Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy?

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Schröder, Sven ^a,b   Beckmann, Kathrin ^a   Franconi, Giovanna ^c   Meyer Hamme, Gesa ^a   Friedemann, Thomas ^a   Greten, Henry Johannes ^b   Rostock, Matthias ^a   Efferth, Thomas ^d  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACORUS CALAMUS RHIZOMA EXTRACT; ANTINEOPLASTIC AGENT; ANTIOXIDANT; CANNABINOID 2 RECEPTOR; CANNABIS; CAPECITABINE; CARBOPLATIN; CHAMOMILE; CISPLATIN; CYANOCOBALAMIN; CYTOCHROME C OXIDASE; FLUOROURACIL; FOLINIC ACID; GINKGO BILOBA EXTRACT; GOSHAJINKIGAN; KAMPO; MATRICARIA CHAMOMILLA EXTRACT; MITOCHONDRIAL DNA; OXALIPLATIN; PACLITAXEL; PLANT EXTRACT; PREGABALIN; PROSTAGLANDIN F2 ALPHA; SAIKO KA RYUKOTSU BOREI TO; SALVIA OFFICINALIS EXTRACT; TEUCRIUM POLIUM EXTRACT; THIAMINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

ACHYRANTHES BIDENTATA; ACORUS CALAMUS; ACORUS CALAMUS RHIZOMA; ACUPUNCTURE; ALLODYNIA; ANALGESIC ACTIVITY; ANCA ASSOCIATED VASCULITIS; ANGELICA SINENSIS; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASTRAGALUS MEMBRANACEUS; AYURVEDA; BEE EXTRACT; BLACK CUMIN; BREAST CANCER; BUPLEURUM; CANCER CHEMOTHERAPY; CANCER PATIENT; CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY; CHINESE; CHINESE HERB; CHINESE MEDICINE; CINNAMON; CLINICAL OBSERVATION; COLORECTAL CANCER; CULTURE MEDIUM; CURCUMA; DIOSCOREA OPPOSITA; DRUG EFFECT; DYSESTHESIA; ENDOMETRIUM CANCER; FRITILLARIA; GERMANDER; GINKGO BILOBA; GLYCYRRHIZA; GYNECOLOGIC CANCER; HERB; HERBAL MEDICINE; HONEYBEE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HYPERALGESIA; IN VITRO STUDY; LUMBRICUS TERRESTRIS; MATRICARIA; MEDICINAL PLANT; MEDLINE; METASTATIC COLORECTAL CANCER; MOTOR COORDINATION; MUSCLE SPASM; MYALGIA; NERVE CELL DEGENERATION; NERVE DEGENERATION; NERVE FIBER DEGENERATION; NERVE REGENERATION; NEUROPATHIC PAIN; NEUROPROTECTION; NONHUMAN; NORADRENERGIC SYSTEM; OBSERVATIONAL STUDY; OCIMUM TENUIFLORUM; OVARY CANCER; OVARY CARCINOMA; PAEONIA SUFFRUTICOSA; PERCEPTIVE THRESHOLD; PERIPHERAL NEUROPATHY; PHYLLANTHUS AMARUS; POSTHERPETIC NEURALGIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; RHIZOME; RUBIA CORDIFOLIA; SALVIA OFFICINALIS; SCIATIC NERVE; SCUTELLARIA BAICALENSIS; SENSORY NERVE CONDUCTION; STREPTOZOCIN DIABETES; TEUCRIUM POLIUM; TUMOR CELL;

EID: 84883158256     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/423713     Document Type: Article

References (193)

1. Wilkes G., Peripheral neuropathy related to chemotherapy. Seminars in Oncology Nursing 2007 23 3 162 173 10.1016/j.soncn.2007.05.001
2. Lipton R. B., Apfel S. C., Dutcher J. P., Rosenberg R., Kaplan J., Berger A., Einzig A. I., Wiernik P., Schaumburg H. H., Taxol produces a predominantly sensory neuropathy. Neurology 1989 39 3 368 373 2-s2.0-0024556011
3. van Gerven J. M. A., Moll J. W. B., van den Bent M. J., Bontenbal M., van der Burg M. E. L., Verweij J., Vecht C. J., Paclitaxel (Taxol) induces cumulative mild neurotoxicity. European Journal of Cancer A 1994 30 8 1074 1077 2-s2.0-0028095121 10.1016/0959-8049(94)90459-6
4. Visovsky C., Collins M., Abbott L., Aschenbrenner J., Hart C., Putting evidence into practice: evidence-based interventions for chemotherapy-induced peripheral neuropathy. Clinical Journal of Oncology Nursing 2007 11 6 901 913 2-s2.0-39149111274
5. Hay J. W., Quality of life effects of chemotherapy-induced neuropathy in ovarian cancer. Proceedings of the American Society of Clinical Oncology 2002 21 abstract 886 222a
6. Lipton R. B., Apfel S. C., Dutcher J. P., Rosenberg R., Kaplan J., Berger A., Einzig A. I., Wiernik P., Schaumburg H. H., Taxol produces a predominantly sensory neuropathy. Neurology 1989 39 3 368 373 2-s2.0-0024556011
7. Hausheer F. H., Schilsky R. L., Bain S., Berghorn E. J., Lieberman F., Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Seminars in Oncology 2006 33 1 15 49 2-s2.0-32244438054 10.1053/j.seminoncol.2005.12.010
8. Corse A. M., Kunel R. W., Barker L. R., Burton J. R., Zieve P. D., Peripheral neuropathy. Principles of Ambulatory Medicine 1999 5th Baltimore, Md, USA Williams & Wilkins 1296 1314
9. Oxaliplatin Prescribing Information. Drugs.com. Hospira Worldwide, 2013, http://www.drugs.com/pro/oxaliplatin.html
10. Hausheer F. H., Schilsky R. L., Bain S., Berghorn E. J., Lieberman F., Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Seminars in Oncology 2006 33 1 15 49 2-s2.0-32244438054 10.1053/j.seminoncol.2005.12.010
11. Chaudhry V., Chaudhry M., Crawford T. O., Simmons-O'Brien E., Griffin J. W., Toxic neuropathy in patients with pre-existing neuropathy. Neurology 2003 60 2 337 340 2-s2.0-0037469227
12. Mielke S., Mross K., Gerds T. A., Schmidt A., Wäsch R., Berger D. P., Lange W., Behringer D., Comparative neurotoxicity of weekly non-break paditaxel infusions over 1 versus 3 h. Anti-Cancer Drugs 2003 14 10 785 792 2-s2.0-1542510041
13. de Gramont A., Boni C., Navaro M., Oxaliplatin/5FU/LV in the adjuvant treatment of stage II and stage III colon cancer: efficacy results with a medican follow-up of 4 years. Journal of Clinical Oncology 2005 23 16
14. Grothey A., Clinical management of oxaliplatin-associated neurotoxicity. Clinical Colorectal Cancer 2005 5 1 S38 S46 2-s2.0-21744443122 10.3816/CCC.2005.s.006
15. Kuncl R. W., George E. B., Toxic neuropathies and myopathies. Current Opinion in Neurology 1993 6 5 695 704 2-s2.0-0027384685
16. Quasthoff S., Hartung H. P., Chemotherapy-induced peripheral neuropathy. Journal of Neurology 2002 249 1 9 17 2-s2.0-0036158822
17. Gregg R. W., Molepo J. M., Monpetit V. J. A., Mikael N. Z., Redmond D., Gadia M., Stewart D. J., Cisplatin neurotoxicity: the relationship between dosage, time, and platinum concentration in neurologic tissues, and morphologic evidence of toxicity. Journal of Clinical Oncology 1992 10 5 795 803 2-s2.0-0026659298
18. Gill J. S., Windebank A. J., Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle. The Journal of Clinical Investigation 1998 101 12 2842 2850 2-s2.0-0032526263
