Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus

Physiological Reviews

Volumn 83, Issue 1, 2003, Pages 163-182

  Olsnes, Sjur ^a   Klingenberg, Olav ^a   Wiȩdłocha, Antoni ^a  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ABRIN; ACIDIC FIBROBLAST GROWTH FACTOR; ANTHRAX TOXIN; BASIC FIBROBLAST GROWTH FACTOR; CASEIN KINASE II; CHOLERA TOXIN; CYTOKINE; DIHYDROFOLATE REDUCTASE; DIPHTHERIA TOXIN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GAMMA INTERFERON; GROWTH FACTOR; INTERLEUKIN 1ALPHA; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NEU DIFFERENTIATION FACTOR; PARATHYROID HORMONE RELATED PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROLACTIN; PROTEIN FARNESYLTRANSFERASE; PROTEIN KINASE C; PROTEIN S 100; RICIN; SHIGA TOXIN; STAT1 PROTEIN; STREPTOLYSIN O; SYNAPTOTAGMIN; TRANSACTIVATOR PROTEIN; UNINDEXED DRUG; VASCULOTROPIN RECEPTOR 2; GROWTH PROMOTOR;

BINDING SITE; CELL FRACTIONATION; CELL MEMBRANE; CELL NUCLEUS; CELL PERMEABILIZATION; CELL TRANSPORT; CELL VACUOLE; CELLULAR DISTRIBUTION; CYTOSOL; ENZYME ACTIVITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; REVIEW; ANIMAL; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CYTOKINES; CYTOSOL; GROWTH SUBSTANCES; HUMANS;

EID: 0037207470     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.00021.2002     Document Type: Review

References (237)

1. AARTS MM, LEVY D, HE B, STREGGER S, CHEN T, RICHARD S, AND HENDERSON JE. Parathyroid hormone-related protein interacts with RNA. J Biol Chem 274: 4832-4838, 1999.
2. AARTS MM, RIX A, GUO J, BRINGHURST R, AND HENDERSON JE. The nucleolar targeting signal (NTS) of parathyroid hormone related protein mediates endocytosis and nucleolar translocation. J Bone Miner Res 14: 1493-1503, 1999.
3. AGUET M, DEMBIC Z, AND MERLIN G. Molecular cloning and expression of the human interferon-gamma receptor. Cell 55: 273-280, 1988.
4. ALBINI A, BARILLARI G, BENELLI R, GALLO RC, AND ENSOLI B. Angiogenic properties of human immunodeficiency virus type 1 Tat protein. Proc Natl Acad Sci USA 92: 4838-4842, 1995.
5. ALBINI A, BENELLI R, PRESTA M, RUSNATI M, ZICHE M, RUBARTELLI A, PAGLIALUNGA G, BUSSOLINO F, AND NOONAN D. HIV-tat protein is a heparin-binding angiogenic growth factor. Oncogene 12: 289-297, 1996.
6. ALBINI A, SOLDI R, GIUNCIUGLIO D, GIRAUDO E, BENELLI R, PRIMO L, NOONAN D, SALIO M, CAMUSSI G, ROCKL W, AND BUSSOLINO F. The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells. Nat Med 2: 1371-1375, 1996.
7. ALOUF JE AND FREER JH. The Comprehensive Sourcebook of Bacterial Protein Toxins. London, Academic, 1999.
8. ARAKAWA T, HSU YR, PARKER CG, AND LAI PH. Role of polycationic C-terminal portion in the structure and activity of recombinant human interferon-gamma. J Biol Chem 261: 8534-8539, 1986.
9. ARESE M, CHEN Y, FLORKIEWICZ RZ, GUALANDRIS A, SHEN B, AND RIFKIN DB. Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals. Mol Biol Cell 10: 1429-1444, 1999.
10. BADER T AND WEITZERBIN J. Nuclear accumulation of interferon gamma. Proc Natl Acad Sci USA 91: 11831-11835, 1994.
11. BAILLY K, SOULET F, LEROY D, AMALRIC F, AND BOUCHE G. Uncoupling of cell proliferation and differentiation activities of basic fibroblast growth factor. FASEB J 14: 333-344, 2000.
12. BAJETTO A, SCHETTINI G, AND CHIMINI G. Nuclear localization of ciliary neurotrophic factor in glial cells. Brain Res 818: 565-569, 1999.
13. 1 phase cell cycle specific in bovine aortic endothelial cells. EMBO J 9: 1511-1517, 1990.
14. BARILLARI G, GENDELMAN R, GALLO RC, AND ENSOLI B. The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc Natl Acad Sci USA 90: 7941-7945, 1993.
15. BELKOWSKI SM, LEVINE JE, AND PRYSTOWSKY MB. Requirement of P13-kinase activity for the nuclear transport of prolactin in cloned murine T lymphocytes. J Neuroimmunol 94: 40-47, 1999.
16. BENNETT RP AND DALBY B. Protein delivery using VP22. Nat Biotechnol 20: 20, 2002.
17. BHAKDI S, BAYLEY H, VALEVA A, VALEV I, WALKER B, WELLER U, KEHOE M, AND PALMER M. Staphylococcal alpha-toxin, streptolysin-O, and Escherichia coli hemolysin: prototypes of pore-forming bacterial bacterial cytolysins. Arch Microbial 165: 73-79, 1996.
18. BONIFACI N, SITIA R, AND RUBARTELLI A. Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding. AIDS 9: 995-1000, 1995.
19. BONNET H, FILHOL O, TRUCHET I, BRETHENOU P, COCHET C, AMALRIC F, AND BOUCHE G. Fibroblast growth factor-2 binds to the regulatory β subunit of CK2 and directly stimulates CK2 activity toward nucleolin. J Biol Chem 271: 24781-24787, 1996.
20. 1 transition. Proc Natl Acad Sci USA 84: 67706774, 1987.
21. BRADLEY KA, MOGRIDGE J, MOUREZ M, COLLIER RJ, AND YOUNG JA. Identification of the cellular receptor for anthrax toxin. Nature 414: 225-229, 2001.
22. BUGLER B, AMALRIC F, AND PRATS H. Alternative initiation of translation determines cytoplasmic or nuclear localization of basic fibroblast growth factor. Mol Cell Biol 11: 573-577, 1991.
23. BUNDRED NJ, RATCLIFFE WA, WALKER RA, COLEY S, MORRISON JM, AND RATCLIFFE JG. Parathyroid hormone related protein and hypercalcaemia in breast cancer. Bone Miner J 303: 1506-1509, 1991.
