Present status and perspectives on the use of alkylresorcinols as biomarkers of wholegrain wheat and rye intake

Journal of Nutrition and Metabolism

Volumn 2012, Issue , 2012, Pages

  Ross, Alastair B ^a  

^a NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

SECALE CEREALE; TRITICUM AESTIVUM;

EID: 84883491212     PISSN: 20900724     EISSN: 20900732     Source Type: Journal    
DOI: 10.1155/2012/462967     Document Type: Review

References (97)

1. Ross A. B., Alkylresorcinols in cereal grains: occurrence, absorption, and possible use as biomarkers of whole grain wheat and rye intake, Ph.D. thesis 2003 Uppsala, Sweden Swedish University of Agricultural Sciences
2. Landberg R., Alkylresorcinols as biomarkers of whole grain wheat and rye intake, Ph.D. thesis 2009 Uppsala, Sweden Swedish University of Agricultural Sciences
3. de Munter J. S. L., Hu F. B., Spiegelman D., Franz M., van Dam R. M., Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Medicine 2007 4 8 1385 1395 2-s2.0-34548459044 10.1371/journal.pmed.0040261 (Pubitemid 47358174)
4. Jacobs J., Marquart L., Slavin J., Kushi L. H., Whole-grain intake and cancer: an expanded review and meta-analysis. Nutrition and Cancer 1998 30 2 85 96 2-s2.0-2642694702 (Pubitemid 28217486)
5. Willett W. C., Nutritional Epidemiology 1998 London, UK Oxford University Press
6. Seal C. J., Jones A. R., Whitney A. D., Whole grains uncovered. Nutrition Bulletin 2006 31 2 129 137 2-s2.0-33744468839 10.1111/j.1467-3010.2006.00559.x (Pubitemid 43805770)
7. Wild C. P., Andersson C., O'Brien N. M., Wilson L., Woods J. A., A critical evaluation of the application of biomarkers in epidemiological studies on diet and health. British Journal of Nutrition 2001 86 supplement 1 S37 S53 2-s2.0-0034814121 (Pubitemid 32916182)
8. Ross A. B., Kamal-Eldin A., Åman P., Dietary alkylresorcinols: absorption, bioactivities, and possible use as biomarkers of whole-grain wheat- and rye-rich foods. Nutrition Reviews 2004 62 3 81 95 2-s2.0-1542283122 10.1301/nr.2004.mar.81-95 (Pubitemid 38436807)
9. Ross A. B., Shepherd M. J., Schüpphaus M., Sinclair V., Alfaro B., Kamal-Eldin A., Åman P., Alkylresorcinols in cereals and cereal products. Journal of Agricultural and Food Chemistry 2003 51 14 4111 4118 2-s2.0-0037899194 10.1021/jf0340456
10. Seitz L. M., Identification of 5-(2-Oxoalkyl)resorcinols and 5-(2-Oxoalkenyl)resorcinols in wheat and rye grains. Journal of Agricultural and Food Chemistry 1992 40 9 1541 1546 2-s2.0-0000700392
11. Ross A. B., Åman P., Andersson R., Kamal-Eldin A., Chromatographic analysis of alkylresorcinols and their metabolites. Journal of Chromatography A 2004 1054 1-2 157 164 2-s2.0-7444253936 10.1016/j.chroma.2004.04.020 (Pubitemid 39445818)
12. Kozubek A., Tyman J. H., Resorcinolic lipids, the natural non-isoprenoid phenolic amphiphiles and their biological activity. Chemical Reviews 1999 99 1 1 25 2-s2.0-0002749330
13. Landberg R., Kamal-Eldin A., Salmenkallio-Marttila M., Rouau X., Åman P., Localization of alkylresorcinols in wheat, rye and barley kernels. Journal of Cereal Science 2008 48 2 401 406 2-s2.0-49449104079 10.1016/j.jcs.2007.09.013
14. Chen Y., Ross A. B., Åman P., Kamal-Eldin A., Alkylresorcinols as markers of whole grain wheat and rye in cereal products. Journal of Agricultural and Food Chemistry 2004 52 26 8242 8246 2-s2.0-11144224479 (Pubitemid 40053721)