19. Yoon M. S., Katsarava Z., Obermann M., Schäfers M., Liedert B., Dzagnidze A., Kribben A., Egensperger R., Limmroth V., Diener H.-C., Thomale J., Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of Cisplatin-induced neuropathy. BMC Neuroscience 2009 10, article 77 2-s2.0-68049094213 10.1186/1471-2202-10-77
20. Joseph E. K., Levine J. D., Mitochondrial electron transport in models of neuropathic and inflammatory pain. Pain 2006 121 1-2 105 114 2-s2.0-32944458095 10.1016/j.pain.2005.12.010
21. Joseph E. K., Levine J. D., Comparison of oxaliplatin- and Cisplatin-induced painful peripheral neuropathy in the rat. The Journal of Pain 2009 10 5 534 541 2-s2.0-67349144101 10.1016/j.jpain.2008.12.003
22. Joseph E. K., Chen X., Bogen O., Levine J. D., Oxaliplatin acts on IB4-positive nociceptors to induce an oxidative stress-dependent acute painful peripheral neuropathy. The Journal of Pain 2008 9 5 463 472 2-s2.0-42749090550 10.1016/j.jpain.2008.01.335
23. Cavaletti G., Tredici G., Braga M., Tazzari S., Experimental peripheral neuropathy induced in adult rats by repeated intraperitoneal administration of taxol. Experimental Neurology 1995 133 1 64 72 2-s2.0-0028999006 10.1006/exnr.1995.1008
24. Peters C. M., Jimenez-Andrade J. M., Kuskowski M. A., Ghilardi J. R., Mantyh P. W., An evolving cellular pathology occurs in dorsal root ganglia, peripheral nerve and spinal cord following intravenous administration of paclitaxel in the rat. Brain Research 2007 1168 1 46 59 2-s2.0-34548226494 10.1016/j.brainres.2007.06.066
25. Shemesh O. A., Spira M. E., Paclitaxel induces axonal microtubules polar reconfiguration and impaired organelle transport: implications for the pathogenesis of paclitaxel-induced polyneuropathy. Acta Neuropathologica 2010 119 2 235 248 2-s2.0-77449107515 10.1007/s00401-009-0586-0
26. Weimer L. H., Medication-induced peripheral neuropathy. Current Neurology and Neuroscience Reports 2003 3 1 86 92 2-s2.0-1842859789
27. Tanner K. D., Levine J. D., Topp K. S., Microtubule disorientation and axonal swelling in unmyelinated sensory axons during vincristine-induced painful neuropathy in rat. Journal of Comparative Neurology 1998 395 481 492
28. Topp K. S., Tanner K. D., Levine J. D., Damage to the cytoskeleton of large diameter sensory neurons and myelinated axons in vincristine-induced painful peripheral neuropathy in the rat. Journal of Comparative Neurology 2000 424 4 563 576 2-s2.0-0034605376
29. Sahenk Z., Brady S. T., Mendell J. R., Studies on the pathogenesis of vincristine-induced neuropathy. Muscle and Nerve 1987 10 1 80 84 2-s2.0-0023088913
30. Lobert S., Vulevic B., Correia J.-J., Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine. Biochemistry 1996 35 21 6806 6814 2-s2.0-0030008570 10.1021/bi953037i
31. Argyriou A. A., Marmiroli P., Cavaletti G., Kalofonos H. P., Epothilone-induced peripheral neuropathy: a review of current knowledge. Journal of Pain and Symptom Management 2011 42 6 931 940 2-s2.0-82755187241 10.1016/j.jpainsymman.2011.02.022
32. Kowalski R. J., Giannakakou P., Hamel E., Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol). The Journal of Biological Chemistry 1997 272 4 2534 2541 2-s2.0-0031027531 10.1074/jbc.272.4.2534
33. Altmann K. H., Wartmann M., O'Reilly T., Epothilones and related structures-a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochimica et Biophysica Acta 2000 1470 3 M79 M91 2-s2.0-0034678986 10.1016/S0304-419X(00)00009-3
34. Argyriou A. A., Iconomou G., Kalofonos H. P., Bortezomib-induced peripheral neuropathy in multiple myeloma: a comprehensive review of the literature. Blood 2008 112 5 1593 1599 2-s2.0-52649114697 10.1182/blood-2008-04- 149385
35. Cavaletti G., Nobile-Orazio E., Bortezomib-induced peripheral neurotoxicity: still far from a painless gain. Haematologica 2007 92 10 1308 1310 2-s2.0-36349031206 10.3324/haematol.11752
36. Cavaletti G., Gilardini A., Canta A., Rigamonti L., Rodriguez-Menendez V., Ceresa C., Marmiroli P., Bossi M., Oggioni N., D'Incalci M., de Coster R., Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat. Experimental Neurology 2007 204 1 317 325 2-s2.0-33847293709 10.1016/j.expneurol.2006.11.010
37. Casafont I., Berciano M. T., Lafarga M., Bortezomib induces the formation of nuclear poly(A) RNA granules enriched in Sam68 and PABPN1 in sensory ganglia neurons. Neurotoxicity Research 2010 17 2 167 178 2-s2.0-77449161209 10.1007/s12640-009-9086-1
38. 2+ is a critical determinant of Velcade (PS-341/Bortezomib) cytotoxicity in myeloma cell lines. Cancer Research 2005 65 9 3828 3836 2-s2.0-18144431710 10.1158/0008-5472.CAN-04- 3684
39. Montagut C., Rovira A., Albanell J., The proteasome: a novel target for anticancer therapy. Clinical and Translational Oncology 2006 8 5 313 317 2-s2.0-33747517230 10.1007/s12094-006-0176-8
40. Chung C. H., Aulino J., Muldowney N. J., Hatakeyama H., Baumann J., Burkey B., Netterville J., Sinard R., Yarbrough W. G., Cmelak A. J., Slebos R. J., Shyr Y., Parker J., Gilbert J., Murphy B. A., Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Annals of Oncology 2010 21 4 864 870 10.1093/annonc/mdp390
41. Cata J. P., Weng H. R., Burton A. W., Villareal H., Giralt S., Dougherty P. M., Quantitative sensory findings in patients with bortezomib-induced pain. The Journal of Pain 2007 8 4 296 306 2-s2.0-34047253561 10.1016/j.jpain.2006.09. 014
42. Lepper E. R., Smith N. F., Cox M. C., Scripture C. D., Figg W. D., Thalidomide metabolism and hydrolysis: mechanisms and implications. Current Drug Metabolism 2006 7 6 677 685 2-s2.0-33747174832 10.2174/138920006778017777
43. Cavaletti G., Marmiroli P., Chemotherapy-induced peripheral neurotoxicity. Nature Reviews Neurology 2010 6 12 657 666 2-s2.0-78649906324 10.1038/nrneurol.2010.160
44. Moore D. H., Donnelly J., McGuire W. P., Almadrones L., Cella D. F., Herzog T. J., Waggoner S. E., Mackey D., Limited access trial using amifostine for protection against Cisplatin- and three-hour paclitaxel-induced neurotoxicity: a phase II study of the Gynecologic Oncology Group. Journal of Clinical Oncology 2003 21 22 4207 4213 2-s2.0-0642347604 10.1200/JCO.2003.02.086
