Functions of orexins in peripheral tissues

Acta Physiologica

Volumn 192, Issue 4, 2008, Pages 471-485

  Heinonen, M V ^a   Purhonen, A K ^a   Makela K A ^a   Herzig, K H ^a,b,c  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Adrenal gland; Insulin secretion; Intestinal motility; Orexin A; Orexin B; Prepro orexin

Indexed keywords

OREXIN; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B;

FEEDING; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INSULIN RELEASE; INTESTINE MOTILITY; METABOLISM; NONHUMAN; NUTRITIONAL STATUS; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REGULATORY MECHANISM; REVIEW; SLEEP; SYMPATHETIC TONE; WAKEFULNESS;

ADRENAL GLANDS; ANIMALS; GASTROINTESTINAL TRACT; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES;

EID: 40049094368     PISSN: 17481708     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2008.01836.x     Document Type: Review

References (107)

1. Adam, J.A., Menheere, P.P., van Dielen, F.M., Soeters, P.B., Buurman, W.A. Greve, J.W. 2002. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord 26, 274 276.
2. Al-Barazanji, K.A., Wilson, S., Baker, J., Jessop, D.S. Harbuz, M.S. 2001. Central orexin-A activates hypothalamic-pituitary-adrenal axis and stimulates hypothalamic corticotropin releasing factor and arginine vasopressin neurones in conscious rats. J Neuroendocrinol 13, 421 424.
3. Antunes, V.R., Brailoiu, G.C., Kwok, E.H., Scruggs, P. Dun, N.J. 2001. Orexins/hypocretins excite rat sympathetic preganglionic neurons in vivo and in vitro. Am J Physiol Regul Integr Comp Physiol 281, R1801 R1807.
4. Arihara, Z., Takahashi, K., Murakami, O., Totsune, K., Sone, M., Satoh, F., Ito, S. Mouri, T. 2001. Immunoreactive orexin-A in human plasma. Peptides 22, 139 142.
5. Asakawa, A., Inui, A., Inui, T., Katsuura, G., Fujino, M.A. Kasuga, M. 2002. Orexin reverses cholecystokinin-induced reduction in feeding. Diabetes Obes Metab 4, 399 401.
6. Baranowska, B., Wolinska-Witort, E., Martynska, L., Chmielowska, M. Baranowska-Bik, A. 2005. Plasma orexin A, orexin B, leptin, neuropeptide Y (NPY) and insulin in obese women. Neuro Endocrinol Lett 26, 293 296.
7. Barreiro, M.L., Pineda, R., Gaytan, F., Archanco, M., Burell, M.A., Castellano, J.M., Hakovirta, H., Nurmio, M., Pinilla, L., Aguilar, E., Toppari, J., Dieguez, C. Tena-Sempere, M. 2005. Pattern of orexin expression and direct biological actions of orexin-a in rat testis. Endocrinology 146, 5164 5175.
8. Barreiro, M.L., Pineda, R., Navarro, V.M., Lopez, M., Suominen, J.S., Pinilla, L., Senaris, R., Toppari, J., Aguilar, E., Diéguez, C. Tena-Sempere, M. 2004. Orexin 1 receptor messenger ribonucleic acid expression and stimulation of testosterone secretion by orexin-A in rat testis. Endocrinology 145, 2297 306.
9. Baumann, C.R. Bassetti, C.L. 2005. Hypocretins (orexins) and sleep-wake disorders. Lancet Neurol 4, 673 682.
10. Bengtsson, M.W., Makela, K., Sjoblom, M., Uotila, S., Akerman, K.E., Herzig, K.H. Flemstrom, G. 2007. Food induced expression of orexin-receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A. Am J Physiol Gastrointest Liver Physiol 293, G501 G509.
11. Blanco, M., García-Caballero, T., Fraga, M., Gallego, R., Cuevas, J., Forteza, J., Beiras, A. Diéguez, C. 2002. Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas. Regul Pept 15, 161 165.
