Trafficking and signaling pathways of nuclear localizing protein ligands and their receptors

BioEssays

Volumn 26, Issue 9, 2004, Pages 993-1004

  Johnson, Howard M ^a   Subramaniam, Prem S ^a   Olsnes, Sjur ^b   Jans, David A ^c  

^a UNIVERSITY OF FLORIDA   (United States)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; GAMMA INTERFERON; LIGAND; STAT1 PROTEIN; TRANSCRIPTION FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON RECEPTOR; GROWTH HORMONE; INTERFERON RECEPTOR; PROLACTIN;

CELL FUNCTION; CYTOSOL; ENZYME INDUCTION; GENE ACTIVATION; INTERNALIZATION; MEDIATOR RELEASE; MOLECULAR INTERACTION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PARACRINE SIGNALING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; REVIEW; SECOND MESSENGER; ACTIVE TRANSPORT; ANIMAL; CELL NUCLEUS; DIMERIZATION; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; DIMERIZATION; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION; GROWTH HORMONE; HUMANS; INTERFERON TYPE II; LIGANDS; PROLACTIN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION;

EID: 4644247974     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.20086     Document Type: Review

References (76)

1. Jans DA, Xiao CY, Lam MH. 2000. Nuclear targeting signal recognition: a key control point in nuclear transport? Bioessays 22:532-544.
2. Jans DA, Forwood JK. 2002. Nuclear protein import: distinct intracellular import receptors for different types of import substrates. In: Citovsky V, Tzvi T, editor. Nuclear import and export. Austin, TX: RG Landes Bioscience Publishers, p 83-109.
3. Stewart M, Baker RP, Bayliss R, Clayton L, Grant RP, et al. 2001. Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import. FEBS Lett 498:145-149.
4. Jans DA, Hassan G. 1998. Nuclear targeting by growth factors, cytokines, and their receptors: a role in signaling? Bioessays 20:400-411.
5. Rakowicz-Szulczynska EM, Rodeck U, Herlyn M, Koprowski H. 1986. Chromatin binding of epidermal growth factor, nerve growth factor, and platelet-derived growth factor in cells bearing the appropriate surface receptors. Proc Natl Acad Sci USA 83:3728-3732.
6. Cao H, Lei ZM, Bian L, Rao CV. 1995. Functional nuclear epidermal growth factor receptors in human choriocarcinoma JEG-3 cells and normal human placenta. Endocrinology 136:3163-3172.
7. Marti U, Wells A. 2000. The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR. Mol Cell Biol Res Commun 3:8-14.
8. Rakowicz-Szulczynska EM, Otwiaska D, Rodeck U, Koprowski H. 1989. Epidermal growth factor (EGF) and monoclonal antibody to cell surface EGF receptor bind to the same chromatin receptor. Arch Biochem Biophys 268:456-464.
9. Marti U, Burwen SJ, Wells A, Barker ME, Huling S, et al. 1991. Localization of epidermal growth factor receptor in hepatocyte nuclei. Hepatology 13:15-20.
10. Holt SJ, Alexander P, Inman CB, Davies DE. 1994. Epidermal growth factor induced tyrosine phosphorylation of nuclear proteins associated with translocation of epidermal growth factor receptor into the nucleus. Biochem Pharmacol 47:117-126.
11. Lin SY, Makino K, Xia W, Matin A, Wen Y, et al. 2001. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3:802-808.
12. Oksvold M, Huitfeldt H, Stang E, Madshus I. 2002. Localizing the EGF receptor. Nat Cell Biol 4:E22-E23.
13. Cohen BD, Siegall CB, Bacus S, Foy L, Green JM, et al. 1998. Role of epidermal growth factor receptor family members in growth and differentiation of breast carcinoma. Biochem Soc Symp 63:199-210.
14. Harris RC, Chung E, Coffey RJ. 2003. EGF receptor ligands. Exp Cell Res 284:2-13.
