메뉴 건너뛰기




Volumn 4, Issue JUL, 2013, Pages

IFN signaling: How a non-canonical model led to the development of IFN mimetics

Author keywords

Cytokines; Interferon mimetics; Interferon receptor; Interferon signaling; JAK STAT signaling

Indexed keywords

ALPHA1 INTERFERON; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GAMMA INTERFERON; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; JANUS KINASE; STEROID HORMONE;

EID: 84883736124     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00202     Document Type: Review
Times cited : (22)

References (84)
  • 1
    • 0036469065 scopus 로고    scopus 로고
    • Signal transduction and the control of gene expression
    • doi:10.1126/science.1066355
    • Brivanlou AH, Darnell JE Jr. Signal transduction and the control of gene expression. Science (2002) 295:813-8. doi:10.1126/science.1066355
    • (2002) Science , vol.295 , pp. 813-818
    • Brivanlou, A.H.1    Darnell Jr., J.E.2
  • 2
    • 33947118714 scopus 로고    scopus 로고
    • Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression
    • doi:10.1091/mbc. E06-09-0802
    • Liao HJ, Carpenter G. Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol Biol Cell (2007) 18:1064-72. doi:10.1091/mbc. E06-09-0802
    • (2007) Mol Biol Cell , vol.18 , pp. 1064-1072
    • Liao, H.J.1    Carpenter, G.2
  • 3
    • 84864124859 scopus 로고    scopus 로고
    • IL-12 family cytokines: immunological playmakers
    • doi:10.1038/ni.2366
    • Vignali DA, Kuchroo VK. IL-12 family cytokines: immunological playmakers. Nat Immunol (2012) 13:722-8. doi:10.1038/ni.2366
    • (2012) Nat Immunol , vol.13 , pp. 722-728
    • Vignali, D.A.1    Kuchroo, V.K.2
  • 4
    • 40949094516 scopus 로고    scopus 로고
    • Nuclear localization of growth hormone receptor: another age of discovery for cytokine action?
    • doi:10.1126/stke.4152007pe69
    • Swanson SM, Kopchick JJ. Nuclear localization of growth hormone receptor: another age of discovery for cytokine action?. Sci STKE (2007) 2007:e69. doi:10.1126/stke.4152007pe69
    • (2007) Sci STKE , vol.2007
    • Swanson, S.M.1    Kopchick, J.J.2
  • 5
    • 48949118327 scopus 로고    scopus 로고
    • Growth hormone receptor; mechanism of action
    • doi:10.1016/j.biocel.2007.07.008
    • Brooks AJ, Wooh JW, Tunny KA, Waters MJ. Growth hormone receptor; mechanism of action. Int J Biochem Cell Biol (2008) 40:1984-9. doi:10.1016/j.biocel.2007.07.008
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1984-1989
    • Brooks, A.J.1    Wooh, J.W.2    Tunny, K.A.3    Waters, M.J.4
  • 6
    • 70349090081 scopus 로고    scopus 로고
    • Epidermal growth factor promotes epidermal growth factor receptor nuclear accumulation by a pathway dependent on cytoskeleton integrity in human breast cancer cells
    • doi:10.1016/j.arcmed.2009.06.007
    • Cortes-Reynosa P, Robledo T, Salazar EP. Epidermal growth factor promotes epidermal growth factor receptor nuclear accumulation by a pathway dependent on cytoskeleton integrity in human breast cancer cells. Arch Med Res (2009) 40:331-8. doi:10.1016/j.arcmed.2009.06.007
    • (2009) Arch Med Res , vol.40 , pp. 331-338
    • Cortes-Reynosa, P.1    Robledo, T.2    Salazar, E.P.3
  • 8
    • 70349975711 scopus 로고    scopus 로고
    • JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    • doi:10.1038/nature08448
    • Dawson MA, Bannister AJ, Gottgens B, Foster SD, Bartke T, Green AR, et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature (2009) 461:819-22. doi:10.1038/nature08448
    • (2009) Nature , vol.461 , pp. 819-822
    • Dawson, M.A.1    Bannister, A.J.2    Gottgens, B.3    Foster, S.D.4    Bartke, T.5    Green, A.R.6
  • 9
    • 0035928897 scopus 로고    scopus 로고
    • So many ligands, so few transcription factors: a new paradigm for signaling through the STAT transcription factors
    • doi:10.1006/cyto.2001.0905
    • Subramaniam PS, Torres BA, Johnson HM. So many ligands, so few transcription factors: a new paradigm for signaling through the STAT transcription factors. Cytokine (2001) 15:175-87. doi:10.1006/cyto.2001.0905
    • (2001) Cytokine , vol.15 , pp. 175-187
    • Subramaniam, P.S.1    Torres, B.A.2    Johnson, H.M.3
  • 10
    • 4644247974 scopus 로고    scopus 로고
    • Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors
    • doi:10.1002/bies.20086
    • Johnson HM, Subramaniam PS, Olsnes S, Jans DA. Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors. Bioessays (2004) 26:993-1004. doi:10.1002/bies.20086
