메뉴 건너뛰기




Volumn 17, Issue 8, 2011, Pages 1003-1009

Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca 2+ release

(28)  Zhou, Qiang a,b,g   Xiao, Jianmin a,g,h   Jiang, Dawei a   Wang, Ruiwu a   Vembaiyan, Kannan a   Wang, Aixia a   Smith, Chris D a   Xie, Cuihong a,b,g   Chen, Wenqian a   Zhang, Jingqun b   Tian, Xixi a   Jones, Peter P a,g,i   Zhong, Xiaowei a   Guo, Ang c   Chen, Haiyan b   Zhang, Lin a   Zhu, Weizhong d   Yang, Dongmei e   Li, Xiaodong f   Chen, Ju f   more..


Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; CALCIUM ION; CARVEDILOL; METOPROLOL; RYANODINE RECEPTOR; UNCLASSIFIED DRUG; VK II 86;

EID: 79961153702     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2406     Document Type: Article
Times cited : (196)

References (53)
  • 2
    • 0038177822 scopus 로고    scopus 로고
    • Limitations of current medical therapies for the heart failure
    • Miller, L.W. Limitations of current medical therapies for the treatment of heart failure. Rev. Cardiovasc. Med. 4 (Suppl. 2), S21-S29 (2003). (Pubitemid 36701294)
    • (2003) Reviews in Cardiovascular Medicine , vol.4 , Issue.SUPPL. 2
    • Miller, L.W.1
  • 3
    • 43049173412 scopus 로고    scopus 로고
    • The role of antiarrhythmic drug therapy for the prevention of sudden cardiac death
    • DOI 10.1016/j.pcad.2007.12.001, PII S0033062007001235
    • Kamath, G.S. & Mittal, S. The role of antiarrhythmic drug therapy for the prevention of sudden cardiac death. Prog. Cardiovasc. Dis. 50, 439-448 (2008). (Pubitemid 351636106)
    • (2008) Progress in Cardiovascular Diseases , vol.50 , Issue.6 , pp. 439-448
    • Kamath, G.S.1    Mittal, S.2
  • 5
    • 3042528532 scopus 로고    scopus 로고
    • Carvedilol: Beta-blockade and beyond
    • Stroe, A.F. & Gheorghiade, M. Carvedilol: beta-blockade and beyond. Rev. Cardiovasc. Med. 5 (Suppl. 1), S18-S27 (2004).
    • (2004) Rev. Cardiovasc. Med. , vol.5 , Issue.SUPPL. 1
    • Stroe, A.F.1    Gheorghiade, M.2
  • 6
    • 3042623640 scopus 로고    scopus 로고
    • Nonselective versus selective β-blockers in the management of chronic heart failure: Clinical implications of the Carvedilol or Metoprolol European Trial
    • Greenberg, B. Nonselective versus selective beta-blockers in the management of chronic heart failure: clinical implications of the carvedilol or Metoprolol European Trial. Rev. Cardiovasc. Med. 5 (Suppl. 1), S10-S17 (2004). (Pubitemid 38811475)
    • (2004) Reviews in Cardiovascular Medicine , vol.5 , Issue.SUPPL. 1
    • Greenberg, B.1
  • 7
    • 78149359059 scopus 로고    scopus 로고
    • Which beta-blocker is most effective in heart failure? Cardiovasc
    • Remme, W.J. Which beta-blocker is most effective in heart failure? Cardiovasc. Drugs Ther. 24, 351-358 (2010).
    • (2010) Drugs Ther. , vol.24 , pp. 351-358
    • Remme, W.J.1
  • 8
    • 0034537884 scopus 로고    scopus 로고
    • Cardioprotection with beta-adrenoceptor blockers. Does lipophilicity matter?
    • Hjalmarson, A. Cardioprotection with beta-adrenoceptor blockers. Does lipophilicity matter? Basic Res. Cardiol. 95 (Suppl. 1), I41-I45 (2000).