15. Schausberger E, Eferl R, Parzefall W, Chabicovsky M, Breit P, et al. 2003. Induction of DNA synthesis in primary mouse hepatocytes is associated with nuclear pro-transforming growth factor alpha and erbb-1 and is independent of c-jun. Carcinogenesis 24:835-841.
16. Wells A, Marti U. 2002. Signalling shortcuts: cell-surface receptors in the nucleus? Nat Rev Mol Cell Biol 3:697-702.
17. MacDonald HS, Kushnaryov VM, Sedmak JJ, Grossberg SE. 1986. Transport of gamma-interferon into the cell nucleus may be mediated by nuclear membrane receptors. Biochem Biophys Res Commun 138:254-260.
18. Bader T, Weitzerbin J. 1994. Nuclear accumulation of interferon gamma. Proc Natl Acad Sci USA 91:11831-11835.
19. Subramaniam PS, Mujtaba MG, Paddy MR, Johnson HM. 1999. The carboxyl terminus of interferon-gamma contains a functional polybasic nuclear localization sequence. J Biol Chem 274:403-407.
20. Subramaniam PS, Torres BA, Johnson HM. 2001. So many ligands, so few transcription factors: a new paradigm for signaling through the STAT transcription factors. Cytokine 15:175-187.
21. Subramaniam PS, Green MM, Larkin J III, Torres BA, Johnson HM. 2001. Nuclear translocation of IFN-gamma is an intrinsic requirement for its biologic activity and can be driven by a heterologous nuclear localization sequence. J Interferon Cytokine Res 21:951-959.
22. Subramaniam PS, Larkin J III, Mujtaba MG, Walter MR, Johnson HM. 2000. The COOH-terminal nuclear localization sequence of interferon gamma regulates STAT1 alpha nuclear translocation at an intracellular site. J Cell Sci 113:2771-2781.
23. Larkin J III, Johnson HM, Subramaniam PS. 2000. Differential nuclear localization of the IFNGR-1 and IFNGR-2 subunits of the IFN-gamma receptor complex following activation by IFN-gamma. J Interferon Cytokine Res 20:565-576.
24. Subramaniam PS, Johnson HM. 2002. Lipid microdomains are required sites for the selective endocytosis and nuclear translocation of IFN-gamma, its receptor chain IFN-gamma receptor-1, and the phosphorylation and nuclear translocation of STAT1alpha. J Immunol 169:1959-1969.
25. Szente BE, Subramaniam PS, Johnson HM. 1995. Identification of IFN-gamma receptor binding sites for JAK2 and enhancement of binding by IFN-gamma and its C-terminal peptide IFN-gamma(95-133). J Immunol 155:5617-5622.
26. Ahmed CM, Burkhart MA, Mujtaba MG, Subramaniam PS, Johnson HM. 2003. The role of IFNgamma nuclear localization sequence in intracellular function. J Cell Sci 116:3089-3098.
27. Muthukumaran G, Donnelly RJ, Ebensperger C, Mariano TM, Garotta G, et al. 1996. The intracellular domain of the second chain of the interferon-gamma receptor is interchangeable between species. J Interferon Cytokine Res 16:1039-1045.
28. Sekimoto T, Imamoto N, Nakajima K, Hirano T, Yoneda Y. 1997. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1. EMBO J 16:7067-7077.
29. Brivanlou AH, Darnell JE Jr. 2002. Signal transduction and the control of gene expression. Science 295:813-818.
30. McBride KM, Banninger G, McDonald C, Reich NC. 2002. Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J 21:1754-1763.
31. Meyer T, Begitt A, Lodige I, van Rossum M, Vinkemeier U. 2002. Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways. EMBO J 21:344-354.
32. Melen K, Kinnunen L, Julkunen I. 2001. Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs. J Biol Chem 276:16447-16455.
33. Fagerlund R, Melen K, Kinnunen L, Julkunen I. 2002. Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5. J Biol Chem 277:30072-30078.