    • (2004) Bioessays , vol.26 , pp. 993-1004
    • Johnson, H.M.1    Subramaniam, P.S.2    Olsnes, S.3    Jans, D.A.4
  • 11
    • 84859452051 scopus 로고    scopus 로고
    • Steroid-like signalling by interferons: making sense of specific gene activation by cytokines
    • doi:10.1042/BJ20112187
    • Johnson HM, Noon-Song EN, Kemppainen K, Ahmed CM. Steroid-like signalling by interferons: making sense of specific gene activation by cytokines. Biochem J (2012) 443:329-38. doi:10.1042/BJ20112187
    • (2012) Biochem J , vol.443 , pp. 329-338
    • Johnson, H.M.1    Noon-Song, E.N.2    Kemppainen, K.3    Ahmed, C.M.4
  • 12
    • 84872065897 scopus 로고    scopus 로고
    • JAKs and STATs in immunity, immunodeficiency, and cancer
    • doi:10.1056/NEJMra1202117
    • O'Shea JJ, Holland SM, Staudt LM. JAKs and STATs in immunity, immunodeficiency, and cancer. N Engl J Med (2013) 368:161-70. doi:10.1056/NEJMra1202117
    • (2013) N Engl J Med , vol.368 , pp. 161-170
    • O'Shea, J.J.1    Holland, S.M.2    Staudt, L.M.3
  • 13
    • 0029618097 scopus 로고
    • Differential recognition of the type I interferon receptor by interferons tau and alpha is responsible for their disparate cytotoxicities
    • doi:10.1073/pnas.92.26.12270
    • Subramaniam PS, Khan SA, Pontzer CH, Johnson HM. Differential recognition of the type I interferon receptor by interferons tau and alpha is responsible for their disparate cytotoxicities. Proc Natl Acad Sci U S A (1995) 92:12270-4. doi:10.1073/pnas.92.26.12270
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 12270-12274
    • Subramaniam, P.S.1    Khan, S.A.2    Pontzer, C.H.3    Johnson, H.M.4
  • 14
    • 15944398345 scopus 로고    scopus 로고
    • Interferon-beta 1b for multiple sclerosis
    • doi:10.1586/14737175.5.2.153
    • Burks J. Interferon-beta 1b for multiple sclerosis. Expert Rev Neurother (2005) 5:153-64. doi:10.1586/14737175.5.2.153
    • (2005) Expert Rev Neurother , vol.5 , pp. 153-164
    • Burks, J.1
  • 15
    • 33745320296 scopus 로고    scopus 로고
    • IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFNgamma- activated genes: evidence of transactivational activity in IFNGR1
    • Ahmed CM, Johnson HM. IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFNgamma- activated genes: evidence of transactivational activity in IFNGR1. J Immunol (2006) 177:315-21.
    • (2006) J Immunol , vol.177 , pp. 315-321
    • Ahmed, C.M.1    Johnson, H.M.2
  • 16
    • 79960057736 scopus 로고    scopus 로고
    • Controlling nuclear JAKs and STATs for specific gene activation by IFNgamma
    • doi:10.1016/j.bbrc.2011.06.047
    • Noon-Song EN, Ahmed CM, Dabelic R, Canton J, Johnson HM. Controlling nuclear JAKs and STATs for specific gene activation by IFNgamma. Biochem Biophys Res Commun (2011) 410:648-53. doi:10.1016/j.bbrc.2011.06.047
    • (2011) Biochem Biophys Res Commun , vol.410 , pp. 648-653
    • Noon-Song, E.N.1    Ahmed, C.M.2    Dabelic, R.3    Canton, J.4    Johnson, H.M.5
  • 17
    • 84871707927 scopus 로고    scopus 로고
    • Type I IFN receptor controls activated TYK2 in the nucleus: implications for EAE therapy
    • doi:10.1016/j.jneuroim.2012.10.006
    • Ahmed CM, Noon-Song EN, Kemppainen K, Pascalli MP, Johnson HM. Type I IFN receptor controls activated TYK2 in the nucleus: implications for EAE therapy. J Neuroimmunol (2013) 254:101-9. doi:10.1016/j.jneuroim.2012.10.006
    • (2013) J Neuroimmunol , vol.254 , pp. 101-109
    • Ahmed, C.M.1    Noon-Song, E.N.2    Kemppainen, K.3    Pascalli, M.P.4    Johnson, H.M.5
  • 18
    • 0028174865 scopus 로고
    • Binding of IFN gamma and its C-terminal peptide to a cytoplasmic domain of its receptor that is essential for function
    • doi:10.1006/bbrc.1994.1691
    • Szente BE, Johnson HM. Binding of IFN gamma and its C-terminal peptide to a cytoplasmic domain of its receptor that is essential for function. Biochem Biophys Res Commun (1994) 201:215-21. doi:10.1006/bbrc.1994.1691
    • (1994) Biochem Biophys Res Commun , vol.201 , pp. 215-221
    • Szente, B.E.1    Johnson, H.M.2
  • 19
    • 84865491407 scopus 로고    scopus 로고
    • Therapeutic peptides
    • doi:10.4155/fmc.12.94
    • Albericio F, Kruger HG. Therapeutic peptides. Future Med Chem (2012) 4:1527-31. doi:10.4155/fmc.12.94
    • (2012) Future Med Chem , vol.4 , pp. 1527-1531
    • Albericio, F.1    Kruger, H.G.2
  • 20
    • 0030994132 scopus 로고    scopus 로고
    • The interferon receptors
    • Pestka S. The interferon receptors. Semin Oncol (1997) 24:S9-18.