15. Landberg R., Kamal-Eldin A., Andersson R., Åman P., Alkylresorcinol content and homologue composition in durum wheat (Triticum durum) kernels and pasta products. Journal of Agricultural and Food Chemistry 2006 54 8 3012 3014 2-s2.0-33646497874 10.1021/jf0530805
16. Ross A. B., Kochhar S., Rapid and sensitive analysis of alkylresorcinols from cereal grains and products using HPLC-Coularray-based electrochemical detection. Journal of Agricultural and Food Chemistry 2009 57 12 5187 5193 2-s2.0-67649221337 10.1021/jf900239t
17. Zarnowski R., Suzuki Y., Yamaguchi I., Pietr S. J., Alkylresorcinols in barley (Hordeum vulgare L. distichon) grains. Zeitschrift fur Naturforschung C 2002 57 1-2 57 62 2-s2.0-0036130563 (Pubitemid 34234333)
18. Andersson A. A., Lampi A. M., Nyström L., Piironen V., Li L., Ward J. L., Gebruers K., Courtin C. M., Delcour J. A., Boros D., Fraś A., Dynkowska W., Rakszegi M., Bedo Z., Shewry P. R., Åman P., Phytochemical and dietary fiber components in barley varieties in the Healthgrain diversity screen. Journal of Agricultural and Food Chemistry 2008 56 21 9767 9776 2-s2.0-58149333548 10.1021/jf802037f
19. Knödler M., Reisenhauer K., Schieber A., Carle R., Quantitative determination of allergenic 5-alk(en)ylresorcinols in mango (mangifera indica l.) peel, pulp, and fruit products by high-performance liquid chromatography. Journal of Agricultural and Food Chemistry 2009 57 9 3639 3644 2-s2.0-66149114882 10.1021/jf803934p
20. Ross A. B., Becker W., Chen Y., Kamal-Eldin A., Åman P., Intake of alkylresorcinols from wheat and rye in the United Kingdom and Sweden. British Journal of Nutrition 2005 94 4 496 499 2-s2.0-27644462539 10.1079/BJN20051511 (Pubitemid 41555488)
21. Stasiuk M., Kozubek A., Biological activity of phenolic lipids. Cellular and Molecular Life Sciences 2010 67 6 841 860 2-s2.0-77949498435 10.1007/s00018-009-0193-1
22. Andersson U., Dey E. S., Holm C., Degerman E., Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity. Molecular Nutrition and Food Research 2011 55 supplement 2 S290 S293 1002/mnfr.201100231
23. Landberg R., Linko A. M., Kamal-Eldin A., Vessby B., Adlercreutz H., Åman P., Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye bran. Journal of Nutrition 2006 136 11 2760 2765 2-s2.0-33751107487 (Pubitemid 44771770)
24. Jansson E., Landberg R., Kamal-Eldin A., Wolk A., Vessby B., Aman P., Presence of alkylresorcinols, potential whole grain biomarkers, in human adipose tissue. British Journal of Nutrition 2010 104 5 633 636 2-s2.0-77956908457 10.1017/S0007114510001169
25. Kamal-Eldin A., Pouru A., Eliasson C., Åman P., Alkylresorcinols as antioxidants: hydrogen donation and peroxyl radical-scavenging effects. Journal of the Science of Food and Agriculture 2001 81 3 353 356 2-s2.0-0035143170 10.1002/1097-0010(200102)81:3353::AID-JSFA826>3.0.CO;2-X (Pubitemid 32109028)
26. Parikka K., Rowland I. R., Welch R. W., Wähälä K., In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols. Journal of Agricultural and Food Chemistry 2006 54 5 1646 1650 2-s2.0-33645458081 10.1021/jf052486e
27. Linko-Parvinen A. M., Landberg R., Tikkanen M. J., Adlercreutz H., Peñalvo J. L., Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins. Journal of Nutrition 2007 137 5 1137 1142 2-s2.0-34247892205 (Pubitemid 46701901)