12. Bourgin, P., Huitron-Resendiz, S., Spier, A.D., Fabre, V., Morte, B., Criado, J.R., Sutcliffe, J.G., Henriksen, S.J. de Lecea, L. 2000. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J Neurosci 20, 7760 7765.
13. Bronsky, J., Nedvidkova, J., Zamrazilova, H., Pechová, M., Chada, M., Kotaska, K., Nevoral, J. Prusa, R. 2006. Dynamic changes of orexin a and leptin in obese children during body weight reduction. Physiol Research 56, 89 96.
14. Burdyga, G., Lal, S., Spiller, D., Jiang, W., Thompson, D., Attwood, S., Saeed, S., Grundy, D., Varro, A., Dimaline, R. Dockray, G.J. 2003. Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. Gastroenterology 124, 129 139.
15. Busquets, X., Barbe, F., Barcelo, A., de la Peña, M., Sigritz, N., Mayorales, L.R., Ladaria, A. Agustí, A. 2004. Decreased plasma levels of orexin-A in sleep apnea. Respiration 7, 575 579.
16. Cai, X.J., Liu, X.H., Evans, M., Clapham, J.C., Wilson, S., Arch, J.R., Morris, R. Williams, G. 2002. Orexins and feeding: special occasions or everyday occurrence? Regul Pept 104, 1 9.
17. Calignano, A., Whittle, B.J., Di Rosa, M. Moncada, S. 1992. Involvement of endogenous nitric oxide in the regulation of rat intestinal motility in vivo. Eur J Pharmacol 229, 273 276.
18. Chen, C.T., Hwang, L.L., Chang, J.K. Dun, N.J. 2000. Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Am J Physiol Regul Integr Comp Physiol 278, R692 R697.
19. Ciriello, J., Li, Z. de Oliveira, C.V. 2003a. Cardioacceleratory responses to hypocretin-1 injections into rostral ventromedial medulla. Brain Res 991, 84 95.
20. Ciriello, J., McMurray, J.C., Babic, T. de Oliveira, C.V. 2003b. Collateral axonal projections from hypothalamic hypocretin neurons to cardiovascular sites in nucleus ambiguus and nucleus tractus solitarius. Brain Res 991, 133 141.
21. Darker, J.G., Porter, R.A., Eggleston, D.S., Smart, D., Brough, S.J., Sabido-David, C. Jerman, J.C. 2001. Structure-activity analysis of truncated orexin-A analogues at the orexin-1 receptor. Bioorg Med Chem Lett, 12, 737 740.
22. Digby, J.E., Chen, J., Tang, J.Y., Lehnert, H., Matthews, R.N. Randeva, H.S. 2006. Orexin receptor expression in human adipose tissue: effects of orexin-A and orexin-B. J Endocrinol 191, 129 136.
23. Ehrstrom, M., Naslund, E., Ma, J., Kirchgessner, A.L. Hellstrom, P.M. 2003. Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA. Am J Physiol Gastrointest Liver Physiol 285, G688 G695.
24. Ehrstrom, M., Naslund, E., Levin, F., Kaur, R., Kirchgessner, A.L., Theodorsson, E. Hellstrom, P.M. 2004. Pharmacokinetic profile of orexin A and effects on plasma insulin and glucagon in the rat. Regul Pept 119, 209 212.
25. Ehrstrom, M., Gustafsson, T., Finn, A., Kirchgessner, A., Gryback, P., Jacobsson, H., Hellstrom, P.M. Naslund, E. 2005a. Inhibitory effect of exogenous orexin a on gastric emptying, plasma leptin, and the distribution of orexin and orexin receptors in the gut and pancreas in man. J Clin Endocrinol Metab 90, 2370 2377.
