RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins

FEBS Letters

Volumn 568, Issue 1-3, 2004, Pages 10-14

  Jeter, Martha L ^a   Ly, Linda V ^a   Fortenberry, Yolanda M ^a   Whinna, Herbert C ^a   White, Rebekah R ^b   Rusconi, Christopher P ^b,c   Sullenger, Bruce A ^b   Church, Frank C ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Regado Biosciences Inc RTP   (United States)

Author keywords

AT, antithrombin; exosite 1 and 2, anion binding exosite 1 and anion binding exosite 2; HCII, heparin cofactor II; Heparin; PCI, protein C inhibitor; RNA aptamer; Serpin; Serpin, serine protease inhibitor; Thrombin

Indexed keywords

ANION; ANTITHROMBIN; APTAMER; ARGININE; ASPARTIC ACID; GLUTAMIC ACID; GLYCOSAMINOGLYCAN; HEPARIN BINDING PROTEIN; HEPARIN COFACTOR II; LYSINE; NUCLEOTIDE; PLASMINOGEN ACTIVATOR INHIBITOR 3; PROTEIN; PROTEIN TOGGLE 25; RNA; SERINE PROTEINASE INHIBITOR; THROMBIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING KINETICS; BINDING SITE; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN RNA BINDING; PROTEINASE INHIBITION;

ANIONS; ANTITHROMBINS; BASE SEQUENCE; BINDING SITES; GLYCOSAMINOGLYCANS; HEPARIN; HEPARIN COFACTOR II; HUMANS; MODELS, MOLECULAR; PROTEIN C INHIBITOR; RNA; THROMBIN;

EID: 2942555464     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.04.087     Document Type: Article

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