28. Suresh M., Kaleysa R. R., Cardol: the antifilarial principle from Anacardium occidentale. Current Science 1990 59 477 479
29. Ross A. B., Chen Y., Frank J., Swanson J. E., Parker R. S., Kozubek A., Lundh T., Vessby B., Åman P., Kamal-Eldin A., Cereal alkylresorcinols elevate γ -tocopherol levels in rats and inhibit γ -tocopherol metabolism in vitro. Journal of Nutrition 2004 134 3 506 510 2-s2.0-12144291047 (Pubitemid 38304929)
30. Zhu Y., Conklin D. R., Chen H., Wang L., Sang S., 5-Alk(en)ylresorcinols as the major active components in wheat bran inhibit human colon cancer cell growth. Bioorganic and Medicinal Chemistry 2011 19 13 3973 3982 10.1016/j.bmc.2011.05.025
31. Sang S., Ju J., Lambert J. D., Lin Y., Hong J., Bose M., Wang S., Bai N., He K., Reddy B. S., Ho C. T., Li F., Yang C. S., Wheat bran oil and its fractions inhibit human colon cancer cell growth and intestinal tumorigenesis in Apcmin/+ mice. Journal of Agricultural and Food Chemistry 2006 54 26 9792 9797 2-s2.0-33846486976 10.1021/jf0620665 (Pubitemid 46158972)
32. Liu L., Winter K. M., Stevenson L., Morris C., Leach D. N., Wheat bran lipophilic compounds with in vitro anticancer effects. Food Chemistry 2012 130 1 156 164 10.1016/j.foodchem.2011.07.023
33. Gasiorowski K., Szyba K., Brokos B., Kozubek A., Antimutagenic activity of alkylresorcinols from cereal grains. Cancer Letters 1996 106 1 109 115 2-s2.0-0030598935 10.1016/0304-3835(96)04294-2 (Pubitemid 26306644)
34. Gasiorowski K., Brokos B., DNA repair of hydrogen peroxide-induced damage in human lymphocytes in the presence of four antimutagens. A study with alkaline single cell gel electrophoresis (comet assay). Cellular and Molecular Biology Letters 2001 6 4 897 911 2-s2.0-0035686201 (Pubitemid 34081335)
35. Gasiorowski K., Brokos B., Kulma A., Ogorzałek A., Skorkowska K., Impact of four antimutagens on apoptosis in genotoxically damaged lymphocytes in vitro. Cellular and Molecular Biology Letters 2001 6 3 649 675 2-s2.0-0035228758 (Pubitemid 33678437)
36. Bylund A., Zhang J. X., Bergh A., Damber J. E., Widmark A., Johansson A., Adlercreutz H., Åman P., Shepherd M. J., Hallmans G., Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate 2000 42 4 304 314 2-s2.0-0033950969 10.1002/(SICI)1097-0045(20000301)42:4304::AID-PROS8>3.0.CO;2-Z (Pubitemid 30104574)
37. Aubertin-Leheudre M., Koskela A., Samaletdin A., Adlercreutz H., Plasma and urinary alkylresorcinol metabolites as potential biomarkers of breast cancer risk in Finnish women: a pilot study. Nutrition and Cancer 2010 62 6 759 764 2-s2.0-77954987804 10.1080/01635581003693058
38. Olsen A., Landberg R., Åman P., Kamal-Eldin A., Christensen J., Johnsen N. F., Overvad K., Tjønneland A., Plasma levels of alkylresorcinols and incidence of endometrial cancer. European Journal of Cancer Prevention 2010 19 1 73 77 2-s2.0-75149164802 10.1097/CEJ.0b013e328333d12a
39. Barron C., Samson M. F., Lullien-Pellerin V., Rouau X., Wheat grain tissue proportions in milling fractions using biochemical marker measurements: application to different wheat cultivars. Journal of Cereal Science 2011 53 3 306 311 10.1016/j.jcs.2011.01.013