26. Ehrstrom, M., Levin, F., Kirchgessner, A.L., Schmidt, P.T., Hilsted, L.M., Gryback, P., Jacobsson, H., Hellstrom, P.M. Naslund, E. 2005b. Stimulatory effect of endogenous orexin A on gastric emptying and acid secretion independent of gastrin. Regul Pept 132, 9 16.
27. Espana, R.A., Baldo, B.A., Kelley, A.E. Berridge, C.W. 2001. Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action. Neuroscience 106, 699 715.
28. Flemstrom, G., Sjoblom, M., Jedstedt, G. Akerman, K.E. 2003. Short fasting dramatically decreases rat duodenal secretory responsiveness to orexin A but not to VIP or melatonin. Am J Physiol Gastrointest Liver Physiol 285, G1091 G1096.
29. Gallmann, E., Arsenijevic, D., Williams, G., Langhans, W. Spengler, M. 2006. Effect of intraperitoneal CCK-8 on food intake and brain orexin-A after 48 h of fasting in the rat. Regul Pept 133, 139 146.
30. Glassmeier, G., Herzig, K.H., Hopfner, M., Lemmer, K., Jansen, A. Scherubl, H. 1998. Expression of functional GABAA receptors in cholecystokinin-secreting gut neuroendocrine murine STC-1 cells. J Physiol 510, 805 814.
31. Hagan, J.J., Leslie, R.A., Patel, S., Evans, M.L., Wattam, T.A., Holmes, S., Benham, C.D., Taylor, S.G., Routledge, C., Hemmati, P., et al. 1999. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci USA 96, 10911 10916.
32. Harris, D.M., Go, V.L., Reeve, J.R., Jr. Wu, S.V. 2002. Stimulation of amylase release by Orexin is mediated by Orexin 2 receptor in AR42J cells. Pancreas 25, 405 410.
33. Heinonen, M.V., Purhonen, A.K., Miettinen, P., Paakkonen, M., Pirinen, E., Alhava, E., Akerman, K. Herzig, K.H. 2005. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul Pept 130, 7 13.
34. Higuchi, S., Usui, A., Murasaki, M., Matsushita, S., Nishioka, N., Yoshino, A., Matsui, T., Muraoka, H., Ishizuka, Y., Kanba, S. Sakurai, T. 2002. Plasma orexin-A is lower in patients with narcolepsy. Neurosci Lett 318, 61 64.
35. Hirota, K., Kushikata, T., Kudo, M., Kudo, T., Smart, D. Matsuki, A. 2003. Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats. Brain Res 981, 143 150.
36. Ida, T., Nakahara, K., Murakami, T., Hanada, R., Nakazato, M. Murakami, N. 2000. Possible involvement of orexin in the stress reaction in rats. Biochem Biophys Res Commun 270, 318 323.
37. Igarashi, N., Tatsumi, K., Nakamura, A., Sakao, S., Takiguchi, Y., Nishikawa, T. Kuriyama, T. 2003. Plasma orexin-A levels in obstructive sleep apnea-hypopnea syndrome. Chest 124, 1381 1385.
38. Jansen, A., Hoepfner, M., Herzig, K.H., Riecken, E.O. Scherubl, H. 2000. GABA(C) receptors in neuroendocrine gut cells: a new GABA-binding site in the gut. Pflugers Arch 441, 294 300.
39. Jaszberenyi, M., Bujdoso, E., Pataki, I. Telegdy, G. 2000. Effects of orexins on the hypothalamic-pituitary-adrenal system. J Neuroendocrinol 12, 1174 1178.
40. Johren, O., Neidert, S.J., Kummer, M., Dendorfer, A. Dominiak, P. 2001. Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats. Endocrinology 142, 3324 3331.
41. Karteris, E., Randeva, H.S., Grammatopoulos, D.K., Jaffe, R.B. Hillhouse, E.W. 2001. Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals. J Clin Endocrinol Metab 86, 4512 4519.
42. Karteris, E., Chen, J. Randeva, H.S. 2004. Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. J Clin Endocrinol Metab 89, 1957 1962.