24. BURGESS WH, SHAHEEN AM, HAMPTON B, DONOHUE PJ, AND WINKLES JA. Structure-function studies of heparin-binding (acidic fibroblast) growth factor-1 using site-directed mutagenesis. J Cell Biochem 45: 131-138, 1991.
25. BURGESS WH, SHAHEEN AM, RAVERA M, JAYE M, DONOHUE PJ, AND WINKLES JA. Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue. J Cell Biol 111: 2129-2138, 1990.
26. CAO Y, EKSTRÖM M, AND PETTERSSON RF. Characterization of the nuclear translocation of acidic fibroblast growth factor. J Cell Sci 104: 77-87, 1993.
27. CARREIRA CM, LAVALLEE TM, TARANTINI F, JACKSON A, LATHROP JT, HAMPTON B, BURGESS WH, AND MACIAG T. S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro. J Biol Chem 273: 22224-22231, 1998.
28. CASEY P AND SEABRA M. Protein prenyltransferases. J Biol Chem 271: 5289-5292, 1996.
29. CHOE S, BENNETT MJ, FUJI G, CURMI PM, KANTARDJIEFF KA, COLLIER RJ, AND EISENBERG D. The crystal structure of diphtheria toxin. Nature 357: 216-222, 1992.
30. CITORES L, KHNYKIN D, SORENSEN V, WESCHE J, KLINGENBERG O, WIȨDŁOCHA A, AND OLSNES S. Modulation of intracellular transport of acidic fibroblast growth factor by mutations in the cytoplasmic receptor domain. J Cell Sci 114: 1677-1689, 2001.
31. CITORES L, WESCHE J, KOLPAKOVA E, AND OLSNES S. Uptake and intracellular transport of acidic fibroblast growth factor: evidence for free and cytoskeleton-anchored fibroblast growth factor receptors. Mol Biol Cell 10: 3835-3848, 1999.
32. CLARK SA AND THEG SM. A folded protein can be transported across the chloroplast envelope and thylakoid membranes. Mol Biol Cell 8: 923-934, 1997.
33. CLEVENGER CV, ALTMANN SW, AND PRYSTOWSKY MB. Requirement of nuclear prolactin for interleukin-2-stimulated proliferation of T lymphocytes. Science 253: 77-79, 1991.
34. CLEVENGER CV, RUSSELL DH, APPASAMY PM, AND PRYSTOWSKY MB. Regulation of interleukin 2-driven T-lymphocyte proliferation by prolactin. Proc Natl Acad Sci USA 87: 6460-6464, 1990.
35. COLLIER RJ. Diphtheria toxin: mode of action and structure. Bacteriol Rev 39: 54-85, 1975.
36. CURTIS BM, WIDMER MB, DEROOS P, AND QWARNSTROM EE. IL-1 and its receptor are translocated to the nucleus. J Immunol 144: 1295-1303, 1990.
37. DAHL JP, BINDA A, CANFIELD VA, AND LEVENSON R. Participation of Na,K-ATPase in FGF-2 secretion: rescue of ouabain-inhibitable FGF-2 secretion by ouabain-resistant Na,K-ATPase alpha subunits. Biochemistry 39: 14877-14883, 2000.
38. DARNELL JE JR, KERR IM, AND STARK GR. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264: 1415-1421, 1994.
39. DAY PJ, OWENS SR, WESCHE J, OLSNES S, ROBERTS LM, AND LORD JM. An interaction between ricin and calreticulin that may have implications for toxin trafficking. J Biol Chem 276: 7202-7208, 2001.
40. DEROSSI D, CHASSAING G, AND PROCHIANTZ A. Trojan peptides: the penetratin system for intracellular delivery. Trends Cell Biol 8: 84-87, 1998.
41. DIRKS RP, ONNEKINK C, JANSEN HJ, DE JONG A, AND BLOEMERS HP. A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein. Nucleic Acids Res 23: 2815-2822, 1995.
42. DONO R, JAMES D, AND ZELLER R. A GR-motif functions in nuclear accumulation of the large FGF-2 isoforms and interferes with mitogenic signalling. Oncogene 16: 2151-2158, 1998.
43. DUESBERY NS, WEBB CP, LEPPLA SH, GORDON VM, KLIMPEL KR, COPELAND TD, AHN NG, OSKARSSON MK, FUKASAWA K, PAULL KD, AND VANDE WOUDE GF. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 280: 734-737, 1998.
44. EALICK SE, COOK WJ, VIJAY-KUMAR S, CARSON M, NAGABHUSHAN TL, TROTTA PP, AND BUGG CE. Three-dimensional structure of recombinant human interferon-gamma. Science 252: 698-702, 1991.
45. EILERS M AND SCHATZ G. Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria. Nature 322: 228-232, 1986.
46. ELLIOTT G AND O'HARE P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88: 223-233, 1997.
47. ENDO Y, MITSUI K, MOTIZUKI M, AND TSURUGI K. The mechanism of action of ricin and related toxic lectins on eukaryotic ribosomes. The site and the characteristics of the modification in 28S ribosomal RNA caused by the toxins. J Biol Chem 262: 5908-5912, 1987.
48. ENDO Y AND TSURUGI K. RNA N-glycosidase activity of ricin A-chain. Mechanism of action of the toxic lectin ricin on eukaryotic ribosomes. J Biol Chem 262: 8128-8130, 1987.
49. ENDO Y, TSURUGI K, YUTSUDO T, TAKEDA Y, OGASAWARA T, AND IGARASHI K. Site of action of a Vero toxin (VT2) from Escherichia coli O157: H7 and of Shiga toxin on eukaryotic ribosomes. RNA N-glycosidase activity of the toxins. Eur J Biochem 171: 45-50, 1988.
50. ENSOLI B, BUONAGURO L, BARILLARI G, FIORELLI V, GENDELMAN R, MORGAN RA, WINGFIELD P, AND GALLO RC. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. J Virol 67: 277-287, 1993.
51. FALNES PO, WESCHE J, AND OLSNES S. Ability of the Tat basic domain and VP22 to mediate cell binding, but not membrane translocation of the diphtheria toxin A-fragment. Biochemistry 40: 4349-4358, 2001.
52. FARRAR MA, FERNANDEZ-LUNA J, AND SCHREIBER RD. Identification of two regions within the cytoplasmic domain of the human interferon-gamma receptor required for function. J Biol Chem 266: 19626-19635, 1991.
53. FARRAR MA AND SCHREIBER RD. The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 11: 571-611, 1993.
54. FAWELL S, SEERY J, DAIKH Y, MOORE C, CHEN LL, PEPINSKY B, AND BARSOUM J. Tat-mediated delivery of heterologous proteins into cells. Proc Natl Acad Sci USA 91: 664-668, 1994.