45. Masuda N., Negoro S., Hausheer F., Nakagawa K., Matsui K., Kudoh S., Takeda K., Yamamoto N., Yoshimura N., Ohashi Y., Fukuoka M., Phase I and pharmacologic study of BNP7787, a novel chemoprotector in patients with advanced non-small cell lung cancer. Cancer Chemotherapy and Pharmacology 2011 67 3 533 542 2-s2.0-78649906551 10.1007/s00280-010-1340-y
46. Gandara D. R., Wiebe V. J., Perez E. A., Makuch R. W., DeGregorio M. W., Cisplatin rescue therapy: experience with sodium thiosulfate, WR2721, and diethyldithiocarbamate. Critical Reviews in Oncology/Hematology 1990 10 4 353 365 2-s2.0-0025221536 10.1016/1040-8428(90)90010-P
47. Tredici G., Braga M., Nicolini G., Miloso M., Marmiroli P., Schenone A., Nobbio L., Frattola L., Cavaletti G., Effect of recombinant human nerve growth factor on Cisplatin neurotoxicity in rats. Experimental Neurology 1999 159 2 551 558 2-s2.0-0032874159 10.1006/exnr.1999.7174
48. Aloe L., Manni L., Properzi F., de Santis S., Fiore M., Evidence that nerve growth factor promotes the recovery of peripheral neuropathy induced in mice by Cisplatin: behavioral, structural and biochemical analysis. Autonomic Neuroscience 2000 86 1-2 84 93 2-s2.0-0034727919 10.1016/S1566-0702(00)00247-2
49. Gao W. Q., Dybdal N., Shinsky N., Murnane A., Schmelzer C., Siegel M., Keller G., Hefti F., Phillips H. S., Winslow J. W., Neurotrophin-3 reverses experimental Cisplatin-induced peripheral sensory neuropathy. Annals of Neurology 1995 38 1 30 37 2-s2.0-0029002671 10.1002/ana.410380108
50. Davis I. D., Kiers L., MacGregor L., Quinn M., Arezzo J., Green M., Rosenthal M., Chia M., Michael M., Bartley P., Harrison L., Daly M., A randomized, double-blinded, placebo-controlled phase II trial of recombinant human leukemia inhibitory factor (rhuLIF, Emfilermin, AM424) to prevent chemotherapy-induced peripheral neuropathy. Clinical Cancer Research 2005 11 5 1890 1898 2-s2.0-20144387524 10.1158/1078-0432.CCR-04-1655
51. Cervellini I., Bello E., Frapolli R., Porretta-Serapiglia C., Oggioni N., Canta A., Lombardi R., Camozzi F., Roglio I., Melcangi R. C., D'incalci M., Lauria G., Ghezzi P., Cavaletti G., Bianchi R., The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13,762 adenocarcinoma-bearing rats. Neurotoxicity Research 2010 18 2 151 160 2-s2.0-77956687924 10.1007/s12640-009-9127-9
52. Bianchi R., Gilardini A., Rodriguez-Menendez V., Oggioni N., Canta A., Colombo T., Michele G. D., Martone S., Sfacteria A., Piedemonte G., Grasso G., Beccaglia P., Ghezzi P., D'Incalci M., Lauria G., Cavaletti G., Cisplatin-induced peripheral neuropathy: neuroprotection by erythropoietin without affecting tumour growth. European Journal of Cancer 2007 43 4 710 717 2-s2.0-33947703740 10.1016/j.ejca.2006.09.028
53. Dicato M., Plawny L., Erythropoietin in cancer patients: pros and cons. Current Opinion in Oncology 2010 22 4 307 311 2-s2.0-77953916219 10.1097/CCO.0b013e32833aa9de
54. Cascinu S., Cordella L., del Ferro E., Fronzoni M., Catalano G., Neuroprotective effect of reduced glutathione on Cisplatin-based chemotherapy in advanced gastric cancer: a randomized double-blind placebo- controlled trial. Journal of Clinical Oncology 1995 13 1 26 32 2-s2.0-0028815902
55. Cascinu S., Catalano V., Cordella L., Labianca R., Giordani P., Baldelli A. M., Beretta G. D., Ubiali E., Catalano G., Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: a randomized, double-blind, placebo-controlled trial. Journal of Clinical Oncology 2002 20 16 3478 3483 2-s2.0-0037102328 10.1200/JCO.2002.07.061
56. Bove L., Picardo M., Maresca V., Jandolo B., Pace A., A pilot study on the relation between Cisplatin neuropathy and vitamin E. Journal of Experimental and Clinical Cancer Research 2001 20 2 277 280 2-s2.0-0034945128
57. Argyriou A. A., Chroni E., Koutras A., Ellul J., Papapetropoulos S., Katsoulas G., Iconomou G., Kalofonos H. P., Vitamin E for prophylaxis against chemotherapy-induced neuropathy: a randomized controlled trial. Neurology 2005 64 1 26 31 2-s2.0-11444259306
58. Argyriou A. A., Chroni E., Koutras A., Iconomou G., Papapetropoulos S., Polychronopoulos P., Kalofonos H. P., Preventing paclitaxel-induced peripheral neuropathy: a phase II trial of vitamin E supplementation. Journal of Pain and Symptom Management 2006 32 3 237 244 2-s2.0-33748206400 10.1016/j.jpainsymman. 2006.03.013
59. Pace A., Giannarelli D., Galiè E., Savarese A., Carpano S., Della Giulia M., Pozzi A., Silvani A., Gaviani P., Scaioli V., Jandolo B., Bove L., Cognetti F., Vitamin E neuroprotection for Cisplatin neuropathy: a randomized, placebo-controlled trial. Neurology 2010 74 9 762 766 2-s2.0-77649243226 10.1212/WNL.0b013e3181d5279e
60. Pisano C., Pratesi G., Laccabue D., Zunino F., Giudice P. L., Bellucci A., Pacifici L., Camerini B., Vesci L., Castorina M., Cicuzza S., Tredici G., Marmiroli P., Nicolini G., Galbiati S., Calvani M., Carminati P., Cavaletti G., Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine. Clinical Cancer Research 2003 9 15 5756 5767 2-s2.0-0345060438
61. Boehmerle W., Zhang K., Sivula M., Heidrich F. M., Lee Y., Jordt S.-E., Ehrlich B. E., Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal calcium sensor-1 degradation. Proceedings of the National Academy of Sciences of the United States of America 2007 104 26 11103 11108 2-s2.0-34547447565 10.1073/pnas.0701546104
62. Carozzi V. A., Chiorazzi A., Canta A., Lapidus R. G., Slusher B. S., Wozniak K. M., Cavaletti G., Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat. Neurotoxicity Research 2010 17 4 380 391 2-s2.0-77953942176 10.1007/s12640-009-9114-1
63. Kurniali P. C., Luo L. G., Weitberg A. B., Role of calcium/magnesium infusion in oxaliplatin-based chemotherapy for colorectal cancer patients. Oncology 2010 24 3 289 292 2-s2.0-77951929941
64. Cavaletti G., Marmiroli P., The role of growth factors in the prevention and treatment of chemotherapy-induced peripheral neurotoxicity. Current Drug Safety 2006 1 1 35 42 2-s2.0-50649089668 10.2174/157488606775252656
65. Albers J., Chaudhry V., Cavaletti G., Donehower R., Interventions for preventing neuropathy caused by Cisplatin and related compounds. Cochrane Database of Systematic Reviews 2007 1 10.1002/14651858.CD005228.pub2 CD005228 2-s2.0-34247874636