43. Kastin, A.J. Akerstrom, V. 1999. Orexin A but not orexin B rapidly enters brain from blood by simple diffusion. J Pharmacol Exp Ther 289, 219 223.
44. Kawada, Y., Ueno, S., Asayama, K., Tsutsui, M., Utsunomiya, K., Toyohira, Y., Morisada, N., Tanaka, K., Shirahata, A. Yanagihara, N. 2003. Stimulation of catecholamine synthesis by orexin-A in bovine adrenal medullary cells through orexin receptor 1. Biochem Pharmacol 66, 141 147.
45. Kayaba, Y., Nakamura, A., Kasuya, Y., Ohuchi, T., Yanagisawa, M., Komuro, I., Fukuda, Y. Kuwaki, T. 2003. Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol 285, R581 R593.
46. Kirchgessner, A.L. 2002. Orexins in the brain-gut axis. Endocr Rev 23, 1 15.
47. Kirchgessner, A.L. Liu, M. 1999. Orexin synthesis and response in the gut. Neuron 24, 941 951.
48. Kobashi, M., Furudono, Y., Matsuo, R. Yamamoto, T. 2002. Central orexin facilitates gastric relaxation and contractility in rats. Neurosci Lett 332, 171 174.
49. Komaki, G., Matsumoto, Y., Nishikata, H., Kawai, K., Nozaki, T., Takii, M., Sogawa, H. Kubo, C. 2001. Orexin-A and leptin change inversely in fasting non-obese subjects. Eur J Endocrinol 144, 645 651.
50. Korczynski, W., Ceregrzyn, M., Kato, I., Wolinski, J. Zabielski, R. 2006. The effect of orexins on intestinal motility in vitro in fed and fasted rats. J Physiol Pharmacol 57, 43 54.
51. Krowicki, Z.K., Burmeister, M.A., Berthoud, H.R., Scullion, R.T., Fuchs, K. Hornby, P.J. 2002. Orexins in rat dorsal motor nucleus of the vagus potently stimulate gastric motor function. Am J Physiol Gastrointest Liver Physiol 283, G465 G472.
52. Kukkonen, J.P., Holmqvist, T., Ammoun, S. Akerman, K.E. 2002. Functions of the orexinergic/hypocretinergic system. Am J Physiol Cell Physiol 283, C1567 C1591.
53. Kuru, M., Ueta, Y., Serino, R., Nakazato, M., Yamamoto, Y., Shibuya, I. Yamashita, H. 2000. Centrally administered orexin/hypocretin activates HPA axis in rats. Neuroreport 11, 1977 1980.
54. Larsson, K.P., Akerman, K.E., Magga, J., Uotila, S., Kukkonen, J.P., Nasman, J. Herzig, K.H. 2003. The STC-1 cells express functional orexin-A receptors coupled to CCK release. Biochem Biophys Res Commun 309, 209 216.
55. de Lecea, L., Kilduff, T.S., Peyron, C., Gao, X., Foye, P.E., Danielson, P.E., Fukuhara, C., Battenberg, E.L., Gautvik, V.T., Bartlett, F.S., 2nd., Frankel, W.N., van den Pol, A.N., Bloom, F.E., Gautvik, K.M. Sutcliffe, J.G. 1998. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95, 322 327.
56. Lee, J.H., Bang, E., Chae, K.J., Kim, J.Y., Lee, D.W. Lee, W. 1999. Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B. Eur J Biochem 266, 831 839.
57. Lin, L., Faraco, J., Li, R., Kadotani, H., Kadotani, H., Rogers, W., Lin, X., Qiu, X., de Jong, P.J., Nishino, S. Mignot, E. 1999. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365 376.
58. Lopez, M., Senaris, R., Gallego, R., García-Caballero, T., Lago, F., Seoane, L., Casanueva, F. Diéguez, C. 1999. Orexin receptors are expressed in the adrenal medulla of the rat. Endocrinology 140, 5991 5994.