55. FIDLER IJ, FOGLER WE, KLEINERMAN ES, AND SAIKI I. Abrogation of species specificity for activation of tumoricidal properties in macrophages by recombinant mouse or human interferon-gamma encapsulated in liposomes. J Immunol 135: 4289-4296, 1985.
56. +-ATPase. J Biol Chem 273:544-551, 1998.
57. FRANKEL AD AND PABO CO. Cellular uptake of the tat protein from human immunodeficiency virus. Cell 55: 1189-1193, 1988.
58. FRIEDMAN S, ZHAN X, AND MACIAG T. Mutagenesis of the nuclear localization sequence in EGF-1 alters protein stability but not mitogenic activity. Biochem Biophys Res Commun 198: 1203-1208, 1994.
59. GILL DM. The arrangement of subunits in cholera toxin. Biochemistry 15: 1242-1248, 1976.
60. GILL DM AND KING CA. The mechanism of action of cholera toxin in pigeon erythrocyte lysates. J Biol Chem 250: 6424-6432, 1975.
61. GLEIZES PE, NOAILLAC-DEPEYRE J, DUPONT MA, AND GAS N. Basic fibroblast growth factor (FGF-2) is addressed to caveolae after binding to the plasma membrane of BHK cells. Eur J Cell Biol 71: 144-153, 1996.
62. GREEN M AND LOEWENSTEIN PM. Autonomous functional domains of chemically synthesized human immunodeficiency virus tat transactivator protein. Cell 55: 1179-1188, 1988.
63. GREEN MM, LARKIN J, SUBRAMANIAM PS III, SZENTE BE, AND JOHNSON HM. Human IFN gamma receptor cytoplasmic domain: expression and interaction with HuIFN gamma. Biochem Biophys Res Commun 243: 170-176, 1998.
64. GRENFELL S, SMITHERS N, MILLER K, AND SOLARI R. Receptor-mediated endocytosis and nuclear transport of human interleukin 1 alpha. Biochem J 264: 813-822, 1989.
65. GRIEB TA AND BURGESS WH. The mitogenic activity of fibroblast growth factor-1 correlates with its internalization and limited proteolytic processing. J Cell Physiol 184: 171-182, 2000.
66. r 24,000 bFGF. J Cell Physiol 161: 149-159, 1994.
67. GUPTA S, AGGARWAL S, AND NAKAMURA S. A possible role of multidrug resistance-associated protein (MRP) in basic fibroblast growth factor secretion by AIDS-associated Kaposi's sarcoma cells: a survival molecule? J Clin Immunol 18: 256-263, 1998.
68. HAKANSSON A, ANDREASSON J, ZHIVOTOVSKY B, KARPMAN D, ORRENIUS S, AND SVANBORG C. Multimeric alpha-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei. Exp Cell Res 246: 451-460, 1999.
69. HARADA S, SMITH RM, HU DQ, AND JARETT L. Dexamethasone inhibits insulin binding to insulin-degrading enzyme and cytosolic insulin-binding protein p82. Biochem Biophys Res Commun 218: 154-158, 1996.
70. HE J AND FURMANSKI P. Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA. Nature 373: 721-724, 1995.
71. HEMMI S, BOHNI R, STARK G, DI MARCO F, AND AGUET M. A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell 76:803-810, 1994.
72. HOLT SJ, ALEXANDER P, INMAN CB, AND DAVIES DE. Ligand-induced translocation of epidermal growth factor receptor to the nucleus of NR6/HER fibroblasts is serum dependent. Exp Cell Res 217: 554-558, 1995.
73. HUG H AND SARRE TF. Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291: 329-343, 1993.
74. HUGHES EA, HAMMOND C, AND CRESSWELL P. Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome. Proc Natl Acad Sci USA 94: 1896-1901, 1997.
75. HYNDS PJ, ROBINSON D, AND ROBINSON C. The sec-independent twin-arginine translocation system can transport both tightly folded and malfolded proteins across the thylakoid membrane. J Biol Chem 273: 34868-34874, 1998.
76. IMAMURA T, ENGLEKA K, ZHAN X, TOKITA Y, FOROUGH R, ROEDER D, JACKSON A, MAIER JA, HLA T, AND MACIAG T. Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science 249: 1567-1570, 1990.
77. IMAMURA T, OKA S, TANAHASHI T, AND OKITA Y. Cell cycle-dependent nuclear localization of exogenously added fibroblast growth factor-1 in BALB/c 3T3 and human vascular endothelial cells. Exp Cell Res 215: 363-372, 1994.
78. IMAMURA T, TOKITA Y, AND MITSUI Y. Identification of a heparin-binding growth factor-1 nuclear translocation sequence by deletion mutation analysis. J Biol Chem 267: 5676-5679, 1992.
79. JACKSON A, FRIEDMAN S, ZHAN X, ENGLEKA KA, FOROUGH R, AND MACIAG T. Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells. Proc Natl Acad Sci USA 89: 10691-10695, 1992.
80. JACKSON A, TARANTINI F, GAMBLE S, FRIEDMAN S, AND MACIAG T. The release of fibroblast growth factor-1 from NIH 3T3 cells in response to temperature involves the function of cysteine residues. J Biol Chem 270: 33-36, 1995.
81. JANS DA. Nuclear signaling pathways for polypeptide ligands and their membrane receptors? FASEB J 8: 841-847, 1994.
82. JANS DA AND HASSAN G. Nuclear targeting by growth factors, cytokines, and their receptors: a role in signaling? Bioessays 20: 400-411, 1998.
83. JO D, NASHABI A, DOXSEE C, LIN Q, UNUTMAZ D, CHEN J, AND RULEY HE. Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase. Nat Biotechnol 19: 929-933, 2001.
84. JOHNSON AE AND HAIGH NG. The ER translocon and retrotranslocation: is the shift into reverse manual or automatic? Cell 102: 709-712, 2000.
85. JOHNSTON CL, COX HC, GOMM JJ, AND COOMBES RC. Fibroblast growth factor receptors (FGFRs) localize in different cellular compartments: a splice variant of FGFR-3 localizes to the nucleus. J Biol Chem 270: 30643-30650, 1995.
86. JOHNSTON JA, WARD CL, AND KOPITO RR. Aggresomes: a cellular response to misfolded proteins. J Cell Biol 143: 1883-1898, 1998.
