M.1    Hamad, I.2
  • 68
    • 0036288638 scopus 로고    scopus 로고
    • Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease
    • Yacyshyn B.R., Chey W.Y., Goff J., Salzberg B., Baerg R., Buchman A.L., et al. Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease. Gut 2002, 51(1):30-36.
    • (2002) Gut , vol.51 , Issue.1 , pp. 30-36
    • Yacyshyn, B.R.1    Chey, W.Y.2    Goff, J.3    Salzberg, B.4    Baerg, R.5    Buchman, A.L.6
  • 69
    • 33750207033 scopus 로고    scopus 로고
    • Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B
    • Kastelein J.J., Wedel M.K., Baker B.F., Su J., Bradley J.D., Yu R.Z., et al. Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B. Circulation 2006, 114(16):1729-1735.
    • (2006) Circulation , vol.114 , Issue.16 , pp. 1729-1735
    • Kastelein, J.J.1    Wedel, M.K.2    Baker, B.F.3    Su, J.4    Bradley, J.D.5    Yu, R.Z.6
  • 70
    • 38949153810 scopus 로고    scopus 로고
    • A phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer
    • Chi K.N., Siu L.L., Hirte H., Hotte S.J., Knox J., Kollmansberger C., et al. A phase I study of OGX-011, a 2′-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clinical Cancer Research 2008, 14(3):833-839.
    • (2008) Clinical Cancer Research , vol.14 , Issue.3 , pp. 833-839
    • Chi, K.N.1    Siu, L.L.2    Hirte, H.3    Hotte, S.J.4    Knox, J.5    Kollmansberger, C.6
  • 71
    • 0025781819 scopus 로고
    • The role of complement in inflammation and phagocytosis
    • Frank M.M., Fries L.F. The role of complement in inflammation and phagocytosis. Immunology Today 1991, 12(9):322-326.
    • (1991) Immunology Today , vol.12 , Issue.9 , pp. 322-326
    • Frank, M.M.1    Fries, L.F.2
  • 72
    • 59349116903 scopus 로고    scopus 로고
    • Knocking down barriers: advances in siRNA delivery
    • Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 8(2):129-138.
    • (2009) Nat Rev Drug Discov , vol.8 , Issue.2 , pp. 129-138
    • Whitehead, K.A.1    Langer, R.2    Anderson, D.G.3
  • 73
    • 71949092463 scopus 로고    scopus 로고
    • Nanomedicine based approaches for the delivery of siRNA in cancer
    • Ozpolat B., Sood A.K., Lopez-Berestein G.J. Nanomedicine based approaches for the delivery of siRNA in cancer. Intern Med 2010, 267(1):44-53.
    • (2010) Intern Med , vol.267 , Issue.1 , pp. 44-53
    • Ozpolat, B.1    Sood, A.K.2    Lopez-Berestein, G.J.3
  • 74
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller M. Non-coding RNAs in human disease. Nat Rev Genet 2011, 12(12):861-874.
    • (2011) Nat Rev Genet , vol.12 , Issue.12 , pp. 861-874
    • Esteller, M.1
  • 75
    • 80054942985 scopus 로고    scopus 로고
    • Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?
    • Fichtlscherer S., Zeiher A.M., Dimmeler S. Circulating microRNAs: biomarkers or mediators of cardiovascular diseases?. Arterioscler Thromb Vasc Biol 2011, 31(11):2383-2390.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.11 , pp. 2383-2390
    • Fichtlscherer, S.1    Zeiher, A.M.2    Dimmeler, S.3
  • 76
    • 80055068418 scopus 로고    scopus 로고
    • The impact of microRNAs on endocrinology
    • Zalts H., Shomron N. The impact of microRNAs on endocrinology. Pediatr Endocrinol Rev 2011, 8(4):354-362.
    • (2011) Pediatr Endocrinol Rev , vol.8 , Issue.4 , pp. 354-362
    • Zalts, H.1    Shomron, N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.