59. Malendowicz, L.K., Tortorella, C. Nussdorfer, G.G. 1999. Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade. J Steroid Biochem Mol Biol 70, 185 188.
60. Malendowicz, L.K., Hochol, A., Ziolkowska, A., Nowak, M., Gottardo, L. Nussdorfer, G.G. 2001. Prolonged orexin administration stimulates steroid-hormone secretion, acting directly on the rat adrenal gland. Int J Mol Med 7, 401 404.
61. Matsumura, K., Tsuchihashi, T. Abe, I. 2001. Central orexin-A augments sympathoadrenal outflow in conscious rabbits. Hypertension 37, 1382 1387.
62. Mazzocchi, G., Malendowicz, L.K., Aragona, F., Rebuffat, P., Gottardo, L. Nussdorfer, G.G. 2001a. Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B. J Clin Endocrinol Metab 86, 4818 4821.
63. Mazzocchi, G., Malendowicz, L.K., Gottardo, L., Aragona, F. Nussdorfer, G.G. 2001b. Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade. J Clin Endocrinol Metab 86, 778 782.
64. Mignot, E. 2004. Sleep, sleep disorders and hypocretin (orexin). Sleep Med 5 (Suppl. 1 S2 S8.
65. de Miguel, M.J. Burrell, M.A. 2002. Immunocytochemical detection of orexin A in endocrine cells of the developing mouse gut. J Histochem Cytochem 50, 63 69.
66. Mitsuma, T., Hirooka, Y., Kayama, M., Mori, Y., Yokoi, Y., Rhue, N., Ping, J., Izumi, M., Ikai, R., Adachi, K. Nogimori, T. 2000a. Radioimmunoassay for orexin A. Life Sci 66, 897 904.
67. Mitsuma, T., Hirooka, Y., Kayma, M., Mori, Y., Yokoi, Y., Izumi, M., Rhue, N., Ping, J., Adachi, K., Ikai, R., Kawai, N., Nakayashiki, A. Nogimori, T. 2000b. Radioimmunoassay for hypocretin 2. Endocr Regul 34, 23 27.
68. Miyasaka, K., Masuda, M., Kanai, S., Sato, N., Kurosawa, M. Funakoshi, A. 2002. Central Orexin-A stimulates pancreatic exocrine secretion via the vagus. Pancreas 25, 400 404.
69. Nakabayashi, M., Suzuki, T., Takahashi, K., Totsune, K., Muramatsu, Y., Kaneko, C., Date, F., Takeyama, J., Darnel, A.D., Moriya, T. Sasano, H. 2003. Orexin-A expression in human peripheral tissues. Mol Cell Endocrinol 205, 43 50.
70. Nanmoku, T., Isobe, K., Sakurai, T., Yamanaka, A., Takekoshi, K., Kawakami, Y., Ishii, K., Goto, K. Nakai, T. 2000. Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells. Biochem Biophys Res Commun 274, 310 315.
71. Nanmoku, T., Isobe, K., Sakurai, T., Yamanaka, A., Takekoshi, K., Kawakami, Y., Goto, K. Nakai, T. 2002. Effects of orexin on cultured porcine adrenal medullary and cortex cells. Regul Pept 104, 125 130.
72. Naslund, E., Ehrstrom, M., Ma, J., Hellstrom, P.M. Kirchgessner, A.L. 2002. Localization and effects of orexin on fasting motility in the rat duodenum. Am J Physiol Gastrointest Liver Physiol 282, G470 G479.
73. Nishino, S., Ripley, B., Overeem, S., Lammers, G.J. Mignot, E. 2000. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355, 39 40.
74. Nowak, K.W., Mackowiak, P., Switonska, M.M., Fabis, M. Malendowicz, L.K. 2000. Acute orexin effects on insulin secretion in the rat: in vivo and in vitro studies. Life Sci 66, 449 454.
