Phospholamban knockout breaks arrhythmogenic Ca2+ waves and suppresses catecholaminergic polymorphic ventricular tachycardia in mice

Circulation Research

Volumn 113, Issue 5, 2013, Pages 517-526

  Bai, Yunlong ^a   Jones, Peter P ^a,b   Guo, Jiqing ^a   Zhong, Xiaowei ^a   Clark, Robert B ^a   Zhou, Qiang ^a   Wang, Ruiwu ^a   Vallmitjana, Alexander ^c   Benitez, Raul ^c   Hove Madsen, Leif ^d   Semeniuk, Lisa ^a   Guo, Ang ^e   Song, Long Sheng ^e   Duff, Henry J ^a   Chen, S R Wayne ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^d HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^e UNIVERSITY OF IOWA   (United States)

Author keywords

Ca2+ leak; Ca2+ waves; Ca2+ triggered arrhythmias; phospholamban; ryanodine receptor calcium release channel; sarcoplasmic reticulum

Indexed keywords

CALCIUM ION; PHOSPHOLAMBAN; RYANODINE RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM SIGNALING; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; DISEASE PREDISPOSITION; HEART MUSCLE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; SPONTANEOUS CALCIUM WAVE; STRESS;

CA2+ LEAK; CA2+ WAVES; CA2+-TRIGGERED ARRHYTHMIAS; PHOSPHOLAMBAN; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; CAFFEINE; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CALCIUM-TRANSPORTING ATPASES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; HYDROQUINONES; ISOPROTERENOL; LITHIUM CHLORIDE; MICE; MICE, KNOCKOUT; MUTATION, MISSENSE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR;

EID: 84883456705     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.301678     Document Type: Article

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