A decade of hypocretins: Past, present and future of the neurobiology of arousal

Acta Physiologica

Volumn 198, Issue 3, 2010, Pages 203-208

  De Lecea, L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Hypothalamus; Optogenetics; Orexin; Sleep; Wakefulness

Indexed keywords

ACETYLCHOLINE; ALPHA AMIDATING ENZYME; CHANNELRHODOPSIN 2; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; COMPLEMENTARY DNA; GLYCINE; HISTAMINE; HORMONE PRECURSOR; MELANIN CONCENTRATING HORMONE; MESSENGER RNA; NEUROPEPTIDE RECEPTOR; NEUROTRANSMITTER; NORADRENALIN; OREXIN; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B; OREXIN RECEPTOR ANTAGONIST; OXYTOCIN; RECEPTOR BLOCKING AGENT; RHODOPSIN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; VASOPRESSIN;

ADDICTION; ADRENERGIC STIMULATION; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; AROUSAL; BLOOD ANALYSIS; BRAIN MAPPING; BRAIN NERVE CELL; BRAIN REGION; CARBOXY TERMINAL SEQUENCE; CATAPLEXY; CEREBROSPINAL FLUID ANALYSIS; CLINICAL RESEARCH; COCAINE DEPENDENCE; CONFERENCE PAPER; DRUG DEPENDENCE; DRUG SELF ADMINISTRATION; GENE EXPRESSION; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; HYPOTHALAMUS; IN SITU HYBRIDIZATION; INNERVATION; INSOMNIA; INTERNEURON; KNOCKOUT GENE; MOLECULAR BIOLOGY; MOUSE MUTANT; NARCOLEPSY; NEUROBIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIFORNICAL AREA; PREOPTIC AREA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RELAPSE; REWARD; SLEEP DISORDER; SLEEP WAKING CYCLE; TISSUE DISTRIBUTION; WAKEFULNESS;

ANIMALS; AROUSAL; BRAIN; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROBIOLOGY; NEURONS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS;

EID: 75749108530     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2009.02004.x     Document Type: Conference Paper

References (55)