    • (2000) Basic Res. Cardiol. , vol.95 , Issue.SUPPL. 1
    • Hjalmarson, A.1
  • 10
    • 0029931785 scopus 로고    scopus 로고
    • Combined alpha-beta blockade (doxazosin plus metoprolol) compared with beta blockade alone in chronic congestive heart failure
    • DOI 10.1016/S0002-9149(97)89342-3
    • Kukin, M.L. et al. Combined alpha-beta blockade (doxazosin plus metoprolol) compared with beta blockade alone in chronic congestive heart failure. Am. J. Cardiol. 77, 486-491 (1996). (Pubitemid 26086637)
    • (1996) American Journal of Cardiology , vol.77 , Issue.7 , pp. 486-491
    • Kukin, M.L.1    Kalman, J.2    Mannino, M.3    Freudenberger, R.4    Buchholz, C.5    Ocampo, O.6
  • 11
    • 34249325904 scopus 로고    scopus 로고
    • Atherosclerosis and oxidant stress: The end of the road for antioxidant vitamin treatment?
    • DOI 10.1007/s10557-007-6027-1
    • Thomson, M.J., Puntmann, V. & Kaski, J.C. Atherosclerosis and oxidant stress: the end of the road for antioxidant vitamin treatment? Cardiovasc. Drugs Ther. 21, 195-210 (2007). (Pubitemid 46817482)
    • (2007) Cardiovascular Drugs and Therapy , vol.21 , Issue.3 , pp. 195-210
    • Thomson, M.J.1    Puntmann, V.2    Kaski, J.-C.3
  • 12
    • 0037059457 scopus 로고    scopus 로고
    • Calcium and cardiac rhythms: Physiological and pathophysiological
    • Bers, D.M. Calcium and cardiac rhythms: physiological and pathophysiological. Circ. Res. 90, 14-17 (2002). (Pubitemid 34074602)
    • (2002) Circulation Research , vol.90 , Issue.1 , pp. 14-17
    • Bers, D.M.1
  • 13
    • 1542613385 scopus 로고    scopus 로고
    • Cellular basis of triggered arrhythmias in heart failure
    • DOI 10.1016/j.tcm.2003.12.002, PII S1050173803001944
    • Pogwizd, S.M. & Bers, D.M. Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc. Med. 14, 61-66 (2004). (Pubitemid 38340848)
    • (2004) Trends in Cardiovascular Medicine , vol.14 , Issue.2 , pp. 61-66
    • Pogwizd, S.M.1    Bers, D.M.2
  • 14
    • 1542409908 scopus 로고    scopus 로고
    • Altered Calcium Handling Is Critically Involved in the Cardiotoxic Effects of Chronic β-Adrenergic Stimulation
    • DOI 10.1161/01.CIR.0000117254.68497.39
    • Engelhardt, S. et al. Altered calcium handling is critically involved in the cardiotoxic effects of chronic β-adrenergic stimulation. Circulation 109, 1154-1160 (2004). (Pubitemid 38332620)
    • (2004) Circulation , vol.109 , Issue.9 , pp. 1154-1160
    • Engelhardt, S.1    Hein, L.2    Dyachenkow, V.3    Kranias, E.G.4    Isenberg, G.5    Lohse, M.J.6
  • 16
    • 33644673205 scopus 로고    scopus 로고
    • Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death
    • Jiang, D. et al. Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death. Circ. Res. 97, 1173-1181 (2005).
