메뉴 건너뛰기




Volumn 3, Issue 1, 2013, Pages

Paradoxical roles of autophagy in different stages of tumorigenesis: Protector for normal or cancer cells

Author keywords

Autophagy; Early tumorigenesis; Metastasis; Protector; Tumor progression

Indexed keywords


EID: 84883525753     PISSN: None     EISSN: 20453701     Source Type: Journal    
DOI: 10.1186/2045-3701-3-35     Document Type: Review
Times cited : (95)

References (73)
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • 10.1016/j.cell.2011.02.013, 21376230
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674. 10.1016/j.cell.2011.02.013, 21376230.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 79957883170 scopus 로고    scopus 로고
    • The multiple roles of autophagy in cancer
    • 10.1093/carcin/bgr031, 3128556, 21317301
    • Rosenfeldt MT, Ryan KM. The multiple roles of autophagy in cancer. Carcinogenesis 2011, 32:955-963. 10.1093/carcin/bgr031, 3128556, 21317301.
    • (2011) Carcinogenesis , vol.32 , pp. 955-963
    • Rosenfeldt, M.T.1    Ryan, K.M.2
  • 4
    • 80053634368 scopus 로고    scopus 로고
    • The dynamic nature of autophagy in cancer
    • 10.1101/gad.17558811, 3197199, 21979913
    • Kimmelman AC. The dynamic nature of autophagy in cancer. Genes Dev 2011, 25:1999-2010. 10.1101/gad.17558811, 3197199, 21979913.
    • (2011) Genes Dev , vol.25 , pp. 1999-2010
    • Kimmelman, A.C.1
  • 5
    • 36249025723 scopus 로고    scopus 로고
    • Autophagy: process and function
    • 10.1101/gad.1599207, 18006683
    • Mizushima N. Autophagy: process and function. Genes Dev 2007, 21:2861-2873. 10.1101/gad.1599207, 18006683.
    • (2007) Genes Dev , vol.21 , pp. 2861-2873
    • Mizushima, N.1
  • 7
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • 10.1091/mbc.E08-12-1249, 2663920, 19225151
    • Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009, 20:1992-2003. 10.1091/mbc.E08-12-1249, 2663920, 19225151.
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3    Kim, Y.M.4    Otto, N.M.5    Cao, J.6    Kundu, M.7    Kim, D.H.8
  • 8
    • 67549110195 scopus 로고    scopus 로고
    • A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
    • 10.4161/auto.5.5.8249, 19287211
    • Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 2009, 5:649-662. 10.4161/auto.5.5.8249, 19287211.
    • (2009) Autophagy , vol.5 , pp. 649-662
    • Mercer, C.A.1    Kaliappan, A.2    Dennis, P.B.3
  • 9
    • 84856800302 scopus 로고    scopus 로고
    • Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks
    • 10.1128/MCB.06159-11, 3255710, 22025673
    • Alers S, Loffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012, 32:2-11. 10.1128/MCB.06159-11, 3255710, 22025673.
    • (2012) Mol Cell Biol , vol.32 , pp. 2-11
    • Alers, S.1    Loffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 10
    • 77950501014 scopus 로고    scopus 로고
    • MTOR regulation of autophagy
    • 10.1016/j.febslet.2010.01.017, 2846630, 20083114
    • Jung CH, Ro SH, Cao J, Otto NM, Kim DH. mTOR regulation of autophagy. FEBS letters 2010, 584:1287-1295. 10.1016/j.febslet.2010.01.017, 2846630, 20083114.
    • (2010) FEBS letters , vol.584 , pp. 1287-1295
    • Jung, C.H.1    Ro, S.H.2    Cao, J.3    Otto, N.M.4    Kim, D.H.5
  • 11
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • 10.1038/ncb2152, 21258367
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011, 13:132-141. 10.1038/ncb2152, 21258367.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 12
    • 77953543377 scopus 로고    scopus 로고
    • The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond
    • 10.1016/j.tcb.2010.03.002, 20356743
    • Funderburk SF, Wang QJ, Yue Z. The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond. Trends Cell Biol 2010, 20:355-362. 10.1016/j.tcb.2010.03.002, 20356743.