87. JOY A, MOFFETT J, NEARY K, MORDECHAI E, STACHOWIAK EK, COONS S, RANKIN-SHAPIRO J, FLORKIEWICZ RZ, AND STACHOWIAK MK. Nuclear accumulation of FGF-2 is associated with proliferation of human astrocytes and glioma cells. Oncogene 14: 171-183, 1997.
88. KIDD S, LIEBER T, AND YOUNG MW. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev 12: 3728-3740, 1998.
89. KIMURA H. Schwannoma-derived growth factor must be transported into the nucleus to exert its mitogenic activity. Proc Natl Acad Sci USA 90: 2165-2169, 1993.
90. KISHIKA Y, YAMAMOTO H, IZUMOTO Y, YOSHIDA K, ENOMOTO H, YAMAMOTO M, KURODA T, ITO H, YOSHIZAKI K, AND NAKAMURA H. Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals. J Biol Chem 277: 10315-10322, 2002.
91. KLEEMANN R, HAUSSER A, GEIGER G, MISCHKE R, BURGER-KENTISCHER A, FLIEGER O, JOHANNES FJ, ROGER T, CALANDRA T, KAPURNIOTU A, GRELL M, FINKELMEIER D, BRUNNER H, AND BERNHAGEN J. Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. Nature 408: 211-216, 2000.
92. KLINGENBERG O AND OLSNES S. Ability of methotrexate to inhibit translocation to the cytosol of dihydrofolate reductase fused to diphtheria toxin. Biochem J 313: 647-653, 1996.
93. KLINGENBERG O, WIȨDŁOCHA A, CITORES L, AND OLSNES S. Requirement of phosphatidylinositol 3-kinase activity for translocation of exogenous aFGF to the cytosol and nucleus. J Biol Chem 275: 11972-11980, 2000.
94. KLINGENBERG O, WIȨDŁOCHA A, AND OLSNES S. Effects of mutations of a phosphorylation site in an exposed loop in acidic fibroblast growth factor. J Biol Chem 274: 18081-18086, 1999.
95. KLINGENBERG O, WIȨDŁOCHA A, RAPAK A, KHNYKIN D, CITORES L, AND OLSNES S. Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus. J Cell Sci 113: 1827-1838, 2000.
96. KLINGENBERG O, WIȨDŁOCHA A, RAPAK A, MUÑOZ R, FALNES PO, AND OLSNES S. Inability of the acidic fibroblast growth factor mutant K132E to stimulate DNA synthesis after translocation into cells. J Biol Chem 273: 11164-11172, 1998.
97. KOEHLER CM, MERCHANT S, AND SCHATZ G. How membrane proteins travel across the mitochondrial intermembrane space. Trends Biochem Sci 24: 428-432, 1999.
98. KOLPAKOVA E, FRENGEN E, STOKKE T, AND OLSNES S. Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein. Biochem J 352: 629-635, 2000.
99. KOLPAKOVA E, WIȨDŁOCHA A, STENMARK H, KLINGENBERG O, FALNES PO, AND OLSNES S. Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor. Biochem J 336: 213-222, 1998.
100. KOMI A, SUZUKI M, AND IMAMURA T. Permeable FGF-1 nuclear localization signal peptide stimulates DNA synthesis in various cell types but is cell-density sensitive and unable to support cell proliferation. Exp Cell Res 243: 408-414, 1998.
101. KOPITO RR. ER quality control: the cytoplasmic connection. Cell 88: 427-430, 1997.
102. LAM MH, BRIGGS LJ, HU W, MARTIN TJ, GILLESPIE MT, AND JANS DA. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. J Biol Chem 274: 7391-7398, 1999.
103. LAMBERT A, SADIR R, BRISSON C, AND MOREL G. In vivo subcellular target compartments of interferon-gamma and interferon-gamma receptor (alpha- and beta-chains) in mouse liver. Cytokine 12: 715-719, 2000.
104. LANDRISCINA M, SOLDI R, BAGALA C, MICUCCI I, BELLUM S, TARANTINI F, PRUDOVSKY I, AND MACIAG T. S100A13 participates in the release of fibroblast growth factor 1 in response to heat shock in vitro. J Biol Chem 276: 22544-22552, 2001.
105. LAVALLEE TM, TARANTINI F, GAMBLE S, CARREIRA CM, JACKSON A, AND MACIAG T. Synaptotagmin-1 is required for fibroblast growth factor-1 release. J Biol Chem 273: 22217-22223, 1998.
106. LEPPLA SA. The bifactorial Bacillus anthracis lethal and oedema toxins. In: The Comprehensive Sourcebook of Bacterial Protein Toxins (2nd ed.), edited by Alouf JE and Freer JH. London: Academic, 1999, p. 243-263.
107. LEPPLA SH. Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci USA 79: 3162-3166, 1982.
108. LEWIS JA, HUQ A, LIU W, AND JACOB A. Induction of gene expression by intracellular interferon-gamma: abrogation of the species specificity barrier. Virology 212: 438-450, 1995.
109. LI R, RIORDAN JF, AND HU G. Nuclear translocation of human angiogenin in cultured human umbilical artery endothelial cells is microtubule and lysosome independent. Biochem Biophys Res Commun 238: 305-312, 1997.
110. LI W AND KELLER G. VEGF nuclear accumulation correlates with phenotypical changes in endothelial cells. J Cell Sci 113: 1525-1534, 2000.
111. LI W, PARK JW, NUIJENS A, SLIWKOWSKI MX, AND KELLER GA. Heregulin is rapidly translocated to the nucleus and its transport is correlated with c-myc induction in breast cancer cells. Oncogene 12: 2473-2477, 1996.
112. LIN SY, MAKINO K, XIA W, MATIN A, WEN Y, KWONG KY, BOURGUIGNON L, AND HUNG MC. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3: 802-808, 2001.
113. LIU Y, JONES M, HINGTGEN CM, BU G, LARIBEE N, TANZI RE, MOIR RD, NATH A, AND HE JJ. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med 6: 1380-1387, 2000.
114. LOBIE PE, MERTANI H, MOREL G, MORALES-BUSTOS O, NORSTEDT G, AND WATERS MJ. Receptor-mediated nuclear translocation of growth hormone. J Biol Chem 269: 21330-21339, 1994.
115. LOBIE PE, WOOD TJ, CHEN CM, WATERS MJ, AND NORSTEDT G. Nuclear translocation and anchorage of the growth hormone receptor. J Biol Chem 269: 31735-31746, 1994.