1. Abrahamson, E.E., Leak, R.K. Moore, R.Y. 2001. The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems. Neuroreport 12, 435 440.
2. Acuna-Goycolea, C. van den Pol, A. 2004. Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal. J Neurosci 24, 8141 8152.
3. Adamantidis, A.R., Zhang, F., Aravanis, A.M., Deisseroth, K. de Lecea, L. 2007. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450, 420 424.
4. Bayer, L., Eggermann, E., Serafin, M., Grivel, J., Machard, D., Muhlethaler, M. Jones, B.E. 2005. Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin vs. melanin concentrating hormone neurons in rat hypothalamic slices. Neuroscience 130, 807 811.
5. Blanco-Centurion, C., Gerashchenko, D. Shiromani, P.J. 2007. Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wake. J Neurosci 27, 14041 14048.
6. Borgland, S.L., Taha, S.A., Sarti, F., Fields, H.L. Bonci, A. 2006. Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49, 589 601.
7. Boutrel, B., Kenny, P.J., Specio, S.E., Martin-Fardon, R., Markou, A., Koob, G.F. de Lecea, L. 2005. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proc Natl Acad Sci USA 102, 19168 19173.
8. Brisbare-Roch, C., Dingemanse, J., Koberstein, R., Hoever, P., Aissaoui, H., Flores, S., Mueller, C., Nayler, O., van Gerven, J., de Haas, S.L. et al. 2007. Promotion of sleep by targeting the orexin system in rats, dogs and humans. Nat Med 13, 150 155. (Pubitemid 46245769)
9. Burdakov, D., Gerasimenko, O. Verkhratsky, A. 2005. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci 25, 2429 2433.
10. + channels mediate inhibition of orexin neurons by glucose. Neuron 50, 711 722.
11. Chemelli, R.M., Willie, J.T., Sinton, C.M., Elmquist, J.K., Scammell, T., Lee, C., Richardson, J.A., Williams, S.C., Xiong, Y., Kisanuki, Y., Fitch, T.E., Nakazato, M., Hammer, R.E., Saper, C.B. Yanagisawa, M. 1999. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98, 437 451.
12. Chen, C.T., Dun, S.L., Kwok, E.H., Dun, N.J. Chang, J.K. 1999. Orexin A-like immunoreactivity in the rat brain. Neurosci Lett 260, 161 164.
13. Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., Sakurai, T., Yanagisawa, M. Nakazato, M. 1999. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA 96, 748 753.
14. Deisseroth, K., Feng, G., Majewska, A.K., Miesenbock, G., Ting, A. Schnitzer, M.J. 2006. Next-generation optical technologies for illuminating genetically targeted brain circuits. J Neurosci 26, 10380 10386.
15. Fu, L.-Y., Acuna-Goycolea, C. van den Pol, A.N. 2004. Neuropeptide Y inhibits hypocretin/orexin neurons by multiple pre-synaptic and post-synaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci 24, 8741 8751.
16. Gautvik, K.M., de Lecea, L., Gautvik, V.T., Danielson, P.E., Tranque, P., Dopazo, A., Bloom, F.E. Sutcliffe, J.G. 1996. Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. Proc Natl Acad Sci USA 93, 8733 8738.
17. Gerashchenko, D., Wisor, J.P., Burns, D., Reh, R.K., Shiromani, P.J., Sakurai, T., de la Iglesia, H.O. Kilduff, T.S. 2008. Identification of a population of sleep-active cerebral cortex neurons. Proc Natl Acad Sci USA 105, 10227 10232.
18. Grivel, J., Cvetkovic, V., Bayer, L., Machard, D., Tobler, I., Muhlethaler, M. Serafin, M. 2005. The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation. J Neurosci 25, 4127 4130.
19. Haas, H.L., Sergeeva, O.A. Selbach, O. 2008. Histamine in the nervous system. Physiol Rev 88, 1183 1241.
20. Halassa, M.M., Florian, C., Fellin, T., Munoz, J.R., Lee, S.Y., Abel, T., Haydon, P.G. Frank, M.G. 2009. Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss. Neuron 61, 213 219.
21. Harris, G.C., Wimmer, M. Jones, G.A. 2005. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437, 556 559.
22. Hassani, O.K., Lee, M.G. Jones, B.E. 2009. Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle. Proc Natl Acad Sci USA 106, 2418 2422.
23. Jaszberenyi, M., Bujdoso, E. Telegdy, G. 2001. The role of neuropeptide y in orexin-induced hypothalamic-pituitary-adrenal activation. J Neuroendocrinol 13, 438 441.
24. Kuru, M., Ueta, Y., Serino, R., Nakazato, M., Yamamoto, Y., Shibuya, I. Yamashita, H. 2000. Centrally administered orexin/hypocretin activates HPA axis in rats. Neuroreport 11, 1977 1980.
25. de Lecea, L. Sutcliffe, J.G. (eds) 2005. Hypocretins: Integrators of Physiological Functions. Springer, New York.
26. de Lecea, L., Kilduff, T.S., Peyron, C., Gao, X., Foye, P.E., Danielson, P.E., Fukuhara, C., Battenberg, E.L., Gautvik, V.T., Bartlett, F.S., 2nd., Frankel, W.N., van den Pol, A.N., Bloom, F.E., Gautvik, K.M. Sutcliffe, J.G. 1998. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95, 322 327.
27. Lee, M.G., Hassani, O.K. Jones, B.E. 2005. Discharge of identified orexin/hypocretin neurons across the sleep-waking cycle. J Neurosci 25, 6716 6720.