    • (2010) Trends Cell Biol , vol.20 , pp. 355-362
    • Funderburk, S.F.1    Wang, Q.J.2    Yue, Z.3
  • 14
    • 51049118332 scopus 로고    scopus 로고
    • The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series
    • 10.1038/embor.2008.163, 2529362, 18704115
    • Geng J, Klionsky DJ. The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. EMBO reports 2008, 9:859-864. 10.1038/embor.2008.163, 2529362, 18704115.
    • (2008) EMBO reports , vol.9 , pp. 859-864
    • Geng, J.1    Klionsky, D.J.2
  • 15
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • 10.1093/emboj/19.21.5720, 305793, 11060023
    • Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000, 19:5720-5728. 10.1093/emboj/19.21.5720, 305793, 11060023.
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5    Noda, T.6    Kominami, E.7    Ohsumi, Y.8    Yoshimori, T.9
  • 16
    • 0038325675 scopus 로고    scopus 로고
    • Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
    • 10.1242/jcs.00381, 12665549
    • Mizushima N, Kuma A, Kobayashi Y, Yamamoto A, Matsubae M, Takao T, Natsume T, Ohsumi Y, Yoshimori T. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J Cell Sci 2003, 116:1679-1688. 10.1242/jcs.00381, 12665549.
    • (2003) J Cell Sci , vol.116 , pp. 1679-1688
    • Mizushima, N.1    Kuma, A.2    Kobayashi, Y.3    Yamamoto, A.4    Matsubae, M.5    Takao, T.6    Natsume, T.7    Ohsumi, Y.8    Yoshimori, T.9
  • 17
    • 33846692198 scopus 로고    scopus 로고
    • Signal integration and diversification through the p62 scaffold protein
    • 10.1016/j.tibs.2006.12.002, 17174552
    • Moscat J, Diaz-Meco MT, Wooten MW. Signal integration and diversification through the p62 scaffold protein. Trends Biochem Sci 2007, 32:95-100. 10.1016/j.tibs.2006.12.002, 17174552.
    • (2007) Trends Biochem Sci , vol.32 , pp. 95-100
    • Moscat, J.1    Diaz-Meco, M.T.2    Wooten, M.W.3
  • 18
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • 10.1038/ncb1426, 16799551
    • Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH, Jung JU. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006, 8:688-699. 10.1038/ncb1426, 16799551.
    • (2006) Nat Cell Biol , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3    Dotan, I.4    Canaani, D.5    Oh, B.H.6    Jung, J.U.7
  • 20
    • 3242877218 scopus 로고    scopus 로고
    • Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
    • 10.1242/jcs.01114, 15138286
    • Gutierrez MG, Munafo DB, Beron W, Colombo MI. Rab7 is required for the normal progression of the autophagic pathway in mammalian cells. J Cell Sci 2004, 117:2687-2697. 10.1242/jcs.01114, 15138286.
    • (2004) J Cell Sci , vol.117 , pp. 2687-2697
    • Gutierrez, M.G.1    Munafo, D.B.2    Beron, W.3    Colombo, M.I.4
  • 21
    • 0035192612 scopus 로고    scopus 로고
    • Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion
    • 10.1091/mbc.12.11.3690, 60286, 11694599
    • Ishihara N, Hamasaki M, Yokota S, Suzuki K, Kamada Y, Kihara A, Yoshimori T, Noda T, Ohsumi Y. Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol Biol Cell 2001, 12:3690-3702. 10.1091/mbc.12.11.3690, 60286, 11694599.
    • (2001) Mol Biol Cell , vol.12 , pp. 3690-3702
    • Ishihara, N.1    Hamasaki, M.2    Yokota, S.3    Suzuki, K.4    Kamada, Y.5    Kihara, A.6    Yoshimori, T.7    Noda, T.8    Ohsumi, Y.9
  • 24
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • 10.1016/j.cell.2007.12.018, 2696814, 18191218
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42. 10.1016/j.cell.2007.12.018, 2696814, 18191218.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 25
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: core molecular machinery and signaling regulation
    • 10.1016/j.ceb.2009.11.014, 2854249, 20034776
    • Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010, 22:124-131. 10.1016/j.ceb.2009.11.014, 2854249, 20034776.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 26
    • 65249108735 scopus 로고    scopus 로고
    • Autophagy genes in immunity
    • 10.1038/ni.1726, 2715365, 19381141
    • Virgin HW, Levine B. Autophagy genes in immunity. Nat Immunol 2009, 10:461-470. 10.1038/ni.1726, 2715365, 19381141.