116. Lu C AND KERBEL RS. Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression. J Cell Biol 120: 1281-1288, 1993.
117. LUNDBERG M AND JOHANSSON M. Is VP22 nuclear homing an artifact? Nat Biotechnol 19: 713-714, 2001.
118. LUNDELL D, LUNN C, DALCARNO D, FOSSETTA J, GREENBERG R, REIM R, GRACE M, AND NARULA S. The carboxyl-terminal region of human interferon gamma is important for biological activity: mutagenic and NMR analysis. Protein Eng 4: 335-341, 1991.
119. LUTZ RJ, TRUJILLO MA, DENHAM KS, WENGER L, AND SINENSKY M. Nucleoplasmic localization of prelamin A: implications for prenylation-dependent lamin A assembly into the nuclear lamina. Proc Natl Acad Sci USA 89: 3000-3004, 1992.
120. MACDONALD HS, KUSHNARYOV VM, SEDMAK JJ, AND GROSSBERG SE. Transport of gamma-interferon into the cell nucleus may be mediated by nuclear membrane receptors. Biochem Biophys Res Commun 138: 254-260, 1986.
121. MAHER PA. Identification and characterization of a novel, intracellular isoform of fibroblast growth factor receptor-1 (FGFR-1). J Cell Physiol 169: 380-390, 1995.
122. MAHER PA. Nuclear translocation of fibroblast growth factor (FGF) receptors in response to FGF-2. J Cell Biol 134: 529-536, 1996.
123. MAHER PA. Nuclear translocation of fibroblast growth factor (FGF) receptors in response to FGF-2. J Cell Biol 134: 529-536, 1996.
124. MAIER JA, STATUTO M, AND RAGNOTTI G. Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells. Mol Cell Biol 14: 1845-1851, 1994.
125. MAIZEL A, BENSAUDE O, PROCHIANTZ A, AND JOLIOT A. A short region of its homeodomain is necessary for engrailed nuclear export and secretion. Development 126: 3183-3190, 1999.
126. MALECKI J, WIȨDŁOCHA A, WESCHE J, AND OLSNES S. Vesicle transmembrane potential is required for translocation to cytosol of externally added FGF-1. EMBO J 21: 4480-4490, 2002.
127. MANN DA AND FRANKEL AD. Endocytosis and targeting of exogenous HIV-1 Tat protein. EMBO J 10: 1733-1739, 1991.
128. MARCHESE C, MANCINI P, BELLEUDI F, FELICI A, GRADINI R, SANSOLINI T, FRATI L, AND TORRISI MR. Receptor-mediated endocytosis of keratinocyte growth factor. J Cell Sci 111: 3517-3527, 1998.
129. MARSTERS SA, PENNICA D, BACH E, SCHREIBER RD, AND ASHKENAZI A. Interferon ganuma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain. Proc Natl Acad Sci USA 92: 5401-5405, 1995.
130. MASSFELDER T, DANN P, WU TL, VASAVADA R, HELWIG JJ, AND STEWART AF. Opposing mitogenic and anti-mitogenic actions of parathyroid hormone-related protein in vascular smooth muscle cells: a critical role for nuclear targeting. Proc Natl Acad Sci USA 94: 13630-13635, 1997.
131. MATLACK KE, MOTHES W, AND RAPOPORT TA. Protein translocation: tunnel vision. Cell 92: 381-390, 1998.
132. MEEROVITCH K, WING S, AND GOLTZMAN D. Proparathyroid hormone-related protein is associated with the chaperone protein BiP and undergoes proteasome-mediated degradation. J Biol Chem 273: 21025-21030, 1998.
133. MELAN MA AND SLUDER G. Redistribution and differential extraction of soluble proteins in permeabilized cultured cells. Implications for immunofluorescence microscopy. J Cell Sci 101: 731-743, 1992.
134. MELLOR H AND PARKER PJ. The extended protein kinase C superfamily. Biochem J 332: 281-292, 1998.
135. MILANI D, MAZZONI M, BORGATTI P, ZAULI G, CANTLEY L, AND CAPITANI S. Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. J Biol Chem 271: 22961-22964, 1996.
136. MILLER DS. Stimulation of RNA and protein synthesis by intracellular insulin. Science 240: 506-509, 1988.
137. MINDELL JA, SILVERMAN JA, COLLIER RJ, AND FINKELSTEIN A. Structure-function relationships in diphtheria toxin channels. III. Residues which affect the cis pH dependence of channel conductance. J Membr Biol 137: 45-57, 1994.
138. MITOLA S, SOZZANI S, LUINI W, PRIMO L, BORSATTI A, WEICH H, AND BUSSOLINO F. Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1. Blood 90: 1365-1372, 1997.
139. MOENNER M, GANNOUN-ZAKI L, BADET J, AND BARRITAULT D. Internalization and limited processing of basic fibroblast growth factor on Chinese hamster lung fibroblasts. Growth Factors 1: 115-123, 1989.
140. MORINI M, BENELLI R, GIUNCIUGLIO D, CARLONE S, ARENA G, NOONAN DM, AND ALBINI A. Kaposi's sarcoma cells of different etiologic origins respond to HIV-Tat through the Flk-1/KDR (VEGFR-2): relevance in AIDS-KS pathology. Biochem Biophys Res Commun 273: 267-271, 2000.
141. MOROIANU J AND RIORDAN JF. Identification of the nucleolar targeting signal of human angiogenin. Biochem Biophys Res Commun 203: 1765-1772, 1994.
142. MOROIANU J AND RIORDAN JF. Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity. Proc Natl Acad Sci USA 91: 1677-1681, 1994.
143. MULLER M, BRISCOE J, LAXTON C, GUSCHIN D, ZIEMIECKI A, SILVEN-NOINEN O, HARPUR AG, BARBIERI G, WITTHUHN BA, AND SCHINDLER C. The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature 366: 129-135, 1993.
144. MUÑOZ R, KLINGENBERG O, WIȨDŁOCHA A, RAPAK A, FALNES PO, AND OLSNES S. Effect of mutation of cytoplasmic receptor domain and of genistein on transport of acidic fibroblast growth factor into cells. Oncogene 15: 525-536, 1997.
145. NAGAHARA H, VOCERO-AKBANI AM, SNYDER EL, HO A, LATHAM DG, LISSY NA, BECKER-HAPAK M, EZHEVSKY SA, AND DOWDY SF. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 4: 1449-1452, 1998.
146. NAGLICH JG AND EIDELS L. Isolation of diphtheria toxin-sensitive mouse cells from a toxin-resistant population transfected with monkey DNA. Proc Natl Acad Sci USA 87: 7250-7254, 1990.