66. Wolf S., Barton D., Kottschade L., Grothey A., Loprinzi C., Chemotherapy-induced peripheral neuropathy: prevention and treatment strategies. European Journal of Cancer 2008 44 11 1507 1515 2-s2.0-45949131693 10.1016/j.ejca.2008.04.018
67. Kannarkat G., Lasher E. E., Schiff D., Neurologic complications of chemotherapy agents. Current Opinion in Neurology 2007 20 6 719 725 2-s2.0-36049048587 10.1097/WCO.0b013e3282f1a06e
68. Muthuraman A., Singh N., Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects. BMC Complementary and Alternative Medicine 2011 11, article 24 2-s2.0-79953113956 10.1186/1472-6882-11-24
69. Muthuraman A., Singh N., Jaggi A. S., Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats. Journal of Natural Medicines 2011 65 2 282 292 2-s2.0-79956308738 10.1007/s11418-010-0486-6
70. Muthuraman A., Singh N., Attenuating effect of hydroalcoholic extract of Acorus calamus in vincristine-induced painful neuropathy in rats. Journal of Natural Medicines 2011 65 3-4 480 487 2-s2.0-79960440138 10.1007/s11418-011- 0525-y
71. 2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats. Journal of Pharmacology and Experimental Therapeutics 2008 327 2 584 591 2-s2.0-54349107444 10.1124/jpet.108.141994
72. Ellis R. J., Toperoff W., Vaida F., van den Brande G., Gonzales J., Gouaux B., Bentley H., Atkinson J. H., Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology 2009 34 3 672 680 2-s2.0-58149463198 10.1038/npp.2008.120
73. Karst M., Salim K., Burstein S., Conrad I., Hoy L., Schneider U., Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial. Journal of the American Medical Association 2003 290 13 1757 1762 2-s2.0-0141593561 10.1001/jama.290.13.1757
74. Ware M. A., Wang T., Shapiro S., Robinson A., Ducruet T., Huynh T., Gamsa A., Bennett G. J., Collet J.-P., Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. Canadian Medical Association Journal 2010 182 14 E694 E701 2-s2.0-77958035149 10.1503/cmaj.091414
75. Rog D. J., Nurmikko T. J., Friede T., Young C. A., Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis. Neurology 2005 65 6 812 819 2-s2.0-25444530723 10.1212/01.wnl.0000176753.45410. 8b
76. Blake D. R., Robson P., Ho M., Jubb R. W., McCabe C. S., Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology 2006 45 1 50 52 2-s2.0-29844435136 10.1093/rheumatology/kei183
77. Berman J. S., Symonds C., Birch R., Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial. Pain 2004 112 3 299 306 2-s2.0-9244223576 10.1016/j.pain.2004.09.013
78. Wilsey B., Marcotte T., Tsodikov A., Millman J., Bentley H., Gouaux B., Fishman S., A randomized, placebo-controlled, crossover trial of cannabis cigarettes in neuropathic pain. The Journal of Pain 2008 9 6 506 521 2-s2.0-44249115281 10.1016/j.jpain.2007.12.010
79. Abrams D. I., Jay C. A., Shade S. B., Vizoso H., Reda H., Press S., Kelly M. E., Rowbotham M. C., Petersen K. L., Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial. Neurology 2007 68 7 515 521 2-s2.0-33847013770 10.1212/01.wnl.0000253187.66183.9c
80. Ellis R. J., Toperoff W., Vaida F., van den Brande G., Gonzales J., Gouaux B., Bentley H., Atkinson J. H., Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial. Neuropsychopharmacology 2009 34 3 672 680 2-s2.0-58149463198 10.1038/npp.2008.120
81. Berman J. S., Symonds C., Birch R., Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial. Pain 2004 112 3 299 306 2-s2.0-9244223576 10.1016/j.pain.2004.09.013
82. Ware M. A., Wang T., Shapiro S., Robinson A., Ducruet T., Huynh T., Gamsa A., Bennett G. J., Collet J.-P., Smoked cannabis for chronic neuropathic pain: a randomized controlled trial. Canadian Medical Association Journal 2010 182 14 E694 E701 2-s2.0-77958035149 10.1503/cmaj.091414
83. Varro E. T., Lynn R. B., James E. R., Pharmacognosy 1988 9th Philadelphia, Pa, USA Lea & Fabigen
84. Norman G. B., Max W., Herbal Drugs and Phytopharmaceuticals 2001 2nd London, UK CRC Press
85. Abad A. N. A., Nouri M. H. K., Gharjanie A., Tavakoli F., Effect of Matricaria chamomilla hydroalcoholic extract on Cisplatin-induced neuropathy in mice. Chinese Journal of Natural Medicines 2011 9 2 126 131 2-s2.0-79956311342 10.3724/SP.J.1009.2011.00126
86. Oztürk G., Anlar O., ErdoǧanE, Kösem M., Ozbek H., Türker A., The effect of Ginkgo extract EGb761 in Cisplatin-induced peripheral neuropathy in mice. Toxicology and Applied Pharmacology 2004 196 1 169 175 10.1016/j.taap.2003.12.006
87. Marshall J., Zakari A., Hwang J. J., Papadopoulos V., Rosenberg A., Silver C., Ginkgo biloba, (GB) extract as a neuroprotective agent in oxaliplatin (Ox)-induced neuropathy. American Society of Clinical Oncologists Annual Meeting Proceedings. Journal of Clinical Oncology 2004 22 supplement 14, abstract 3670
88. Abad A. N. A., Nouri M. H. K., Tavakkoli F., Effect of Salvia officinalis hydroalcoholic extract on vincristine-induced neuropathy in mice. Chinese Journal of Natural Medicines 2011 9 5 354 358 2-s2.0-80053268400 10.3724/SP.J.1009.2011.00354
89. Park J. W., Jeon J. H., Yoon J. W., Jung T. Y., Kwon K. R., Cho C. K., Lee Y. W., Sagar S., Wong R., Yoo H. S., Effects of sweet bee venom pharmacopuncture treatment for chemotherapy-induced peripheral neuropathy: a case series. Integrative Cancer Therapies 2011 11 2 166 171 10.1177/ 1534735411413265
90. Yoon J., Jeon J. H., Lee Y. W., Cho C. K., Kwon K. R., Shin J. E., Sagar S., Wong R., Yoo H. S., Sweet bee venom pharmacopuncture for chemotherapy-induced peripheral neuropathy. Journal of Acupuncture and Meridian Studies 2012 5 4 156 165 10.1016/j.jams.2012.05.003
91. Xu F., Xu S., Wang L., Chen C., Zhou X., Lu Y., Zhang H., Antinociceptive efficacy of verticinone in murine models of inflammatory pain and paclitaxel induced neuropathic pain. Biological and Pharmaceutical Bulletin 2011 34 9 1377 1382 2-s2.0-80052489856 10.1248/bpb.34.1377
92. Sun Y. Y., Jia Y. J., Huang M. N., Chen J., Buyang huanwu decoction in prevention of peripheral neuropathy after chemotherapy: a clinical observation. Guangming Journal of Chinese Medicine 2008 23 7 958 959
93. Deng J. H., Zou S. L., Observation on TCM treatment of 32 cases of chemotherapy-induced peripheral neuropathy. Journal of Practical Traditional Chinese Internal Medicine 2007 21 2