    • (2009) Nat Immunol , vol.10 , pp. 461-470
    • Virgin, H.W.1    Levine, B.2
  • 27
    • 84877628647 scopus 로고    scopus 로고
    • Autophagy in human health and disease
    • 10.1056/NEJMra1205406, 23406030
    • Choi AM, Ryter SW, Levine B. Autophagy in human health and disease. N Engl J Med 2013, 368:651-662. 10.1056/NEJMra1205406, 23406030.
    • (2013) N Engl J Med , vol.368 , pp. 651-662
    • Choi, A.M.1    Ryter, S.W.2    Levine, B.3
  • 28
    • 78751510276 scopus 로고    scopus 로고
    • Controlling autophagy: a new concept for clearing liver disease
    • 10.1002/hep.24090, 21254183
    • Tacke F, Trautwein C. Controlling autophagy: a new concept for clearing liver disease. Hepatology 2011, 53:356-358. 10.1002/hep.24090, 21254183.
    • (2011) Hepatology , vol.53 , pp. 356-358
    • Tacke, F.1    Trautwein, C.2
  • 29
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • 10.1038/45257, 10604474
    • Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676. 10.1038/45257, 10604474.
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3    Brown, K.4    Kempkes, B.5    Hibshoosh, H.6    Levine, B.7
  • 32
    • 34547132328 scopus 로고    scopus 로고
    • Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3
    • Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, Lopez-Otin C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Clin Invest 2007, 282:18573-18583.
    • (2007) J Clin Invest , vol.282 , pp. 18573-18583
    • Marino, G.1    Salvador-Montoliu, N.2    Fueyo, A.3    Knecht, E.4    Mizushima, N.5    Lopez-Otin, C.6
  • 35
    • 34347404887 scopus 로고    scopus 로고
    • Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    • 10.1101/gad.1565707, 1899472, 17606641
    • Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007, 21:1621-1635. 10.1101/gad.1565707, 1899472, 17606641.
    • (2007) Genes Dev , vol.21 , pp. 1621-1635
    • Karantza-Wadsworth, V.1    Patel, S.2    Kravchuk, O.3    Chen, G.4    Mathew, R.5    Jin, S.6    White, E.7
  • 36
    • 34249863298 scopus 로고    scopus 로고
    • Autophagy suppresses tumor progression by limiting chromosomal instability
    • 10.1101/gad.1545107, 1877749, 17510285
    • Mathew R, Kongara S, Beaudoin B, Karp CM, Bray K, Degenhardt K, Chen G, Jin S, White E. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev 2007, 21:1367-1381. 10.1101/gad.1545107, 1877749, 17510285.
    • (2007) Genes Dev , vol.21 , pp. 1367-1381
    • Mathew, R.1    Kongara, S.2    Beaudoin, B.3    Karp, C.M.4    Bray, K.5    Degenhardt, K.6    Chen, G.7    Jin, S.8    White, E.9
  • 38
    • 84255200364 scopus 로고    scopus 로고
    • Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis
    • 10.1158/0008-5472.CAN-11-2170, 3242898, 22037873
    • Xie R, Wang F, McKeehan WL, Liu L. Autophagy enhanced by microtubule- and mitochondrion-associated MAP1S suppresses genome instability and hepatocarcinogenesis. Cancer Res 2011, 71:7537-7546. 10.1158/0008-5472.CAN-11-2170, 3242898, 22037873.
    • (2011) Cancer Res , vol.71 , pp. 7537-7546
    • Xie, R.1    Wang, F.2    McKeehan, W.L.3    Liu, L.4
  • 39
    • 30344479916 scopus 로고    scopus 로고
    • Cancer is a functional repair tissue
    • 10.1016/j.mehy.2005.09.041, 16290925
    • Meng X, Riordan NH. Cancer is a functional repair tissue. Med Hypotheses 2006, 66:486-490. 10.1016/j.mehy.2005.09.041, 16290925.
    • (2006) Med Hypotheses , vol.66 , pp. 486-490
    • Meng, X.1    Riordan, N.H.2
  • 40
    • 36849089101 scopus 로고    scopus 로고
    • Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
    • 10.1016/j.cell.2007.10.035, 18083104
    • Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007, 131:1149-1163. 10.1016/j.cell.2007.10.035, 18083104.