40. Hemery Y., Lullien-Pellerin V., Rouau X., Abecassis J., Samson M. F., Åman P., von Reding W., Spoerndli C., Barron C., Biochemical markers: efficient tools for the assessment of wheat grain tissue proportions in milling fractions. Journal of Cereal Science 2009 49 1 55 64 2-s2.0-57149097054 10.1016/j.jcs.2008.07.006
41. Linko A. M., Parikka K., Wähälä K., Adlercreutz H., Gas chromatographic-mass spectrometric method for the determination of alkylresorcinols in human plasma. Analytical Biochemistry 2002 308 2 307 313 2-s2.0-0037108853 10.1016/S0003-2697(02)00226-9 (Pubitemid 35177144)
42. American Association of Cereal Chemists,. AACC Members Agree on Definition of Whole Grain. 1999. 30-5-2011
43. Ross A. B., Kamal-Eldin A., Lundin E. A., Zhang J. X., Hallmans G., Åman P., Cereal alkylresorcinols are absorbed by humans. Journal of Nutrition 2003 133 7 2222 2224 2-s2.0-0038267386 (Pubitemid 36841544)
44. Ross A. B., Shepherd M. J., Knudsen K. E. B., Glitso L. V., Bowey E., Phillips J., Rowland I., Guo Z. X., Massy D. J. R., Åman P., Kamal-Eldin A., Absorption of dietary alkylresorcinols in ileal-cannulated pigs and rats. British Journal of Nutrition 2003 90 4 787 794 2-s2.0-0141906225 10.1079/BJN2003965 (Pubitemid 37270761)
45. Landberg R., Åman P., Friberg L. E., Vessby B., Adlercreutz H., Kamal-Eldin A., Dose response of whole-grain biomarkers: alkylresorcinols in human plasma and their metabolites in urine in relation to intake. American Journal of Clinical Nutrition 2009 89 1 290 296 2-s2.0-58149392358 10.3945/ajcn.2008.26709
46. Jansson E., Landberg R., Kamal-Eldin A., Wolk A., Vessby B., Aman P., Presence of alkylresorcinols, potential whole grain biomarkers, in human adipose tissue. British Journal of Nutrition 2010 104 5 633 636 2-s2.0-77956908457 10.1017/S0007114510001169
47. Ross A. B., Åman P., Kamal-Eldin A., Identification of cereal alkylresorcinol metabolites in human urine-potential biomarkers of wholegrain wheat and rye intake. Journal of Chromatography B 2004 809 1 125 130 10.1016/j.jchromb.2004.06.015 (Pubitemid 38998429)
48. Koskela A., Linko-Parvinen A. M., Hiisivuori P., Samaletdin A., Kamal-Eldin A., Tikkanen M. J., Adlercreutz H., Quantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detection. Clinical Chemistry 2007 53 7 1380 1383 2-s2.0-34347388811 10.1373/clinchem.2006.084764 (Pubitemid 47020999)
49. Koskela A., Samaletdin A., Aubertin-Leheudre M., Adlercreutz H., Quantification of alkylresorcinol metabolites in plasma by high-performance liquid chromatography with coulometric electrode array detection. Journal of Agricultural and Food Chemistry 2008 56 17 7678 7681 2-s2.0-52649146990 10.1021/jf801252s
50. Linko A. M., Ross A. B., Kamal-Eldin A., Serena A., Kjær A. K. B., Jørgensen H., Peñalvo J. L., Adlercreutz H., Åman P., Knudsen K. E. B., Kinetics of the appearance of cereal alkylresorcinols in pig plasma. British Journal of Nutrition 2006 95 2 282 287 2-s2.0-33644908800 10.1079/BJN20051642
51. Ross A. B., Bruce S. J., Blondel-Lubrano A., Oguey-Araymon S., Beaumont M., Bourgeois A., Nielsen-Moennoz C., Vigo M., Fay L. -B., Kochhar S., Bibiloni R., Pittet A. C., Emady-Azar S., Grathwohl D., Rezzi S., A whole-grain cereal-rich diet increases plasma betaine, and tends to decrease total and LDL-cholesterol compared with a refined-grain diet in healthy subjects. British Journal of Nutrition 2011 105 10 1492 1502 10.1017/S0007114510005209
