-
1
-
-
79952232216
-
Global cancer statistics
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. Cancer J Clin 2010; 61: 69-90.
-
(2010)
Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
7044229778
-
Primary liver cancer: Worldwide incidence and trends
-
Bosch FX, Ribes J, Diaz M, Cleries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004; 127(5 Suppl 1): S5-S16.
-
(2004)
Gastroenterology
, vol.127
, Issue.5 SUPPL. 1
-
-
Bosch, F.X.1
Ribes, J.2
Diaz, M.3
Cleries, R.4
-
3
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6: 463-477.
-
(2004)
Dev Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
4
-
-
36249025723
-
Autophagy: Process and function
-
Mizushima N. Autophagy: process and function. Genes Dev 2007; 21: 2861-2873.
-
(2007)
Genes Dev
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
5
-
-
69949106925
-
The double-edged sword of autophagy modulation in cancer
-
White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009; 15: 5308-5316.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5308-5316
-
-
White, E.1
Dipaola, R.S.2
-
6
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100: 15077-15082.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
7
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112: 1809-1820.
-
(2003)
J Clin Invest
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
-
8
-
-
33745751085
-
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
-
Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8: 688-699.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 688-699
-
-
Liang, C.1
Feng, P.2
Ku, B.3
Dotan, I.4
Canaani, D.5
Oh, B.H.6
-
9
-
-
34848899280
-
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
-
Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol 2007; 9: 1142-1151.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1142-1151
-
-
Takahashi, Y.1
Coppola, D.2
Matsushita, N.3
Cualing, H.D.4
Sun, M.5
Sato, Y.6
-
10
-
-
34547132328
-
Tissuespecific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/ autophagin-3
-
Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, Lopez-Otin C. Tissuespecific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/ autophagin-3. J Biol Chem 2007; 282: 18573-18583.
-
(2007)
J Biol Chem
, vol.282
, pp. 18573-18583
-
-
Marino, G.1
Salvador-Montoliu, N.2
Fueyo, A.3
Knecht, E.4
Mizushima, N.5
Lopez-Otin, C.6
-
11
-
-
79955377420
-
Autophagydeficient mice develop multiple liver tumors
-
Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S et al. Autophagydeficient mice develop multiple liver tumors. Genes Dev 2011; 25: 795-800.
-
(2011)
Genes Dev
, vol.25
, pp. 795-800
-
-
Takamura, A.1
Komatsu, M.2
Hara, T.3
Sakamoto, A.4
Kishi, C.5
Waguri, S.6
-
12
-
-
79955469013
-
Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis
-
Altman BJ, Jacobs SR, Mason EF, Michalek RD, MacIntyre AN, Coloff JL et al. Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis. Oncogene 2011; 30: 1855-1867.
-
(2011)
Oncogene
, vol.30
, pp. 1855-1867
-
-
Altman, B.J.1
Jacobs, S.R.2
Mason, E.F.3
Michalek, R.D.4
Macintyre, A.N.5
Coloff, J.L.6
-
13
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 2011; 25: 460-470.
-
(2011)
Genes Dev
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
Fan, J.4
Strohecker, A.M.5
Karsli-Uzunbas, G.6
-
14
-
-
79960401862
-
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
-
Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 2011; 25: 1510-1527.
-
(2011)
Genes Dev
, vol.25
, pp. 1510-1527
-
-
Wei, H.1
Wei, S.2
Gan, B.3
Peng, X.4
Zou, W.5
Guan, J.L.6
-
17
-
-
67650377329
-
Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma
-
Nagata H, Hatano E, Tada M, Murata M, Kitamura K, Asechi H et al. Inhibition of c-Jun NH2-terminal kinase switches Smad3 signaling from oncogenesis to tumor- suppression in rat hepatocellular carcinoma. Hepatology (Baltimore, MD) 2009; 49: 1944-1953.
-
(2009)
Hepatology (Baltimore, MD)
, vol.49
, pp. 1944-1953
-
-
Nagata, H.1
Hatano, E.2
Tada, M.3
Murata, M.4
Kitamura, K.5
Asechi, H.6
-
18
-
-
54849176000
-
Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis
-
Huang KW, Huang YC, Tai KF, Chen BH, Lee PH, Hwang LH. Dual therapeutic effects of interferon-alpha gene therapy in a rat hepatocellular carcinoma model with liver cirrhosis. Mol Ther 2008; 16: 1681-1687.
-
(2008)
Mol Ther
, vol.16
, pp. 1681-1687
-
-
Huang, K.W.1
Huang, Y.C.2
Tai, K.F.3
Chen, B.H.4
Lee, P.H.5
Hwang, L.H.6
-
19
-
-
30344479916
-
Cancer is a functional repair tissue
-
Meng X, Riordan NH. Cancer is a functional repair tissue. Med Hypotheses 2006; 66: 486-490.
-
(2006)
Med Hypotheses
, vol.66
, pp. 486-490
-
-
Meng, X.1
Riordan, N.H.2
-
20
-
-
0037207461
-
Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection
-
Wang Y, Kato N, Hoshida Y, Yoshida H, Taniguchi H, Goto T et al. Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection. Hepatology (Baltimore, MD) 2003; 37: 65-71.