    • (2007) Cell , vol.131 , pp. 1149-1163
    • Komatsu, M.1    Waguri, S.2    Koike, M.3    Sou, Y.S.4    Ueno, T.5    Hara, T.6    Mizushima, N.7    Iwata, J.8    Ezaki, J.9    Murata, S.10
  • 42
    • 84876893671 scopus 로고    scopus 로고
    • FIP200 is required for maintenance and differentiation of postnatal neural stem cells
    • 10.1038/nn.3365, 23542691
    • Wang C, Liang CC, Bian ZC, Zhu Y, Guan JL. FIP200 is required for maintenance and differentiation of postnatal neural stem cells. Nat Neurosci 2013, 16:532-542. 10.1038/nn.3365, 23542691.
    • (2013) Nat Neurosci , vol.16 , pp. 532-542
    • Wang, C.1    Liang, C.C.2    Bian, Z.C.3    Zhu, Y.4    Guan, J.L.5
  • 43
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • 10.1016/j.cell.2010.01.025, 2866629, 20303878
    • Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010, 140:883-899. 10.1016/j.cell.2010.01.025, 2866629, 20303878.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 44
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • 10.1016/j.ccr.2006.06.001, 2857533, 16843265
    • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G, Mukherjee C, Shi Y, Gelinas C, Fan Y, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer cell 2006, 10:51-64. 10.1016/j.ccr.2006.06.001, 2857533, 16843265.
    • (2006) Cancer cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6    Mukherjee, C.7    Shi, Y.8    Gelinas, C.9    Fan, Y.10
  • 45
    • 57649181445 scopus 로고    scopus 로고
    • Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in alpha-1-antitrypsin deficiency
    • 10.1038/cdd.2008.103, 18617899
    • Perlmutter DH. Autophagic disposal of the aggregation-prone protein that causes liver inflammation and carcinogenesis in alpha-1-antitrypsin deficiency. Cell Death Differ 2009, 16:39-45. 10.1038/cdd.2008.103, 18617899.
    • (2009) Cell Death Differ , vol.16 , pp. 39-45
    • Perlmutter, D.H.1
  • 47
    • 84875995650 scopus 로고    scopus 로고
    • Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats
    • 10.1038/cddis.2013.35, 3734842, 23429287
    • Sun K, Guo XL, Zhao QD, Jing YY, Kou XR, Xie XQ, Zhou Y, Cai N, Gao L, Zhao X, et al. Paradoxical role of autophagy in the dysplastic and tumor-forming stages of hepatocarcinoma development in rats. Cell Death Dis 2013, 4:e501. 10.1038/cddis.2013.35, 3734842, 23429287.
    • (2013) Cell Death Dis , vol.4
    • Sun, K.1    Guo, X.L.2    Zhao, Q.D.3    Jing, Y.Y.4    Kou, X.R.5    Xie, X.Q.6    Zhou, Y.7    Cai, N.8    Gao, L.9    Zhao, X.10
  • 49
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • 10.1038/nature09663, 21124315
    • Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011, 469:221-225. 10.1038/nature09663, 21124315.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 50
    • 79952184583 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
    • 10.1084/jem.20102049, 3058571, 21282379
    • Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY, Sack MN, Kastner DL, Siegel RM. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 2011, 208:519-533. 10.1084/jem.20102049, 3058571, 21282379.
    • (2011) J Exp Med , vol.208 , pp. 519-533
    • Bulua, A.C.1    Simon, A.2    Maddipati, R.3    Pelletier, M.4    Park, H.5    Kim, K.Y.6    Sack, M.N.7    Kastner, D.L.8    Siegel, R.M.9
  • 53
    • 79960401862 scopus 로고    scopus 로고
    • Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    • 10.1101/gad.2051011, 3143941, 21764854
    • Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 2011, 25:1510-1527. 10.1101/gad.2051011, 3143941, 21764854.
    • (2011) Genes Dev , vol.25 , pp. 1510-1527
    • Wei, H.1    Wei, S.2    Gan, B.3    Peng, X.4    Zou, W.5    Guan, J.L.6
  • 54
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • 10.1038/nature00858, 12110890
    • Scaffidi P, Misteli T, Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 2002, 418:191-195. 10.1038/nature00858, 12110890.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 55
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev 2008, 8:967-975.