94. Pan L., Gao H., Xing X. R., Combined application of traditional Chinese medicine prevention of taxol chemotherapy-induced peripheral neuropathy: a clinical observation. Neimenggu Zhong Yi Yao 2012 3 28
95. Sima L., Pan L., Influence of Chinese herb on chemotherapy-induced peripheral neuropathy. Annals of Oncology 2009 20 supplement 3 iii45 iii46 10. 1093/annonc/mdp189
96. Hashimoto K., Sakuma Y., Kotani J., Histological study of a paclitaxel-induced peripheral neuropathy model treated with goshajnkigan. The Journal of Osaka Dental University 2004 38 2 109 112
97. Hashimoto K., Sakuma Y., Kotani J., Goshajinkigan improves paclitaxel-induced peripheral neuropathy in rats. The Journal of Osaka Dental University 2006 40 1 47 52
98. Ushio S., Egashira N., Sada H., Kawashiri T., Shirahama M., Masuguchi K., Oishi R., Goshajinkigan reduces oxaliplatin-induced peripheral neuropathy without affecting anti-tumour efficacy in rodents. European Journal of Cancer 2012 48 9 1407 1413 2-s2.0-80052393513 10.1016/j.ejca.2011.08.009
99. Shindo Y., Tenma K., Imano H., Hibino M., Yoshino K., Nakamura M., Reduction of oxaliplatin-related neurotoxicity by Gosha-jinki-gan. Gan to Kagaku Ryoho 2008 35 5 863 865 2-s2.0-45549104855
100. Nishioka M., Shimada M., Kurita N., Iwata T., Morimoto S., Yoshikawa K., Higashijima J., Miyatani T., Kono T., The Kampo medicine, Goshajinkigan, prevents neuropathy in patients treated by FOLFOX regimen. International Journal of Clinical Oncology 2011 16 4 322 327 2-s2.0-80052738134 10.1007/s10147-010- 0183-1
101. Kono T., Mamiya N., Chisato N., Ebisawa Y., Yamazaki H., Watari J., Yamamoto Y., Suzuki S., Asama T., Kamiya K., Efficacy of Goshajinkigan for peripheral neurotoxicity of oxaliplatin in patients with advanced or recurrent colorectal cancer. Evidence-Based Complementary and Alternative Medicine 2011 2011 8 2-s2.0-79952239072 10.1093/ecam/nep200 418481
102. Yamamoto T., Murai T., Ueda M., Katsuura M., Oishi M., Miwa Y., Okamoto Y., Uejima E., Taguchi T., Noguchi S., Kurokawa N., Clinical features of paclitaxel-induced peripheral neuropathy and role of Gosya-jinki-gan Gan to Kagaku Ryoho 2009 36 1 89 92 2-s2.0-60549106253
103. Kaku H., Kumagai S., Onoue H., Takada A., Shoji T., Miura F., Yoshizaki A., Sato S., Kigawa J., Arai T., Tsunoda S., Tominaga E., Aoki D., Sugiyama T., Objective evaluation of the alleviating effects of Goshajinkigan on peripheral neuropathy induced by paclitaxel/carboplatin therapy: a multicenter collaborative study. Experimental and Therapeutic Medicine 2012 3 1 60 65 2-s2.0-84855400940 10.3892/etm.2011.375
104. Yamada T., Kan H., Matsumoto S., Koizumi M., Sasaki J., Tani A., Yokoi K., Uchida E., Reduction in oxaliplatin-related neurotoxicity by the administration of Keishikajutsubuto (TJ-18)and powdered processed aconite root Gan to Kagaku Ryoho 2012 39 11 1687 1691
105. Tatsumi T., Kishi D., Kogure T., The efficacy of ogikeishigomotsuto on chronic cumulative sensory neuropathy induced by Oxaliplatin-case report and literature view. Journal of Traditional Medicines 2009 26 3 136 140
106. Hidaka T., Shima T., Nagira K., Ieki M., Nakamura T., Aono Y., Kuraishi Y., Arai T., Saito S., Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice. European Journal of Pain 2009 13 1 22 27 2-s2.0-58149199933 10.1016/j.ejpain.2008.03.003
107. Fujii K., Okamoto S., Saitoh K., Sasaki N., Takano M., Tanaka S., Kudoh K., Kita T., Tode T., Kikuchi Y., The efficacy of Shakuyaku-Kanzo-to for peripheral nerve dysfunction in paclitaxel combination chemotherapy for epithelial ovarian carcinoma. Gan to Kagaku Ryoho 2004 31 10 1537 1540 2-s2.0-7244232559
108. Hosokawa A., Ogawa K., Ando T., Suzuki N., Ueda A., Kajiura S., Kobayashi Y., Tsukioka Y., Horikawa N., Yabushita K., Fukuoka Sugiyama T J., Preventive effect of traditional Japanese medicine on neurotoxicity of FOLFOX for metastatic colorectal cancer: a multicenter retrospective study. Anticancer Research 2012 32 7 2545 2550
109. Defeudis F. V., Bilobalide and neuroprotection. Pharmacological Research 2002 46 6 565 568 2-s2.0-0036451982 10.1016/S1043-6618(02)00233-5
110. DeFeudis F. V., Papadopoulos V., Drieu K., Ginkgo biloba extracts and cancer: a research area in its infancy. Fundamental and Clinical Pharmacology 2003 17 4 405 417 2-s2.0-0042169046 10.1046/j.1472-8206.2003.00156.x
111. Ahlemeyer B., Krieglstein J., Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry 2003 36 supplement 1 8 14 2-s2.0-0041825261
112. Dorman H. J. P., Deans S. G., Noble R. C., Evaluation in vitro of plant essential oils as natural antioxidants. Journal of Essential Oil Research 1995 7 6 645 651 2-s2.0-0029403329 10.1080/10412905.1995.9700520
113. Hohmann J., Zupkó I., Rédei D., Csányi M., Falkay G., Máthé I., Janicsák G., Protective effects of the aerial parts of Salvia officinalis, Melissa officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme-independent lipid peroxidation. Planta Medica 1999 65 6 576 578 2-s2.0-0032803507 10.1055/s-2006-960830
114. Malencić D., Gasic O., Popović M., Boza P., Screening for antioxidant properties of Salvia reflexa hornem. Phytotherapy Research 2000 14 7 546 548
115. Zupkó I., Hohmann J., Rédei D., Falkay G., Janicsák G., Máthé I., Antioxidant activity of leaves of Salvia species in enzyme-dependent and enzyme-independent systems of lipid peroxidation and their phenolic constituents. Planta Medica 2001 67 4 366 368 2-s2.0-0034950160 10.1055/s-2001-14327
116. Wang C. N., Chi C. W., Lin Y. L., Chen C. F., Shiao Y. J., The neuroprotective effects of phytoestrogens on amyloid β protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. The Journal of Biological Chemistry 2001 276 7 5287 5295 2-s2.0-0035895957 10.1074/jbc.M006406200
117. Howes M. J., Perry N. S., Houghton P. J., Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytotherapy Research 2003 17 1 1 18 2-s2.0-0037272674 10.1002/ptr.1280
118. Maklad Y. A., Aboutabl E. A., El-Sherei M. M., Meselhy K. M., Bioactivity studies of Salvia transsylvanica (Schur ex Griseb) grown in Egypt. Phytotherapy Research 1999 13 2 147 150