147. NAKANISHI Y, KIHARA K, MIZUNO K, MASAMUNE Y, YOSHITAKE Y, AND NISHIKAWA K. Direct effect of basic fibroblast growth factor on gene transcription in a cell-free system. Proc Natl Acad Sci USA 89: 5216-5220, 1992.
148. NI CY, MURPHY MP, GOLDE TE, AND CARPENTER G. γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294: 2179-2181, 2001.
149. O'BRIEN AD, TESH VL, DONOHUE-ROLFE A, JACKSON MP, OLSNES S, SANDVIG K, LINDBERG AA, AND KEUSCH GT. Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis. Curr Top Microbiol Immunol 180: 65-94, 1992.
150. OHSUMI T, ICHIMURA T, SUGANO H, OMATA S, ISOBE T, AND KUWANO R. Ribosome-binding protein p34 is a member of the leucine-rich-repeat-protein superfamily. Biochem J 294: 465-472, 1993.
151. OLSNES S, REFSNES K, AND PIHL A. Mechanism of action of the toxic lectins abrin and ricin. Nature 249: 627-631, 1974.
152. OLSNES S, REISBIG R, AND EIKLID K. Subunit structure of Shigella cytotoxin. J Biol Chem 256: 8732-8738, 1981.
153. PAPPENHEIMER AM JR. Diphtheria toxin. Annu Rev Biochem 46: 69-94, 1977.
154. PATRY V, BUGLER B, MARET A, POTIER M, AND PRATS H. Endogenous basic fibroblast growth factor isoforms involved in different intracellular protein complexes. Biochem J 326: 259-264, 1997.
155. PEITZ M, PFANNKUCHE K, RAJEWSKY K, AND EDENHOFER F. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc Natl Acad Sci USA 99: 4489-4494, 2002.
156. PENG H, MOFFETT J, MYERS J, FANG X, STACHOWIAK EK, MAHER P, KRATZ E, HINES J, FLUHARTY SJ, MIZUKOSHI E, BLOOM DC, AND STACHOWIAK MK. Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors. Mol Biol Cell 12: 449-462, 2001.
157. PENG H, MYERS J, FANG X, STACHOWIAK EK, MAHER PA, MARTINS GG, POPESCU G, BEREZNEY R, AND STACHOWIAK MK. Integrative nuclear FGFR1 signaling (INFS) pathway mediates activation of the tyrosine hydroxylase gene by angiotensin II, depolarization and protein kinase C. J Neurochem 81: 506-524, 2002.
158. PERROT-APPLANAT M, GUALILLO O, BUTEAU H, EDERY M, AND KELLY PA. Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation. J Cell Sci 110: 1123-1132, 1997.
159. PHELAN A, ELLIOTT G, AND O'HARE P. Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nat Biotechnol 16: 440-443, 1998.
160. PINTUCCI G, QUARTO N, AND RIFKIN DB. Methylation of high molecular weight fibroblast growth factor-2 determines posttranslational increases in molecular weight and affects its intracellular distribution. Mol Biol Cell 7: 1249-1258, 1996.
161. PIOTROWICZ RS, MARTIN JL, DILLMAN WH, AND LEVIN EG. The 27-kDa heat shock protein facilitates basic fibroblast growth factor release from endothelial cells. J Biol Chem 272: 7042-7047, 1997.
162. PRESTLE J, PFIZENMAIER K, BRENNER J, AND JOHANNES FJ. Protein kinase C mu is located at the Golgi compartment. J Cell Biol 134: 1401-1410, 1996.
163. PROCHIANTZ A. Homeodomain-derived peptides. In and out of the cells. Ann NY Acad Sci 886: 172-179, 1999.
164. PROCHIANTZ A. Messenger proteins: homeoproteins, TAT and others. Curr Opin Cell Biol 12: 400-406, 2000.
165. PROCHIANTZ A AND THEODORE L. Nuclear/growth factors. Bioessays 17: 39-44, 1995.
166. PRUDOVSKY I, SAVION N, ZHAN X, FRIESEL R, Xu J, Hou J, MCKEEHAN WL, AND MACIAG T. Intact and functional fibroblast growth factor (FGF) receptor-1 trafficks near the nucleus in response to FGF-1. J Biol Chem 269: 31720-31724, 1994.
167. PRUDOVSKY IA, SAVION N, LAVALLEE TM, AND MACIAG T. The nuclear trafficking of extracellular fibroblast growth factor (FGF)-1 correlates with the perinuclear association of the FGF receptor-lalpha isoforms but not the FGF receptor-1beta isoforms. J Biol Chem 271: 14198-14205, 1996.
168. RAPAK A, FALNES PO, AND OLSNES S. Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol. Proc Natl Acad Sci USA 94: 3783-3788, 1997.
169. RAPOPORT TA, JUNGNICKEL B, AND KUTAY U. Protein transport across the
170. RAZIUDDIN A, SARKAR FH, DUTKOWSKI R, SHULMAN L, RUDDLE FH, AND GUPTA SL. Receptors for human alpha and beta interferon but not for gamma interferon are specified by human chromosome 21. Proc Natl Acad Sci USA 81: 5504-5508, 1984.
171. REILLY JF AND MAHER PA. Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation. J Cell Biol 152: 1307-1312, 2001.
172. RIESE J, ZELLER R, AND DONO R. Nucleo-cytoplasmic translocation and secretion of fibroblast growth factor-2 during avian gastrulation. Mech Dev 49: 13-22, 1995.
173. ROGHANI M AND MOSCATELLI D. Basic fibroblast growth factor is internalized through both receptor-mediated and heparan sulfate-mediated mechanisms. J Biol Chem 267: 22156-22162, 1992.
174. ROMISCH K. Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane. J Cell Sci 112: 4185-4191, 1999.
175. ROTH M, NAUCK M, TAMM M, PERRUCHOUD AP, ZIESCHE R, AND BLOCK LH. Intracellular interleukin 6 mediates platelet-derived growth factor-induced proliferation of nontransformed cells. Proc Natl Acad Sci USA 92: 1312-1316, 1995.
176. RYCYZYN MA, REILLY SC, O'MALLEY K, AND CLEVENGER CV. Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation. Mol Endocrinol 14: 1175-1186, 2000.
177. SADIR R, LORTAT-JACOB H, AND MOREL G. Internalization and nuclear translocation of IFN-gamma and IFN-gammaR: an ultrastructural approach. Cytokine 12: 711-714, 2000.
178. SANCEAU J, SONDERMEYER P, BERANGER F, FALCOFF R, AND VAQUERO C. Intracellular human gamma-interferon triggers an antiviral state in transformed murine L cells. Proc Natl Acad Sci USA 84:2906-2910, 1987.