34. Melen K, Fagerlund R, Franke J, Kohler M, Kinnunen L, et al. 2003. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. J Biol Chem 278:28193-28200.
35. Begitt A, Meyer T, van Rossum M, Vinkemeier U. 2000. Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain. Proc Natl Acad Sci USA 97:10418-10423.
36. McBride KM, McDonald C, Reich NC. 2000. Nuclear export signal located within the DNA-binding domain of the STAT1 transcription factor. EMBO J 19:6196-6206.
37. Vinkemeier U, Cohen SL, Moarefi I, Chait BT, Kuriyan J, et al. 1996. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites. EMBO J 15:5616-5626.
38. Mason DA, Fleming RJ, Goldfarb DS. 2002. Drosophila melanogaster importin alpha1 and alpha3 can replace importin alpha2 during spermatogenesis but not oogenesis. Genetics 161:157-170.
39. Kobe B. 1999. Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha. Nat Struct Biol 6:388-397.
40. Conti E, Uy M, Leighton L, Blobel G, Kuriyan J. 1998. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha. Cell 94:193-204.
41. Fontes MR, Teh T, Jans D, Brinkworth RI, Kobe B. 2003. Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha. J Biol Chem 278:27981-27987.
42. Catimel B, Teh T, Fontes MR, Jennings IG, Jans DA, et al. 2001. Biophysical characterization of interactions involving importin-alpha during nuclear import. J Biol Chem 276:34189-34198.
43. Harreman MT, Model MR, Fanara P, Model AE, Corbett AH. 2003. The auto-inhibitory function of importin alpha is essential in vivo. J Biol Chem 278:5854-5863.
44. Gilchrist D, Rexach M. 2003. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278:51937-51949.
45. Sekimoto T, Nakajima K, Tachibana T, Hirano T, Yoneda Y. 1996. Interferon-gamma-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4. J Biol Chem 271:31017-31020.
46. Mauecki J, Wesche J, Skjerpen CS, Wiedlocha A, Olsnes S. 2003. Translocation of FGF-1 and FGF-2 across vesicular membranes occurs during G1-phase by a common mechanism. Mol Biol Cell 15:801-814.
47. Pintucci G, Quarto N, Rifkin DB. 1996. Methylation of high molecular weight fibroblast growth factor-2 determines post-translational increases in molecular weight and affects its intracellular distribution. Mol Biol Cell 7:1249-1258.
48. Olsnes S, Klingenberg O, Wiedlocha A. 2003. Transport of exogenous growth factors and cytokines to the cytosol and to the nucleus. Physiol Rev 83:163-182.
49. Bouche G, Gas N, Prats H, Baldin V, Tauber JP, et al. 1987. Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0-G1 transition. Proc Natl Acad Sci USA 84:6770-6774.
50. Baldin V, Roman AM, Bosc-Bierne I, Amalric F, Bouche G. 1990. Translocation of bFGF to the nucleus is G1 phase cell cycle specific in bovine aortic endothelial cells. EMBO J 9:1511-1517.
51. Imamura T, Engleka K, Zhan X, Tokita Y, Forough R, et al. 1990. Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science 249:1567-1570.
52. Imamura T, Oka S, Tanahashi T, Okita Y. 1994. Cell cycle-dependent nuclear localization of exogenously added fibroblast growth factor-1 in BALB/c 3T3 and human vascular endothelial cells. Exp Cell Res 215:363-372.
53. Sano H, Forough R, Maier JA, Case JP, Jackson A, et al. 1990. Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints. J Cell Biol 110:1417-1426.
54. Cao Y, Ekstrom M, Pettersson RF. 1993. Characterization of the nuclear translocation of acidic fibroblast growth factor. J Cell Sci 104:77-87.