75. Nowak, K.W., Strowski, M.Z., Switonska, M.M., Kaczmarek, P., Singh, V., Fabis, M., Mackowiak, P., Nowak, M. Malendowicz, L.K. 2005. Evidence that orexins A and B stimulate insulin secretion from rat pancreatic islets via both receptor subtypes. Int J Mol Med 15, 969 972.
76. Okumura, T., Takeuchi, S., Motomura, W., Yamada, H., Egashira Si, S., Asahi, S., Kanatani, A., Ihara, M. Kohgo, Y. 2001. Requirement of intact disulfide bonds in orexin-A-induced stimulation of gastric acid secretion that is mediated by OX1 receptor activation. Biochem Biophys Res Commun 280, 976 981.
77. de Oliveira, C.V. Ciriello, J. 2003. Cardiovascular responses to hypocretin-1 in nucleus ambiguous of the ovariectomized female rat. Brain Res 986, 148 156.
78. Ouedraogo, R., Naslund, E. Kirchgessner, A.L. 2003. Glucose regulates the release of orexin-a from the endocrine pancreas. Diabetes 52, 111 117.
79. Qu, X.W., Wang, H., Rozenfeld, R.A., Huang, W. Hsueh, W. 1999. Type I nitric oxide synthase (NOS) is the predominant NOS in rat small intestine. Regulation by platelet-activating factor. Biochim Biophys Acta 1451, 211 217.
80. Randeva, H.S., Karteris, E., Grammatopoulos, D. Hillhouse, E.W. 2001. Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. J Clin Endocrinol Metab 86, 4808 4813.
81. Rodgers, R.J., Halford, J.C., Nunes de Souza, R.L., Canto de Souza, A.L., Piper, D.C., Arch, J.R., Upton, N., Porter, R.A., Johns, A. Blundell, J.E. 2001. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur J Neurosci 13, 1444 1452.
82. Rodgers, R.J., Ishii, Y., Halford, J.C. Blundell, J.E. 2002. Orexins and appetite regulation. Neuropeptides 36, 303 325.
83. Russell, S.H., Small, C.J., Dakin, C.L., Abbott, C.R., Morgan, D.G., Ghatei, M.A. Bloom, S.R. 2001. The central effects of orexin-A in the hypothalamic-pituitary-adrenal axis in vivo and in vitro in male rats. J Neuroendocrinol 13, 561 566.
84. Sakurai, T. 2007. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 8, 171 181.
85. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richarson, J.A., Kozlowski, G.P., Wilson, S., et al. 1998. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573 585.
86. Sakurai, S., Nishijima, T., Takahashi, S., Yamauchi, K., Arihara, Z. Takahashi, K. 2004. Clinical significance of daytime plasma orexin-A-like immunoreactivity concentrations in patients with obstructive sleep apnea hypopnea syndrome. Respiration, 71, 380 384.
87. Samson, W.K., Gosnell, B., Chang, J.K., Resch, Z.T. Murphy, T.C. 1999. Cardiovascular regulatory actions of the hypocretins in brain. Brain Res 831, 248 253.
88. Satoh, Y., Uchida, M., Fujita, A., Nishio, H., Takeuchi, T. Hata, F. 2001. Possible role of orexin A in nonadrenergic, noncholinergic inhibitory response of muscle of the mouse small intestine. Eur J Pharmacol 428, 337 342.
89. Satoh, Y., Okishio, Y., Azuma, Y.T., Nakajima, H., Hata, F. Takeuchi, T. 2006. Orexin A affects ascending contraction depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum. Neuropharmacology 51, 466 473.
90. Shirasaka, T., Nakazato, M., Matsukura, S., Takasaki, M. Kannan, H. 1999. Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol 277, R1780 R1785.
91. Silveyra, P., Catalano, P.N., Lux-Lantos, V. Libertun, C. 2007a. Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal. Am J Physiol Endocrinol Metab 292, E820 E828.