28. Li, Y., Gao, X.-B., Sakurai, T. van den Pol, A.N. 2002. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron: a potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36, 1169 1181.
29. Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P.J., Nishino, S. Mignot, E. 1999. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365 376.
30. Liu, Z.-W. Gao, X.-B. 2007. Adenosine inhibits activity of hypocretin/orexin neurons by the a1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. J Neurophysiol 97, 837 848.
31. Mileykovskiy, B.Y., Kiyashchenko, L.I. Siegel, J.M. 2005. Behavioral correlates of activity in identified hypocretin/orexin neurons. Neuron 46, 787 798.
32. Moruzzi, G. Magoun, H.W. 1949. Brain stem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1, 455 473.
33. Muraki, Y., Yamanaka, A., Tsujino, N., Kilduff, T.S., Goto, K. Sakurai, T. 2004. Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor. J Neurosci 24, 7159 7166.
34. Nambu, T., Sakurai, T., Mizukami, K., Hosoya, Y., Yanagisawa, M. Goto, K. 1999. Distribution of orexin neurons in the adult rat brain. Brain Res 827, 243 260.
35. Narita, M., Nagumo, Y., Hashimoto, S., Khotib, J., Miyatake, M., Sakurai, T., Yanagisawa, M., Nakamachi, T., Shioda, S. Suzuki, T. 2006. Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci 26, 398 405.
36. Pañeda, C., Winsky-Sommerer, R., Boutrel, B. de Lecea, L. 2005. The corticotropin-releasing factor-hypocretin connection: implications in stress response and addiction. Drug News Perspect 18, 250 255.
37. Peyron, C., Tighe, D.K., van den Pol, A.N., de Lecea, L., Heller, H.C., Sutcliffe, J.G. Kilduff, T.S. 1998. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18, 9996 10015.
38. Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R. et al. 2000. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6, 991 997.
39. Sakurai, T. 1999. Orexins and orexin receptors: implication in feeding behavior. Regul Pept 85, 25 30. (Pubitemid 29505282)
40. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richarson, J.A., Kozlowski, G.P., Wilson, S. et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 1 page following 696.
41. Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. Yanagisawa, M. 2005. Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 46, 297 308.
42. Samson, W.K., Taylor, M.M., Follwell, M. Ferguson, A.V. 2002. Orexin actions in hypothalamic paraventricular nucleus: physiological consequences and cellular correlates. Regul Pept 104, 97 103. (Pubitemid 34119379)
43. Scammell, T.E. 2003. The neurobiology, diagnosis, and treatment of narcolepsy. Ann Neurol 53, 154 166.
44. Sherin, J.E., Shiromani, P.J., McCarley, R.W. Saper, C.B. 1996. Activation of ventrolateral preoptic neurons during sleep. Science 271, 216 219.
45. Shirasaka, T., Nakazato, M., Matsukura, S., Takasaki, M. Kannan, H. 1999. Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol 277, R1780 R1785.
46. Thannickal, T.C., Moore, R.Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M. Siegel, J.M. 2000. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27, 469 474.
47. Tsujino, N., Yamanaka, A., Ichiki, K., Muraki, Y., Kilduff, T.S., Yagami, K.-i., Takahashi, S., Goto, K. Sakurai, T. 2005. Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor. J Neurosci 25, 7459 7469.
48. Usui, H., Falk, J.D., Dopazo, A., de Lecea, L., Erlander, M.G. Sutcliffe, J.G. 1994. Isolation of clones of rat striatum-specific mRNAs by directional tag PCR subtraction. J Neurosci 14, 4915 4926.
49. Willie, J.T., Chemelli, R.M., Sinton, C.M., Tokita, S., Williams, S.C., Kisanuki, Y.Y., Marcus, J.N., Lee, C., Elmquist, J.K., Kohlmeier, K.A., Leonard, C.S., Richardson, J.A., Hammer, R.E. Yanagisawa, M. 2003. Distinct narcolepsy syndromes in orexin receptor-2 and orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes. Neuron 38, 715 730.
50. Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A.J., Sakurai, T., Kilduff, T.S., Horvath, T.L. de Lecea, L. 2004. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. J Neurosci 24, 11439 11448.
51. Wollmann, G., Acuna-Goycolea, C. van den Pol, A.N. 2005. Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptors. J Neurophysiol 94, 2195 2206.
52. Xie, X., Crowder, T.L., Yamanaka, A., Morairty, S.R., LeWinter, R.D., Sakurai, T. Kilduff, T.S. 2006. GABAB receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. J Physiol 574, 399 414.
53. Yamanaka, A., Beuckmann, C.T., Willie, J.T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K.-i., Sugiyama, F., Goto, K., Yanagisawa, M. Sakurai, T. 2003a. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38, 701 713.
54. Yamanaka, A., Muraki, Y., Tsujino, N., Goto, K. Sakurai, T. 2003b. Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun 303, 120 129.
55. Yoshida, K., McCormack, S., Espana, R.A., Crocker, A. Scammell, T.E. 2006. Afferents to the orexin neurons of the rat brain. J Comp Neurol 494, 845 861.