    • (1997) Semin Oncol , vol.24
    • Pestka, S.1
  • 21
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I- and type-II-interferon-mediated signalling
    • doi:10.1038/nri1604
    • Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol (2005) 5:375-86. doi:10.1038/nri1604
    • (2005) Nat Rev Immunol , vol.5 , pp. 375-386
    • Platanias, L.C.1
  • 22
    • 0032577678 scopus 로고    scopus 로고
    • Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
    • doi:10.1016/S0092-8674(00)81443-9
    • Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE Jr, and Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell (1998) 93:827-39. doi:10.1016/S0092-8674(00)81443-9
    • (1998) Cell , vol.93 , pp. 827-839
    • Chen, X.1    Vinkemeier, U.2    Zhao, Y.3    Jeruzalmi, D.4    Darnell Jr., J.E.5    Kuriyan, J.6
  • 23
    • 0034725639 scopus 로고    scopus 로고
    • Signaling by covalent heterodimers of interferon-gamma. Evidence for onesided signaling in the active tetrameric receptor complex
    • doi:10.1074/jbc. M909607199
    • Krause CD, Lunn CA, Izotova LS, Mirochnitchenko O, Kotenko SV, Lundell DJ, et al. Signaling by covalent heterodimers of interferon-gamma. Evidence for onesided signaling in the active tetrameric receptor complex. J Biol Chem (2000) 275:22995-3004. doi:10.1074/jbc. M909607199
    • (2000) J Biol Chem , vol.275 , pp. 22995-3004
    • Krause, C.D.1    Lunn, C.A.2    Izotova, L.S.3    Mirochnitchenko, O.4    Kotenko, S.V.5    Lundell, D.J.6
  • 24
    • 0034716932 scopus 로고    scopus 로고
    • Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma
    • doi:10.1006/jmbi.2000.3734
    • Landar A, Curry B, Parker MH, Digiacomo R, Indelicato SR, Nagabhushan TL, et al. Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma. J Mol Biol (2000) 299:169-79. doi:10.1006/jmbi.2000.3734
    • (2000) J Mol Biol , vol.299 , pp. 169-179
    • Landar, A.1    Curry, B.2    Parker, M.H.3    Digiacomo, R.4    Indelicato, S.R.5    Nagabhushan, T.L.6
  • 25
    • 0042375986 scopus 로고    scopus 로고
    • The biology of IL-12: coordinating innate and adaptive immune responses
    • doi:10.1016/S1359-6101(03)00043-1
    • Watford WT, Moriguchi M, Morinobu A, and O'Shea JJ. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine Growth Factor Rev (2003) 14:361-8. doi:10.1016/S1359-6101(03)00043-1
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 361-368
    • Watford, W.T.1    Moriguchi, M.2    Morinobu, A.3    O'Shea, J.J.4
  • 26
    • 79951682333 scopus 로고    scopus 로고
    • Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
    • doi:10.1038/ni.1995
    • Yang XP, Ghoreschi K, Steward-Tharp SM, Rodriguez-Canales J, Zhu J, Grainger JR, et al. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol (2011) 12:247-54. doi:10.1038/ni.1995
    • (2011) Nat Immunol , vol.12 , pp. 247-254
    • Yang, X.P.1    Ghoreschi, K.2    Steward-Tharp, S.M.3    Rodriguez-Canales, J.4    Zhu, J.5    Grainger, J.R.6
  • 28
    • 0035903236 scopus 로고    scopus 로고
    • The receptor interaction region of Tyk2 contains a motif required for its nuclear localization
    • doi:10.1074/jbc. M103559200
    • Ragimbeau J, Dondi E, Vasserot A, Romero P, Uze G, Pellegrini S. The receptor interaction region of Tyk2 contains a motif required for its nuclear localization. J Biol Chem (2001) 276:30812-8. doi:10.1074/jbc. M103559200
    • (2001) J Biol Chem , vol.276 , pp. 30812-8
    • Ragimbeau, J.1    Dondi, E.2    Vasserot, A.3    Romero, P.4    Uze, G.5    Pellegrini, S.6
  • 29
    • 16344364870 scopus 로고    scopus 로고
    • The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities
    • doi:10.1091/mbc. E04-08-0664
    • Hao A, Novotny-Diermayr V, Bian W, Lin B, Lim CP, Jing N, et al. The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. Mol Biol Cell (2005) 16:1569-83. doi:10.1091/mbc. E04-08-0664
    • (2005) Mol Biol Cell , vol.16 , pp. 1569-1583
    • Hao, A.1    Novotny-Diermayr, V.2    Bian, W.3    Lin, B.4    Lim, C.P.5    Jing, N.6
  • 30
    • 33746531672 scopus 로고    scopus 로고
    • Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells
    • doi:10.1128/MCB.02095-05
    • Nilsson J, Bjursell G, Kannius-Janson M. Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells. Mol Cell Biol (2006) 26:5663-74. doi:10.1128/MCB.02095-05
    • (2006) Mol Cell Biol , vol.26 , pp. 5663-5674
    • Nilsson, J.1    Bjursell, G.2    Kannius-Janson, M.3
  • 31
    • 78650516974 scopus 로고    scopus 로고
    • LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease
    • doi:10.1038/ncb2135
    • Griffiths DS, Li J, Dawson MA, Trotter MW, Cheng YH, Smith AM, et al. LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease. Nat Cell Biol (2011) 13:13-21. doi:10.1038/ncb2135
    • (2011) Nat Cell Biol , vol.13 , pp. 13-21
    • Griffiths, D.S.1    Li, J.2    Dawson, M.A.3    Trotter, M.W.4    Cheng, Y.H.5    Smith, A.M.6
  • 32