    • (2005) Circ. Res. , vol.97 , pp. 1173-1181
    • Jiang, D.1
  • 17
    • 0019942895 scopus 로고
    • Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers
    • Kass, R.S. & Tsien, R.W. Fluctuations in membrane current driven by intracellular calcium in cardiac Purkinje fibers. Biophys. J. 38, 259-269 (1982). (Pubitemid 12019588)
    • (1982) Biophysical Journal , vol.38 , Issue.3 , pp. 259-269
    • Kass, R.S.1
  • 18
    • 0020642781 scopus 로고
    • 2+ in mammalian cardiac muscle
    • Orchard, C.H., Eisner, D. & Allen, D. Oscillations of intracellular Ca2+ in mammalian cardiac muscle. Nature 304, 735-738 (1983). (Pubitemid 13037721)
    • (1983) Nature , vol.304 , Issue.5928 , pp. 735-738
    • Orchard, C.H.1    Eisner, D.A.2    Allen, D.G.3
  • 19
    • 0020603463 scopus 로고
    • ++-dependent cellular mechanical oscillations
    • Stern, M.D., Kort, A., Bhatnagar, G. & Lakatta, E. Scattered-light intensity fluctuations in diastolic rat cardiac muscle caused by spontaneous Ca++-dependent cellular mechanical oscillations. J. Gen. Physiol. 82, 119-153 (1983). (Pubitemid 13034088)
    • (1983) Journal of General Physiology , vol.82 , Issue.1 , pp. 119-153
    • Stern, M.D.1    Kort, A.A.2    Bhatnagar, G.M.3    Lakatta, E.G.4
  • 21
    • 0022968995 scopus 로고
    • Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle
    • Marban, E., Robinson, S.W. & Wier, W.G. Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. J. Clin. Invest. 78, 1185-1192 (1986). (Pubitemid 17181555)
    • (1986) Journal of Clinical Investigation , vol.78 , Issue.5 , pp. 1185-1192
    • Marban, E.1    Robinson, S.W.2    Wier, W.G.3
  • 22
    • 0034721607 scopus 로고    scopus 로고
    • Sarcoplasmic reticulum Ca2+ release causes myocyte depolarization. Underlying mechanism and threshold for triggered action potentials
    • Schlotthauer, K. & Bers, D.M. Sarcoplasmic reticulum Ca2+ release causes myocyte depolarization. Underlying mechanism and threshold for triggered action potentials. Circ. Res. 87, 774-780 (2000).
    • (2000) Circ. Res. , vol.87 , pp. 774-780
    • Schlotthauer, K.1    Bers, D.M.2
  • 23
    • 69249189946 scopus 로고    scopus 로고
    • Arrhythmogenic consequences of intracellular calcium waves
    • Xie, L.H. & Weiss, J.N. Arrhythmogenic consequences of intracellular calcium waves. Am. J. Physiol. Heart Circ. Physiol. 297, H997-H1002 (2009).
    • (2009) Am. J. Physiol. Heart Circ. Physiol. , vol.297
    • Xie, L.H.1    Weiss, J.N.2
  • 24
    • 20344400985 scopus 로고    scopus 로고
    • Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor
    • Cerrone, M. et al. Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor. Circ. Res. 96, e77-e82 (2005).
    • (2005) Circ. Res. , vol.96
    • Cerrone, M.1
  • 29
    • 77952491660 scopus 로고    scopus 로고
    • Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor
    • Uchinoumi, H. et al. Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor. Circ. Res. 106, 1413-1424 (2010).
    • (2010) Circ. Res. , vol.106 , pp. 1413-1424
    • Uchinoumi, H.1
  • 31
    • 0141752833 scopus 로고    scopus 로고
    • 2+ leak in intact ventricular myocytes from rabbits in heart failure
    • DOI 10.1161/01.RES.0000093399.11734.B3
    • Shannon, T.R., Pogwizd, S.M. & Bers, D.M. Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ. Res. 93, 592-594 (2003). (Pubitemid 37222154)
    • (2003) Circulation Research , vol.93 , Issue.7 , pp. 592-594
    • Shannon, T.R.1    Pogwizd, S.M.2    Bers, D.M.3
  • 33
    • 66549094345 scopus 로고    scopus 로고
    • Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic ventricular tachycardia
    • Hayashi, M. et al. Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic ventricular tachycardia. Circulation 119, 2426-2434 (2009).
    • (2009) Circulation , vol.119 , pp. 2426-2434
    • Hayashi, M.1
  • 35
    • 0033674550 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of carvedilol and its enantiomers in patients with congestive heart failure
    • Tenero, D. et al. Steady-state pharmacokinetics of carvedilol and its enantiomers in patients with congestive heart failure. J. Clin. Pharmacol. 40, 844-853 (2000).
    • (2000) J. Clin. Pharmacol. , vol.40 , pp. 844-853
    • Tenero, D.1
  • 36
    • 64149085800 scopus 로고    scopus 로고
    • Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
    • Watanabe, H. et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat. Med. 15, 380-383 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 380-383
    • Watanabe, H.1
  • 37
    • 74149094943 scopus 로고    scopus 로고
    • Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass
    • Hilliard, F.A. et al. Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. J. Mol. Cell. Cardiol. 48, 293-301 (2010).