52. Söderholm P. P., Koskela A. H., Lundin J. E., Tikkanen M. J., Adlercreutz H. C., Plasma pharmacokinetics of alkylresorcinol metabolites: new candidate biomarkers for whole-grain rye and wheat intake. American Journal of Clinical Nutrition 2009 90 5 1167 1171 2-s2.0-70350641306 10.3945/ajcn.2009. 28290
53. Söderholm P. P., Lundin J. E., Koskela A. H., Tikkanen M. J., Adlercreutz H. C., Pharmacokinetics of alkylresorcinol metabolites in human urine. British Journal of Nutrition 2011 106 7 1040 1044
54. Landberg R., Kamal-Eldin A., Andersson S. O., Johansson J. E., Zhang J. X., Hallmans G., Åman P., Reproducibility of plasma alkylresorcinols during a 6-week rye intervention study in men with prostate cancer. Journal of Nutrition 2009 139 5 975 980 2-s2.0-65349093907 10.3945/jn.108.099952
55. Landberg R., Åman P., Kamal-Eldin A., A rapid gas chromatography-mass spectrometry method for quantification of alkylresorcinols in human plasma. Analytical Biochemistry 2009 385 1 7 12 2-s2.0-57749196384 10.1016/j.ab.2008.10.031
56. Ross A. B., Redeuil K., Vigo M., Rezzi S., Nagy K., Quantification of alkylresorcinols in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2010 24 5 554 560 2-s2.0-77049115419 10.1002/rcm.4409
57. Linko A. M., Adlercreutz H., Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes. British Journal of Nutrition 2005 93 1 11 13 2-s2.0-14144253938 10.1079/BJN20041281
58. Nagy K., Ross A. B., Fay L. B., Bourgeois A., Kussmann M., Gas chromatography/tandem mass spectrometry analysis of alkylresorcinols in red blood cells. Rapid Communications in Mass Spectrometry 2008 22 24 4098 4104 2-s2.0-60149090353 10.1002/rcm.3836
59. Marklund M., Landberg R., Åman P., Kamal-Eldin A., Determination of alkylresorcinol metabolites in human urine by gas chromatography-mass spectrometry. Journal of Chromatography B 2010 878 11-12 888 894 2-s2.0-77949491361 10.1016/j.jchromb.2010.02.007
60. Marklund M., Landberg R., Åman P., Kamal-Eldin A., Comparison of gas chromatography-mass spectrometry and high-performance liquid chromatography with coulometric electrode array detection for determination of alkylresorcinol metabolites in human urine. Journal of Chromatography B 2011 879 9-10 647 651 10.1016/j.jchromb.2011.01.034
61. Guyman L. A., Adlercreutz H., Koskela A., Li L., Beresford S. A. A., Lampe J. W., Urinary 3-(3,5-dihydroxyphenyl)-1-propanoic acid, an alkylresorcinol metabolite, is a potential biomarker of whole-grain intake in a U.S. population. Journal of Nutrition 2008 138 10 1957 1962 2-s2.0-54749103917
62. Montonen J., Landberg R., Kamal-Eldin A., Åman P., Knueppel S., Boeing H., Pischon T., Reliability of fasting plasma alkylresorcinol concentrations measured 4 months apart. European Journal of Clinical Nutrition 2010 64 7 698 703 2-s2.0-77955012586 10.1038/ejcn.2010.71
63. Ross A. B., Bourgeois A., Macharia H. N., Kochhar S., Jebb S. A., Brownlee I. A., Seal C. J., Plasma alkylresorcinols as a biomarker of whole grain food consumption in a large population: Results From the WHOLEheart Intervention Study. American Journal of Clinical Nutrition 2012 95 1 204 211
