Reducing ryanodine receptor open probability as a means to abolish spontaneous Ca2+ release and increase Ca2+ transient amplitude in adult ventricular myocytes

Circulation Research

Volumn 98, Issue 10, 2006, Pages 1299-1305

  Venetucci, L A ^a   Trafford, A W ^a   Diaz M E ^a,b   O'Neill, S C ^a   Eisner, D A ^a,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Unit of Cardiac Physiology   (United Kingdom)

Author keywords

Arrhythmias; Calcium; Sarcoplasmic reticulum; Spontaneous release

Indexed keywords

CALCIUM ION; ISOPRENALINE; RYANODINE RECEPTOR; TETRACAINE; CALCIUM; CALCIUM CHANNEL L TYPE; CARDIOTONIC AGENT;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; HEART ARRHYTHMIA; HEART VENTRICLE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; RAT; SARCOLEMMA; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE; VOLTAGE CLAMP; ANIMAL; DIASTOLE; DRUG EFFECT; HEART MUSCLE CELL; METABOLISM; PATCH CLAMP; PHYSIOLOGY; SYSTOLE; WISTAR RAT;

ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CARDIOTONIC AGENTS; DIASTOLE; HEART VENTRICLES; ISOPROTERENOL; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOLEMMA; SYSTOLE; TETRACAINE;

EID: 33744973372     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000222000.35500.65     Document Type: Article

References (36)

1. Bers DM. Excitation-Contraction Coupling and Cardiac Contractile Force. 2nd ed. Dordrecht, The Netherlands: Kluwer Academic Publishers; 2001.
2. Wier WG, Kort AA, Stern MD, Lakatta EG, Marban E. Cellular calcium fluctuations in mammalian heart: direct evidence from noise analysis of aequorin signals in Purkinje fibers. Proc Natl Acad Sci U S A. 1983;80:7367-7371.
3. 2+ in mammalian cardiac muscle. Nature. 1983;304:735-738.
4. i in single heart cells revealed by fura-2. Science. 1987;235:325-328.
5. 2+ waves in rat ventricular myocytes. J Physiol (Lond). 1999;518:173-186.
6. Ferrier GR, Saunders JH, Mendez C. A cellular mechanism for the generation of ventricular arrhythmias by acetylstrophanthidin. Circ Res. 1973;32:600-609.
7. Lipp P, Pott L. Transient inward current in guinea-pig atrial myocytes reflects a change of sodium-calcium exchange current. J Physiol (Lond). 1988;397:601-630.
8. Lederer WJ, Tsien RW. Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibers. J Physiol (Lond). 1976;263:73-100.
9. Pogwizd SM. Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits. Circulation. 1995;92:1034-1048.
10. Scoote M, Williams AJ. The cardiac ryanodine receptor (calcium release channel): emerging role in heart failure and arrhythmia pathogenesis. Cardiovasc Res. 2002;56:359-372.
11. Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004;304:292-296.
12. Yano M, Kobayashi S, Kohno M, Doi M, Tokuhisa T, Okuda S, Suetsugu M, Hisaoka T, Obayashi M, Ohkusa T, Kohno M, Matsuzaki M. FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure. Circulation. 2003;107:477-484.
13. 2+ release and calcium content in rat ventricular myocytes. J Physiol (Lond). 1997;502:471-479.
14. 2+ content and membrane current in isolated rat ventricular myocytes. J Physiol (Lond). 1998;507:759-769.
15. Eisner DA, Nichols CG, O'Neill SC, Smith GL, Valdeolmillos M. The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells. J Physiol (Lond). 1989;411:393-418.
16. 2+ channel in the guinea-pig heart. Pflugers Arch. 1985;405:285-293.
17. Allen DG, Kurihara S. Calcium transients in mammalian ventricular muscle. Eur Heart J. 1980;1:5-15.
18. Carmeliet E, Morad M, Van der Heyden G, Vereecke J. Electrophysiological effects of tetracaine in single guinea-pig ventricular myocytes. J Physiol (Lond). 1986;376:143-161.
19. 2+ release. J Physiol (Lond). 1997;501:3-16.
20. Negretti N, Varro A, Eisner DA. Estimate of net calcium fluxes and sarcoplasmic reticulum calcium content during systole in rat ventricular myocytes. J Physiol (Lond). 1995;486:581-591.
21. Valdeolmillos M, Eisner DA. The effects of ryanodine on calcium-overloaded sheep cardiac Purkinje fibers. Circ Res. 1985;56:452-456.
22. Allen DG, Eisner DA, Pirolo JS, Smith GL. The relationship between intracellular calcium and contraction in calcium-overloaded ferret papillary muscles. J Physiol (Lond). 1985;364:169-182.
23. 2+-dependent twitch potentiation m individual cardiac myocytes. A mechanism for maximum inotropy in the myocardium. J Gen Physiol. 1988;91:133-155.
24. i waves in cardiac myocytes. Am J Physiol. 1996;270:C148-C159.
25. Eisner DA, Trafford AW, Díaz ME, Overend CL, O'Neill SC. The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation. Cardiovasc Res. 1998;38:589-604.
26. Maier LS, Bers DM. Calcium, calmodulin, and calcium-calmodulin kinase II: heartbeat to heartbeat and beyond. J Mol Cell Cardiol. 2002;34:919-939.
27. 2+ transient in rat ventricular myocytes. Circ Res. 2002;91:585-593.
28. Györke S, Lukyanenko V, Györke I. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol (Lond). 1997;500:297-309.
29. Inesi G, De Meis L. Regulation of steady state filling in sarcoplasmic reticulum. Roles of back-inhibition, leakage and slippage of the calcium pump. J Biol Chem. 1989;264:5929-5936.
30. Choi HS, Trafford AW, Eisner DA. Measurement of calcium entry and exit in quiescent rat ventricular myocytes. Pflugers Arch. 2000;440:600-608.
31. 2+ exchanger in normal and failing rat heart. J Physiol (Lond). 2005;567:493-504.
32. Boyett MR, Kirby MS, Orchard CH. Rapid regulation of the "second inward current" by intracellular calcium in isolated rat and ferret ventricular myocytes. J Physiol (Lond). 1988;407:77-102.
33. 2+ release in heart. Science. 1993;260:807-809.
34. Sitsapesan R, Montgomery RAP, Williams AJ. New insights into the gating mechanisms of cardiac Ryanodine receptors revealed by rapid changes in ligand concentration. Circ Res. 1995;77:765-772.
35. DelPrincipe F, Egger M, Niggli E. Calcium signalling in cardiac muscle: refractoriness revealed by coherent activation. Nat Cell Biol. 1999;1:323-329.
36. Callewaert G, Vereecke J, Carmeliet E. Existence of a calcium-dependent potassium channel in the membrane of cow cardiac Purkinje cells. Pflugers Arch. 1986;406:424-426.