A key role for orexin in panic anxiety

Nature Medicine

Volumn 16, Issue 1, 2010, Pages 111-115

  Johnson, Philip L ^a   Truitt, William ^a   Fitz, Stephanie D ^a   Minick, Pamela E ^a   Dietrich, Amy ^a   Sanghani, Sonal ^a   Träskman Bendz, Lil ^b   Goddard, Andrew W ^a   Brundin, Lena ^b   Shekhar, Anantha ^a,c  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c Indiana Clinical and Translational Sciences Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; OREXIN; OREXIN 1 RECEPTOR;

ANIMAL MODEL; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME ACTIVITY; GENE SILENCING; MALE; NERVE CELL; NONHUMAN; PANIC; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT;

ADULT; ALPRAZOLAM; ANIMALS; ANXIETY; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; NEURONS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; PANIC DISORDER; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SODIUM LACTATE;

RATTUS;

EID: 73849143579     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2075     Document Type: Article

References (33)

1. Goddard, A.W. et al. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Arch. Gen. Psychiatry 58, 556-561 (2001).
2. Goddard, A.W. et al. Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. Am. J. Psychiatry 161, 2186-2193 (2004).
3. Roy-Byrne, P.P., Craske, M.G. & Stein, M.B. Panic disorder. Lancet 368, 1023-1032 (2006).
4. Johnson, P.L. & Shekhar, A. Panic-prone state induced in rats with GABA dysfunction in the dorsomedial hypothalamus is mediated by NMDA receptors. J. Neurosci. 26, 7093-7104 (2006).
5. Johnson, P.L., Truitt, W.A., Fitz, S.D., Lowry, C.A. & Shekhar, A. Neural pathways underlying lactate-induced panic. Neuropsychopharmacology 33, 2093-2107 (2008).
6. Shekhar, A. et al. Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus. J. Neurosci. 26, 9205-9215 (2006).
7. Shekhar, A. & Keim, S.R. The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorder. J. Neurosci. 17, 9726-9735 (1997).
8. Shekhar, A. & Keim, S.R. LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats. Neuropharmacology 39, 1139-1146 (2000).
9. Shekhar, A., Keim, S.R., Simon, J.R. & McBride, W.J. Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions. Pharmacol. Biochem. Behav. 55, 249-256 (1996).
10. Sakurai, T. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat. Rev. Neurosci. 8, 171-181 (2007).
11. Brisbare-Roch, C. et al. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat. Med. 13, 150-155 (2007). (Pubitemid 46245769)
12. Ferguson, A.V. & Samson, W.K. The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function. Front. Neuroendocrinol. 24, 141-150 (2003).
13. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) 4th edn. 429-440 (American Psychiatric Association, Washington, DC, 2005).
14. Liebowitz, M.R. et al. Possible mechanisms for lactate's induction of panic. Am. J. Psychiatry 143, 495-502 (1986).
15. Cowley, D.S., Dager, S.R., Roy-Byrne, P.P., Avery, D.H. & Dunner, D.L. Lactate vulnerability after alprazolam versus placebo treatment of panic disorder. Biol. Psychiatry 30, 49-56 (1991).
16. Liebowitz, M.R. et al. Alprazolam in the treatment of panic disorders. J. Clin. Psychopharmacol. 6, 13-20 (1986).
17. Gorman, J.M. et al. Anxiogenic effects of CO2 and hyperventilation in patients with panic disorder. Am. J. Psychiatry 151, 547-553 (1994).
18. Shekhar, A., Sajdyk, T.J., Gehlert, D.R. & Rainnie, D.G. The amygdala, panic disorder, and cardiovascular responses. Ann. NY Acad. Sci. 985, 308-325 (2003).
19. de Lecea, L. et al. The hypocretins: hypothalamus-specifc peptides with neuroexcitatory activity. Proc. Natl. Acad. Sci. USA 95, 322-327 (1998).
20. Kayaba, Y. et al. Attenuated defense response and low basal blood pressure in orexin knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285, R581-R593 (2003).
21. Chou, T.C. et al. Orexin (hypocretin) neurons contain dynorphin. J. Neurosci. 21, RC168 (2001).
22. Ishii, Y. et al. Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867. Behav. Brain Res. 157, 331-341 (2005).
23. Johnson, P.L., Truitt, W.A., Fitz, S.D., Lowry, C.A. & Shekhar, A. Neural pathways underlying lactate-induced panic. Neuropsychopharmacology 33, 2093-2107 (2007).
24. Rupprecht, R. et al. Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science 325, 490-493 (2009).
25. Andreatini, R. et al. The brain decade in debate: II. Panic or anxiety? From animal models to a neurobiological basis. Braz. J. Med. Biol. Res. 34, 145-154 (2001).
26. Boshuisen, M.L., Ter Horst, G.J., Paans, A.M., Reinders, A.A. & den Boer, J.A. rCBF differences between panic disorder patients and control subjects during anticipatory anxiety and rest. Biol. Psychiatry 52, 126-135 (2002).
27. Grillon, C., Ameli, R., Goddard, A., Woods, S.W. & Davis, M. Baseline and fear-potentiated startle in panic disorder patients. Biol. Psychiatry 35, 431-439 (1994).
28. Ludewig, S., Ludewig, K., Geyer, M.A., Hell, D. & Vollenweider, F.X. Prepulse inhibition defcits in patients with panic disorder. Depress. Anxiety 15, 55-60 (2002).
29. Salomon, R.M. et al. Diurnal variation of cerebrospinal fuid hypocretin-1 (Orexin-A) levels in control and depressed subjects. Biol. Psychiatry 54, 96-104 (2003).
30. Brundin, L., Bjorkqvist, M., Petersen, A. & Traskman-Bendz, L. Reduced orexin levels in the cerebrospinal fuid of suicidal patients with major depressive disorder. Eur. Neuropsychopharmacol. 17, 573-579 (2007).
31. Samuels, B.C., Zaretsky, D.V. & DiMicco, J.A. Dorsomedial hypothalamic sites where disinhibition evokes tachycardia correlate with location of raphe-projecting neurons. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287, R472-R478 (2004).
32. Shekhar, A., Keim, S.R., Simon, J.R. & McBride, W.J. Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions. Pharmacol. Biochem. Behav. 55, 249-256 (1996).
33. De Boer, S.F. & Koolhaas, J.M. Defensive burying in rodents: ethology, neurobiology and psychopharmacology. Eur. J. Pharmacol. 463, 145-161 (2003).