    • 80155146810 scopus 로고    scopus 로고
    • JAKs go nuclear: emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth
    • doi:10.3109/08977194.2011.614949
    • Zouein FA, Duhe RJ, Booz GW. JAKs go nuclear: emerging role of nuclear JAK1 and JAK2 in gene expression and cell growth. Growth Factors (2011) 29:245-52. doi:10.3109/08977194.2011.614949
    • (2011) Growth Factors , vol.29 , pp. 245-252
    • Zouein, F.A.1    Duhe, R.J.2    Booz, G.W.3
  • 33
    • 0030878257 scopus 로고    scopus 로고
    • Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase
    • doi:10.1074/jbc.272.28.17694
    • Ram PA, Waxman DJ. Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J Biol Chem (1997) 272:17694-702. doi:10.1074/jbc.272.28.17694
    • (1997) J Biol Chem , vol.272 , pp. 17694-17702
    • Ram, P.A.1    Waxman, D.J.2
  • 34
    • 30044437118 scopus 로고    scopus 로고
    • Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation
    • doi:10.1073/pnas.0509714102
    • Lu X, Levine R, Tong W, Wernig G, Pikman Y, Zarnegar S, et al. Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformation. Proc Natl Acad Sci U S A (2005) 102:18962-7. doi:10.1073/pnas.0509714102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18962-18967
    • Lu, X.1    Levine, R.2    Tong, W.3    Wernig, G.4    Pikman, Y.5    Zarnegar, S.6
  • 35
    • 41949118675 scopus 로고    scopus 로고
    • Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F
    • doi:10.1074/jbc. M707125200
    • Lu X, Huang LJ, Lodish HF. Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F. J Biol Chem (2008) 283:5258-66. doi:10.1074/jbc. M707125200
    • (2008) J Biol Chem , vol.283 , pp. 5258-5266
    • Lu, X.1    Huang, L.J.2    Lodish, H.F.3
  • 36
    • 33748308794 scopus 로고    scopus 로고
    • JAK signaling globally counteracts heterochromatic gene silencing
    • doi:10.1038/ng1860
    • Shi S, Calhoun HC, Xia F, Li J, Le L, Li WX. JAK signaling globally counteracts heterochromatic gene silencing. Nat Genet (2006) 38:1071-6. doi:10.1038/ng1860
    • (2006) Nat Genet , vol.38 , pp. 1071-1076
    • Shi, S.1    Calhoun, H.C.2    Xia, F.3    Li, J.4    Le, L.5    Li, W.X.6
  • 37
    • 0029838412 scopus 로고    scopus 로고
    • Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection
    • doi:10.1089/jir.1996.16.507
    • Rutherford MN, Kumar A, Coulombe B, Skup D, Carver DH, Williams BR. Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection. J Interferon Cytokine Res (1996) 16:507-10. doi:10.1089/jir.1996.16.507
    • (1996) J Interferon Cytokine Res , vol.16 , pp. 507-510
    • Rutherford, M.N.1    Kumar, A.2    Coulombe, B.3    Skup, D.4    Carver, D.H.5    Williams, B.R.6
  • 38
    • 0034921078 scopus 로고    scopus 로고
    • Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice
    • doi:10.1089/107999001750277871
    • Ahmed CM, Wills KN, Sugarman BJ, Johnson DE, Ramachandra M, Nagabhushan TL, et al. Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice. J Interferon Cytokine Res (2001) 21:399-408. doi:10.1089/107999001750277871
    • (2001) J Interferon Cytokine Res , vol.21 , pp. 399-408
    • Ahmed, C.M.1    Wills, K.N.2    Sugarman, B.J.3    Johnson, D.E.4    Ramachandra, M.5    Nagabhushan, T.L.6
  • 39
    • 0033931384 scopus 로고    scopus 로고
    • Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma
    • doi:10.1089/10799900050044769
    • Larkin J 3rd, Johnson HM, Subramaniam PS. Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma. J Interferon Cytokine Res (2000) 20:565-76. doi:10.1089/10799900050044769
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 565-576
    • Larkin, J.1    Johnson, H.M.2    Subramaniam, P.S.3
  • 40
    • 0033841017 scopus 로고    scopus 로고
    • The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site
    • Subramaniam PS, Larkin J 3rd, Mujtaba MG, Walter MR, Johnson HM. The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site. J Cell Sci (2000) 113(Pt 15):2771-81.
    • (2000) J Cell Sci , vol.113 , Issue.PART 15 , pp. 2771-2781
    • Subramaniam, P.S.1    Larkin, J.2    Mujtaba, M.G.3    Walter, M.R.4    Johnson, H.M.5
  • 41
    • 0041885255 scopus 로고    scopus 로고
    • The role of IFNgamma nuclear localization sequence in intracellular function
    • doi:10.1242/jcs.00528
    • Ahmed CM, Burkhart MA, Mujtaba MG, Subramaniam PS, Johnson HM. The role of IFNgamma nuclear localization sequence in intracellular function. J Cell Sci (2003) 116:3089-98. doi:10.1242/jcs.00528
    • (2003) J Cell Sci , vol.116 , pp. 3089-3098
    • Ahmed, C.M.1    Burkhart, M.A.2    Mujtaba, M.G.3    Subramaniam, P.S.4    Johnson, H.M.5
  • 42
    • 0028971989 scopus 로고
    • Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its Cterminal peptide IFN-gamma(95-133)
    • Szente BE, Subramaniam PS, Johnson HM. Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its Cterminal peptide IFN-gamma(95-133). J Immunol (1995) 155:5617-22.