64. Andersson A., Marklund M., Diana M., Landberg R., Plasma alkylresorcinol concentrations correlate with whole grain wheat and rye intake and show moderate reproducability over a 2- to 3-month period in free-living Swedish adults. Journal of Nutrition 2011 141 9 1712 1718
65. Spencer J. P., Abd El Mohsen M. M., Minihane A. M., Mathers J. C., Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. British Journal of Nutrition 2008 99 1 12 22 2-s2.0-37349048147 10.1017/S0007114507798938 (Pubitemid 350286133)
66. Aubertin-Leheudre M., Koskela A., Marjamaa A., Adlercreutz H., Plasma alkylresorcinols and urinary alkylresorcinol metabolites as biomarkers of cereal fiber intake in finnish women. Cancer Epidemiology Biomarkers and Prevention 2008 17 9 2244 2248 2-s2.0-53349171341 10.1158/1055-9965.EPI-08-0215
67. Al-Delaimy W. K., Ferrari P., Slimani N., Pala V., Johansson I., Nilsson S., Mattisson I., Wirfalt E., Galasso R., Palli D., Víneis P., Tumino R., Dorronsoro M., Pera G., Ocké M. C., Bueno-De-Mesquita H. B., Overvad K., Chirlaque M. D., Trichopoulou A., Naska A., Tjønneland A., Olsen A., Lund E., Alsaker E. H. R., Barricarte A., Kesse E., Boutron-Ruault M. C., Clavel-Chapelon F., Key T. J., Spencer E., Bingham S., Welch A. A., Sanchez-Perez M. J., Nagel G., Linseisen J., Quirós J. R., Peeters P. H. M., van Gils C. H., Boeing H., van Kappel A. L., Steghens J. P., Riboli E., Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European prospective investigation into cancer and nutrition (EPIC). European Journal of Clinical Nutrition 2005 59 12 1387 1396 2-s2.0-24344434734 10.1038/sj.ejcn.1602252 (Pubitemid 43135154)
68. Carlsen M. H., Karlsen A., Lillegaard I. T. L., Gran J. M., Drevon C. A., Blomhoff R., Andersen L. F., Relative validity of fruit and vegetable intake estimated from an FFQ, using carotenoid and flavonoid biomarkers and the method of triads. British Journal of Nutrition 2011 105 10 1530 1538 10.1017/S0007114510005246
69. Burri B. J., Nguyen T., Neidlinger T. R., Absorption estimates improve the validity of the relationship between dietary and serum lycopene. Nutrition 2010 26 1 82 89 2-s2.0-71549144750 10.1016/j.nut.2009.06.020
70. Landberg R., Kamal-Eldin A., Åman P., Christensen J., Overvad K., Tjønneland A., Olsen A., Determinants of plasma alkylresorcinol concentration in Danish post-menopausal women. European Journal of Clinical Nutrition 2011 65 94 101 2-s2.0-77956690405 10.1038/ejcn.2010.193
71. Poppitt S. D., Kilmartin P., Butler P., Keogh G. F., Assessment of erythrocyte phospholipid fatty acid composition as a biomarker for dietary MUFA, PUFA or saturated fatty acid intake in a controlled cross-over intervention trial. Lipids in Health and Disease 2005 4 2-s2.0-31344460354 10.1186/1476-511X-4-30 (Pubitemid 43136443)
72. MacDonald H. M., Hardcastle A. C., Duthie G. G., Duthie S. J., Aucott L., Sandison R., Shearer M. J., Reid D. M., Changes in vitamin biomarkers during a 2-year intervention trial involving increased fruit and vegetable consumption by free-living volunteers. British Journal of Nutrition 2009 102 10 1477 1486 2-s2.0-73749087778 10.1017/S0007114509990377
73. Smith-Warner S. A., Elmer P. J., Tharp T. M., Fosdick L., Randall B., Gross M., Wood J., Potter J. D., Increasing vegetable and fruit intake: randomized intervention and monitoring in an at-risk population. Cancer Epidemiology Biomarkers and Prevention 2000 9 3 307 317 2-s2.0-0034022891 (Pubitemid 30165444)