55. Burgess WH, Shaheen AM, Ravera M, Jaye M, Donohue PJ, et al. 1990. Possible dissociation of the heparin-binding and mitogenic activities of heparin-binding (acidic fibroblast) growth factor-1 from its receptor-binding activities by site-directed mutagenesis of a single lysine residue. J Cell Biol 111:2129-2138.
56. Wiedlocha A, Falnes PO, Madshus IH, Sandvig K, Olsnes S. 1994. Dual mode of signal transduction by externally added acidic fibroblast growth factor. Cell 76:1039-1051.
57. Wiedlocha A, Falnes PO, Rapak A, Klingenberg O, Munoz R, et al. 1995. Translocation of cytosol of exogenous, CAAX-tagged acidic fibroblast growth factor. J Biol Chem 270:30680-30685.
58. Munoz R, Klingenberg O, Wiedlocha A, Rapak A, Falnes PO, et al. 1997. Effect of mutation of cytoplasmic receptor domain and of genistein on transport of acidic fibroblast growth factor into cells. Oncogene 15:525-536.
59. Klingenberg O, Wiedlocha A, Rapak A, Khnykin D, Citores L, et al. 2000. Requirement for C-terminal end of fibroblast growth factor receptor 4 in translocation of acidic fibroblast growth factor to cytosol and nucleus. J Cell Sci 113:1827-1838.
60. Malecki J, Wiedlocha A, Wesche J, Olsnes S. 2002. Vesicle transmembrane potential is required for translocation to the cytosol of externally added FGF-1. EMBO J 21:4480-4490.
61. Wesche J, Wiedlocha A, Falnes PO, Choe S, Olsnes S. 2000. Externally added aFGF mutants do not require extensive unfolding for transport to the cytosol and the nucleus in NIH/3T3 cells. Biochemistry 39:15091-15100.
62. Reilly JF, Maher PA. 2001. Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation. J Cell Biol 152:1307-1312.
63. Kidd S, Lieber T, Young MW. 1998. Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos. Genes Dev 12:3728-3740.
64. Wesche J, Rapak A, Olsnes S. 1999. Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol. J Biol Chem 274:34443-34449.
65. Clevenger CV, Altmann SW, Prystowsky MB. 1991. Requirement of nuclear prolactin for interleukin-2-stimulated proliferation of T lymphocytes. Science 253:77-79.
66. Clevenger CV, Sillman AL, Prystowsky MB. 1990. Interleukin-2 driven nuclear translocation of prolactin in cloned T-lymphocytes. Endocrinology 127:3151-3159.
67. Rycyzyn MA, Reilly SC, O'Malley K, Clevenger CV. 2000. Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation. Mol Endocrinol 14:1175-1186.
68. Bukrinsky MI. 2002. Cyclophilins: unexpected messengers in intercellular communications. Trends Immunol 23:323-325.
69. Romisch K. 1999. Surfing the Sec61 channel: bidirectional protein translocation across the ER membrane. J Cell Sci 112:4185-4191.
70. Rycyzyn MA, Clevenger CV. 2002. The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer. Proc Natl Acad Sci USA 99:6790-6795.
71. Zhu T, Goh EL, Graichen R, Ling L, Lobie PE. 2001. Signal transduction via the growth hormone receptor. Cell Signal 13:599-616.
72. Baumann G. 2002. Growth hormone binding protein. The soluble growth hormone receptor. Minerva Endocrinol 27:265-276.
73. Mertani HC, Waters MJ, Morel G. 1996. Cellular trafficking of exogenous growth hormone in dwarf rat pituitary. Neuroendocrinology 63:257-268.
74. Lobie PE, Wood TJ, Chen CM, Waters MJ, Norstedt G. 1994. Nuclear translocation and anchorage of the growth hormone receptor. J Biol Chem 269:31735-31746.
75. Lobie PE, Barnard R, Waters MJ. 1991. The nuclear growth hormone receptor binding protein. Antigenic and physicochemical characterization. J Biol Chem 266:22645-22652.
76. Graichen R, Sandstedt J, Goh EL, Isaksson OG, Tornell J, et al. 2003. The growth hormone-binding protein is a location-dependent cytokine receptor transcriptional enhancer. J Biol Chem 278:6346-6354.