    • (2008) Nat Rev , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 56
    • 79959944026 scopus 로고    scopus 로고
    • Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?
    • 10.1038/nrclinonc.2011.83, 21629216
    • De Bock K, Mazzone M, Carmeliet P. Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not?. Nat Rev Clin Oncol 2011, 8:393-404. 10.1038/nrclinonc.2011.83, 21629216.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 393-404
    • De Bock, K.1    Mazzone, M.2    Carmeliet, P.3
  • 57
    • 66349121718 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
    • 10.1128/MCB.00166-09, 2682037, 19273585
    • Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J, Mazure NM. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 2009, 29:2570-2581. 10.1128/MCB.00166-09, 2682037, 19273585.
    • (2009) Mol Cell Biol , vol.29 , pp. 2570-2581
    • Bellot, G.1    Garcia-Medina, R.2    Gounon, P.3    Chiche, J.4    Roux, D.5    Pouyssegur, J.6    Mazure, N.M.7
  • 59
    • 79551553480 scopus 로고    scopus 로고
    • Dissecting the dynamic turnover of GFP-LC3 in the autolysosome
    • 10.4161/auto.7.2.14181, 3039769, 21107021
    • Ni HM, Bockus A, Wozniak AL, Jones K, Weinman S, Yin XM, Ding WX. Dissecting the dynamic turnover of GFP-LC3 in the autolysosome. Autophagy 2011, 7:188-204. 10.4161/auto.7.2.14181, 3039769, 21107021.
    • (2011) Autophagy , vol.7 , pp. 188-204
    • Ni, H.M.1    Bockus, A.2    Wozniak, A.L.3    Jones, K.4    Weinman, S.5    Yin, X.M.6    Ding, W.X.7
  • 60
    • 84856003912 scopus 로고    scopus 로고
    • Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
    • 10.1158/1078-0432.CCR-11-1282, 22080440
    • Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi RK, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res 2012, 18:370-379. 10.1158/1078-0432.CCR-11-1282, 22080440.
    • (2012) Clin Cancer Res , vol.18 , pp. 370-379
    • Lazova, R.1    Camp, R.L.2    Klump, V.3    Siddiqui, S.F.4    Amaravadi, R.K.5    Pawelek, J.M.6
  • 61
    • 77953708091 scopus 로고    scopus 로고
    • Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma
    • 10.4161/auto.6.3.11303, 20150769
    • Wan XB, Fan XJ, Chen MY, Xiang J, Huang PY, Guo L, Wu XY, Xu J, Long ZJ, Zhao Y, et al. Elevated Beclin 1 expression is correlated with HIF-1alpha in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy 2010, 6:395-404. 10.4161/auto.6.3.11303, 20150769.
    • (2010) Autophagy , vol.6 , pp. 395-404
    • Wan, X.B.1    Fan, X.J.2    Chen, M.Y.3    Xiang, J.4    Huang, P.Y.5    Guo, L.6    Wu, X.Y.7    Xu, J.8    Long, Z.J.9    Zhao, Y.10
  • 62
    • 77957993522 scopus 로고    scopus 로고
    • Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia
    • 10.1038/sj.bjc.6605904, 2967071, 20842118
    • Koukourakis MI, Giatromanolaki A, Sivridis E, Pitiakoudis M, Gatter KC, Harris AL. Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia. Br J Cancer 2010, 103:1209-1214. 10.1038/sj.bjc.6605904, 2967071, 20842118.
    • (2010) Br J Cancer , vol.103 , pp. 1209-1214
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Sivridis, E.3    Pitiakoudis, M.4    Gatter, K.C.5    Harris, A.L.6
  • 63
    • 84878997506 scopus 로고    scopus 로고
    • Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition
    • 10.1093/carcin/bgt063, 23430956
    • Li J, Yang B, Zhou Q, Wu Y, Shang D, Guo Y, Song Z, Zheng Q, Xiong J. Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial-mesenchymal transition. Carcinogenesis 2013, 34:1343-1351. 10.1093/carcin/bgt063, 23430956.