179. SANDVIG K, GARRED O, PRYDZ K, KOZLOV JV, HANSEN SH, AND VAN DEURS B. Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum. Nature 358: 510-512, 1992.
180. SANDVIG K AND OLSNES S. Diphtheria toxin entry into cells is facilitated by low pH. J Cell Biol 87: 828-832, 1980.
181. SANDVIG K AND OLSNES S. Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and effects of low pH on the toxin molecule. J Biol Chem 256: 9068-9076, 1981.
182. SANO H, FOROUGH R, MAIER JA, CASE JP, JACKSON A, ENGLEKA K, MACIAG T, AND WILDER RL. Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints. J Cell Biol 110: 1417-1426, 1990.
183. SCHABER MD, O'HARA MB, GARSKY VM, MOSSER SC, BERGSTROM JD, MOORES SL, MARSHALL MS, FRIEDMAN PA, DIXON RA, AND GIBBS JB. Polyisoprenylation of ras in vitro by a farnesyl-protein transferase. J Biol Chem 265: 14701-14704, 1990.
184. SCHEDLICH LJ, LE PAGE SL, FIRTH SM, BRIGGS LJ, JANS DA, AND BAXTER RC. Nuclear import of insulin-like growth factor-binding protein-3 and -5 is mediated by the importin beta subunit. J Biol Chem 275: 23462-23470, 2000.
185. SCHWARZE SR, HO A, VOCERO-AKBANI A, AND DOWDY SF. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science 285: 1569-1572, 1999.
186. SHERMAN L, STOCKER KM, MORRISON R, AND CIMENT G. Basic fibroblast growth factor (bFGF) acts intracellularly to cause the transdifferentiation of avian neural crest-derived Schwann cell precursors into melanocytes. Development 118: 1313-1326, 1993.
187. SHUAI K, HORVATH CM, HUANG LH, QURESHI SA, COWBURN D, AND DARNELL JE JR. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76: 821-828, 1994.
188. SILVERMAN JA, MINDELL JA, ZHAN H, FINKELSTEIN A, AND COLLIER RJ. Structure-function relationships in diphtheria toxin channels. I. Determining a minimal channel-forming domain. J MembrBiol 137: 17-28, 1994.
189. SINENSKY M, FANTLE K, TRUJILLO M, MCLAIN T, KUPFER A, AND DALTON M. The processing pathway of prelamin A. J Cell Sci 107: 61-67, 1994.
190. SKARPEN E, JOHANNESSEN LE, BJERK K, FASTENG H, GUREN TK, LINDEMAN B, THORESEN GH, CHRISTOFFERSEN T, STANG E, HUITFELDT HS, AND MADSHUS IH. Endocytosed epidermal growth factor (EGF) receptors contribute to the EGF-mediated growth arrest in A431 cells by inducing a sustained increase in p21/CIP1. Exp Cell Res 243: 161-172, 1998.
191. SKJERPEN CS, NILSEN T, WESCHE J, AND OLSNES S. Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity. EMBO J. In press.
192. SKJERPEN CS, WESCHE J, AND OLSNES S. Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor. J Biol Chem 277: 23864-23871, 2002.
193. SLODOWSKI BOHM J, SCHONE B, AND OTTO B. Carboxy-terminal truncated rhuIFN-gamma with a substitution of Gln133 or Ser132 to leucine leads to higher biological activity than in the wild type. Eur J Biochem 202: 1133-1140, 1991.
194. SMITH MD AND SCHNELL DJ. Peroxisomal protein import. The paradigm shifts. Cell 105: 293-296, 2001.
195. SMITH MR, MUEGGE K, KELLER JR, KUNG HF, YOUNG HA, AND DURUM SK. Direct evidence for an intracellular role for IFN-gamma. Microinjection of human IFN-gamma induces Ia expression on murine macrophages. J Immunol 144: 1777-1782, 1990.
196. SOH J, DONNELLY RJ, KOTENKO S, MARIANO TM, COOK JR, WANG N, EMANUEL S, SCHWARTZ B, MIKI T, AND PESTKA S. Identification and sequence of an accessory factor required for activation of the human interferon gamma receptor. Cell 76: 793-802, 1994.
197. SOROKIN A, MOHAMMADI M, HUANG J, AND SCHLESSINGER J. Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766. J Biol Chem 269: 17056-17061, 1994.
198. SRINIVASAN R, GILLETT CE, BARNES DM, AND GULLICK WJ. Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Res 60: 1483-1487, 2000.
199. STACHOWIAK EK, MAHER PA, TUCHOLSKI J, MORDECHAI E, JOY A, MOFFETT J, COONS S, AND STACHOIVLAK MK. Nuclear accumulation of fibroblast growth factor receptors in human glial cells: association with cell proliferation. Oncogene 14: 2201-2211, 1997.
200. STACHOWIAK MK, MAHER PA, JOY A, MORDECHAI E, AND STACHOWIAK EK. Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells. Mol Biol Cell 7: 1299-1317, 1996.
201. STACHOWIAK MK, MAHER PA, JOY A, MORDECHAI E, AND STACHOWIAK EK. Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor action. Mol Brain Res 38: 161-165, 1996.
202. STACHOWIAK MK, MOFFET J, MAHER P, TUCHOLSKI J, AND STACHOWIAK EK. Growth factor regulation of cell growth and proliferation in the nervous system. A new intracrine nuclear mechanism. Mol Neurobiol 15: 257-283, 1997.
203. STEVENSON FT, TURCK J, LOCKSLEY RM, AND LOVETT DH. The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein. Proc Natl Acad Sci USA 94: 508-513, 1997.
204. SUBRAMANIAM PS, LARKIN J, MUJTABA MG III, WALTER MR, AND JOHNSON HM. The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site. J Cell Sci 113: 2771-2781, 2000.
205. SUBRAMANIAM PS, MUJTABA MG, PADDY MR, AND JOHNSON HM. The carboxyl terminus of interferon-gamma contains a functional polybasic nuclear localization sequence. J Biol Chem 274: 403-407, 1999.
206. SZENTE BE AND JOHNSON HM. Binding of IFN gamma and its C-terminal peptide to a cytoplasmic domain of its receptor that is essential for function. Biochem Biophys Res Commun 201: 215-221, 1994.
207. SZENTE BE, SOOS JM, AND JOHNSON HW. The C-terminus of IFN gamma is sufficient for intracellular function. Biochem Biophys Res Commun 203: 1645-1654, 1994.
