Selective expression of nonsecreted interferon by an adenoviral vector confers antiproliferative and antiviral properties and causes reduction of tumor growth in nude mice

Journal of Interferon and Cytokine Research

Volumn 21, Issue 6, 2001, Pages 399-408

  Ahmed, C M I ^a,b   Wills, K N ^a   Sugarman, B J ^a   Johnson, D E ^a   Ramachandra, M ^a   Nagabhushan, T L ^a   Howe, J A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; ALPHA2ALPHA1 INTERFERON; HYBRID PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEIN KINASE; PROTEIN KINASE R; RECOMBINANT ALPHA2B INTERFERON; RETINOBLASTOMA PROTEIN; STAT1 PROTEIN; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOKINE RESPONSIVE ELEMENT; DRUG MECHANISM; FEMALE; GENE ACTIVATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; VIRUS INFECTION; VIRUS RECOMBINANT; VIRUS RESISTANCE;

ADENOVIRIDAE; ALPHA-FETOPROTEINS; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL DIVISION; CELL LINE; DNA PRIMERS; ENCEPHALOMYOCARDITIS VIRUS; FEMALE; GENE EXPRESSION; GENETIC VECTORS; HUMANS; INTERFERON ALFA-2B; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0034921078     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999001750277871     Document Type: Article

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