74. Kristensen M. B., Toubro S., Jensen M. G., Ross A. B., Riboldi G., Petronio M., Bügel S., Tetens I., Astrup A., Whole grain compared to refined wheat decreases body fat following a 12-week calorie restricted dietary intervention in postmenopausal women. Submitted. Journal of Nutrition
75. Landberg R., Alkylresorcinols as Biomarkers of Whole Grain Wheat and Rye Intake, Ph.D. Thesis 2009 Swedish University of Agricultural Sciences
76. Ross A. B., Pineau N., Kochhar S., Bourgeois A., Beaumont M., Decarli B., Validation of a FFQ for estimating whole-grain cereal food intake. British Journal of Nutrition 2009 102 11 1547 1551 2-s2.0-73749084289 10.1017/S0007114509990845
77. Landberg R., Kamal-Eldin A., Andersson A., Vessby B., Åman P., Alkylresorcinols as biomarkers of whole-grain wheat and rye intake: plasma concentration and intake estimated from dietary records. American Journal of Clinical Nutrition 2008 87 4 832 838 2-s2.0-42249106391 (Pubitemid 351549226)
78. Potischman N., Biologic and methodologic issues for nutritional biomarkers. Journal of Nutrition 2003 133 supplement 3 875S 880S 2-s2.0-0037370094 (Pubitemid 36266680)
79. Kaaks R. J., Biochemical markers as additional measurements in studies of the accuracy of dietary questionnaire measurements: conceptual issues. American Journal of Clinical Nutrition 1997 65 supplement 4 1232S 1239S 2-s2.0-0030903116 (Pubitemid 27152593)
80. Ocké M. C., Kaaks R. J., Biochemical markers as additional measurements in dietary validity studies: application of the method of triads with examples from the European prospective investigation into cancer and nutrition. American Journal of Clinical Nutrition 1997 65 supplement 4 1240S 1245S 2-s2.0-0030902225 (Pubitemid 27152594)
81. Marshall J. R., Methodologic and statistical considerations regarding use of biomarkers of nutritional exposure in epidemiology. Journal of Nutrition 2003 133 supplement 3 881S 887S 2-s2.0-0037372257 (Pubitemid 36262796)
82. Ross A. B., Alkylresorcinols in Cereal Grains: Occurrence, Absorption, and Possible Use as Biomarkers of Whole Grain Wheat and Rye Intake, Ph.D. thesis 2003 Swedish University of Agricultural Sciences
83. Ross A. B., Kamal-Eldin A., Jung C., Shepherd M. J., Åman P., Gas chromatographic analysis of alkylresorcinols in rye (Secale cereale L) grains. Journal of the Science of Food and Agriculture 2001 81 14 1405 1411 2-s2.0-0034773741 10.1002/jsfa.956 (Pubitemid 33001747)
84. Mullin W. J., Wolynetz M. S., Emery J. P., A comparison of methods for the extraction and quantitation of Alk(en)ylresorcinols. Journal of Food Composition and Analysis 1992 5 3 216 223 2-s2.0-0003012777
85. Mattila P., Pihlava J. M., Hellström J., Contents of phenolic acids, alkyl- and alkenylresorcinols, and avenanthramides in commercial grain products. Journal of Agricultural and Food Chemistry 2005 53 21 8290 8295 2-s2.0-27644595319 10.1021/jf051437z (Pubitemid 41564639)
86. Landberg R., Andersson A. A. M., Åman P., Kamal-Eldin A., Comparison of GC and colorimetry for the determination of alkylresorcinol homologues in cereal grains and products. Food Chemistry 2009 113 4 1363 1369 2-s2.0-55949113511 10.1016/j.foodchem.2008.08.072
