Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR

Circulation Research

Volumn 106, Issue 3, 2010, Pages 536-545

  Tan, Zhi Yong ^a,b   Lu, Yongjun ^a,b   Whiteis, Carol A ^a,b   Simms, Annabel E ^c   Paton, Julian F R ^d   Chapleau, Mark W ^a,b,e   Abboud, François M ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Carotid body glomus cells; Ion channels; PH sensitivity; Prehypertensive SHR; Sympathetic nerve activity

Indexed keywords

ACID SENSING ION CHANNEL; AMILORIDE SENSITIVE ACID SENSING SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL; MEMBRANE PROTEIN; POTASSIUM CHANNEL; QUINIDINE; SODIUM CYANIDE; TASK1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID BODY; CHEMORECEPTOR; CONTROLLED STUDY; DEPOLARIZATION; GENE OVEREXPRESSION; HYPERTENSION; MEMBRANE STEADY POTENTIAL; NONHUMAN; PATHOGENESIS; PH; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHETIC INNERVATION; SYMPATHETIC NERVE; WESTERN BLOTTING;

AMILORIDE; ANIMALS; CAROTID BODY; GENE EXPRESSION REGULATION; HYDROGEN-ION CONCENTRATION; HYPERTENSION; NERVE TISSUE PROTEINS; PHRENIC NERVE; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; QUINIDINE; RATS; RATS, INBRED SHR; RATS, INBRED WKY; SODIUM CHANNELS; SODIUM CYANIDE; SYMPATHETIC NERVOUS SYSTEM; TIME FACTORS;

EID: 77649120606     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.109.206946     Document Type: Article

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