    • (1995) J Immunol , vol.155 , pp. 5617-5622
    • Szente, B.E.1    Subramaniam, P.S.2    Johnson, H.M.3
  • 43
    • 17444382366 scopus 로고    scopus 로고
    • Peptide mimetics of gamma interferon possess antiviral properties against vaccinia virus and other viruses in the presence of poxvirus B8R protein
    • doi:10.1128/JVI.79.9.5632-5639.2005
    • Ahmed CM, Burkhart MA, Subramaniam PS, Mujtaba MG, Johnson HM. Peptide mimetics of gamma interferon possess antiviral properties against vaccinia virus and other viruses in the presence of poxvirus B8R protein. J Virol (2005) 79:5632-9. doi:10.1128/JVI.79.9.5632-5639.2005
    • (2005) J Virol , vol.79 , pp. 5632-5639
    • Ahmed, C.M.1    Burkhart, M.A.2    Subramaniam, P.S.3    Mujtaba, M.G.4    Johnson, H.M.5
  • 44
    • 34249299791 scopus 로고    scopus 로고
    • The complex language of chromatin regulation during transcription
    • doi:10.1038/nature05915
    • Berger SL. The complex language of chromatin regulation during transcription. Nature (2007) 447:407-12. doi:10.1038/nature05915
    • (2007) Nature , vol.447 , pp. 407-412
    • Berger, S.L.1
  • 45
    • 79954480753 scopus 로고    scopus 로고
    • Early epigenetic events regulate the adaptive immune response gene CIITA
    • doi:10.4161/epi.6.4.14516
    • Mehta NT, Truax AD, Boyd NH, Greer SF. Early epigenetic events regulate the adaptive immune response gene CIITA. Epigenetics (2011) 6:516-25. doi:10.4161/epi.6.4.14516
    • (2011) Epigenetics , vol.6 , pp. 516-525
    • Mehta, N.T.1    Truax, A.D.2    Boyd, N.H.3    Greer, S.F.4
  • 46
    • 77955484240 scopus 로고    scopus 로고
    • Enhancement of antiviral immunity by small molecule antagonist of suppressor of cytokine signaling
    • doi:10.4049/jimmunol.0902895
    • Ahmed CM, Dabelic R, Martin JP, Jager LD, Haider SM, Johnson HM. Enhancement of antiviral immunity by small molecule antagonist of suppressor of cytokine signaling. J Immunol (2010) 185:1103-13. doi:10.4049/jimmunol.0902895
    • (2010) J Immunol , vol.185 , pp. 1103-1113
    • Ahmed, C.M.1    Dabelic, R.2    Martin, J.P.3    Jager, L.D.4    Haider, S.M.5    Johnson, H.M.6
  • 48
    • 33947638071 scopus 로고    scopus 로고
    • IFN mimetic as a therapeutic for lethal vaccinia virus infection: possible effects on innate and adaptive immune responses
    • Ahmed CM, Martin JP, Johnson HM. IFN mimetic as a therapeutic for lethal vaccinia virus infection: possible effects on innate and adaptive immune responses. J Immunol (2007) 178:4576-83.
    • (2007) J Immunol , vol.178 , pp. 4576-4583
    • Ahmed, C.M.1    Martin, J.P.2    Johnson, H.M.3
  • 49
    • 0032583518 scopus 로고    scopus 로고
    • Unrestricted agonist activity on murine and human cells of a lipopeptide derived from IFN-gamma
    • doi:10.1006/bbrc.1998.9831
    • Thiam K, Loing E, Delanoye A, Diesis E, Gras-Masse H, Auriault C, et al. Unrestricted agonist activity on murine and human cells of a lipopeptide derived from IFN-gamma. Biochem Biophys Res Commun (1998) 253:639-47. doi:10.1006/bbrc.1998.9831
    • (1998) Biochem Biophys Res Commun , vol.253 , pp. 639-647
    • Thiam, K.1    Loing, E.2    Delanoye, A.3    Diesis, E.4    Gras-Masse, H.5    Auriault, C.6
  • 50
    • 42449154473 scopus 로고    scopus 로고
    • Poxviridae: the viruses and their replication, 3rd ed.
    • Philadelphia, PA: Lippincott Williams and Wilkins
    • Moss B. Poxviridae: the viruses and their replication. 3rd ed. In: DM Knipe and PM Howley----- editors. Fields Virology. Philadelphia, PA: Lippincott Williams and Wilkins (2007). p. 2905-46.
    • (2007) DM Knipe and PM Howley----- editors. Fields Virology , pp. 2905-2946
    • Moss, B.1
  • 51
    • 0034467234 scopus 로고    scopus 로고
    • The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN
    • doi:10.1128/JVI.74.23.11230-11239.2000
    • Alcami A, Symons JA, Smith GL. The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cells from the antiviral effects of IFN. J Virol (2000) 74:11230-9. doi:10.1128/JVI.74.23.11230-11239.2000
    • (2000) J Virol , vol.74 , pp. 11230-9
    • Alcami, A.1    Symons, J.A.2    Smith, G.L.3
  • 52
    • 0032080885 scopus 로고    scopus 로고
    • Interferon-alpha and chemohormonal therapy for patients with advanced melanoma: final results of a phase I-II study of the Cancer Biotherapy Research Group and the Mid-Atlantic Oncology Program
    • doi:10.1002/(SICI)1097-0142(19980501)82:9<1677::AID-CNCR13>3.0.CO;2-1
    • Stark JJ, Dillman RO, Schulof R, Wiemann MC, Barth NM, Honeycutt PJ, et al. Interferon-alpha and chemohormonal therapy for patients with advanced melanoma: final results of a phase I-II study of the Cancer Biotherapy Research Group and the Mid-Atlantic Oncology Program. Cancer (1998) 82:1677-81. doi:10.1002/(SICI)1097-0142(19980501)82:9<1677::AID-CNCR13>3.0.CO;2-1
    • (1998) Cancer , vol.82 , pp. 1677-1681
    • Stark, J.J.1    Dillman, R.O.2    Schulof, R.3    Wiemann, M.C.4    Barth, N.M.5    Honeycutt, P.J.6
  • 53
    • 0034767753 scopus 로고    scopus 로고
    • Antiviral actions of interferons
    • doi:10.1128/CMR.14.4.778-809.2001
    • Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev (2001) 14:778-809. doi:10.1128/CMR.14.4.778-809.2001
