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In this paper, the authors identify CD44, a cell-surface adhesion molecule, as a γ-secretase substrate. Importantly, they also show that the released cytoplasmic domain enters the nucleus and has transcriptional activity.
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Okamoto I., Kawano Y., Murakami D., Sasayama T., Araki N., Miki T., Wong A.J., Saya H. Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J. Cell Biol. 155:2001;755-762 In this paper, the authors identify CD44, a cell-surface adhesion molecule, as a γ-secretase substrate. Importantly, they also show that the released cytoplasmic domain enters the nucleus and has transcriptional activity.
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Lin S.-Y., Makino K., Xia W., Matin A., Wen Y., Kwong K.Y., Bourguignon L., Hung M.-C. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat. Cell Biol. 3:2001;802-808 The authors confirm previous reports of ErbB-1 in the nucleus and show that localization is ligand-dependent and that the growth-factor-receptor complex is translocated from the plasma membrane to the nucleoplasm. Also, several different assays are employed to provide evidence that ErbB-1 acts as a transcription factor.
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