Design, characterization, and structure of a biologically active single-chain mutant of human IFN-γ

Journal of Molecular Biology

Volumn 299, Issue 1, 2000, Pages 169-179

  Landar, Aimee ^a,b   Curry, Brandi ^a,b   Parker, Matthew H ^a   DiGiacomo, Ruth ^c   Indelicato, Stephen R ^c   Nagabhushan, T L ^c   Rizzi, Giovanni ^c   Walter, Mark R ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Crystal structure; Cytokine receptor; Interferon; Protein engineering; Signal transduction

Indexed keywords

AMINO ACID; ASPARTIC ACID; CITRIC ACID; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; HISTIDINE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MUTANT PROTEIN;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ANTIGEN EXPRESSION; ANTIVIRAL ACTIVITY; ARTICLE; CALORIMETRY; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ELECTRICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; TITRIMETRY;

EID: 0034716932     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3734     Document Type: Article

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