119. Rodrigues M. R. A., Kanazawa L. K. S., Neves T. L. M. D., Silva C. F. D., Horst H., Pizzolatti M. G., Santos A. R. S., Baggio C. H., Werner M. F. D. P., Antinociceptive and anti-inflammatory potential of extract and isolated compounds from the leaves of Salvia officinalis in mice. Journal of Ethnopharmacology 2012 139 2 519 526 2-s2.0-84856010661 10.1016/j.jep.2011.11. 042
120. Yoon S. Y., Roh D. H., Kwon Y. B., Kim H. W., Seo H. S., Han H. J., Lee H. J., Beitz A. J., Lee J. H., Acupoint stimulation with diluted bee venom (apipuncture) potentiates the analgesic effect of intrathecal clonidine in the rodent formalin test and in a neuropathic pain model. The Journal of Pain 2009 10 3 253 263 2-s2.0-60849102766 10.1016/j.jpain.2008.09.002
121. Kang S. Y., Roh D. H., Yoon S. Y., Moon J. Y., Kim H. W., Lee H. J., Beitz A. J., Lee J. H., Repetitive treatment with diluted bee venom reduces neuropathic pain via potentiation of locus coeruleus noradrenergic neuronal activity and modulation of spinal NR1 phosphorylation in rats. The Journal of Pain 2012 13 2 155 166 2-s2.0-84856499859 10.1016/j.jpain.2011.10.012
122. Wang Q. R., Yi Lin Gai Cuo: Correcting the Errors in the Forest of Medicine 2007 Boulder, Colo, USA Blue Poppy Press
123. Qian Y.,. Xiaoer Yaozheng Zhijue. With coments by X. Z. Yan, J. S. Guo. People's Medical Publishing House. 2006
124. Zhang Z. J., On Cold Damage (Shang Han Lun) 2000 Translation & Commentaries by Y. Feng, N. Wiseman, C. Mitchell and Y. Feng Boulder, Colo, USA Blue Poppy Press
125. Yan Y. H.,. Jisheng fang, first published in 1253. Reprint Shangwu Yin Shu Guan, Taibei, Taiwan, 1975
126. Japan Society for Oriental Medicine, Introduction to Kampo. Japanese Traditional Medicine 2005 Tokio, Japan Elsevier
127. Niwa Y., Miyachi Y., Antioxidant action of natural health products and Chinese herbs. Inflammation 1986 10 1 79 91 2-s2.0-0022655834
128. Kim B. J., Kim J. H., Kim H. P., Heo M. Y., Biological screening of 100 plant extracts for cosmetic use (II): anti-oxidative activity and free radical scavenging activity. International Journal of Cosmetic Science 1997 19 6 299 307 2-s2.0-0030726027 10.1046/j.1467-2494.1997.171726.x
129. Tawata M., Kurihara A., Nitta K., Iwase E., Gan N., Onaya T., The effects of Goshajinkigan, a herbal medicine, on subjective symptoms and vibratory threshold in patients with diabetic neuropathy. Diabetes Research and Clinical Practice 1994 26 2 121 128 2-s2.0-0028558594 10.1016/0168-8227(94)90149-X
130. Kono T., Mishima H., Shimada M., Morita S., Sakamoto J., Preventive effect of Goshajinkigan on peripheral neurotoxicity of FOLFOX therapy: a placebo-controlled double-blind randomized phase II study (the GONE Study). Japanese Journal of Clinical Oncology 2009 39 12 847 849 2-s2.0-70849136155 10.1093/jjco/hyp100
131. Nakanishi M., Arimitsu J., Kageyama M., Otsuka S., Inoue T., Nishida S., Yoshikawa H., Kishida Y., Efficacy of traditional Japanese herbal medicines- Keishikajutsubuto (TJ-18) and Bushi-matsu (TJ-3022)-against postherpetic neuralgia aggravated by self-reported cold stimulation: a case series. The Journal of Alternative and Complementary Medicine 2012 18 7 686 692 10.1089/acm.2010.0745
132. Zhang J. Z., Gui Yao Lue (Essential Prescriptions from the Golden Chamber) 2013 Translated by Nigel Wiseman Taos, NM, USA Paradigm Publications
133. Hikiami H., Yagi K., Nakata S., Oka H., Goto H., Shibahar N., Shimada Y., Two cases of numbness and pain of neuropathy due to ANCA-associated vasculitis successfully treated with ogikeishigomotsuto. Kampo Medicine 2007 58 3 495 501 10.3937/kampomed.58.495
134. Fujiwara H., Urabe T., Ueda K., Mizunoe T., Date K., Nakano M., Honda N., Sakashita T., Fujito N., Prevention of arthralgia and myalgia from paclitaxel and carboplatin combination chemotherapy with Shakuyaku-kanzo-to. Gan to Kagaku Ryoho 2000 27 7 1061 1064 2-s2.0-0034223133
135. Hasegawa K., Mizutani Y., Kuramoto H., Nagao S., Masuyama H., Hongo A., Kodama J., Yoshinouchi M., Hiramatsu Y., Kudo T., Okuda H., The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia. Gan to Kagaku Ryoho 2002 29 4 569 574 2-s2.0-0036546738
136. Yamamoto K., Hoshiai H., Noda K., Effects of Shakuyaku-kanzo-to on muscle pain from combination chemotherapy with paclitaxel and carboplatin. Gynecologic Oncology 2001 81 2 333 334 2-s2.0-0035018146 10.1006/gyno.2001.6168
137. Derry S., Sven-Rice A., Cole P., Topical capsaicin (high concentration) for chronic neuropathic pain in adults. Cochrane Database of Systematic Reviews 2013 2 10.1002/14651858.CD007393.pub3 2-s2.0-75349113778 CD007393
138. Shibata K., Sugawara T., Fujishita K., The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice. PLoS ONE 2011 6 8 e23510 10.1371/journal.pone.0023510
139. Xu H., Arita H., Hayashida M., Zhang L., Sekiyama H., Hanaoka K., Pain-relieving effects of processed Aconiti tuber in CCI-neuropathic rats. Journal of Ethnopharmacology 2006 103 3 392 397 2-s2.0-31344461060 10.1016/j.jep.2005.08.050
140. Tatsumi S., Mabuchi T., Abe T., Xu L., Minami T., Ito S., Analgesic effect of extracts of Chinese medicinal herbs Moutan cortex and Coicis semen on neuropathic pain in mice. Neuroscience Letters 2004 370 2-3 130 134 2-s2.0-5644239867 10.1016/j.neulet.2004.08.043
141. Kanter M., Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochemical Research 2008 33 1 87 96 2-s2.0-36949037103 10.1007/s11064-007- 9419-5
142. Muthuraman A., Diwan V., Jaggi A. S., Singh N., Singh D., Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats. Journal of Ethnopharmacology 2008 120 1 56 62 2-s2.0-53649090466 10.1016/j.jep.2008.07.049
143. Baluchnejadmojarad T., Roghani M., Roghani-Dehkordi F., Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test. Journal of Ethnopharmacology 2005 97 2 207 210 2-s2.0-13544266365 10.1016/j.jep.2004.10.030
144. Kassuya C. A. L., Silvestre A. A., Rehder V. L. G., Calixto J. B., Anti-allodynic and anti-oedematogenic properties of the extract and lignans from Phyllanthus amarus in models of persistent inflammatory and neuropathic pain. European Journal of Pharmacology 2003 478 2-3 145 153 2-s2.0-0142169047 10.1016/j.ejphar.2003.08.079