    • (2001) Clin Microbiol Rev , vol.14 , pp. 778-809
    • Samuel, C.E.1
  • 55
    • 20844456591 scopus 로고    scopus 로고
    • Enhanced benefit of increasing interferon beta-1a dose and frequency in relapsing multiple sclerosis: the EVIDENCE Study
    • doi:10.1001/archneur.62.5.785
    • Schwid SR, Thorpe J, Sharief M, Sandberg-Wollheim M, Rammohan K, Wendt J, et al. Enhanced benefit of increasing interferon beta-1a dose and frequency in relapsing multiple sclerosis: the EVIDENCE Study. Arch Neurol (2005) 62:785-92. doi:10.1001/archneur.62.5.785
    • (2005) Arch Neurol , vol.62 , pp. 785-792
    • Schwid, S.R.1    Thorpe, J.2    Sharief, M.3    Sandberg-Wollheim, M.4    Rammohan, K.5    Wendt, J.6
  • 56
    • 0041854172 scopus 로고    scopus 로고
    • Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance
    • doi:10.2165/00002018-200326110-00006
    • Francis GS, Grumser Y, Alteri E, MicaleffA, O'Brien F, Alsop J, et al. Hepatic reactions during treatment of multiple sclerosis with interferon-beta-1a: incidence and clinical significance. Drug Saf (2003) 26:815-27. doi:10.2165/00002018-200326110-00006
    • (2003) Drug Saf , vol.26 , pp. 815-827
    • Francis, G.S.1    Grumser, Y.2    Alteri, E.3    Micaleff, A.4    O'Brien, F.5    Alsop, J.6
  • 57
    • 80051983083 scopus 로고    scopus 로고
    • Structural linkage between ligand discrimination and receptor activation by type I interferons
    • doi:10.1016/j.cell.2011.06.048
    • Thomas C, Moraga I, Levin D, Krutzik PO, Podoplelova Y, Trejo A, et al. Structural linkage between ligand discrimination and receptor activation by type I interferons. Cell (2011) 146:621-32. doi:10.1016/j.cell.2011.06.048
    • (2011) Cell , vol.146 , pp. 621-632
    • Thomas, C.1    Moraga, I.2    Levin, D.3    Krutzik, P.O.4    Podoplelova, Y.5    Trejo, A.6
  • 58
    • 10044243777 scopus 로고    scopus 로고
    • New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis
    • doi:10.1016/j.imlet.2004.07.017
    • El Behi M, Dubucquoi S, Lefranc D, Zephir H, De Seze J, Vermersch P, et al. New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Lett (2005) 96:11-26. doi:10.1016/j.imlet.2004.07.017
    • (2005) Immunol Lett , vol.96 , pp. 11-26
    • El Behi, M.1    Dubucquoi, S.2    Lefranc, D.3    Zephir, H.4    De Seze, J.5    Vermersch, P.6
  • 59
    • 72649089017 scopus 로고    scopus 로고
    • Knowns and unknowns in the future of multiple sclerosis treatment
    • doi:10.1016/S0022-510X(09)71298-5
    • Stuve O. Knowns and unknowns in the future of multiple sclerosis treatment. J Neurol Sci (2009) 287(Suppl 1):S30-6. doi:10.1016/S0022-510X(09)71298-5
    • (2009) J Neurol Sci , vol.287 , Issue.SUPPL. 1
    • Stuve, O.1
  • 60
    • 0037103134 scopus 로고    scopus 로고
    • Lipid microdomains are required sites for the selective endocytosis and nuclear translocation of IFN-gamma, its receptor chain IFN-gamma receptor-1, and the phosphorylation and nuclear translocation of STAT1alpha
    • Subramaniam PS, Johnson HM. Lipid microdomains are required sites for the selective endocytosis and nuclear translocation of IFN-gamma, its receptor chain IFN-gamma receptor-1, and the phosphorylation and nuclear translocation of STAT1alpha. J Immunol (2002) 169:1959-69.
    • (2002) J Immunol , vol.169 , pp. 1959-1969
    • Subramaniam, P.S.1    Johnson, H.M.2
  • 61
    • 0037023701 scopus 로고    scopus 로고
    • Cytokine signaling: STATS in plasma membrane rafts
    • doi:10.1074/jbc. M200018200
    • Sehgal PB, Guo GG, Shah M, Kumar V, Patel K. Cytokine signaling: STATS in plasma membrane rafts. J Biol Chem (2002) 277:12067-74. doi:10.1074/jbc. M200018200
    • (2002) J Biol Chem , vol.277 , pp. 12067-74
    • Sehgal, P.B.1    Guo, G.G.2    Shah, M.3    Kumar, V.4    Patel, K.5
  • 62
    • 33745626171 scopus 로고    scopus 로고
    • Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors
    • doi:10.1091/mbc. E06-01-0076
    • Marchetti M, Monier MN, Fradagrada A, Mitchell K, Baychelier F, Eid P, et al. Stat-mediated signaling induced by type I and type II interferons (IFNs) is differentially controlled through lipid microdomain association and clathrin-dependent endocytosis of IFN receptors. Mol Biol Cell (2006) 17:2896-909. doi:10.1091/mbc. E06-01-0076
    • (2006) Mol Biol Cell , vol.17 , pp. 2896-2909
    • Marchetti, M.1    Monier, M.N.2    Fradagrada, A.3    Mitchell, K.4    Baychelier, F.5    Eid, P.6
  • 63
    • 0037377217 scopus 로고    scopus 로고
    • Nuclear localization and possible functions of receptor tyrosine kinases
    • doi:10.1016/S0955-0674(03)00015-2
    • Carpenter G. Nuclear localization and possible functions of receptor tyrosine kinases. Curr Opin Cell Biol (2003) 15:143-8. doi:10.1016/S0955-0674(03)00015-2
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 143-148
    • Carpenter, G.1
  • 64
    • 84864589406 scopus 로고    scopus 로고
    • Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family
    • doi:10.1186/2045-3701-2-13
    • Wang YN, Hung MC. Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family. Cell Biosci (2012) 2:13. doi:10.1186/2045-3701-2-13
    • (2012) Cell Biosci , vol.2 , pp. 13
    • Wang, Y.N.1    Hung, M.C.2
  • 65
    • 0034855942 scopus 로고    scopus 로고
