Effects of intravenous infusion of phosphorothioate oligonucleotides on coagulation, complement activation and hemodynamics

Nucleosides and Nucleotides

Volumn 16, Issue 7-9, 1997, Pages 1673-1676

  Henry, Scott P ^a   Monteith, David ^a   Kornbrust, Doug J ^a   Levin, Arthur A ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD CLOTTING; COMPLEMENT ACTIVATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE;

ANIMALIA;

EID: 0030778162     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319708006253     Document Type: Conference Paper

References (3)

1. Crooke, S.T. and Bennett C.F. (1996) PROGRESS IN ANTISENSE OLIGONUCLEOTIDE THERAPEUTICS. Ann. Rev. Pharmacol. Toxicol. 36:107-29
2. Galbraith W.M. et. al. (1994) COMPLEMENT ACTIVATION AND HEMODYNAMIC CHANGES FOLLOWING INTRAVENOUS ADMINISTRATION OF PHOSPHOROTHIOATE OLIGONUCLEOTIDE IN THE MONKEY. Antisense Res. Dev. 4:201-206.
3. Kajita, T. and Hugli, T.E. (1990) C5a -INDUCED NEUTROPHILIA; A PRIMARY HUMORAL MECHANISM FOR RECRUITMENT OF NEUTROPHILS. Am. J. Path. 137:467-477