    • (2010) J. Mol. Cell. Cardiol. , vol.48 , pp. 293-301
    • Hilliard, F.A.1
  • 38
    • 79959193265 scopus 로고    scopus 로고
    • Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class i antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia
    • Hwang, H.S. et al. Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia. Circ. Arrhythm Electrophysiol. 4, 128-135 (2011).
    • (2011) Circ. Arrhythm Electrophysiol , vol.4 , pp. 128-135
    • Hwang, H.S.1
  • 39
    • 0026011647 scopus 로고
    • Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial
    • Echt, D.S. et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N. Engl. J. Med. 324, 781-788 (1991).
    • (1991) N. Engl. J. Med. , vol.324 , pp. 781-788
    • Echt, D.S.1
  • 40
    • 0038662725 scopus 로고    scopus 로고
    • β-Blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure
    • DOI 10.1161/01.CIR.0000068316.53218.49
    • Reiken, S. et al. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation 107, 2459-2466 (2003). (Pubitemid 36605229)
    • (2003) Circulation , vol.107 , Issue.19 , pp. 2459-2466
    • Reiken, S.1    Wehrens, X.H.T.2    Vest, J.A.3    Barbone, A.4    Klotz, S.5    Mancini, D.6    Burkhoff, D.7    Marks, A.R.8
  • 42
    • 0036135118 scopus 로고    scopus 로고
    • Synthesis and evaluation of radiolabeled antagonists for imaging of β-adrenoceptors in the brain with PET
    • DOI 10.1016/S0197-0186(01)00081-X, PII S019701860100081X
    • Doze, P. et al. Synthesis and evaluation of radiolabeled antagonists for imaging of beta-adrenoceptors in the brain with PET. Neurochem. Int. 40, 145-155 (2002). (Pubitemid 34019191)
    • (2002) Neurochemistry International , vol.40 , Issue.2 , pp. 145-155
    • Doze, P.1    Elsinga, P.H.2    Maas, B.3    Van Waarde, A.4    Wegman, T.5    Vaalburg, W.6
  • 44
    • 0026749343 scopus 로고
    • Stereoselective disposition and tissue distribution of carvedilol enantiomers in rats
    • Fujimaki, M. Stereoselective disposition and tissue distribution of carvedilol enantiomers in rats. Chirality 4, 148-154 (1992).
    • (1992) Chirality , vol.4 , pp. 148-154
    • Fujimaki, M.1
  • 45
    • 0027525302 scopus 로고
    • Carvedilol stereopharmacokinetics in rats: Affinities to blood constituents and tissues
    • Stahl, E., Mutschler, E., Baumgartner, U. & Spahn-Langguth, H. Carvedilol stereopharmacokinetics in rats: affinities to blood constituents and tissues. Arch. Pharm. (Weinheim) 326, 529-533 (1993). (Pubitemid 23287141)
    • (1993) Archiv der Pharmazie , vol.326 , Issue.9 , pp. 529-533
    • Stahl, E.1    Mutschler, E.2    Baumgartner, U.3    Spahn-Langguth, H.4
  • 49
    • 0026779879 scopus 로고
    • Carvedilol, a new vasodilator and β adrenoceptor antagonist, is an antioxidant and free radical scavenger
    • Yue, T.L. et al. Carvedilol, a new vasodilator and β adrenoceptor antagonist, is an antioxidant and free radical scavenger. J. Pharmacol. Exp. Ther. 263, 92-98 (1992).
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 92-98
    • Yue, T.L.1
  • 51
    • 2942650804 scopus 로고    scopus 로고
    • Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure
    • Okafor, C.C. et al. Chronic treatment with carvedilol improves ventricular function and reduces myocyte apoptosis in an animal model of heart failure. BMC Physiol. 3, 6 (2003).
    • (2003) BMC Physiol , vol.3 , pp. 6
    • Okafor, C.C.1
  • 53
    • 70349754219 scopus 로고    scopus 로고
    • Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells
    • Chen, B., Wu, Y., Mohler, P.J., Anderson, M.E. & Song, L.S. Local control of Ca2+-induced Ca2+ release in mouse sinoatrial node cells. J. Mol. Cell. Cardiol. 47, 706-715 (2009).
    • (2009) J. Mol. Cell. Cardiol. , vol.47 , pp. 706-715
    • Chen, B.1    Wu, Y.2    Mohler, P.J.3    Anderson, M.E.4    Song, L.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.