Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass

Journal of Molecular and Cellular Cardiology

Volumn 48, Issue 2, 2010, Pages 293-301

  Hilliard, Fredrick A ^a,b   Steele, Derek S ^c   Laver, Derek ^d   Yang, Zhaokang ^c   Le Marchand, Sylvain J ^a   Chopra, Nagesh ^a   Piston, David W ^a   Huke, Sabine ^a   Knollmann, Björn C ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Calcium sparks; Catecholaminergic polymorphic ventricular Tachycardia; Flecainide; RyR2; Tetracaine

Indexed keywords

CALCIUM ION; FLECAINIDE; RYANODINE RECEPTOR; TETRACAINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CELL ISOLATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME INHIBITION; HEART MUSCLE CELL; HEART VENTRICLE WALL; LIPID BILAYER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOPLASMIC RETICULUM;

ANIMALS; ARRHYTHMIAS, CARDIAC; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CELL MEMBRANE PERMEABILITY; FLECAINIDE; HUMANS; MICE; MYOCYTES, CARDIAC; RATS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TETRACAINE;

MUS; RATTUS;

EID: 74149094943     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.10.005     Document Type: Article

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