Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation

Cardiovascular Research

Volumn 87, Issue 1, 2010, Pages 50-59

  Sedej, Simon ^a   Heinzel, Frank R ^a   Walther, Stefanie ^a   Dybkova, Nataliya ^b   Wakula, Paulina ^a   Groborz, Jan ^b   Gronau, Phillip ^b   Maier, Lars S ^b   Vos, Marc A ^c   Lai, F Anthony ^d   Napolitano, Carlo ^e   Priori, Silvia G ^e   Kockskämper, Jens ^a   Pieske, Burkert ^a,b  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF PAVIA   (Italy)

Author keywords

Delayed afterdepolarization; JTV 519; Ouabain; Ryanodine receptor; Sodium

Indexed keywords

4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; OUABAIN; RYANODINE RECEPTOR 2; SODIUM ION; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALCIUM; CATECHOLAMINE; ENZYME INHIBITOR; K201 COMPOUND; RYANODINE RECEPTOR; SODIUM; THIAZEPINE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CONTROLLED STUDY; GENE MUTATION; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SARCOPLASMIC RETICULUM; WESTERN BLOTTING; WILD TYPE; ACTION POTENTIAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CALCIUM SIGNALING; CONFOCAL MICROSCOPY; DRUG EFFECTS; FEMALE; GENE TARGETING; GENETICS; HUMAN; MALE; METABOLISM; MUTATION; PATCH CLAMP TECHNIQUE; PHOSPHORYLATION; TACHYCARDIA, VENTRICULAR; TIME; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; CALCIUM; CALCIUM SIGNALING; CATECHOLAMINES; ENZYME INHIBITORS; FEMALE; GENE KNOCK-IN TECHNIQUES; HUMANS; MALE; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MUTATION; MYOCYTES, CARDIAC; OUABAIN; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SODIUM; SODIUM-POTASSIUM-EXCHANGING ATPASE; TACHYCARDIA, VENTRICULAR; THIAZEPINES; TIME FACTORS;

EID: 77955161545     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq007     Document Type: Article

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