In the RyR2R4496C mouse model of CPVT, β-adrenergic stimulation induces ca waves by increasing SR Ca content and not by decreasing the threshold for Ca Waves

Circulation Research

Volumn 107, Issue 12, 2010, Pages 1483-1489

  Kashimura, Takeshi ^a   Briston, Sarah J ^a   Trafford, Andrew W ^a   Napolitano, Carlo ^b,c   Priori, Silvia G ^b,c   Eisner, David A ^a   Venetucci, Luigi A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b IRCCS   (Italy)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

arrhythmia; ryanodine receptor; sarcoplasmic reticulum

Indexed keywords

CALCIUM; ISOPRENALINE; RYANODINE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM SIGNALING; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CONTROLLED STUDY; HEART MUSCLE CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; VOLTAGE CLAMP;

ADRENERGIC AGENTS; ANIMALS; CALCIUM; CALCIUM SIGNALING; DISEASE MODELS, ANIMAL; ISOPROTERENOL; MICE; MUTATION, MISSENSE; MYOCYTES, CARDIAC; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TACHYCARDIA, VENTRICULAR;

EID: 78650694515     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.227744     Document Type: Article

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