92. Silveyra, P., Lux-Lantos, V.A. Libertun, C. 2007b. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle. Effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab 293, E977 E985.
93. Smart, D., Haynes, A.C., Williams, G. Arch, J.R. 2002. Orexins and the treatment of obesity. Eur J Pharmacol 440, 199 212.
94. Smith, P.M., Samson, W.K. Ferguson, A.V. 2007. Cardiovascular actions of orexin-A in the rat subfornical organ. J Neuroendocrinol 19, 7 13.
95. Spinazzi, R., Rucinski, M., Neri, G., Malendowicz, L.K. Nussdorfer, G.G. 2005. Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells. J Clin Endocrinol Metab 90, 3544 3549.
96. Spinazzi, R., Andreis, P.G., Rossi, G.P. Nussdorfer, G.G. 2006. Orexins in the regulation of the hypothalamic-pituitary-adrenal axis. Pharmacol Rev 58, 46 57.
97. Sugimoto, T., Nagake, Y., Sugimoto, S., Akagi, S., Ichikawa, H., Nakamura, Y., Ogawa, N. Makino, H. 2002. Plasma orexin concentrations in patients on hemodialysis. Nephron 90, 379 383.
98. Switonska, M.M., Kaczmarek, P., Malendowicz, L.K. Nowak, K.W. 2002. Orexins and adipoinsular axis function in the rat. Regul Pept 104, 69 73.
99. Takahashi, N., Okumura, T., Yamada, H. Kohgo, Y. 1999. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem Biophys Res Commun 254, 623 627.
100. Takahashi, K., Arihara, Z., Suzuki, T., Sone, M., Kikuchi, K., Sasano, H., Murakami, O. Totsune, K. 2006. Expression of orexin-A and orexin receptors in the kidney and the presence of orexin-A-like immunoreactivity in human urine. Peptides 27, 871 877.
101. Tanida, M., Niijima, A., Shen, J., Yamada, S., Sawai, H., Fukuda, Y. Nagai, K. 2006. Dose-different effects of orexin-A on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats. Exp Biol Med (Maywood) 231, 1616 1625.
102. Tomasik, P.J., Spodaryk, M. Sztefko, K. 2004. Plasma concentrations of orexins in children. Ann Nutr Metab 48, 215 220.
103. Tsujino, N., Yamanaka, A., Ichiki, K., Muraki, Y., Kilduff, T.S., Yagami, K., Takahashi, S., Goto, K. Sakurai, T. 2005. Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor. J Neurosci 25, 7459 7469.
104. Williams, G., Bing, C., Cai, X.J., Harrold, J.A., King, P.J. Liu, X.H. 2001. The hypothalamus and the control of energy homeostasis: different circuits, different purposes. Physiol Behav 74, 683 701.
105. Yamada, H., Okumura, T., Motomura, W., Kobayashi, Y. Kohgo, Y. 2000. Inhibition of food intake by central injection of anti-orexin antibody in fasted rats. Biochem Biophys Res Commun 267, 527 531.
106. Ziolkowska, A., Spinazzi, R., Albertin, G., Nowak, M., Malendowicz, L.K., Tortorella, C. Nussdorfer, G.G. 2005. Orexins stimulate glucocorticoid secretion from cultured rat and human adrenocortical cells, exclusively acting via the OX1 receptor. J Steroid Biochem Mol Biol 96, 423 429.
107. Zwirska-Korczala, K., Adamczyk-Sowa, M., Sowa, P., Pilc, K., Suchanek, R., Pierzchala, K., Namyslowski, G., Misiolek, M., Sodowski, K., Kato, I., Kuwahara, A. Zabielski, R. 2007. Role of leptin, ghrelin, angiotensin II and orexins in 3T3 L1 preadipocyte cells proliferation and oxidative metabolism. J Physiol Pharmacol 58 (Suppl. 1 53 64.