    • (2013) Carcinogenesis , vol.34 , pp. 1343-1351
    • Li, J.1    Yang, B.2    Zhou, Q.3    Wu, Y.4    Shang, D.5    Guo, Y.6    Song, Z.7    Zheng, Q.8    Xiong, J.9
  • 64
    • 80054031545 scopus 로고    scopus 로고
    • Overcoming anoikis-pathways to anchorage-independent growth in cancer
    • 10.1242/jcs.072165, 21940791
    • Guadamillas MC, Cerezo A, Del Pozo MA. Overcoming anoikis-pathways to anchorage-independent growth in cancer. J Cell Sci 2011, 124:3189-3197. 10.1242/jcs.072165, 21940791.
    • (2011) J Cell Sci , vol.124 , pp. 3189-3197
    • Guadamillas, M.C.1    Cerezo, A.2    Del Pozo, M.A.3
  • 65
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • 10.1083/jcb.124.4.619, 2119917, 8106557
    • Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994, 124:619-626. 10.1083/jcb.124.4.619, 2119917, 8106557.
    • (1994) J Cell Biol , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 66
    • 77951212660 scopus 로고    scopus 로고
    • Autophagy and metastasis: another double-edged sword
    • 10.1016/j.ceb.2009.10.008, 2854304, 19945838
    • Kenific CM, Thorburn A, Debnath J. Autophagy and metastasis: another double-edged sword. Curr Opin Cell Biol 2010, 22:241-245. 10.1016/j.ceb.2009.10.008, 2854304, 19945838.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 241-245
    • Kenific, C.M.1    Thorburn, A.2    Debnath, J.3
  • 67
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • 2262959, 18094039
    • Fung C, Lock R, Gao S, Salas E, Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 2008, 19:797-806. 2262959, 18094039.
    • (2008) Mol Biol Cell , vol.19 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5
  • 68
    • 50849088969 scopus 로고    scopus 로고
    • Extracellular matrix regulation of autophagy
    • 10.1016/j.ceb.2008.05.002, 2613490, 18573652
    • Lock R, Debnath J. Extracellular matrix regulation of autophagy. Curr Opin Cell Biol 2008, 20:583-588. 10.1016/j.ceb.2008.05.002, 2613490, 18573652.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 583-588
    • Lock, R.1    Debnath, J.2
  • 69
    • 78649467513 scopus 로고    scopus 로고
    • Does tumour dormancy offer a therapeutic target?
    • Goss PE, Chambers AF. Does tumour dormancy offer a therapeutic target?. Nat Rev 2010, 10:871-877.
    • (2010) Nat Rev , vol.10 , pp. 871-877
    • Goss, P.E.1    Chambers, A.F.2
  • 70
  • 71
    • 5144235557 scopus 로고    scopus 로고
    • Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
    • 10.1016/j.ccr.2004.06.025, 15324699
    • White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U, Muller WJ. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 2004, 6:159-170. 10.1016/j.ccr.2004.06.025, 15324699.
    • (2004) Cancer Cell , vol.6 , pp. 159-170
    • White, D.E.1    Kurpios, N.A.2    Zuo, D.3    Hassell, J.A.4    Blaess, S.5    Mueller, U.6    Muller, W.J.7
  • 72
    • 57449121645 scopus 로고    scopus 로고
    • The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
    • 2582930, 19033662
    • Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Mills GB, et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J Clin Invest 2008, 118:3917-3929. 2582930, 19033662.
    • (2008) J Clin Invest , vol.118 , pp. 3917-3929
    • Lu, Z.1    Luo, R.Z.2    Lu, Y.3    Zhang, X.4    Yu, Q.5    Khare, S.6    Kondo, S.7    Kondo, Y.8    Yu, Y.9    Mills, G.B.10
  • 73
    • 84877332222 scopus 로고    scopus 로고
    • Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
    • 10.4161/auto.23997, 23519090
    • Yue W, Hamai A, Tonelli G, Bauvy C, Nicolas V, Tharinger H, Codogno P, Mehrpour M. Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance. Autophagy 2013, 9:714-729. 10.4161/auto.23997, 23519090.
    • (2013) Autophagy , vol.9 , pp. 714-729
    • Yue, W.1    Hamai, A.2    Tonelli, G.3    Bauvy, C.4    Nicolas, V.5    Tharinger, H.6    Codogno, P.7    Mehrpour, M.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.