145. Pandhare R. B., Sangameswaran B., Mohite P. B., Attenuating effect of Sesbania sesban (L) Merr. extract on neuropathic pain in streptozotocin-induced diabetic rats: an evidence of neuroprotective effects. Phytopharmacology 2012 2 1 190 201
146. Eisenberg D. M., Harris E. S. J., Littlefield B. A., Cao S., Craycroft J. A., Scholten R., Bayliss P., Fu Y., Wang W., Qiao Y., Zhao Z., Chen H., Liu Y., Kaptchuk T., Hahn W. C., Wang X., Roberts T., Shamu C. E., Clardy J., Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation-rationale, methods and preliminary results from a Sino-American collaboration. Fitoterapia 2011 82 1 17 33 2-s2.0-79151479223 10.1016/j.fitote.2010.11.017
147. Luo Q., Cai Y., Yan J., Sun M., Corke H., Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sciences 2004 76 2 137 149 2-s2.0-7044271148 10.1016/j.lfs.2004.04.056
148. Suzuki Y., Goto K., Ishige A., Komatsu Y., Kamei J., Antinociceptive effect of Gosha-jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic mice. The Japanese Journal of Pharmacology 1999 79 2 169 175 2-s2.0-0033065612 10.1254/jjp.79.169
149. Raskin I., Ripoll C., Can an apple a day keep the doctor away? Current Pharmaceutical Design 2004 10 27 3419 3429 2-s2.0-4644229286 10.2174/1381612043383070
150. Schmidt B. M., Ribnicky D. M., Lipsky P. E., Raskin I., Revisiting the ancient concept of botanical therapeutics. Nature Chemical Biology 2007 3 7 360 366 2-s2.0-34250702156 10.1038/nchembio0707-360
151. Shu H., Arita H., Hayashida M., Sekiyama H., Hanaoka K., Effects of processed Aconiti tuber and its ingredient alkaloids on the development of antinociceptive tolerance to morphine. Journal of Ethnopharmacology 2006 103 3 398 405 2-s2.0-31344472680 10.1016/j.jep.2005.08.017
152. Murayama M., Mori T., Bando H., Amiya T., Studies on the constituents of Aconitum species. IX. The pharmacological properties of pyro-type aconitine alkaloids, components of processed aconite powder 'kako-bushi-matsu': analgesic, antiinflammatory and acute toxic activities. Journal of Ethnopharmacology 1991 35 2 159 164 2-s2.0-0025953831
153. Yamada K., Suzuki E., Nakaki T., Watanabe S., Kanba S., Aconiti tuber increases plasma nitrite and nitrate levels in humans. Journal of Ethnopharmacology 2005 96 1-2 165 169 2-s2.0-9644281485 10.1016/j.jep.2004.09. 028
154. Mitamura M., Boussery K., Horie S., Murayama T., van de Voorde J., Vasorelaxing effect of mesaconitine, an alkaloid from Aconitum japonicum, on rat small gastric artery: possible involvement of endothelium-derived hyperpolarizing factor. The Japanese Journal of Pharmacology 2002 89 4 380 387 2-s2.0-0036671913 10.1254/jjp.89.380
155. Suzuki Y., Goto K., Ishige A., Komatsu Y., Kamei J., Effects of Gosha-jinki-gan, a Kampo medicine, on peripheral tissue blood flow in streptozotocin-induced diabetic rats. Methods and Findings in Experimental and Clinical Pharmacology 1998 20 4 321 328 2-s2.0-0031812336 10.1358/mf.1998.20.4. 485687
156. Cui Y., Yan Z., Hou S., Chang Z., Effect of radix Rehmanniae preparata on the expression of c-fos and NGF in hippocampi and learning and memory in rats with damaged thalamic arcuate nucleus. Zhong Yao Cai 2004 27 8 589 592 2-s2.0-14144256765
157. Choi J. G., Moon M., Jeong H. U., Kim M. C., Kim S. Y., Oh M. S., Cistanches Herba enhances learning and memory by inducing nerve growth factor. Behavioural Brain Research 2011 216 2 652 658 2-s2.0-78149497158 10.1016/j.bbr.2010.09.008
158. Matsumoto C., Kojima T., Ogawa K., Kamegai S., Oyama T., Shibagaki Y., Kawasaki T., Fujinaga H., Takahashi K., Hikiami H., Goto H., Kiga C., Koizumi K., Sakurai H., Muramoto H., Shimada Y., Yamamoto M., Terasawa K., Takeda S., Saiki I., A proteomic approach for the diagnosis of 'Oketsu' (blood stasis), a pathophysiologic concept of Japanese traditional (Kampo) medicine. Evidence-Based Complementary and Alternative Medicine 2008 5 4 463 474 2-s2.0-56749105951 10.1093/ecam/nem049
159. Li C. R., Zhou Z., Zhu D., Sun Y. N., Dai J. M., Wang S. Q., Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitogen-activated protein kinases. International Journal of Biochemistry and Cell Biology 2007 39 2 426 438 2-s2.0-33845221922 10.1016/j.biocel.2006.09.011
160. Zhu Y., Dang S., Hua Z., Advanced achievements about neuroprotective mechanisms of paeoniflorin. Zhongguo Zhong Yao Za Zhi 2010 35 11 1490 1493 2-s2.0-77956104102 10.4268/cjcmm20101129
161. Chunnian H., Yong P., Yuxiong F., Bing P., Zhe W., Peigen X., Quick comparison of Radix Paeonia Alba, Radix Paeonia Rubra, and Cortex Moutan by high performance liquid chromatography coupled with monolithic columns and their chemical pattern recognition. Pharmacognosy Magazine 2012 8 31 237 243 10.4103/0973-1296.99290
162. Lu M. C., Yao C. H., Wang S. H., Lai Y. L., Tsai C. C., Chen Y. S., Effect of Astragalus membranaceus in rats on peripheral nerve regeneration: in vitro and in vivo studies. Journal of Trauma 2010 68 2 434 440 2-s2.0-77249159967 10.1097/TA.0b013e31819adb38
163. Yu J., Zhang Y., Sun S., Shen J., Qiu J., Yin X., Yin H., Jiang S., Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats. Canadian Journal of Physiology and Pharmacology 2006 84 6 579 587 2-s2.0-33750215522 10.1139/Y06-015
164. Tang N. Y., Liu C. H., Su S. Y., Jan Y. M., Hsieh C. T., Cheng C. Y., Shyu W. C., Hsieh C. L., Uncaria rhynchophylla (Miq) Jack plays a role in neuronal protection in kainic acid-treated rats. American Journal of Chinese Medicine 2010 38 2 251 263 2-s2.0-77951673399 10.1142/S0192415X10007828
165. Zhang H. Y., Liu Y. H., Wang H. Q., Xu J. H., Hu H. T., Puerarin protects PC12 cells against β -amyloid-induced cell injury. Cell Biology International 2008 32 10 1230 1237 2-s2.0-52949146386 10.1016/j.cellbi.2008.07. 006
166. Zhang H., Liu Y., Lao M., Ma Z., Yi X., Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. Experimental Gerontology 2011 46 1 30 37 2-s2.0-78649812471 10.1016/j.exger.2010.09.013
167. Sha D., Li L., Ye L., Liu R., Xu Y., Icariin inhibits neurotoxicity of β -amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts. Neuroreport 2009 20 17 1564 1567 2-s2.0-75149115354 10.1097/WNR.0b013e328332d345