87. Sampietro D. A., Vattuone M. A., Catalán C. A. N., A new colorimetric method for determination of alkylresorcinols in ground and whole-cereal grains using the diazonium salt Fast Blue RR. Food Chemistry 2009 115 3 1170 1174 2-s2.0-62249107938 10.1016/j.foodchem.2008.12.086
88. Tluscik F., Kozubek A., Mejbaum-Katzenellebogen W., Alkylresorcinols in rye (Secale cereale L.) grains. VI. colorimetric micromethod for the determination of alkylresorcinols with the use of diazonium salt, Fast Blue B. Acta Societatis Botanicorum Poloniae 1981 50 645 651
89. Katina K., Liukkonen K. H., Kaukovirta-Norja A., Adlercreutz H., Heinonen S. M., Lampi A. M., Pihlava J. M., Poutanen K., Fermentation-induced changes in the nutritional value of native or germinated rye. Journal of Cereal Science 2007 46 3 348 355 2-s2.0-35448963045 10.1016/j.jcs.2007.07.006 (Pubitemid 47633140)
90. Katina K., Laitila A., Juvonen R., Liukkonen K. H., Kariluoto S., Piironen V., Landberg R., Åman P., Poutanen K., Bran fermentation as a means to enhance technological properties and bioactivity of rye. Food Microbiology 2007 24 2 175 186 2-s2.0-33749056540 10.1016/j.fm.2006.07.012 (Pubitemid 44462728)
91. Andersson A. A. M., Kamal-Eldin A., Fraś A., Boros D., Åman P., Alkylresorcinols in wheat varieties in the Healthgrain diversity screen. Journal of Agricultural and Food Chemistry 2008 56 21 9722 9725 2-s2.0-58149327180 10.1021/jf8011344
92. Andersson A. A. M., Kamal-Eldin A., Åman P., Effects of environment and variety on alkylresorcinols in wheat in the Healthgrain diversity screen. Journal of Agricultural and Food Chemistry 2010 58 17 9299 9305 2-s2.0-77956251227 10.1021/jf904526d
93. Nyström L., Lampi A. M., Andersson A. A. M., Kamal-Eldin A., Gebruers K., Courtin C. M., Delcour J. A., Li L., Ward J. L., Fraś A., Boros D., Rakszegi M., Bedo Z., Shewry P. R., Piironen V., Phytochemicals and dietary fiber components in rye varieties in the Healthgrain diversity screen. Journal of Agricultural and Food Chemistry 2008 56 21 9758 9766 2-s2.0-58149327178 10.1021/jf801065r
94. Shewry P. R., Piironen V., Lampi A. M., Edelmann M., Kariluoto S., Nurmi T., Fernandez-Orozco R., Andersson A. A. M., Åman P., Fraś A., Boros D., Gebruers K., Dornez E., Courtin C. M., Delcour J. A., Ravel C., Charmet G., Rakszegi M., Bedo Z., Ward J. L., Effects of genotype and environment on the content and composition of phytochemicals and dietary fiber components in rye in the Healthgrain diversity screen. Journal of Agricultural and Food Chemistry 2010 58 17 9372 9383 2-s2.0-77956236244 10.1021/jf100053d
95. Linko A. M., Juntunen K. S., Mykkänen H. M., Adlercreutz H., Whole-grain rye bread consumption by women correlates with plasma alkylresorcinols and increases their concentration compared with low-fiber wheat bread. Journal of Nutrition 2005 135 3 580 583 2-s2.0-14944378583 (Pubitemid 40365221)
96. Aubertin-Leheudre M., Koskela A., Samaletdin A., Adlercreutz H., Plasma alkylresorcinol metabolites as potential biomarkers of whole-grain wheat and rye cereal fibre intakes in women. British Journal of Nutrition 2010 103 3 339 343 2-s2.0-77449110065 10.1017/S0007114509992315
97. Aubertin-Leheudre M., Koskela A., Samaletdin A., Adlercreutz H., Responsiveness of urinary and plasma alkylresorcinol metabolites to rye intake in finnish women. Cancers 2010 2 2 513 522 10.3390/cancers2020513