Antagonism of orexin receptors significantly lowers blood pressure in spontaneously hypertensive rats

Journal of Physiology

Volumn 591, Issue 17, 2013, Pages 4237-4248

  Li, Aihua ^a   Hindmarch, Charles C T ^b   Nattie, Eugene E ^a   Paton, Julian F R ^c  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALMOREXANT; MESSENGER RNA; NORADRENALIN; OREXIN; OREXIN A MRNA; OREXIN RECEPTOR; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; ISOQUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; CEREBROSPINAL FLUID ANALYSIS; CIRCADIAN RHYTHM; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; GENE EXPRESSION; HEART RATE; HYPERTENSION; MALE; MEDULLA OBLONGATA; NON RAPDID EYE MOVEMENT SLEEP; NONHUMAN; NORADRENALIN BLOOD LEVEL; PATHOPHYSIOLOGY; PLASMA; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REM SLEEP; SYMPATHETIC TONE; WAKEFULNESS; WISTAR KYOTO RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; BLOOD PRESSURE; CEREBROSPINAL FLUID; GENETICS; METABOLISM; SPONTANEOUSLY HYPERTENSIVE RAT;

ACETAMIDES; ANIMALS; BLOOD PRESSURE; HYPERTENSION; ISOQUINOLINES; MEDULLA OBLONGATA; NOREPINEPHRINE; OREXIN RECEPTORS; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RNA, MESSENGER;

EID: 84883271864     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.256271     Document Type: Article

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