168. Ho Y. S., Yu M. S., Yik S. Y., So K. F., Yuen W. H., Chang R. C., Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons. Cellular and Molecular Neurobiology 2009 29 8 1233 1244 2-s2.0-77049085291 10.1007/s10571-009-9419-x
169. Wang Y. H., Du G. H., Ginsenoside Rg1 inhibits β -secretase activity in vitro and protects against A β -induced cytotoxicity in PC12 cells. Journal of Asian Natural Products Research 2009 11 7 604 612 2-s2.0-70449674742 10.1080/10286020902843152
170. Hoi C. P., Ho Y. P., Baum L., Chow A. H. L., Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells. Phytotherapy Research 2010 24 10 1538 1542 2-s2.0-78649413538 10.1002/ptr.3178
171. Zhao H. W., Li X. Y., Ginkgolide A, B, and huperzine A inhibit nitric oxide-induced neurotoxicity. International Immunopharmacology 2002 2 11 1551 1556 2-s2.0-0036801868 10.1016/S1567-5769(02)00093-0
172. Kim E. H., Jang M. H., Shin M. C., Shin M. S., Kim C. J., Protective effect of aqueous extract of Ginseng radix against 1-methyl-4-phenylpyridinium- induced apoptosis in PC12 cells. Biological and Pharmaceutical Bulletin 2003 26 12 1668 1673 2-s2.0-4644325964 10.1248/bpb.26.1668
173. 2-induced cytotoxicity in cultured PC12 cells. Chinese Medicine 2010 5, article 38 2-s2.0-77958602327 10.1186/1749-8546-5-38
174. Li X., Matsumoto K., Murakami Y., Tezuka Y., Wu Y., Kadota S., Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice. Pharmacology Biochemistry and Behavior 2005 82 2 345 352 2-s2.0-28444474253 10.1016/j.pbb.2005.09.004
175. Wang W., Wang D. Q., Progress of study on brain protective effect and mechanism of Polygonum multiflorum. Zhongguo Zhong Xi Yi Jie He Za Zhi 2005 25 10 955 959 2-s2.0-33747886787
176. +-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation. Neuroscience Letters 2010 483 1 1 5 2-s2.0-77956124557 10.1016/j.neulet.2010.07. 027
177. Faust K., Gehrke S., Yang Y., Yang L., Beal M. F., Lu B., Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease. BMC Neuroscience 2009 10, article 109 2-s2.0-70349574602 10.1186/1471-2202-10-109
178. Tian L. L., Wang X. J., Sun Y. N., Li C. R., Xing Y. L., Zhao H. B., Duan M., Zhou Z., Wang S. Q., Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents 6-hydroxydopamine induced apoptosis in SH-SY5Y cells. International Journal of Biochemistry and Cell Biology 2008 40 3 409 422 2-s2.0-39049123781 10.1016/j.biocel.2007.08.005
179. Wang S. X., Hu L. M., Gao X. M., Guo H., Fan G. W., Anti-inflammatory activity of salvianolic acid B in microglia contributes to its neuroprotective effect. Neurochemical Research 2010 35 7 1029 1037 2-s2.0-77953197744 10.1007/s11064-010-0151-1
180. Xia W. J., Yang M., Fok T. F., Li K., Chan W. Y., Ng P.-C., Ng H. K., Chik K. W., Wang C. C., Gu G. J. S., Woo K. S., Fung K. P., Partial neuroprotective effect of pretreatment with tanshinone IIA on neonatal hypoxia-ischemia brain damage. Pediatric Research 2005 58 4 784 790 2-s2.0-25444507106 10.1203/01.PDR.0000180550.99162.BC
181. Shin E. J., Bach J. H., Nguyen T. T. L., Nguyen X. K. T., Jung B. D., Oh K. W., Kim M. J., Ko S. K., Jang C. G., Ali S. F., Kim H. C., Gastrodia elata bl attenuates methamphetamine-induced dopaminergic toxicity via inhibiting oxidative burdens. Current Neuropharmacology 2011 9 1 118 121 2-s2.0-79953065594 10.2174/157015911795016967
182. Hsieh C. L., Chen C. L., Tang N. Y., Chuang C. M., Hsieh C. T., Chiang S. Y., Lin J. G., Hsu S. F., Gastrodia elata BL mediates the suppression of nnos and microglia activation to protect against neuronal damage in kainic acid-treated rats. American Journal of Chinese Medicine 2005 33 4 599 611 2-s2.0-23944451375 10.1142/S0192415X0500320X
183. Li S. Y., Jia Y. H., Sun W. G., Tang Y., An G. S., Ni J. H., Jia H. T., Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus. Free Radical Biology and Medicine 2010 48 4 597 608 2-s2.0-74149085909 10.1016/j.freeradbiomed.2009. 12.004
184. Fan L. H., Wang K. Z., Cheng B., Wang C. S., Dang X. Q., Anti-apoptotic and neuroprotective effects of Tetramethylpyrazine following spinal cord ischemia in rabbits. BMC Neuroscience 2006 7, article 48 2-s2.0-33747161887 10.1186/1471-2202-7-48
185. Park J. H., Lee H. J., Koh S. B., Ban J. Y., Seong Y. H., Protection of NMDA-induced neuronal cell damage by methanol extract of Zizyphi Spinosi Semen in cultured rat cerebellar granule cells. Journal of Ethnopharmacology 2004 95 1 39 45 2-s2.0-4544243070 10.1016/j.jep.2004.06.011
186. Li F. Q., Wang T., Pei Z., Liu B., Hong J. S., Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons. Journal of Neural Transmission 2005 112 3 331 347 2-s2.0-20044389086 10.1007/s00702-004-0213-0
187. Ma C., Wang W., Chen Y. Y., Liu R. N., Wang R. F., Du L. J., Neuroprotective and antioxidant activity of compounds from the aerial parts of Dioscorea opposita. Journal of Natural Products 2005 68 8 1259 1261 2-s2.0-24744466701 10.1021/np050021c
188. Xue B., Jiao J., Zhang L., Li K.-R., Gong Y.-T., Xie J.-X., Wang X.-M., Triptolide upregulates NGF synthesis in rat astrocyte cultures. Neurochemical Research 2007 32 7 1113 1119 2-s2.0-34249695397 10.1007/s11064-006-9253-1
189. Zhang H. Y., Tang X. C., Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. Trends in Pharmacological Sciences 2006 27 12 619 625 2-s2.0-33750943629 10.1016/j.tips.2006.10.004
190. Rafii M. S., Walsh S., Little J. T., Behan K., Reynolds B., Ward C., Jin S., Thomas R., Aisen P. S., A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology 2011 76 16 1389 1394 2-s2.0-79955444505 10.1212/WNL.0b013e318216eb7b
191. Gao L., Xiang L., Luo Y., Wang G., Li J., Qi J., Gentisides C-K: nine new neuritogenic compounds from the traditional Chinese medicine Gentiana rigescens Franch. Bioorganic and Medicinal Chemistry 2010 18 19 6995 7000 2-s2.0-77956649468 10.1016/j.bmc.2010.08.020
192. Cui Y., Yan Z., Hou S., Chang Z., Effect of radix Rehmanniae preparata on the expression of c-fos and NGF in hippocampi and learning and memory in rats with damaged thalamic arcuate nucleus. Zhong Yao Cai 2004 27 8 589 592 2-s2.0-14144256765
193. Zhu Y., Dang S., Hua Z., Advanced achievements about neuroprotective mechanisms of paeoniflorin. Zhongguo Zhong Yao Za Zhi 2010 35 11 1490 1493 2-s2.0-77956104102 10.4268/cjcmm20101129