    • Nuclear localization of EGF receptor and its potential new role as a transcription factor
    • doi:10.1038/ncb0901-802
    • Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, et al. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol (2001) 3:802-8. doi:10.1038/ncb0901-802
    • (2001) Nat Cell Biol , vol.3 , pp. 802-808
    • Lin, S.Y.1    Makino, K.2    Xia, W.3    Matin, A.4    Wen, Y.5    Kwong, K.Y.6
  • 66
    • 77956265420 scopus 로고    scopus 로고
    • COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport
    • doi:10.1016/j.bbrc.2010.07.096
    • Wang YN, Wang H, Yamaguchi H, Lee HJ, Lee HH, Hung MC. COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport. Biochem Biophys Res Commun (2010) 399:498-504. doi:10.1016/j.bbrc.2010.07.096
    • (2010) Biochem Biophys Res Commun , vol.399 , pp. 498-504
    • Wang, Y.N.1    Wang, H.2    Yamaguchi, H.3    Lee, H.J.4    Lee, H.H.5    Hung, M.C.6
  • 67
    • 78649681031 scopus 로고    scopus 로고
    • The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus
    • doi:10.1074/jbc. M110.158659
    • Wang YN, Yamaguchi H, Huo L, Du Y, Lee HJ, Lee HH, et al. The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem (2010) 285:38720-9. doi:10.1074/jbc. M110.158659
    • (2010) J Biol Chem , vol.285 , pp. 38720-9
    • Wang, Y.N.1    Yamaguchi, H.2    Huo, L.3    Du, Y.4    Lee, H.J.5    Lee, H.H.6
  • 68
    • 0037207470 scopus 로고    scopus 로고
    • Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus
    • Olsnes S, Klingenberg O, Wiedlocha A. Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus. Physiol Rev (2003) 83:163-82.
    • (2003) Physiol Rev , vol.83 , pp. 163-182
    • Olsnes, S.1    Klingenberg, O.2    Wiedlocha, A.3
  • 69
    • 24944578655 scopus 로고    scopus 로고
    • Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor
    • doi:10.1111/j.1600-0854.2005.00332.x
    • Bryant DM, Stow JL. Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor. Traffic (2005) 6:947-54. doi:10.1111/j.1600-0854.2005.00332.x
    • (2005) Traffic , vol.6 , pp. 947-954
    • Bryant, D.M.1    Stow, J.L.2
  • 70
    • 37249065138 scopus 로고    scopus 로고
    • Integrative nuclear signaling in cell development - a role for FGF receptor-1
    • doi:10.1089/dna.2007.0664
    • Stachowiak MK, Maher PA, Stachowiak EK. Integrative nuclear signaling in cell development - a role for FGF receptor-1. DNA Cell Biol (2007) 26:811-26. doi:10.1089/dna.2007.0664
    • (2007) DNA Cell Biol , vol.26 , pp. 811-826
    • Stachowiak, M.K.1    Maher, P.A.2    Stachowiak, E.K.3
  • 71
    • 0025129942 scopus 로고
    • Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence
    • doi:10.1126/science.1699274
    • Imamura T, Engleka K, Zhan X, Tokita Y, Forough R, Roeder D, et al. Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science (1990) 249:1567-70. doi:10.1126/science.1699274
    • (1990) Science , vol.249 , pp. 1567-1570
    • Imamura, T.1    Engleka, K.2    Zhan, X.3    Tokita, Y.4    Forough, R.5    Roeder, D.6
  • 72
    • 33751162364 scopus 로고    scopus 로고
    • Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail
    • doi:10.1242/jcs.03209
    • Sorensen V, Wiedlocha A, Haugsten EM, Khnykin D, Wesche J, Olsnes S. Different abilities of the four FGFRs to mediate FGF-1 translocation are linked to differences in the receptor C-terminal tail. J Cell Sci (2006) 119:4332-41. doi:10.1242/jcs.03209
    • (2006) J Cell Sci , vol.119 , pp. 4332-4341
    • Sorensen, V.1    Wiedlocha, A.2    Haugsten, E.M.3    Khnykin, D.4    Wesche, J.5    Olsnes, S.6
  • 73
    • 84859603522 scopus 로고    scopus 로고
    • Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1
    • doi:10.1111/j.1600-0854.2012.01341.x
    • Zhen Y, Sorensen V, Skjerpen CS, Haugsten EM, Jin Y, Walchli S, et al. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. Traffic (2012) 13:650-64. doi:10.1111/j.1600-0854.2012.01341.x
    • (2012) Traffic , vol.13 , pp. 650-664
    • Zhen, Y.1    Sorensen, V.2    Skjerpen, C.S.3    Haugsten, E.M.4    Jin, Y.5    Walchli, S.6
  • 74
    • 77955500692 scopus 로고    scopus 로고
    • Modulation of steroid hormone receptor activity
    • doi:10.1016/S0079-6123(08) 81009-6
    • Stanisic V, Lonard DM, and O'Malley BW. Modulation of steroid hormone receptor activity. Prog Brain Res (2010) 181:153-76. doi:10.1016/S0079-6123(08) 81009-6
    • (2010) Prog Brain Res , vol.181 , pp. 153-176
    • Stanisic, V.1    Lonard, D.M.2    O'Malley, B.W.3
  • 75
    • 33750448996 scopus 로고    scopus 로고
    • Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3
    • doi:10.1016/j.molcel.2006.10.011
    • Vicent GP, Ballare C, Nacht AS, Clausell J, Subtil-Rodriguez A, Quiles I, et al. Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol Cell (2006) 24:367-81. doi:10.1016/j.molcel.2006.10.011
    • (2006) Mol Cell , vol.24 , pp. 367-381
    • Vicent, G.P.1    Ballare, C.2    Nacht, A.S.3    Clausell, J.4    Subtil-Rodriguez, A.5    Quiles, I.6
  • 76
    • 34250690433 scopus 로고    scopus 로고
    • Kinases and protein phosphorylation as regulators of steroid hormone action
    • Weigel NL, Moore NL. Kinases and protein phosphorylation as regulators of steroid hormone action. Nucl Recept Signal (2007) 5:e005.