-
(2003)
Hepatology (Baltimore, MD)
, vol.37
, pp. 65-71
-
-
Wang, Y.1
Kato, N.2
Hoshida, Y.3
Yoshida, H.4
Taniguchi, H.5
Goto, T.6
-
21
-
-
34248141100
-
A cytokine-mediated link between innate immunity, inflammation, and cancer
-
Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 2007; 117: 1175-1183.
-
(2007)
J Clin Invest
, vol.117
, pp. 1175-1183
-
-
Lin, W.W.1
Karin, M.2
-
22
-
-
0029004176
-
Damage to mitochondrial DNA induced by the hepatocarcinogen diethylnitrosamine in ovo
-
Enzmann H, Kuhlem C, Loser E, Bannasch P. Damage to mitochondrial DNA induced by the hepatocarcinogen diethylnitrosamine in ovo. Mutation Res 1995; 329: 113-120.
-
(1995)
Mutation Res
, vol.329
, pp. 113-120
-
-
Enzmann, H.1
Kuhlem, C.2
Loser, E.3
Bannasch, P.4
-
23
-
-
33751072935
-
Bioenergetics and the formation of mitochondrial reactive oxygen species
-
Adam-Vizi V, Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 2006; 27: 639-645.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 639-645
-
-
Adam-Vizi, V.1
Chinopoulos, C.2
-
24
-
-
78650890352
-
Regulation of autophagy by ROS: Physiology and pathology
-
Scherz-Shouval R, Elazar Z. Regulation of autophagy by ROS: physiology and pathology. Trends Biochem Sci 2011; 36: 30-38.
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 30-38
-
-
Scherz-Shouval, R.1
Elazar, Z.2
-
25
-
-
75149138984
-
Modulation of intercellular ROS signaling of human tumor cells
-
Bechtel W, Bauer G. Modulation of intercellular ROS signaling of human tumor cells. Anticancer Res 2009; 29: 4559-4570.
-
(2009)
Anticancer Res
, vol.29
, pp. 4559-4570
-
-
Bechtel, W.1
Bauer, G.2
-
27
-
-
79551634458
-
Autophagy in tumorigenesis and energy metabolism: Friend by day, foe by night
-
Mathew R,White E. Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night. Curr Opinion Genet Dev 2011; 21: 113-119.
-
(2011)
Curr Opinion Genet Dev
, vol.21
, pp. 113-119
-
-
Mathew, R.1
White, E.2
-
28
-
-
79251517382
-
Regulation of cancer cell metabolism
-
Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev 2011; 11: 85-95.
-
(2011)
Nat Rev
, vol.11
, pp. 85-95
-
-
Cairns, R.A.1
Harris, I.S.2
Mak, T.W.3
-
29
-
-
79957883170
-
The multiple roles of autophagy in cancer
-
Rosenfeldt MT, Ryan KM. The multiple roles of autophagy in cancer. Carcinogenesis 2011; 32: 955-963.
-
(2011)
Carcinogenesis
, vol.32
, pp. 955-963
-
-
Rosenfeldt, M.T.1
Ryan, K.M.2
-
30
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
31
-
-
33751299346
-
DNA damage checkpoints and cancer
-
Shimada M, Nakanishi M. DNA damage checkpoints and cancer. J Mol Histol 2006; 37: 253-260.
-
(2006)
J Mol Histol
, vol.37
, pp. 253-260
-
-
Shimada, M.1
Nakanishi, M.2
-
32
-
-
34547644483
-
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
-
Lu J, Chew EH, Holmgren A. Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide. Proc Natl Acad Sci USA 2007; 104: 12288-12293.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12288-12293
-
-
Lu, J.1
Chew, E.H.2
Holmgren, A.3
-
33
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140: 883-899.
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
34
-
-
78651393239
-
A role for mitochondria in NLRP3 inflammasome activation
-
Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469: 221-225.
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
35
-
-
79952184583
-
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
-
Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY et al. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 2011; 208: 519-533.
-
(2011)
J Exp Med
, vol.208
, pp. 519-533
-
-
Bulua, A.C.1
Simon, A.2
Maddipati, R.3
Pelletier, M.4
Park, H.5
Kim, K.Y.6
-
36
-
-
2942593991
-
ROS stress in cancer cells and therapeutic implications
-
Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 2004; 7: 97-110.
-
(2004)
Drug Resist Updat
, vol.7
, pp. 97-110
-
-
Pelicano, H.1
Carney, D.2
Huang, P.3
-
37
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu PP, Sabatini DM. Cancer cell metabolism: Warburg and beyond. Cell 2008; 134: 703-707.
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
38
-
-
77957656802
-
A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy
-
Gibson SB. A matter of balance between life and death: targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy. Autophagy 2010; 6: 835-837.
-
(2010)
Autophagy
, vol.6
, pp. 835-837
-
-
Gibson, S.B.1
-
39
-
-
33846002728
-
A mitochondria-K channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
-
Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R et al. A mitochondria-K channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 2007; 11: 37-51.
-
(2007)
Cancer Cell
, vol.11
, pp. 37-51
-
-
Bonnet, S.1
Archer, S.L.2
Allalunis-Turner, J.3
Haromy, A.4
Beaulieu, C.5
Thompson, R.6
|