Urinary 3-(3,5-dihydroxyphenyl)-1-propanoic acid, an alkylresorcinol metabolite, is a potential biomarker of whole-grain intake in a U.S. population

Journal of Nutrition

Volumn 138, Issue 10, 2008, Pages 1957-1962

  Guyman, Laura A ^a,b   Adlercreutz, Herman ^c   Koskela, Anja ^c   Li, Lin ^b   Beresford, Shirley A A ^a,b   Lampe, Johanna W ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3,5 DIHYDROXYPHENYL) 1 PROPANOIC AICD; BIOLOGICAL MARKER; PROPIONIC ACID; RESORCINOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FIBER; FOOD INTAKE; GRAIN; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; POPULATION RESEARCH; RISK FACTOR; UNITED STATES; URINALYSIS;

AVENA; HORDEUM; SECALE CEREALE; TRITICUM AESTIVUM; ZEA MAYS;

EID: 54749103917     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/138.10.1957     Document Type: Article

References (27)

1. Salmeron J, Ascherio A, Rimm EB, Colditz GA, Spiegelman D, Jenkins DJ, Stampfer MJ, Wing AL, Willett WC. Dietary fiber, glycemic load, and risk of NIDDM in men. Diabetes Care. 1997;20:545-50.
2. Meyer KA, Kushi LH, Jacobs DR Jr, Slavin J, Sellers TA, Folsom AR. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am J Clin Nutr. 2000;71:921-30.
3. McKeown NM, Meigs JB, Liu S, Wilson PW, Jacques PF. Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr. 2002;76:390-8.
4. Jacobs DR Jr, Meyer KA, Kushi LH, Folsom AR. Whole-grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women's Health Study. Am J Clin Nutr. 1998;68:248-57.
5. Liu S, Stampfer MJ, Hu FB, Giovannucci E, Rimm E, Manson JE, Hennekens CH, Willett WC. Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study. Am J Clin Nutr. 1999;70:412-9.
6. Jacobs DR Jr, Marquart L, Slavin J, Kushi LH. Whole-grain intake and cancer: an expanded review andmeta-analysis. Nutr Cancer. 1998;30:85-96.
7. Linko AM, Ross AB, Kamal-Eldin A, Serena A, Kjaer AK, Jorgensen H, Penalvo JL, Adlercreutz H, Aman P, et al. Kinetics of the appearance of cereal alkylresorcinols in pig plasma. Br J Nutr. 2006;95:282-7.
8. Lang R, Jebb SA. Who consumes whole grains, and how much? Proc Nutr Soc. 2003;62:123-7.
9. Ross AB, Kamal-Eldin A, Aman P. Dietary alkylresorcinols: absorption, bioactivities, and possible use as biomarkers of whole-grain wheat- and rye-rich foods. Nutr Rev. 2004;62:81-95.
10. Ross AB, Shepherd MJ, Schupphaus M, Sinclair V, Alfaro B, Kamal-Eldin A, Aman P. Alkylresorcinols in cereals and cereal products. J Agric Food Chem. 2003;51:4111-8.
11. Chen Y, Ross AB, Aman P, Kamal-Eldin A. Alkylresorcinols as markers of whole grain wheat and rye in cereal products. J Agric Food Chem. 2004;52:8242-6.
12. Ross AB, Kamal-Eldin A, Lundin EA, Zhang JX, Hallmans G, Aman P. Cereal alkylresorcinols are absorbed by humans. J Nutr. 2003;133:2222-4.
13. Linko-Parvinen AM, Landberg R, Tikkanen MJ, Adlercreutz H, Penalvo JL. Alkylresorcinols from whole-grain wheat and rye are transported in human plasma lipoproteins. J Nutr. 2007;137:1137-42.
14. Linko AM, Adlercreutz H. Whole-grain rye and wheat alkylresorcinols are incorporated into human erythrocyte membranes. Br J Nutr. 2005; 93:11-3.
15. Ross AB, Aman P, Kamal-Eldin A. Identification of cereal alkylresorcinol metabolites in human urine-potential biomarkers of wholegrain wheat and rye intake. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 809:125-30.
16. Koskela A, Linko-Parvinen AM, Hiisivuori P, Samaletdin A, Kamal-Eldin A, Tikkanen MJ, Adlercreutz H. Quantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detection. Clin Chem. 2007;53:1380-3.
17. Linko AM, Juntunen KS, Mykkanen HM, Adlercreutz H. Whole-grain rye bread consumption by women correlates with plasma alkylresorcinols and increases their concentration compared with low-fiber wheat bread. J Nutr. 2005;135:580-3.
18. Mellen PB, Liese AD, Tooze JA, Vitolins MZ, Wagenknecht LE, Herrington DM. Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Am J Clin Nutr. 2007;85:1495-502.
19. Chang JL, Bigler J, Schwarz Y, Li SS, Li L, King IB, Potter JD, Lampe JW. UGT1A1 polymorphism is associated with serum bilirubin concentrations in a randomized, controlled, fruit and vegetable feeding trial. J Nutr. 2007;137:890-7.
20. Schakel SF, Buzzard IM, Gebhardt SE. Procedures for estimating nutrient values for food composition databases. J Food Comp Anal. 1997:102-14.
21. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect. 2005;113:192-200.
22. Willett W. Nutritional epidemiology. 2nd ed. New York: Oxford University Press; 1998.
23. Ross AB, Chen Y, Frank J, Swanson JE, Parker RS, Kozubek A, Lundh T, Vessby B, Aman P, et al. Cereal alkylresorcinols elevate gamma-tocopherol levels in rats and inhibit gamma-tocopherol metabolism in vitro. J Nutr. 2004;134:506-10.
24. Yu BH, Kies C. Wheat products as acceptable substitutes for rice. Plant Foods Hum Nutr. 1993;44:79-85.
25. Willett W, Stampfer M. Implications of total energy intake for epidemiologic analyses. In: Willett W, ed. Nutritional epidemiology. New York: Oxford University Press; 1998. p. 273-301.
26. Cleveland LE, Moshfegh AJ, Albertson AM, Goldman JD. Dietary intake of whole grains. J Am Coll Nutr. 2000;19:S331-8.
27. Landberg R, Linko AM, Kamal-Eldin A, Vessby B, Adlercreutz H, Aman P. Human plasma kinetics and relative bioavailability of alkylresorcinols after intake of rye bran. J Nutr. 2006;136:2760-5.