208. TARANTINI F, GAMBLE S, JACKSON A, AND MACIAG T. The cysteine residue responsible for the release of fibroblast growth factor-1 residues in a domain independent of the domain for phosphatidylserine binding. J Biol Chem 270: 29039-29042, 1995.
209. TARANTINI F, LAVALLEE T, JACKSON A, GAMBLE S, CARREIRA CM, GARFINKEL S, BURGESS WH, AND MACIAG T. The extravesicular domain of synaptotagmin-1 is released with the latent fibroblast growth factor-1 homodimer in response to heat shock. J Biol Chem 273: 22209-22216, 1998.
210. TARANTINI F, MICUCCI, I, BELLUM S, LANDRISCINA M, GARFINKEL S, PRUDOVSKY I, AND MACIAG T. The precursor but not the mature form of IL-1α blocks the release of FGF1 in response to heat shock. J Biol Chem 276: 5147-5151, 2001.
211. TYAGI M, RUSNATI M, PRESTA M, AND GIACCA M. Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. J Biol Chem 276: 3254-3261, 2001.
212. UNGERMANN C, NEUPERT W, AND CYR DM. The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria. Science 266: 1250-1253, 1994.
213. VAN DEURS B, TONNESSEN TI, PETERSEN OW, SANDVIG K, AND OLSNES S. Routing of internalized ricin and ricin conjugates to the Golgi complex. J Cell Biol 102: 37-47, 1986.
214. VIGNERI R, GOLDFINE ID, WONG KY, SMITH GJ, AND PEZZINO V. The nuclear envelope. The major site of insulin binding in rat liver nuclei. J Biol Chem 253: 2098-2103, 1978.
215. VITALE G, PELLIZZARI R, RECCHI C, NAPOLITANI G, MOCK M, AND MONTECUCCO C. Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages. Biochem Biophys Res Commun 248: 706-711, 1998.
216. VIVES E, BRODIN P, AND LEBLEU B. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J Biol Chem 272: 16010-16017, 1997.
217. VOGEL BE, LEE SJ, HILDEBRAND A, CRAIG W, PIERSCHBACHER MD, WONG-STAAL F, AND RUOSLAHTI E. A novel integrin specificity exemplified by binding of the alpha v beta 5 integrin to the basic domain of the HIV Tat protein and vitronectin. J Cell Biol 121: 461-468, 1993.
218. WAHAB NA, BRINKMAN H, AND MASON RM. Uptake and intracellular transport of the connective tissue growth factor: a potential mode of action. Biochem J 359: 89-97, 2001.
219. WATLING D, GUSCHIN D, MULLER M, SILVENNOINEN O, WITTHUHN BA, QUELLE FW, ROGERS NC, SCHINDLER C, STARK GR, AND IHLE JN. Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature 366: 166-170, 1993.
220. WEEKS BS, DESAI K, LOEWENSTEIN PM, KLOTMAN ME, KLOTMAN PE, GREEN M, AND KLEINMAN HK. Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein. J Biol Chem 268: 5279-5284, 1993.
221. WEITZMANN MN AND SAVAGE N. Nuclear internalisation and DNA binding activities of interleukin-1, interleukin-1 receptor and interleukin-1/receptor complexes. Biochem Biophys Res Commun 187: 1166-1171, 1992.
222. WERNER ED, BRODSKY JL, AND MCCRACKEN AA. Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate. Proc Natl Acad Sci USA 93: 13797-13801, 1996.
223. WESCHE J, ELLIOT JL, FALNES PO, OLSNES S, AND COLLIER RJ. Characterization of membrane translocation by anthrax protective antigen. Biochemistry 45: 15737-15746, 1998.
224. WESCHE J, RAPAK A, AND OLSNES S. Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol. J Biol Chem 274: 34443-34449, 1999.
225. WESCHE J, WIȨDŁOCHA A, FALNES PO, CHOE S, AND OLSNES S. Externally added aFGF mutants do not require extensive unfolding for transport to the cytosol and the nucleus in NIH/3T3 cells. Biochemistry 39: 15091-15100, 2000.
226. WETMORE C, CAO YH, PETTERSSON RF, AND OLSON L. Brain-derived neurotrophic factor: subcellular compartmentalization and interneuronal transfer as visualized with anti-peptide antibodies. Proc Natl Acad Sci USA 88: 9843-9847, 1991.
227. WETZEL R, PERRY LJ, VEILLEUX C, AND CHANG G. Mutational analysis of the C-terminus of human interferon-gamma. Protein Eng 3: 611-623, 1990.
228. WIȨDŁOCHA A, FALNES P, MADSHUS IH, SANDVIG K, AND OLSNES S. Dual mode of signal transduction by externally added acidic fibroblast growth factor. Cell 76: 1039-1051, 1994.
229. WIȨDŁOCHA A, FALNES PO, RAPAK A, KLINGENBERG O, MUÑOZ R, AND OLSNES S. Translocation to cytosol of exogenous, C AAX-tagged acidic fibroblast growth factor. J Biol Chem 270: 30680-30685, 1995.
230. WIȨDŁOCHA A, FALNES PO, RAPAK A, MUÑOZ R, KLINGENBER O, AND OLSNES S. Stimulation of proliferation of a human osteosarcoma cell line by exogenous acidic fibroblast growth factor requires both activation of receptor tyrosine kinase and growth factor internalization. Mol Cell Biol 16: 270-280, 1996.
231. WIȨDŁOCHA A, MADSHUS IH, MACH H, MIDDAUGH CR, AND OLSNES S. Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector. EMBO J 11: 4835-4842, 1992.
232. WIERTZ EJ, JONES TR, SUN L, BOGYO M, GEUZE HJ, AND PLOEGH HL. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell 84: 769-779, 1996.
233. XIE Y AND HUNG MC. Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation. Biochem Biophys Res Commun 203: 1589-1598, 1994.
234. XIONG X, CHONG E, AND SKACH WR. Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the ER membrane. J Biol Chem 274: 2616-2624, 1999.
235. YU A AND MALEK TR. The proteasome regulates receptor-mediated endocytosis of interleukin-2. J Biol Chem 276: 381-385, 2001.
236. YU ZX, BIRO S, FU YM, SANCHEZ J, SMALE G, SASSE J, FERRANS VJ, AND CASSCELLS W. Localization of basic fibroblast growth factor in bovine endothelial cells: immunohistochemical and biochemical studies. Exp Cell Res 204: 247-259, 1993.
237. ZHANG Y, KORNFELD H, CRUIKSHANK WW, KIM S, REARDON CC, AND CENTER DM. Nuclear translocation of the N-terminal prodomain of interleukin-16. J Biol Chem 276: 1299-1303, 2001.