    • (2007) Nucl Recept Signal , vol.5
    • Weigel, N.L.1    Moore, N.L.2
  • 77
    • 78049329473 scopus 로고    scopus 로고
    • Minireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin
    • doi:10.1210/me.2010-0027
    • Vicent GP, Nacht AS, Zaurin R, Ballare C, Clausell J, Beato M. Minireview: role of kinases and chromatin remodeling in progesterone signaling to chromatin. Mol Endocrinol (2010) 24:2088-98. doi:10.1210/me.2010-0027
    • (2010) Mol Endocrinol , vol.24 , pp. 2088-2098
    • Vicent, G.P.1    Nacht, A.S.2    Zaurin, R.3    Ballare, C.4    Clausell, J.5    Beato, M.6
  • 78
    • 11244280137 scopus 로고    scopus 로고
    • Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer
    • Lo HW, Xia W, Wei Y, Ali-Seyed M, Huang SF, Hung MC. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res (2005) 65:338-48.
    • (2005) Cancer Res , vol.65 , pp. 338-348
    • Lo, H.W.1    Xia, W.2    Wei, Y.3    Ali-Seyed, M.4    Huang, S.F.5    Hung, M.C.6
  • 79
    • 33746561717 scopus 로고    scopus 로고
    • Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1
    • doi:10.1002/jcb.20876
    • Lo HW, Ali-Seyed M, Wu Y, Bartholomeusz G, Hsu SC, Hung MC. Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. J Cell Biochem (2006) 98:1570-83. doi:10.1002/jcb.20876
    • (2006) J Cell Biochem , vol.98 , pp. 1570-1583
    • Lo, H.W.1    Ali-Seyed, M.2    Wu, Y.3    Bartholomeusz, G.4    Hsu, S.C.5    Hung, M.C.6
  • 80
    • 63749084159 scopus 로고    scopus 로고
    • Scaffolding actions of membrane-associated progesterone receptors
    • doi:10.1016/j.steroids.2008.12.004
    • Hagan CR, Faivre EJ, Lange CA. Scaffolding actions of membrane-associated progesterone receptors. Steroids (2009) 74:568-72. doi:10.1016/j.steroids.2008.12.004
    • (2009) Steroids , vol.74 , pp. 568-572
    • Hagan, C.R.1    Faivre, E.J.2    Lange, C.A.3
  • 81
    • 10044228385 scopus 로고    scopus 로고
    • The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence
    • doi:10.1016/j.febslet.2004.10.085
    • Subramaniam PS, Johnson HM. The IFNAR1 subunit of the type I IFN receptor complex contains a functional nuclear localization sequence. FEBS Lett (2004) 578:207-10. doi:10.1016/j.febslet.2004.10.085
    • (2004) FEBS Lett , vol.578 , pp. 207-210
    • Subramaniam, P.S.1    Johnson, H.M.2
  • 82
    • 78651481470 scopus 로고    scopus 로고
    • The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins
    • doi:10.1089/jir.2010.0100
    • Cheon H, Yang J, Stark GR. The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins. J Interferon Cytokine Res (2011) 31:33-40. doi:10.1089/jir.2010.0100
    • (2011) J Interferon Cytokine Res , vol.31 , pp. 33-40
    • Cheon, H.1    Yang, J.2    Stark, G.R.3
  • 83
    • 79955799333 scopus 로고    scopus 로고
    • A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells
    • doi:10.1371/journal.pone.0019605
    • Jaganathan S, Yue P, Paladino DC, Bogdanovic J, Huo Q, Turkson J. A functional nuclear epidermal growth factor receptor, SRC and Stat3 heteromeric complex in pancreatic cancer cells. PLoS ONE (2011) 6:e19605. doi:10.1371/journal.pone.0019605
    • (2011) PLoS ONE , vol.6
    • Jaganathan, S.1    Yue, P.2    Paladino, D.C.3    Bogdanovic, J.4    Huo, Q.5    Turkson, J.6
  • 84
    • 79956070963 scopus 로고    scopus 로고
    • Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer
    • doi:10.1158/0008-5472.CAN-10-3074
    • Cerliani JP, Guillardoy T, Giulianelli S, Vaque JP, Gutkind JS, Vanzulli SI, et al. Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer. Cancer Res (2011) 71:3720-31. doi:10.1158/0008-5472.CAN-10-307
    • (2011) Cancer Res , vol.71 , pp. 3720-3731
    • Cerliani, J.P.1    Guillardoy, T.2    Giulianelli, S.3    Vaque, J.P.4    Gutkind, J.S.5    Vanzulli, S.I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.